No Abstract Available.
Calmodulin* ; Cell Death* ; Humans* ; Retinoblastoma*

PURPOSE: Central retinal vein occlusion is classified as ischemic and non-ischemic types. Ischemic type has poor visual prognosis because of neovascular complications. Fluorescein angiography shows lower reproducibility and predictability of neovascularization and has complications although it has been the standard method for classification. This study was made to determine the usefulness of the electroretinogram (ERG) in the classification and predictor of neovascularization. METHODS: Forty-two eyes with central retinal vein occlusion were classified as ischemic and non-ischemic groups by means of indirect ophthalmoscope and fluorescein angiography finding. All patients were examined with standard electroretinogram and followed. During the follow-up period, development of neovascularization was evaluated. All parameters of electroretinogram were analyzed. RESULTS: Compared to the control group, a and b wave amplitudes in maximal combined response, b/a ratio, b wave amplitude in cone response, and b wave implicit time in 30Hz flicker response showed statistically significant difference in only ischemic central retinal vein occlusion (P<0.05). Compared to the control group, a and b wave amplitudes in maximal combined response, b/a ratio show statistically significant difference in only central retinal vein occlusion with rubeosis. CONCLUSIONS: Standard electroretinogram is thought to be a useful method for classifying the central retinal vein occlusion and predicting the rubeosis in central retinal vein occlusion.
Classification* ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Ophthalmoscopes ; Prognosis ; Retinal Vein*

PURPOSE: We described a patient with decreased vision due to circumscribed choroidal hemangioma and the patient was treated with transpupillary thermotherapy. METHODS: A 40-year-old male with circumscribed choroidal hemangioma combined with serous retinal detachment involving macula was managed by 2 sessions of transpupillary thermotherapy with 810 mm infrared diode laser. RESULTS: Improvement of central visual acuity, atrophy of circumscribed choroidal hemangioma and reabsorption of serous retinal detachment were observed without any complication during 6 months follow up period after 2 sessions of transpupillary thermotherapy. CONCLUSIONS: Transpupillary thermotherapy is a safer and alternatively effective treatment in circumscribed choroidal hemangioma with serous retinal detachment rather than ordinary photocoagulation or radiotherapy.
Adult ; Atrophy ; Choroid* ; Follow-Up Studies ; Hemangioma* ; Humans ; Hyperthermia, Induced* ; Lasers, Semiconductor ; Light Coagulation ; Male ; Radiotherapy ; Retinal Detachment ; Visual Acuity

PURPOSE: The outcome after operations for intermittent exotropia were frequently unsatisfactory because of high incidence of postoperative undercorrection, overcorrection or recurrence. The author studied surgical outcome of each operation method in intermittent exotropia. METHODS: The results of surgical treatment in 90 patients with intermittent exotropia were reviewed. The operative procedure were devided into 3 groups-bilateral rectus muscle recessions, unilateral lateral rectus muscle recession and medial rectus muscle resection and medial rectus muscle resection of dominant eye and lateral rectus muscle recession of non-dominant eye. The success of operation was defined as a final alignment of orthotropia, esotropia less than 5 prism diopter or exotropia less than 10 prism diopter in primary position at postoperative 6 months. RESULTS: The method of of operation in medial rectus muscle resection of dominant eye and lateral rectus muscle recession of non-dominant eye lead to higher success rate than other surgical method (96.7%) and the difference with statistically significant (p=0.03). The success rate of bilateral rectus muscle recessions group was 76.6%, and that of unilateral lateral rectus muscle recession and medial rectus muscle resection group was 80.0%. CONCLUSIONS: This result suggested that medial rectus muscle resection of dominant eye and lateral rectus muscle recession of non-dominant eye might be a most effective surgical method for intermittent exotropia.
Esotropia ; Exotropia* ; Humans ; Incidence ; Recurrence ; Surgical Procedures, Operative

PURPOSE: This study aimed to analyze the clinical characteristics, results of operational method and causes of operational failure in rhegmatogenous retinal detachment except macula hole induced retinal detachment, and to analyze several factors of vision. METHOD: We reviewed the records of 720 patients, 743 eyes with regmatogenous retinal detachment who had undergone operation from January 1990 to December 1999, and followed up for at least 3 months or longer. RESULT: Scleral buckling (728 eyes, 98.0%), gas injection (9 eyes, 1.2%) and vitrctomy (6 eyes, 0.8%) were done as a primary operation. Anatomical success rate was 684 eyes(34.9%). A good visual acuity ( V A >or=0.5) was achieved in 239 eyes (34.9%), reasonable vision (VA 0.4~0.15) in 192 eyes(28.1%), ambulatory vision (VA 0.1~0.02) in 95 eyes (13.8%), whereas 158 eyes (23.2%) became blind (VA Animals ; Beak ; Humans ; Reoperation ; Retinal Detachment* ; Retinaldehyde* ; Scleral Buckling ; Visual Acuity

Background and Objectives: The outcome benefits of β-blockers in chronic coronary artery disease (CAD) have not been fully assessed. We evaluated the prognostic impact of β-blockers on patients with chronic CAD after percutaneous coronary intervention (PCI). Methods: A total of 3,075 patients with chronic CAD were included from the Grand DrugEluting Stent registry. We analyzed β-blocker prescriptions, including doses and types, in each patient at 3-month intervals from discharge. After propensity score matching, 1,170 pairs of patients (β-blockers vs. no β-blockers) were derived. Primary outcome was defined as a composite endpoint of all-cause death and myocardial infarction (MI). We further analyzed the outcome benefits of different doses (low-, medium-, and high-dose) and types (conventional or vasodilating) of β-blockers. Results: During a median (interquartile range) follow-up of 3.1 (3.0–3.1) years, 134 (5.7%) patients experienced primary outcome. Overall, β-blockers demonstrated no significant benefit in primary outcome (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.63–1.24), all-cause death (HR, 0.87; 95% CI, 0.60–1.25), and MI (HR, 1.25; 95% CI, 0.49–3.15). In subgroup analysis, β-blockers were associated with a lower risk of all-cause death in patients with previous MI and/ or revascularization (HR, 0.38; 95% CI, 0.14–0.99) (p for interaction=0.045). No significant associations were found for the clinical outcomes with different doses and types of β-blockers. Conclusions Overall, β-blocker therapy was not associated with better clinical outcomes in patients with chronic CAD undergoing PCI. Limited mortality benefit of β-blockers may exist for patients with previous MI and/or revascularization.

PURPOSE: To evaluate the incidence and clinical features of age-related macular degeneration (AMD) in Korea. METHODS: Web-based (www.armd-nova.or.kr) registration was conducted for AMD patients aged 50 or more who were newly diagnosed by retinal specialists in Korea from August 20, 2005 to August 20, 2006. Patient data including ophthalmologic examination, fundus photography, fluorescein angiogram and/or indocyanin green angiogram (ICG), past medical history, behavioral habit, combined systemic diseases were up-loaded. RESULTS: Among finally enrolled 1,141 newly diagnosed AMD patients, 690 patients (60.5%) were male and 451 patients (39.5%) were female. The average age of AMD patients was 69.7+/-8.0. Early AMD was observed in 190 patients and 951 patients had late AMD. Classic choroidal neovascular membrane (CNVM) was observed in 18.6% of exudative AMD patients and 63.4 % had occult CNVM. Subfoveal CNVM was observed in 80.4% of the patients with CNVM. Among the 580 exudative AMD eyes that performed indocyanin green angiography (ICG), 184 eyes (31.7%) had polypoidal choroidal vasculopathy (PCV) and 36 eyes (6.2%) showed retinal angiomatous proliferation (RAP). Age, male gender, smoking, diabetes and hypertension significantly increased the risk of the AMD among Koreans. CONCLUSIONS: Because of the low rate of participation by retinal specialists, definite incidence of AMD was not obtainable. However, the estimated 1-year AMD incidence in the Pusan area of Korea is at least 0.4%. In contrast to Western people, 31.7% of exudative AMD cases were revealed to be PCV and 6.2% were revealed to be RAP. This discrepancy between ethnic groups should be considered in the diagnosis and treatment modality selection of Korean AMD patients.
Aged ; Angiography ; Choroid ; Ethnic Groups ; Eye ; Female ; Fluorescein ; Humans ; Hypertension ; Incidence ; Korea ; Macular Degeneration ; Male ; Membranes ; Photography ; Retinaldehyde ; Smoke ; Smoking ; Specialization

BACKGROUND: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. METHODS: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m² or proteinuria as at least grade 2+ of urine protein. RESULTS: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m² (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m² along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m². CONCLUSION: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m² and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.
Anemia ; Antigens, Surface ; Bilirubin ; Case-Control Studies* ; Female ; Glomerular Filtration Rate ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis B, Chronic* ; Hepatitis, Chronic* ; Humans ; Male ; Multivariate Analysis ; Prevalence ; Proteinuria ; Renal Insufficiency, Chronic*