BACKGROUND: Centrotemporal spikes (CTS) are the hallmark of the syndrome of benign childhood epilepsy with centrotemporal spikes or Rolandic seizures. However, they also can be encountered in other symptomatic epilepsies or may incidentally be found in non-epileptic children with or without neurological symptoms. We investigated clinical and electroencephalographic characteristics of children with CTS on EEG. METHODS: A 7 year material of children with CTS on EEG were reviewed. Sixty-eight children were found. RESULTS: Among them, 55 patients exhibited recurrent rolandic seizures of benign course (so-called benign rolandic epilepsy ; BRE), 9 children suffered from chronic headache without clinical seizure, three patients showed multiple types of seizures or rolandic seizures with some degree of mental retardation, and one child was asymptomatic. In 55 BRE cases, seven children (13%) had a preceding history of febrile convulsions, and a positive family history of epilepsy was found in 9 patients. Generalized spike and wave discharges were observed in 9 patients (16.7%), but none of them experienced clinical absence seizure. In 25 of 29 BRE patients who showed overt lateralized ictal manifestations on history, symptoms were correlated with the main foci of spike discharges. Of the nine children, found to have CTS during evaluation of chronic intermittent or daily headache, the headache was successfully controlled by antiepileptic drugs in two cases. CONCLUSION: Most children with CTS were compatible to the BRE without any causative lesional factor. However, nonepileptic cases were not uncommon and, though rare, atypical cases were also present in children with CTS on EEG.
Anticonvulsants ; Child* ; Electroencephalography* ; Epilepsy ; Epilepsy, Absence ; Epilepsy, Rolandic ; Headache ; Headache Disorders ; Humans ; Intellectual Disability ; Seizures ; Seizures, Febrile

No abstract available.
Aminosalicylic Acid* ; Cycloserine* ; Prothionamide* ; Retreatment* ; Tuberculosis, Pulmonary*

Trichogenic tumors are very rare and described as cutaneous neoplasms probably derived from hair germ which develops into hair follicles. We report a case of trichoblastic fibroma on the left parietal scalp of a 45-year-old man. The lesion was a solitary, firm, non-tender, 2×2cm subcutaneous nodule. The histopathological study showed a well circumscribed dermal tumor composed of abundant basophilic palisading basaloid lobules with some keratinous cysts, hair follicle differentiation and fibroblastic stroma.
Basophils ; Fibroblasts ; Fibroma* ; Hair ; Hair Follicle ; Humans ; Middle Aged ; Rabeprazole ; Scalp

No abstract available.
Humans

Seizure induced transient brain CT or MRI abnormalities following status epilepticus have previously been reported. However, focal transient imaging abnormalities involving hippocampus or mesial temporal lobe as a consequence of seizure are rare findings. We report 2 patients with transient mesial temporal abnormalities on MRI associated with partial seizure of temporal lobe origin. A 59-year-old man with a 4-month history of occasional epigastric rising sensation had developed frequent olfactory hallucination 7 days prior to presentation. On brain MRI, T2 signal was increased in the right mesial temporal region, and the lesion showed mild mass effects and partial enhancement after gadolinium injection. Interictal spikes were noted from right nasopharyngeal electrode, but there was no clinical or electrical evidence of status epilepticus during prolonged scalp/sphenoidal EEG monitoring. His seizures were successfully controlled by phenytoin. T2 high signal was markedly decreased and prior enhancement was no longer seen on brain MRI done 5 weeks later. A 33-year old woman with a 6 month history of occasional vacant staring and oral automatism with amnesia complained progressive memory impairment. Right amygdala and hippocampal head was enlarged and showed T2 high signal without contrast enhancement. EEG with sphenoidal electrodes showed right sphenoidal spikes. Her seizures were controlled by carbamazepine and brain MRI became unremarkable 6 weeks later. Suggested mechanisms and significance of the transient imaging abnormalities following seizures will be briefly reviewed.
Adult ; Amnesia ; Amygdala ; Automatism ; Brain ; Carbamazepine ; Electrodes ; Electroencephalography ; Female ; Gadolinium ; Hallucinations ; Head ; Hippocampus ; Humans ; Magnetic Resonance Imaging ; Memory ; Middle Aged ; Phenytoin ; Seizures* ; Sensation ; Status Epilepticus ; Temporal Lobe*

No abstract available.
Cranial Nerve Diseases ; Uveitis*

Isolated left brachiocephalic artery with right aortic arch is extremely rare congenital anormaly. This malformation can cause subclavian steal phenomenon. We report the duplex sonographic and conventional angiographic findings of isolated left brachiocephalic artery in a 22-year-old female presented with dizziness.
Aorta, Thoracic ; Arteries ; Dizziness ; Female ; Humans ; Subclavian Steal Syndrome ; Young Adult

A 7 year-old girl presented with generalized muscle weakness and delayed motor development. She was able to stand up at 15 months and began to walk at 4 years of age. A nerve conduction study showed severe demyelinating neuropa-thy .There was no family history of peripheral neuropathy, and her parents and younger brother were clinically and electrophysiologically normal. A sural nerve biopsy showed moderate loss of myelinated fibers with onion-bulb forma-tions. Many teased nerve fibers revealed typical tomaculous changes. However the molecular genetic study of the patient confirms the duplication of 17p11.2-p22 on a polymerase chain reaction using D17S261 as a primer but not in her parents.
Biopsy ; Charcot-Marie-Tooth Disease ; Child ; Female ; Genotype ; Humans ; Molecular Biology ; Muscle Weakness ; Myelin Sheath ; Nerve Fibers ; Neural Conduction ; Parents ; Peripheral Nervous System Diseases ; Phenotype ; Polymerase Chain Reaction ; Siblings ; Sural Nerve

PURPOSE: No precise data are available showing how magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) can be applied to diagnosis for the first attack of a suspected cerebrovascular disease in Korea. The purpose of this study was to evaluate the application level of MRI and MRA as diagnostic tools and the related factors to the use of these techniques. MATERIALS AND METHODS: This study used the health benefit claim data of 89,890 patients who were hospitalized for the first time due to suspected cerebrovascular disease in 2007 without having visited medical institutions as an outpatient or inpatient from 2003 to 2006. RESULTS: Of the 89,890 cases, 28.4% took both MRI and MRA, 10.7% took only MRI and 6.9% took only MRA. The related factors identified in the multivariate logistic regression analysis were gender, type of insurance, type of medical institution, type of department, duration of hospitalization, and type of disease. CONCLUSION: This study showed that the application level of MRI and MRA as diagnostic measures for the first attack of a suspected cerebrovascular diseases varied depending on several factors. It is necessary to study more accurate levels of computerized tomography (CT), computerized tomography angiography (CTA), MRI or MRA as measures to diagnose a first attack of suspected cerebrovascular disease.
Adolescent ; Adult ; Aged ; Cerebral Angiography ; Cerebrovascular Disorders/*diagnosis/radiography ; Female ; Humans ; Magnetic Resonance Angiography/*utilization ; Magnetic Resonance Imaging/*utilization ; Male ; Middle Aged ; Odds Ratio ; Republic of Korea ; Tomography, X-Ray Computed ; Young Adult

No abstract available.
Brain Diseases* ; Brain Stem* ; Humans ; Hypertensive Encephalopathy ; Stroke, Lacunar*