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5.Electron Microscopic Study of the Renal Proximal and Distal Convuluted Tubular Epithelial and Distal Convoluted Tubular Epithelial Cells after Administration of Aspirin.

Sung Gum HONG ; Cheul Woon BACK ; Im Ju KANG ; Byung Heon KIM ; Dong Koo LEE

Journal of the Korean Pediatric Society 1983;26(6):564-572

6.Significance of Eosinophils and Eosinophil Cationic Protein in Induced Sputum in Childhood Asthma.

Seung Hee JUNG ; Do Young SONG ; Im Ju KANG

Pediatric Allergy and Respiratory Disease 1999;9(2):167-177

PURPOSE: Airway eosinophilic inflammation is a characteristic feature of asthma. Sputum analysis can be used as a non-invasive tool to assess severity of the airway inflammation. This study was performed to compare relationships between sputum eosinophils to other parameters of airway inflammation and to evaluate the clinical utility of sputum eosinophils and ECP in childhood asthma. METHODS: A total of 40 asthmatic children over 6 years of age were divided into two groups : Group A of 15 current symptomatic subjects and Group B of 25 stable asymptomatic subjects with history of asthma for 2 weeks. Eosinophils in induced sputum were compared with the severity of asthma symptom, pulmonary function, bronchial hyperresponsiveness by methacholine, sputum ECP, blood eosinophils and serum ECP. RESULTS: 1) Asthmatics had a significantly higher proportion of sputum eosinophils than the control subjects (15.2+/-17.8% VS 3.8+/-4.5%, P<0.01). Group A had a significantly higher proportion of sputum eosinophils than group B (22.9+/-21.7% VS 11.2+/-14.8%, P<0.05). 2) Sputum eosinophils were correlated with symptom scores in asthmatics (r=0.76, P<0.01), inversely correlated with FEV1 in group A (r=-0.65, P<0.01) and with LogPC20 in group B (r=-0.45, P<0.05). 3) Sputum eosinophils were correlated with sputum ECP for group A; r=0.77 (P<0.01) and for group B; r=0.39 (P<0.05) but not correlated with serum ECP. 4) Sputum eosinophils were correlated with blood eosinophils in group A (r=0.67, P<0.05), but not in group B. CONCLUSION: This study suggests that the proportion of eosinophils and the level of ECP in induced sputum may be sensitive and accurate means of assessing the airway inflammation in childhood asthma, and their relationships with blood eosinophils or serum ECP are to be studied further.
Asthma* ; Child ; Eosinophil Cationic Protein* ; Eosinophils* ; Humans ; Inflammation ; Methacholine Chloride ; Sputum*

1.Splenomegaly and Splenectomy.

2.Significance of Brain CT in Children with Seizure.

3.A Case of Congenital Hypoplastic Anemia.

4.A Study on Twins.

5.Electron Microscopic Study of the Renal Proximal and Distal Convuluted Tubular Epithelial and Distal Convoluted Tubular Epithelial Cells after Administration of Aspirin.

6.Significance of Eosinophils and Eosinophil Cationic Protein in Induced Sputum in Childhood Asthma.

7.One Case of Infantile Nephrotic Syndrome.

8.Clinical Observation of Acute Viral Hepatitis in Childhood.

9.Clinical Study of Urinary Tract Infection in Children and Infancy and the Significance of IVP.

10.Clinical Study of Urinary Tract Infection in Children and Infancy and the Significance of IVP.

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