1.Research progress on immunocyte senescence - review.
Bo YANG ; Xiao-Hua CHI ; Xue-Chun LU ; Shuai TUO ; Feng ZHANG ; Wen-Ying ZHANG ; Chao-Wei TUO ; Wei-Dong HAN ; Shan-Qian YAO
Journal of Experimental Hematology 2012;20(3):782-787
The function of immune system degenerates in an aging-dependent manner and this results in immunosenescence. Human immune system includes two parts: genetic/innate immunity and adaptive immunity. The former is involved in monocytes, nature killer cells, and dendritic cells, the later is involved in acquired B and T lymphocytes. During the aging of immunity system, the both parts of immunity are damaged to some degree. Generally, innate immunity seems well-retained and the acquired immunity is degenerative seriously with aging. Immunocyte senescence is closely related to the elderly decreased ability to control infectious disease, cancer and to their generally poor response to vaccination. This review summarized the research progress on immunosenescence characteristics in aged phase.
Age Factors
;
Aging
;
immunology
;
Antibody Formation
;
immunology
;
Cellular Senescence
;
Humans
;
Immunity, Cellular
;
immunology
;
Lymphocyte Activation
2.The effect of radiation therapy on cellular immune response in patients with squamous cell lung carcinoma.
Soo Taek UH ; Chul Hyun KIM ; Yeon Tae CHUNG ; Yong Hun KIM ; Choon Sik PARK ; Hi Bahl LEE ; Seung Jae HUH
Tuberculosis and Respiratory Diseases 1991;38(1):25-33
No abstract available.
Humans
;
Immunity, Cellular*
;
Lung*
3.Genetic marker and cellular immune response of Behcet's disease.
Kyung Sook PARK ; Ho Youn KIM ; Dong Jun PARK
Korean Journal of Immunology 1991;13(1):99-104
No abstract available.
Genetic Markers*
;
Immunity, Cellular*
4.Advances in methodologies for evaluating cell-mediated immune responses.
Zhanhao LU ; Rui LUO ; Tao WANG ; Dailang ZHONG ; Hua-Ji QIU ; Yuan SUN
Chinese Journal of Biotechnology 2023;39(12):4759-4772
Cell-mediated immune response is an important part of machinery in maintaining the body's homeostasis. After the innate immune system selectively activates the adaptive immune system, the cell-mediated immunity exerts its killing and clearance functions. Therefore, evaluating the level of cell-mediated immune response is crucial in the diagnosis and treatment of cancer, monitoring the immune status after organ transplantation, diagnosing and preventing viral diseases, and evaluating the effectiveness of vaccines and other areas. From the initial overall assessment of the immune effects in vivo to the precise detection of the number and function of multiple immune cells, the evaluation methods of cell-mediated immune response have greatly advanced. However, cell-mediated immune response involves multiple levels in the body, and it's difficult to choose the numerous detection methods available. The article systematically compares the evaluation methods of cell-mediated immune response at four different levels: the organism, the tissue and organ, the immune cells and the immune molecules, with the aim to facilitate the applications of related technologies.
Humans
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Immunity, Cellular
;
Neoplasms/therapy*
;
Immunity, Innate
5.Clinical significance of cellular immunity in the renal interstitium of IgA nephropathy.
Tae See CHUNG ; Young Joo KWON ; Won Yong CHO ; Hyoung Kyu KIM ; Nam Hee WON
Korean Journal of Nephrology 1991;10(2):157-165
No abstract available.
Glomerulonephritis, IGA*
;
Immunity, Cellular*
;
Immunoglobulin A*
6.Clinical significance of cellular immunity in the renal interstitium of IgA nephropathy.
Tae See CHUNG ; Young Joo KWON ; Won Yong CHO ; Hyoung Kyu KIM ; Nam Hee WON
Korean Journal of Nephrology 1991;10(2):157-165
No abstract available.
Glomerulonephritis, IGA*
;
Immunity, Cellular*
;
Immunoglobulin A*
7.Investigation of Cell Mediated Immunity in Patients with Behcet's Syndrome, Using the DNCB Sensitization.
Dong Sik BANG ; Sung Nack LEE ; Duck Hyun KIM ; In Whan NAM
Korean Journal of Dermatology 1985;23(6):769-773
Various immunologic investigations of 159 patients with Behqets syndrome undertaken included; the DNCB sensitization test, total T-cells and T-cell subsets and the lymphocyte transformation test using PHA. The percentage of positive esponsiveness to DNCB decreased in the order of possible (65%), suspected (60%), incomplete (37%) and complete type (37%), The number of patients with impaired LTT was larger in the group of patients with DNCB( + ) responsiveness (seventeen of 32) than in DNCB(+) group (six of 25), There was significant impairment of cell mediated immunity in Behcets syndrome compared to normal subjects, when analyzed by the impaired LTT and decreased proportions of helper T-cells.
Behcet Syndrome*
;
Dinitrochlorobenzene*
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Humans
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Immunity, Cellular*
;
Lymphocyte Activation
;
T-Lymphocyte Subsets
;
T-Lymphocytes
;
T-Lymphocytes, Helper-Inducer
8.Lymphocyte and Serum Immunoglobulin Studies in Behcet's Syndrome.
Eun So LEE ; Dong Sik BANG ; Seung Hun LEE ; Sung Nack LEE
Korean Journal of Dermatology 1987;25(6):734-744
In our investigation, various immunologic aspects of 129 patients with complete and incomplete type of Behcet's syndrome were taken under consideration : quantitation of total T-cells by E-rosette method and B-cells by EAC-rosette method, helper/inducer T and suppressor/cytotoxic T-cells by monoclonal antibody technique(OKT4, OKT8), lymphocyte transformation test with PHA, quantitation of serum r-globulin by electro phoresis and quantitations of serum IgG, IgA, IgM, C3, C4 by immunodiffusion. From the results, the cell mediated immunity in Behcet's syndrome is not influenced by the number of patterns of four major symptoms or the activity of each major symptom at the time of test. However the humoral immunity is considered to be influenced by the above parameters.
B-Lymphocytes
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Behcet Syndrome*
;
Humans
;
Immunity, Cellular
;
Immunity, Humoral
;
Immunodiffusion
;
Immunoglobulin A
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Immunoglobulin G
;
Immunoglobulin M
;
Immunoglobulins*
;
Lymphocyte Activation
;
Lymphocytes*
;
T-Lymphocytes
9.The effects of RU 41.740, a glycoprotein extract from klebsiella pneumoniae, on peripheral blood mononuclear cells.
Moon Kyu KIM ; Dong Soo KIM ; Hyun Ok KIM
Journal of the Korean Pediatric Society 1992;35(8):1066-1072
No abstract available.
Glycoproteins*
;
Immunity, Cellular
;
Klebsiella pneumoniae*
;
Klebsiella*
10.Regulation of cellular immunity in cryptococcosis III. induction ofcryptococcus neoformans-specific T cells and hybridoma.
Tai You HA ; Young Min PARK ; Yoon Kyu PARK ; Hern Ku LEE ; Chong Wook PARK
Korean Journal of Immunology 1992;14(1):15-23
No abstract available.
Cryptococcosis*
;
Hybridomas*
;
Immunity, Cellular*
;
T-Lymphocytes*