We report a case of Buerger's disease manifested by a scrotal mass, in view of its rarity. A tender bean sized mass was palpated in the left scrotum of a 34 year-old male heavy smoker, who had a history of right pain two years ago which subsided spontaneously. The left testis with the paratesticular tissue was excised. Vessels of the spermatic cord and epididymis showed microscopic changes of Buerger's disease. The involved arteries and veins revealed a predominantly subacute pattern with granulomatous inflammation and Langhans' type giant cells within the thrombi.
Male ; Humans

To elucidate the significance of the nesidiodysplasia of pancreas, histological re-evaluation and immunohistochemical studies for insulin, glucagon and somatostatin were done on 16 consecutive cases (5 premature babies, 2 stillborns, 5 infants and 3 adults) in which paraffin blocks of the pancreas were available. Only one infant was hypoglycemic. All 16 pancreases showed changes of nesidiodysplasia which appeared immunohistochemically to have isulin, glucagon and /or somatostatin. The histologic patterns of nesidiodysplasia included ductoendocrine proliferation, endocrine cell dysplasia, adenomatosis, septal islet, islket cell hypertrophy and islet hypertrophy. All the patterns of nesidiodysplasia except for the adenomatosis were seen in premature babies, infants, stillborns and adults with or without hypoglycemia. The adenomatosis was found only in the hypoglycemic infant. The result suggests that all patterns of nesidiodysplasia of other than the adenomatosis does not imply the pathologic basis of hypoglycemia.
Infant ; Adult ; Male ; Female ; Humans

This is to describe a neonatal hepatitis with pericellular hepatic fibrosis and Mallory bodies in a sero-positive infant for IgM anti-CMV. A necropsy of the liver revealed severe heaptocellular swelling with many intracytoplasmic hyaline bodies, pronounced fibrosis of a creeping type, bile stasis with ductular proliferation, and the lack of parenchymal regeneration. These microscopical changes of the liver resembled those of Indian Childhood Cirrhosis (ICC). In the present case the patient's serum IgM anti-CMV is the only clue for the etiological diagnosis.
Infant ; Child ; Male ; Female ; Infant, Newborn ; Humans

No abstract available.
Nevus, Pigmented*

Pancreatic islet cell adenoma is a benign tumor of pancreatic beta-cell and a rare cause of hyperinsulinemic hypoglycemia in children. The authors experienced a case of pancreatic islet cell adenoma(Insulinoma)in a 11 year and 8 month old male who had frequent loss of consciousness and seizure. Enucleation was done after localization of tumor by selective celiac artery angiography and abdominal computed tomography. Diagnosis was confirmed by histologic findings as pancreatic-adenoma, gyriform growth pattern. A brief review of related literature was made.
Adenoma* ; Angiography ; Celiac Artery ; Child ; Diagnosis ; Humans ; Hyperinsulinism ; Hypoglycemia ; Infant ; Islets of Langerhans ; Male ; Seizures ; Unconsciousness

In order to observe the effect on cardiovascular depression due to ether, halothane or penthrane anesthesia with pretreatment of propranolol (1mg) , change in the blood pressure and pulse rate were measured after intravenous administration of atropine(0.5mg), ephedrine(20mg) or aramine(2mg) to healthy volunteers. The results were as follos, 1) In conscious patients, intravenous administration of propranolol(1mg) caused a statistically significant decrease in pulse rate but no significant change in the blood pressure. 2) The atropine group showed that blood pressure increased by 33/23(p<0.01), 15/13(p<0.01) and 3/4(NS) mmHg, and pulse rate also increased by 20(p<0.01), 24(p<0.05), 11(p<0.05) per min. respectively during ether, halothane and penthrane anesthesia. 3) The ephedrine group showed that blood pressure decreased by 5/0(NS) during ether anesthesia, and increased by 27/17(p<0.01) and 30/15(p<0.01) mmHg during halothane and penthrane anesthesia respectively. Pulse rate decreased by 7(p<0.05) per min. during ether anesthesia but showed no significant change during halothane and Penthrane anesthesia. 4) The aramine group showed that blood pressure increased by 70/34(p<0.01), 29/19(p<0.01) and 28/19Ip<0.001) mmHg during ether, halothane and Penthrane anesthesia respectively. Pulse rate increased by 7(NS) per min. during ether anesthesia and decreased by 8(p<0.05) per min. during halothane and Penthrane anesthesia respectively. 5) The above results have shown that atropine caused effective correction of the cardiovascular depression induced by ether, halothane and Penthrane anesthesia with pretreatment of propranolol. Ephedrine showed futher depression and aramine effected elevation of the blood pressure.
Administration, Intravenous ; Anesthesia* ; Atropine ; Blood Pressure ; Depression ; Ephedrine ; Ether* ; Halothane* ; Healthy Volunteers ; Heart Rate* ; Humans ; Metaraminol ; Methoxyflurane* ; Propranolol*

PURPOSE: Apolipoprotein E (Apo E) is composed of 299 amino acids, and is classified into three subtypes (E2, E3, E4), which respectively have influences on serum lipid levels. Arteriogenic erectile dysfunction (AED) is related to hyperlipidemia, hypertension, DM and traumas of the pelvis and perineum. Therefore, we evaluated the frequency and relationship of an apolipoprotein E gene in patients with erectile dysfunction. MATERIALS AND METHODS: 202 patients, with no history of either trauma in the pelvis or perineum, and radiation therapy, were selected from patients with erectile dysfunction. History taking, physical examination, Apo E genotyping and penile Doppler ultrasonography were performed. Serum cholesterol, triglyceride, high and low density lipoprotein (HDL and LDL), and apolipoprotein A and B were also measured. RESULTS: Apo E genotypes were E2/2, E2/3, E3/3, E2/4, E3/4 and E4/4, with distributions of 0.5, 11.7, 70.4, 0.5, 15.8 and 1.0%, respectively. As a result of penile Doppler ultrasonography, 112 patients turned out to have an AED. In the AED group, the serum triglyceride increased significantly (p<0.05), but there were no differences in the serum cholesterol, HDL, LDL or the apolipoprotein A and B. The distributions of apo E genotypes E2/3, E3/3 and E3/4 were 13.9, 68.6 and 17.6%, respectively, in the AED group. The serum triglyceride (TG) was significantly higher in the E3/4 than the E2/3 or E3/3 genotypes. CONCLUSIONS: AED is related to age, smoking, hypertension, DM and high TG, and the Apo E genotype of E3/4, with a high level of TG. However, an Apo E gene is, generally, not considered a diagnostic tool of erectile dysfunction. In the future, it should be clarified if the Apo E gene can be used as diagnostic tool for AED.
Amino Acids ; Apolipoproteins E ; Apolipoproteins* ; Cholesterol ; Cholesterol, HDL ; Erectile Dysfunction* ; Genotype ; Humans ; Hyperlipidemias ; Hypertension ; Lipoproteins ; Male ; Pelvis ; Perineum ; Physical Examination ; Smoke ; Smoking ; Triglycerides ; Ultrasonography, Doppler

No abstract available.
DNA* ; Lymphoma, Non-Hodgkin*

Classic Kaposi's sarcoma is a human herpesvirus-8 associated with a multicentric lymphoangioproliferative tumor primarily arising in the lower extremities, but rarely in the head and neck. We herein report a 63-year-old man with primary classic Kaposi's sarcoma on the face. He presented with asymptomatic, erythematous papules on the nasal ala which had been noticed 2 months earlier. Histopathologic examination and nested polymerase chain reaction analysis in the tissue disclosed typical features of Kaposi's sarcoma.
Head ; Humans ; Lower Extremity ; Middle Aged ; Neck ; Polymerase Chain Reaction ; Sarcoma, Kaposi*

Antineutrophil cytoplasmic antibodies (ANCA) are closely linked to primary systemic vasculitis, and ANCA detection has became an important diagnostic hallmark of ANCA-associated vasculitis (AAV). However, it has been reported that tuberculosis is associated with positivity for ANCA and it is difficult to differentiate clinically between tuberculosis and AAV. We report a patient with the concomitant appearance of AAV and pulmonary tuberculosis. Positivity for ANCA should be carefully interpreted as indicative of AAV, especially in countries with a high prevalence of tuberculosis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Antibodies, Antineutrophil Cytoplasmic ; Humans ; Peripheral Nerves ; Prevalence ; Systemic Vasculitis ; Tuberculosis ; Tuberculosis, Pulmonary