No abstract available.
Statistics as Topic*

No abstract available.
Humans ; Pneumoconiosis*

No abstract available.
Ultrasonography, Prenatal*

The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease (CKD) to predict putative microRNA (miRNA) in CKD-mineral bone disorder (CKD-MBD) and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system.PubMed searches using MeSH terms and keywords related to CKD,uremia,and mRNA arrays were conducted.Through a computational analysis,a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD-MBD was determined.Additionally,changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells.A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified.Furthermore,miRNA expression profiles were inferred,and computational analyses were performed with the imputed microRNA regulation based on weighted ranked expression and putative microRNA targets (IMRE) method to identify miRNAs associated with CKD occurrence.TLR4 and miR-146b levels were significantly associated with CKD-MBD.TLR4 levels were significantly downregulated,whereas pri-miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells.Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis,and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.

No abstract available.
Animals ; Rats*

No abstract available.
Animals ; Coal* ; Dust* ; Lung* ; Rats* ; Silicon Dioxide*

We describe a case of cavitary metastasis to the lungs from a small angiosarcoma of the scalp, in which themetastatic lesions were complicated by pneumothorax and pulmonary hemorrhage. On high-resolution CT, the lesionssimulated the findings of Langerhans cell histiocytosis. Thin-walled cavitary metastatic lesions were similar tothose of thin walled air cysts in Langerhans cell histiocytosis. Ground-glass opacity simulated the findings ofsmoke r's respiratory bronchiolitis in Langerhans cell histio-cytosis but histologically represented hemorrhageduring metastasis of the angiosarcoma.
Bronchiolitis ; Hemangiosarcoma* ; Hemorrhage ; Histiocytosis, Langerhans-Cell ; Lung* ; Neoplasm Metastasis ; Pneumothorax ; Sarcoma ; Scalp

Background: The brain magnetic resonance imaging (MRI) findings seen in patients with Bell's palsy are abnormal contrast enhancement of affected facial nerves. Previous evaluation included mainly patients who had experienced palsy for several weeks and there are no studies to date on patients with late stage of Bell’s palsy. This study investigated the findings of MRI of Bell's palsy after 3 months of symptom onset to assess how long the enhancement last. Methods: Among the patients with Bell's palsy (idiopathic unilateral facial palsy) who visited the hospital, 9 patients who underwent contrast-enhanced MRI of the internal auditory canal after 3 months of symptom onset were reviewed retrospectively. MRI examination results were investigated along with the patient's clinical symptoms and electrodiagnostic test results. Based on the MRI results, the frequency of abnormal contrast enhancement and contrast-enhanced areas were investigated. Results: 9 patients were included. 6 of them did MRI imaging because of incomplete recovery of facial palsy and the others did because of complication of facial palsy including synkinesis and hemifacial spasm. Time interval between symptom onset and evaluation was 17 months (3-84). Of 9 patients, 2 showed abnormal enhancement of affected nerve and they performed MRI after 5 months and 12 months of symptom onset, respectively. Conclusions Abnormal enhancement of facial nerve in Bell’s palsy could last up to one year. This awareness can be helpful in interpretation of MRI of Bell’s palsy.

BACKGROUND AND OBJECTIVES: We aimed to assess the usefulness of a threshold-based, 3-dimensional (3D) segmentation in comparison with the traditional 2-dimensional (2D) short axis-based method for measurement of epicardial fat volume with 64-slice multidetector computed tomography (MDCT). SUBJECTS AND METHODS: One hundred patients (52 males; mean age, 58.36+/-11.0 years) who underwent coronary CT angiography were enrolled in this study. The epicardial fat volume was measured using the two methods. The existing method was the 2D short axis-based method and the new method was the threshold-based 3D segmentation. Pearson's correlation was used to compare the two measurement methods. We also assessed the relationship between the epicardial fat volume and coronary artery disease (CAD). RESULTS: There were a strong correlation between the epicardial fat volumes determined using the two methods (r=0.956, p<0.001). The mean overestimation of epicardial fat volume by the threshold-based 3D method was 59.89+/-12.00% compared to the 2D short-axis based method. Using the 3D method, the epicardial fat volume was significantly higher in the CAD group than in the controls (165.07+/-48.22 cm3 vs. 108.39+/-48.03 cm3, p<0.001). CONCLUSION: Threshold-based 3D segmentation is another easy and useful tool for measuring the epicardial fat volume.
Angiography ; Coronary Artery Disease ; Humans ; Intra-Abdominal Fat ; Multidetector Computed Tomography ; Pericardium ; Tomography, X-Ray Computed