Amitriptylin hydrochloride is used as the internal standard in place of desipramine hydrochloride to determine the amount of imipramine hydrochloride by HPLC method. Results: Amitriptylin have the same structure as imipramin and the resolution degree between amitriptylin and imipramin is 1.8 while resolution degree between iminodibenzyl and imipramin is very high (R=10.7) because molecule structure of iminodibenzyl do not have branch-circuit. The suitability of chromatographic system through coefficient got high stable results with RSD<1.0%. Amitryptilin hydrochloride can be used as the internal standard in place of desipramine hydrochloride if necessary to test splitting degree in determination of imipramine hydrochloride
Imipramine ; Chromatography ; High Pressure Liquid

No abstract available.
Animals ; Imipramine* ; Lymphocytes* ; Plasma* ; Rats*

Cyclic vomiting syndrome is characterized by recurrent episodes of stereotyped vomiting separated by regular symptom-free periods. We describe a case of cyclic vomiting syndrome developed after stroke, which has not been reported to date. A 69-year-old woman experienced recurrent vomiting following left cerebral infarct. The patient's vomiting pattern was consistent with cyclic vomiting syndrome, and the diagnosis of cyclic vomiting syndrome was established by exclusion of other known disorders which could have resulted in vomiting. She was treated with imipramine hydrochloride and her symptom was well controlled.
Aged ; Female ; Humans ; Imipramine ; Stroke ; Vomiting

No abstract available.
Animals ; Cerebral Cortex* ; Imipramine* ; Rats* ; Receptors, Adrenergic*

No abstract available.
Child* ; Deamino Arginine Vasopressin* ; Humans ; Imipramine*

The treatment of choice for primary nocturnal enuresis (PNE) in Korea remains imipramine which has proven to be effective in approximately 50 to 80%, but it is an antidepressant with toxic side effects and risk of overdose. Recently desmopressin (DDAVP, 1-desamino-8-Darginine-vasopressin) has been introduced for the treatment and its effect has been promising in many reports. To find the efficacy and safety of intranasal desmopressin, we evaluated the results of therapy in 48 enuretic children (34 boys and 14 girls). Mean age was 9.8 years (range 5-16). All the children were evaluated at least 3 months after the treatment with intranasal desmopressin. The overall response rate was 83.3%. The number of wet night per week before and after intranasal desmopressin treatment was 6.42 and 1.83 nights per week respectively. No side effects were observed. These data shows that the intranasal desmopressin therapy is effective and safe for the treatment of PNE.
Child ; Deamino Arginine Vasopressin* ; Enuresis ; Humans ; Imipramine ; Korea ; Nocturnal Enuresis*

PURPOSE: To evaluate the effectiveness of combined imipramine and desmopressin in the treatment of enuretic patients who did not respond to imipramine. MATERIALS AND METHODS: Initially 83 children were treated with imipramine, as a primary treatment for 4 weeks. To 38 patients who did not respond to imipramine, low-dose desmopressin were additionally given per os. During the study, the patients were divided into three categories; 1) complete responder with 0-1 wet nights per week, 2) intermediate responders with 2-3 wet nights per week and 3) non-responders with more than three wet nights per week. RESULTS: The response rate of combined imipramine and desmopressin was 73.7% (28/38) and 11 patients out of 28 patients showed recurrence after the discontinuation of medication. No serious side effects were observed. CONCLUSIONS: Combined therapy was effective in enuretic children who did not respond to imipramine treatment.
Child ; Deamino Arginine Vasopressin* ; Enuresis* ; Humans ; Imipramine* ; Recurrence

BACKGROUND: We examined the usefulness of urine osmolality, as a predictive factor in the treatment of monosymptomatic nocturnal enuresis (NE) with combination therapy of imipramine and desmopressin. METHODS: From May 2014 to April 2015, 59 monosymptomatic NE patients participated in this study. Early morning urine osmolality was measured at 1 week and 1 day before combination therapy of imipramine and desmopressin, and at 1 week and 2 weeks after therapy. The response to combination therapy was evaluated at 3 months after treatment. The mean period of combination therapy was 6.4+/-4.2 weeks. Therapeutic response was classified as complete (0-1 wet night/week), partial (over 50% reduction of night) and non-responders (less than 50% reduction of night). RESULTS: The cumulative rate of the complete and partial responders was 76.3%. Among the 3 groups, the statistically lowest value of pre-treatment urine osmolality was observed in the complete responder group (p<0.001). Urine osmolality increased in all groups after treatment, however, statistically the greatest difference between pre and post-treatment urine osmolality was observed in the complete responder group (p=0.024). No serious side effects were observed. CONCLUSION: Early morning urine osmolality and change of urine osmolality between pre and post-treatment have predictive values in the response to combined imipramine and desmopressin for treatment of monosymptomatic NE.
Deamino Arginine Vasopressin* ; Enuresis ; Humans ; Imipramine* ; Nocturnal Enuresis* ; Osmolar Concentration*

These experiments were performed to investigate the effect of saline, stress, imipramine, stress -imipramine and/or stress -tryptophan on serotonin immunoreactivity in raphe nucleus of the rats (200 ~220 g, body weight). The animals were injected i.p. with imipramine (15 mg/kg) and tryptophan (15 mg/kg) after electric shocks for 20 days. The result by immunohistochemical methods were as follows; 1. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were significantly increased in stress treated group compared to saline treated group. 2. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were decreased in imipramine treated group compared all the other group. 3. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were significantly decreased in stress -imipramine treated group compared to stress alone treated group but were significantly increased in stress -imipramine treated group compared to imipramine treated group. 4. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were significantly increased in stress -tryptophan treated group compared to stress alone and saline treated group. These experiments indicated that serotonin immunoreactive neurons in raphe nucleus of midbrain were increased due to the activation of stress and decreased by suppresing activation of stress through imipramine treatment.
Animals ; Imipramine* ; Mesencephalon ; Neurons ; Raphe Nuclei* ; Rats* ; Serotonin ; Shock ; Tryptophan*

These experiments were performed to investigate the effect of saline, tryptophan, tryptophan-imipramine and/or imipramine on serotonin immunoreactivity in raphe nucleus of midbrain of the rats (180~200 g, body weight). The animals were injected i.p. with tryptophan (15 mg/kg) and imipramine (15 mg/kg) for 20 days. The result by immunohistochemical methods were as follows; 1. Serotonin-immunoreactive neurons in the raphe of midbrain were significantly increased in tryptophan treated group compared to imipramine treated group. 2. Serotonin-immunoreactive neurons in the raphe of midbrain were decreased in imipramine treated group compared all the other group. 3. Serotonin-immunoreactive neurons in the raphe of midbrain were significantly decreased in tryptophanimipramine treated group compared to imipramine treated group. These experiments indicated that serotonin immunoreactive neurons in raphe of midbrain were increased due to the activation of tryptophan and decreased by suppresing activation of tryptophan through imipramine treatment.
Animals ; Imipramine* ; Mesencephalon* ; Neurons ; Raphe Nuclei* ; Rats* ; Serotonin ; Tryptophan*