1.mechanism of Cell Death induced by ZnCl2 and Calmodulin Antagonist in Human Retinoblastoma Cells.
Hui Joung JOUNG ; Young Hwan EUM ; Hwan Tae PARK ; Ill Han YUN
Journal of the Korean Ophthalmological Society 2000;41(12):2686-2698
No Abstract Available.
Calmodulin*
;
Cell Death*
;
Humans*
;
Retinoblastoma*
2.A case of intralobar pulmonary sequestration.
Hae Sook SEO ; Mun Hwan PARK ; Myung Seon RHEE ; Nam Soo RHU ; Dong Ill CHO
Tuberculosis and Respiratory Diseases 1993;40(6):736-741
No abstract available.
Bronchopulmonary Sequestration*
3.A Case of Hepatocellular Carcinoma after Hepatic Artery Ligation.
Jeong Ill SUH ; Joon Hwan KIM ; Dong Joon LEE ; Ki Yoon KIM ; Ho Jung KANG ; Chan Won PARK ; Heon Ju LEE
Yeungnam University Journal of Medicine 1996;13(1):146-151
Majority of .hepatocellular carcinoma is evolved from a well differentiated cancerous condition such as hypetptastic lesions eg; adenomatous hyperplasia in cirrhotic liver or de no vo carcinogenesis and prolifenation along with dedifferentiation. Adenomatous hyperplasia is may be seen in severe acute hepatic injury, like svhmassive hepatic necrosis, or in chronic liver diseases, particularly liver cirrhosis and it has recently attracted much interest from both clinicians and pathologists because it is regarded as a precursor lesion of hepatocObdar carcinoma. Hepatic. denomatous hyperplasia resembling focal nodular hyperplasia might have developed from localized vascular changes associated with chronic liver disease, pre-existing arterial malformation and early stage of angiogenesis in hepatocarcinogenesis. .fie present a patient who developed hepatocellular carcinoma after hepatic artery ligation.
Carcinogenesis
;
Carcinoma, Hepatocellular*
;
Focal Nodular Hyperplasia
;
Hepatic Artery*
;
Humans
;
Hyperplasia
;
Ligation*
;
Liver
;
Liver Cirrhosis
;
Liver Diseases
;
Necrosis
4.A Case of Rhabdomyosarcoma in the Liver.
Dong Jun LEE ; Ji Sung YOON ; Joon Hwan KIM ; Chan Won PARK ; Jeong Ill SUH ; Heon Ju LEE ; Ki Kweon KIM
Yeungnam University Journal of Medicine 1996;13(2):360-366
Pure primary hepatic rhabdomyosarcoma in adult is very uncommon. There have been only five previous case of primary rhabdomyosarcoma of the adult liver. A case of hepatic ihabdomyosarcoma was diagnosed in a 52 year-old female. She was admitted to the hospital due to the epigastric pain and weight loss. A CT scan of the abdomen showed a large hypodense mass with focal calcification occupies most of the both lobes of the liver. The liver biopsy showed massive liver tumor composed entirely of oval shaped cells showing light microscopic and immunohistochemical evidence of rhabdomyoblastic differentiation. We report a case of hepatic rhabdomyosarcoma with review of literature.
Abdomen
;
Adult
;
Biopsy
;
Female
;
Humans
;
Liver*
;
Rhabdomyosarcoma*
;
Tomography, X-Ray Computed
;
Weight Loss
5.Respiratory Assist by Use of Electrical Diaphragmatic Pacing.
Joong Hwan OH ; Eun Gi KIM ; Jae Jeung SUH ; Ill Hwan PARK ; Bu Yeon KIM ; Sang Hun LEE ; Chong Kook LEE ; Young Hee LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 2001;34(6):441-446
BACKGROUND: Electrical breathing pacing has many advantages over mechanical ventilation. However, clinically permanent diaphragmatic pacing has been applied to limited patients and few temporary pacing has been reported. Our purpose is to investigate the feasibility of temporary electrical diaphragm pacing in explothoracotomy canine cases. METHODS: Five dogs were studied under the general anesthesia. Left 5th intercostal space was opened. Self designed temporary pacing leads were placed around the left phrenic nerve and connected to the myostimulator. Chest wall was closed after tube insertion with underwater drainage. Millar catheter was introduced to the aorta and right atrium. Swan-Ganz catheter was introduced to the pulmonary artery. When the self respiration was shallow with deep anesthesia, hemodynamic and tidal volume were measured with the stimulator on. RESULTS: Tidal volume increased from 143.3 +/- 51.3 ml to 272.3 +/- 87.4 ml(p=0.004). Right atrial diastolic pressure decreased from 0.7 +/- 4.0 mmHg to -10.5 +/- 4.7 mmHg(p=0.005). Pulmonary arterial diastolic pressure decreased from 6.1 +/- 2.5 mmHg to 1.2 +/- 4.8 mmHg(p<0.001). The height of water level in chest tube to show intrathoracic pressure change was from 10.3 +/- 6.7cmH2O to 20.0 +/- 5.3 cmH2O. CONCLUSION: Temporary electrical diaphragmatic pacing is a simple method to assist respiration in explothoracotomy canine cases. Self designed pacing lead is implantable and removable. Negative pressure ventilation has favorable effects on the circulatory system. Therefore, clinical application of temporary breathing pacing is feasible in thoracotomy patients to assist cardiorespiratory function.
Anesthesia
;
Anesthesia, General
;
Animals
;
Aorta
;
Blood Pressure
;
Catheters
;
Chest Tubes
;
Diaphragm
;
Dogs
;
Drainage
;
Heart Atria
;
Hemodynamics
;
Humans
;
Phrenic Nerve
;
Pulmonary Artery
;
Respiration
;
Respiration, Artificial
;
Thoracic Wall
;
Thoracotomy
;
Tidal Volume
;
Ventilation
;
Water
6.The Changes of Arterial Ketone Body Ratio and Osmolal Gap during Hemorrhagic Shock in Rabbit.
Ill Hwan KIM ; Keung Woo LEE ; Young Kyun CHOI ; Young Jae KIM ; Jin Yoo PARK ; Chee Mahn SHIN ; Ju Yuel PARK
Korean Journal of Anesthesiology 1994;27(5):421-427
The ratio of acetoacetate to 8-hydroxybutyrate (ketone body ratio) in the blood may reflects the mitochondrial free NAD+/NADH ratio in the liver. Also arterial ketone body ratio will reflects the energy status of the hepatocytes, because mitochondrial free NAD+/NADH ratio is closely related to oxidative phosphorylation. Arterial ketone body ratio and osmolal gap, the difference between measured osmolality and calculated osmolality, were measured 30 min after the induction of hemorrhagic shock with mean arterial blood pressure at 40 mmHg in ten rabbits. Arterial ketone body ratios decreased significantly (p<0.05) from 0.74+/-0.17 to 0.38+/-0.09 and osmolal gap increased significantly (p<0.05) from 17.7+/-5.9 mOsm/Kg to 32.8+/-12.3 mOsm/Kg at 30 min after the induction of hemorrhagic shock. These results suggest that in hemorrhagic shock, decreased arterial ketone body ratio which reflects the inhibition of the TCA cycle is associated with increase of osmolal gap.
Arterial Pressure
;
Hepatocytes
;
Liver
;
Osmolar Concentration
;
Oxidative Phosphorylation
;
Rabbits
;
Shock, Hemorrhagic*
7.Expression of Aquaporin-4 in Placenta of Preeclampsia.
In Ha LEE ; Man Gi KIM ; Yu Rae KIM ; Seung Hwa HONG ; Yeon Jin PARK ; Ill Woon JI ; Eun Hwan JEONG ; Hak Soon KIM
Korean Journal of Obstetrics and Gynecology 2006;49(1):49-54
OBJECTIVE: This study was to determine whether aquaporin-4, which plays role as a transcellular water channel, is expressed in human placenta, and to compare the degree of its expression between preeclamptic women and normal pregnant women. METHODS: Placentas were obtained from severely preeclamptic women and normal pregnant women who were delivered neonates by cesarean section before the onset of labor in the Chungbuk National University Hospital. Immunohistochemistry with aquaporin-4 antibody was performed using paraffin-embedded tissue section. Signal of aquaporin-4 expression was observed with light microscope. RESULTS: Immunohistochemistry demonstrated expression of aquaporin-4 in the placentas of both preeclamptic women and normal pregnant women. The degree of expression was not different in both group. CONCLUSION: Aquaporin-4 was expressed in the human placenta, but may not be related to the pathogenesis of preeclampsia.
Cesarean Section
;
Chungcheongbuk-do
;
Female
;
Humans
;
Immunohistochemistry
;
Infant, Newborn
;
Placenta*
;
Pre-Eclampsia*
;
Pregnancy
;
Pregnant Women
8.A Study of the Causes and the Predictive Factors in Failed Vaginal Birth After Cesarean Section.
Kyu Sang KYOUNG ; A Ra CHO ; Young Mi LEE ; Min Ah PARK ; Eun Hwan JEONG ; Ill Woon JI
Korean Journal of Perinatology 2007;18(4):385-390
OBJECTIVE:The purpose of this study was to determine the factors associated with successful vaginal birth after cesarean section (VBAC), and to analyze the causes of failed VBAC. METHODS:This study was performed based on 193 pregnant women who tried vaginal delivery after cesarean section in Chungbuk National University Hospital from January 1997 to December 2005. Maternal age, gestational age, cervical dilatation at admisson, maternal body mass index (BMI), neonatal bodyweight, history of prior vaginal delivery, and indication of prior cesarean section were retrospectively analyzed between the successful group and the failed group of women who tried labor. The causes of the failed trial were analyzed. RESULTS:Seventy nine percent (153/193) was successful in the trial of VBAC and 21% (40/193) failed. There were no difference in maternal age or gestational age between two groups. The success rate was significantly higher when cervical dilatation at admission was more extended, BMI of pregnant women before pregnancy and birth was lower, and birthweight of newborn was lower. Maternal request was the major cause of failure (47.5%), and others were failure to progress, non-reassuring fetal monitoring and failed induction. CONCLUSION:The factors that had significant differences in this study can be used as predictor of successful VBAC. And failed trial of VBAC due to maternal request can be decreased by adequate explanation regarding the complication of emergency operation, and enough pain control during labor.
Body Mass Index
;
Cesarean Section
;
Chungcheongbuk-do
;
Emergencies
;
Female
;
Fetal Monitoring
;
Gestational Age
;
Humans
;
Infant, Newborn
;
Labor Stage, First
;
Maternal Age
;
Parturition
;
Pregnancy
;
Pregnant Women
;
Retrospective Studies
;
Vaginal Birth after Cesarean*
9.Quality Assurance of Volumetric Modulated Arc Therapy for Elekta Synergy.
Su Jung SHIM ; Jang Bo SHIM ; Sang Hoon LEE ; Chul Kee MIN ; Kwang Hwan CHO ; Dong Oh SHIN ; Jin Ho CHOI ; Sung Ill PARK ; Sam Ju CHO
Korean Journal of Medical Physics 2012;23(1):33-41
For applying the quality assurance (QA) of volumetric modulated arc therapy (VMAT) introduced in Eulji Hospital, we classify it into three different QA steps, treatment planning QA, pretreatment delivering QA, and treatment verifying QA. These steps are based on the existing intensity modulated radiation therapy (IMRT) QA that is currently used in our hospital. In each QA step, the evaluated items that are from QA program are configured and documented. In this study, QA program is not only applied to actual patient treatment, but also evaluated to establish a reference of clinical acceptance in pretreatment delivering QA. As a result, the confidence limits (CLs) in the measurements for the high-dose and low-dose regions are similar to the conventional IMRT level, and the clinical acceptance references in our hospital are determined to be 3 to 5% for the high-dose and the low-dose regions, respectively. Due to the characteristics of VMAT, evaluation of the intensity map was carried out using an ArcCheck device that was able to measure the intensity map in all directions, 360degrees. With a couple of dosimetric devices, the gamma index was evaluated and analyzed. The results were similar to the result of individual intensity maps in IMRT. Mapcheck, which is a 2-dimensional (2D) array device, was used to display the isodose distributions and gave very excellent local CL results. Thus, in our hospital, the acceptance references used in practical clinical application for the intensity maps of 360degrees directions and the coronal isodose distributions were determined to be 93% and 95%, respectively. To reduce arbitrary uncertainties and system errors, we had to evaluate the local CLs by using a phantom and to cooperate with multiple organizations to participate in this evaluation. In addition, we had to evaluate the local CLs by dividing them into different sections about the patient treatment points in practical clinics.
Humans
;
Radiotherapy, Intensity-Modulated
10.A Preliminary Comparison of Efficacy of Intravaginal Misoprostol with Intravenous Sulprostone for Termination of Second-Trimester Pregnancy.
Sang Kyoung LEE ; Man Gi KIM ; Yu Re KIM ; Seung Hwa HONG ; Yeon Jin PARK ; Ill Woon JI ; Eun Hwan JEONG ; Hak Soon KIM
Korean Journal of Obstetrics and Gynecology 2006;49(2):309-314
OBJECTIVE: The purpose of this study was to compare the efficacy of intravaginal misoprostol and that of intravenous sulprostone for termination of second-trimester pregnancy. METHODS: Fouty-six patients were randomly assigned to misoprostol and sulprostone group, and the misoprostol group was further divided into two groups according to gestational age. In the misoprostol group, the patients at or before 20 weeks of gestation received 400 microgram of intravaginal misoprostol every 4 hours until labor pain was established, 200 microgram every 6 hours after 20 weeks of gestation. In the sulprostone group, intravenous sulprostone was infused at the speed of 100 microgram/hr regardless of gestational age. RESULTS: At or before 20 weeks of gestation, the mean time from induction to completion of termination was shorter, and the success rate within 24 hours was higher in the misoprostol group than in the sulprostone group (9.0 vs. 20.2 hours; 86% vs 50%). After 20 weeks, the mean induction time was longer at misoprostol group than sulprostol group but, there was no significant difference in success rate within 24 hours (14.7 vs. 7.1 hours; 83% vs. 86%). There was no significant difference in the prevalence of complication between two groups. CONCLUSION: Misoprostol is superior to sulprostone for termination of pregnancy at or before 20 weeks of gestation, but both have almost equal effectiveness after 20 weeks of gestation. Considering less cost and complication, the efficacy of misoprostol should be further investigated for termination of second-trimester pregnancy.
Female
;
Gestational Age
;
Humans
;
Labor Pain
;
Misoprostol*
;
Pregnancy*
;
Prevalence