Symptomatic pacing lead-associated thrombosis is very uncommon occurring in 0.5-3.5% of pacemaker implants. Especially thrombisis-induced total occlusion occures almost in late stage over several months to years but acute thrombosis occurring several days after venous pacing has not been reported. In this case, We performed upper limb venography in the patient who presented edema and pain of neck, left upper limb and headache as well as intermittent cough occurring in bending forward. A venogram confirmed acute thrombus completely occluding the left brachiocephalic vein and the patient received intravenous heparin and was maintained on warfarin. Repeated veno- graphy after treatment for 30 days revealed persistent thrombus with total occlusion which not be improved signi- ficantly copmpared to previous venogram and collateral veins diverting the blood to the contralateral side and into the superior vena cava was developed. The patient's symptoms resolved almost and that is likely to be due to the development of collateral venous channels.
Brachiocephalic Veins* ; Cough ; Edema ; Headache ; Heparin ; Humans ; Neck ; Phlebography ; Thrombosis* ; Upper Extremity ; Veins ; Vena Cava, Superior ; Warfarin

PURPOSE: A part of seizure disorders, hemosiderin deposits are noted in epileptogenic lesions cytopathologically and iron status may affect the seizure threshold. To investigate this possibility, measures of iron sufficiency were evaluated. METHODS: Children between 6 months and 5 years of age with febrile illnesss with (n=45) or without simple febrile seizures(n=50) were eligible for study. Children with the central nervous system(meningitis or encephalitis) infection, developmental delay, neurologic deficit, or past history of febrile seizures were excluded. RESULTS: The hemoglobin level was 11.99+/-0.96 gm/dL in the febrile seizure and 11.44+/-1.6 gm/dL in the control group. The mean corpuscular volume was 77.9+/-6.2 fL in the febrile seizure group and 74.6+/-10.5 fL in the control group. The mean corpuscular hemoglobin was 26.8+/-2.1 pg in the febrile seizure group and 25.4+/-3.6 pg in the control group. The platelet count was 348.6+/-141.4(x10(9)/L) in the febrile seizure group and 382.3+/-107.3(x10(9)/L) in the control group. The ferritin was 27.5+/-20.2 mg/L in the febrile seizure group and 22.5+/-15.6 mg/L in the control group. CONCLUSION: A relationship between iron deficiency and a reduced risk of febrile seizures is consistent with the study hypothesis that iron deficiency may thereby raise the febrile seizure threshold. Therefore, the effects of antioxidants on the frequency of febrile seizures could be evaluated to test this hypothesis more directly. Studies using iron chelators would be necessary to delineate these possible effects.
Anemia ; Anemia, Iron-Deficiency* ; Antioxidants ; Chelating Agents ; Child ; Epilepsy ; Erythrocyte Indices ; Ferritins ; Hemosiderin ; Humans ; Iron* ; Neurologic Manifestations ; Platelet Count ; Seizures ; Seizures, Febrile*

PURPOSE: A part of seizure disorders, hemosiderin deposits are noted in epileptogenic lesions cytopathologically and iron status may affect the seizure threshold. To investigate this possibility, measures of iron sufficiency were evaluated. METHODS: Children between 6 months and 5 years of age with febrile illnesss with (n=45) or without simple febrile seizures(n=50) were eligible for study. Children with the central nervous system(meningitis or encephalitis) infection, developmental delay, neurologic deficit, or past history of febrile seizures were excluded. RESULTS: The hemoglobin level was 11.99+/-0.96 gm/dL in the febrile seizure and 11.44+/-1.6 gm/dL in the control group. The mean corpuscular volume was 77.9+/-6.2 fL in the febrile seizure group and 74.6+/-10.5 fL in the control group. The mean corpuscular hemoglobin was 26.8+/-2.1 pg in the febrile seizure group and 25.4+/-3.6 pg in the control group. The platelet count was 348.6+/-141.4(x10(9)/L) in the febrile seizure group and 382.3+/-107.3(x10(9)/L) in the control group. The ferritin was 27.5+/-20.2 mg/L in the febrile seizure group and 22.5+/-15.6 mg/L in the control group. CONCLUSION: A relationship between iron deficiency and a reduced risk of febrile seizures is consistent with the study hypothesis that iron deficiency may thereby raise the febrile seizure threshold. Therefore, the effects of antioxidants on the frequency of febrile seizures could be evaluated to test this hypothesis more directly. Studies using iron chelators would be necessary to delineate these possible effects.
Anemia ; Anemia, Iron-Deficiency* ; Antioxidants ; Chelating Agents ; Child ; Epilepsy ; Erythrocyte Indices ; Ferritins ; Hemosiderin ; Humans ; Iron* ; Neurologic Manifestations ; Platelet Count ; Seizures ; Seizures, Febrile*

The typical radiographic findings of bronchiolitis obliterans organizing pneumonia (BOOP) are known to be patchy air-space consolidation that is often subpleural, and with or without ground-glass opacities. However, there are scant radiologic reports about the micronodular pattern of BOOP. We report here on a case of BOOP that manifested as diffusely scattered ill-defined centrilobular micronodules on HRCT.
Bronchiolitis Obliterans* ; Bronchiolitis* ; Cryptogenic Organizing Pneumonia*

It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the LD50 was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its LD50 was very high over 5 g/kg and any side effects were not found.
Animals ; Blood Pressure ; Body Temperature ; Cats ; Contracts ; Drinking ; Esophagitis ; Ethanol ; Gastritis ; Guinea Pigs ; Heart Rate ; Intestine, Large ; Lethal Dose 50 ; Mice ; Rats ; Respiration ; Seizures ; Stereotyped Behavior