No Abstract Available.
Humans ; Kidney Failure, Chronic* ; Rupture* ; Tendons*

Purpose: To analyze the causes and to prevent dislocations of the hip joint that occur in patients who underwent revisions of total hip arthroplasties by changing only the polyethylene liners and femoral heads, subsequent to primary total hip arthroplasties. Materials and Methods: We evaluated 28 patients who underwent acetabular component revisions of total hip arthroplasties subsequent to primary total hip arthroplasties. The average age of the patients was 55 years old and all 28 patients had operations through the posterolateral approach. In 17 of the cases, the acetabular cups, polyethylene liners, and femoral heads were changed; in 10 cases, just the polyethylene liners and femoral heads were changed; and in 1 case, only the polyethylene liner was changed. Results: We observed 7 cases of hip dislocations that occurred among a total of 28 cases after revisions of total hip arthroplasties. In all 7 cases, the polyethylene liners and femoral heads were changed, but not the acetabular cups. In additional, in all 7 cases of dislocation, the patients were non-compliant and started weight-bearing prematurely after revisions of the total hip arthroplasties Conclusion: We observed new dislocations in the 7 cases in which the polyethylene liners and femoral heads were changed. The main reasons were inadequate soft tissue tension and hip joint laxity. Therefore, it is necessary to increase the neck length, use elevated rim polyethylene liners, readjust the acetabular cups to their optimal positions, and apply hip abduction braces to patients early after revision of total hip arthroplasties in order to lessen the danger of dislocations.
Acetabulum* ; Arthroplasty ; Braces ; Dislocations* ; Head ; Hip ; Hip Dislocation ; Hip Joint ; Humans ; Neck ; Polyethylene ; Risk Factors* ; Weight-Bearing

No abstract available.
Carbon*

PURPOSE: To assess the effect of intraoperative periarticular local injection in total knee arthroplasty. MATERIALS AND METHODS: We studied 36 patients (72 knees) that underwent bilateral simultaneous primary total knee replacement between October, 2005 and December, 2006. The study group (36 ipsilateral knees) received a 60 ml intraoperative periarticular injection containing a mixture of bupivacaine, epinephrine, morphine, ketorolac, and saline. The injection was made in the posterior capsule and surrounding soft tissues, muscles, and subcutaneous tissues. The control group (36 contralateral knees) did not receive this injection. Postoperative pain levels were evaluated at 2, 8, 24, 48, and 72 hours and 7 and 14 days using the Visual Analogue Scale (VAS). Hemo-vac drains were evaluated at postoperative days 1, 2, 3, 4, and 5. RESULTS: There was no side-to-side difference of VAS in both the study group and the control group according to the side chosen. Preoperative VAS was not significantly different between the two groups. There was a significant decrease in the VAS of the study group patients at 2, 8, 24, 48, and 72 hours postoperative, with the most significant decrease seen at 2 hours. Postoperative bleeding was significantly lower in the study group on the first day, with no difference seen thereafter between the two groups. CONCLUSION: Intraoperative periarticular local injection provides better immediate postoperative pain control in total knee arthroplasty.
Arthroplasty ; Arthroplasty, Replacement, Knee ; Bupivacaine ; Epinephrine ; Hemorrhage ; Humans ; Ketorolac ; Knee ; Morphine ; Muscles ; Pain, Postoperative ; Subcutaneous Tissue

PURPOSE: The purpose of our study is to provide useful information for the prevalence of obesity by the standard weight for height and the relationship of the body image to dieting methods for weight control in children. METHODS: The survey was performed by an anthropometry and a special questionnaire on children in grades 5 to 6 at elementary schools from May to June 1997 in Kwangju city. RESULTS: 1) Selected individuals were categorized into obese, normal, thin by the standard weight for height and body image. The prevalence of obesity by the standard weight for height was 19.5%, normal was 70.5%, thin was 10.1% in males and respectively 10.5%, 66.3%, 23.1% in females. The prevalence of obesity in regards to body image was 18.4%, normal was 58.4%, thin was 23.2% in males and respectively 24.5%, 58.6%, 16.9% in females. 2) The obese body image was 6.8% in normal and thin groups in males and 19.4% in females. The body image of obese children who do not perceive themselves as obese was 32.6% in males and 28.7% in females. 3) The standard body image was 88.8% as realized by themselves, 77.9% when they compared themselves to friends, 62.7% as told by parents, 56.8% as told by friends, and 29.9% when they compared themselves to celebrities. 4) The source of information for dieting treatment was 44% from radio and television, 30% from books, newspapers, magazines, 17% from family and 9% from friends and seniors. 5) The prevalence of dieting according to the standard weight for height was 18.0% in thin, 18.7% in normal and 36.7% in obese group in males and respectively 17.8%, 22.4%, 46.3% in females. There was a statistically significant correlation between males and females (p < 0.0005). 6) The prevalence of dieting up to 2 weeks in the thin and normal groups as recognized by weight centile was 17.3% according to body image. The prevalence of dieting up to 2 weeks in the obese groups was 37.2% according to body image (p < 0.001). CONCLUSION: We suggest that many students perceived their body size incorrectly and tried weight control. The incorrect perception of body size seems to cause the problem of failure to thrive, malnutrition etc. It is necessary for further study to find and prevent side effects by unnecessary weight control and to provide proper health education and management about obesity.
Anthropometry ; Body Image ; Body Size ; Child ; Diet ; Failure to Thrive ; Female ; Friends ; Gwangju ; Health Education ; Humans ; Male ; Malnutrition ; Obesity ; Parents ; Periodicals ; Periodicals as Topic ; Prevalence ; Television

We managed surgically a case of local recurrence in esophageal cancer Twenty month after transthoracic subtotal esophagectomy and csophago-gastrostomy, he su(fared from dysphagia. Chest CT and percutaneous needle aspiration biopsy showed. Local recurrence involving residual esophagus, thyroid gland, posterior membraneous portion of trachea. We did cervical esophagectomy, laryngectomy thyroidectomy, partial resection of trachea and reconstruction with free jejunal antograft successfully.
Biopsy, Needle ; Deglutition Disorders ; Esophageal Neoplasms* ; Esophagectomy ; Esophagus ; Laryngectomy ; Needles ; Recurrence* ; Thyroid Gland ; Thyroidectomy ; Tomography, X-Ray Computed ; Trachea ; Transplants*

PURPOSE: To evaluate usefulness of Navigation system by comparing the radiographic results of femoral and tibial component position between conventional total knee replacement (TKA) and Navigation-assisted TKA. MATERIALS AND METHODS: From December 2003 to January 2006, TKA with Scorpio(R)(Osteonics, NJ,USA) were preformed for 53 knees of 41 patients. Among them, 26 knees (Group A) were operated by conventional TKA and 27 knees (Group B) were by Navigation-assisted TKA. We measured the femorotibial angle (omega), femoral component coronal (alpha) and sagittal angle(gamma), tibial component coronal (beta) and sagittal angle (delta) according to the radiographic evaluation of American Knee Society. We also measured the coronal femoral component angle to the femoral mechanical axis (theta) and femoro-tibial mechanical axis. RESULTS: alpha, omega and thetaangle showed no significant difference between two groups (p>0.05). beta, gammaand delta angle were 89.2+/-1.9, 4.3+/-1.7, 81.4+/-2.9 degree in group A and 90.5+/-1.2, 2.8+/-1.6, 86.6+/-2.2 degree in group B, respectively. There was statistically significant difference in beta, gammaand deltaangle (p<0.05). The range of deviation from desired angle showed no significant difference in femoro-tibial mechanical axis and betaangle. However, there was statistically significant difference in thetaangle with more accuracy in group B (p=0.0001) CONCLUSION: There were statistically significant differences in betaand gammaangle between conventional TKA and Navigation assisted TKA. We could get more accurate femoral component coronal angle to the mechanical axis with the Navigation system.
Arthroplasty* ; Arthroplasty, Replacement, Knee ; Axis, Cervical Vertebra ; Humans ; Knee*

PURPOSE: To compare clinical outcomes after arthroscopic ACL reconstruction using bone-patellar tendon- bone autograft and using fresh-frozen Achilles tendon allograft. MATERIALS AND METHODS: We enrolled 61 patients who underwent anterior cruciate ligament reconstruction by means of bone-patellar tendon-bone autograft or Achilles tendon allograft between March, 2002 and December, 2006. The bone-patellar tendon-bone group included 29 patients (mean age 30.4 years), and the Achilles tendon allograft group included 32 patients (mean age 32.5 years). The mean follow-up was 18.2 months and 25.7 months in each group, respectively. Preoperative and last follow-up clinical results were evaluated through physical examination, KT-2000 arthrometer, stress roentgenogram, IKDC knee rating system, and Lysholm knee score. RESULTS: The mean side-to-side difference in anterior translation, as measured by KT-2000 arthrometer, was significantly improved from 6.4 mm+/-3.0 to 3.2 mm+/-1.9 in the bone-patellar tendon-bone group, and from 7.6 mm+/-3.1 to 2.9 mm+/-2.0 in the Achilles tendon allograft group (p<0.001). The Achilles tendon allograft group improved more significantly than did the bone-patellar tendon-bone group (p=0.045). The mean side-to-side difference on stress roentgenogram was significantly improved from 5.3 mm+/-2.5 to 2.0 mm+/-2.1 in the bone-patellar tendon-bone group, and from 6.0 mm+/-3.4 to 2.2 mm+/-2.1 in the Achilles tendon allograft group (p<0.001). There was no significant difference between the two groups. According to the IKDC knee rating system at last follow-up, 26 (89.7%) patients in the bone-patellar tendon-bone group and 28 (87.5%) patients in the Achilles allograft group were normal or nearly normal. The mean Lysholm knee score significantly improved from 69.9 to 90.2 in the bone-patellar tendon-bone group, and from 64.4 to 91.4 in the Achilles tendon allograft group (p<0.001). CONCLUSION: Both bone-patellar tendon-bone and Achilles tendon allograft groups showed satisfactory clinical results, with no significant difference in outcomes between the groups. We suggest that both bone-patellar tendon-bone autograft and Achilles tendon allograft be considered as graft substitutes for anterior cruciate ligament reconstruction.
Achilles Tendon ; Anterior Cruciate Ligament ; Anterior Cruciate Ligament Reconstruction ; Follow-Up Studies ; Humans ; Knee ; Physical Examination ; Transplantation, Homologous ; Transplants

PURPOSE: To examine the correlation between the Navigation and radiographic measurements for the postoperative mechanical axis and component position in total knee arthroplasty. MATERIALS AND METHODS: From December 2005 to May 2006, Navigation assisted MIS TKA was performed on 46 knees of 34 patients. After fixing the components, the mechanical axis (MA) of the lower extremity, femoral component position to the mechanical axis in the coronal plane (theta), tibial component position in the coronal (beta) and sagittal (sigma) planes was measured using the Navigation. Two observers measured the same angles using the postoperative follow-up radiographs. The measurements were compared and the correlation between the Navigation and radiographic measurement was analyzed. RESULTS: The average Navigation measurements were valgus 0.02+/-1.09 degrees for MA, varus 0.05+/-0.96 degrees for theta, valgus 0.02+/-0.86 degrees for beta and 4.03+/-1.25 degrees for sigma. The mean radiographic measurements of observer 1 were valgus 0.71+/-3.73 degrees for MA, valgus 1.14+/-1.72 degrees for theta, valgus 0.90+/-1.47 degrees for beta and 4.51+/-2.03 degrees for sigma. Those of observer 2 were valgus 0.12+/-3.39 degrees, valgus 0.16+/-1.96 degrees, valgus 0.30+/-1.65 degrees and 3.85+/-1.60 degrees, respectively. CONCLUSION: The average of measurement for the component position showed a statistically significant difference in the MA (p=0.001), theta (p=0.000) and beta (p=0.000) among three groups. There were a relatively high correlation between observer 1 and 2 for the radiographic measurements (r=0.67-0.96). However there was a very low correlation between the Navigation and radiographic measurements (r=0.10-0.39). Therefore, the possibility of a difference between the Navigation and radiographic measurement need to be considered when evaluating the component position.
Arthroplasty* ; Axis, Cervical Vertebra ; Follow-Up Studies ; Humans ; Knee* ; Lower Extremity

Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied for the determination of carisbamate in rat plasma to support in vitro and in vivo studies. A quadratic regression (weighted 1/concentration2), with an equation y = ax2 + bx + c, was used to fit calibration curves over the concentration range from 9.05 to 6,600 ng/mL for carisbamate in rat plasma. Preclinical in vitro and in vivo studies of carisbamate have been studied through the developed bioanalytical method. Based on these study results, human pharmacokinetic (PK) profile has been predicted using physiologically based pharmacokinetic (PBPK) modeling. The PBPK model was optimized and validated by using the in vitro and in vivo data. The human PK of carisbamate after oral dosing of 750 mg was simulated by using this validated PBPK model. The human PK parameters and profiles predicted from the validated PBPK model were similar to the clinical data. This PBPK model developed from the preclinical data for carisbamate would be useful for predicting the PK of carisbamate in various clinical settings.