It has been estimated that chromosomal abnormality occurs in 0.4% of live births. A balanced translocation between chromosome 2 and 18, t (2;18) (p23;q23), is extremely rare. We report a neonate whose karyotype was 46, XY t (2;18) (p23;q23). He had multiple anomalies such as micrognathia, low-set ears, short neck, undescended testes, atrial septal defect, and decreased physical activity. Chromosomal analysis with G banding in high resolution showed a balanced translocation t (2;18) (p23;q23). The same chromosomal abnormality was found on the family for 3 generations.
Chromosome Aberrations ; Chromosomes, Human, Pair 2 ; Cryptorchidism ; Ear ; Family Characteristics ; Heart Septal Defects, Atrial ; Humans ; Infant, Newborn ; Karyotype ; Live Birth ; Male ; Motor Activity ; Neck

PURPOSE: The purpose of the study was to identify factors influencing health promotion behavior of late-middle aged women. METHODS: The subjects were 128 women who were attending a cultural center located in B metropolitan city. Data were collected from July 1 to July 31, 2016. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffé test, Pearson correlation coefficient, Stepwise multiple regression with SPSS/WIN 23.0 program. RESULTS: Health promotion behavior of later middle-aged women was different by general characteristics such as religion, exercise, economic satisfaction, life satisfaction, and leisure time activities. Health promotion behavior had a positive relationship with health perception and perception of successful aging, and a negative relationship with aging anxiety. Health perception, perception of successful aging, exercise, leisure time activities (exercise and social activity) were verified significant factors influencing health promotion behavior accounted for 38%. CONCLUSION: The results indicate that health perception and perception of successful aging influence health promotion behavior of late-middle age women. It would provide the basic data for the development of program aimed at improving health promotion behavior of late-middle age women.
Aging* ; Anxiety* ; Female ; Health Promotion* ; Humans ; Leisure Activities

PURPOSE: The purpose of this study was to examine the effects of integrated menopause management program derived theoretical framework of King (1981)'s goal attainment theory model for middle aged women. METHODS: This research was a nonequivalent control group non-synchronized design. The subjects of this study were 37 middle aged women in Busan and experiencing menopause; 17 for the experimental group and 20 for the control group. Experimental group was educated for 1 hour group interchange activity and five minutes individual interchange activity, once a week during 8 weeks. Measurement for comparison were taken two times, at baseline, 8wks. The effects were evaluated with menopause symptom, menopause knowledge, menopause attitude and menopause management. RESULTS: The experimental group was significantly lower than control group on menopause symptom (F=5.936, p=.010) and higher than control group on menopause knowledge (F=12.031, p=.001) and menopause management (F=5.861, p=.010) after integrated menopause management program. However integrated menopause management program did not make significant differences on menopause attitude (F=0.105, p=.374). CONCLUSION: Results indicate that integrated menopause management program could be an effective intervention decreasing menopause symptom and for increasing menopause knowledge, menopause management in middle aged women.
Female ; Humans ; Menopause ; Middle Aged

OBJECTIVES: The purpose of this study is to determine the infertility stress, resilience, intimacy and infertility-related quality of life of infertility women in an infertility clinic, and to reveal associated factors of infertility-related quality of life. METHODS: As a descriptive study, data was collected from 92 infertility women in an infertility clinic. Data was analyzed using t-test, analysis of variance, Pearson correlation coefficients and stepwise multiple regression. RESULTS: Infertility stress, resilience, intimacy and infertility-related quality of life averaged 3.1±0.5, 3.7±0.3, 3.3±0.3, 3.2±0.5 respectively. The infertility-related quality of life varied with a statistical significance by marital period, the presence of a burdensome person and burdensome person. Infertility-related quality of life had a negative correlation with infertility stress (r=−0.69, p<0.001), and a positive correlation with resilience (r=0.23, p=0.28) and intimacy (r=0.22, p=0.030). Meaningful variables that influenced infertility-related quality of life were ‘need for parenthood,’ ‘social concern in infertility stress’ and ‘positive factor in resilience,’ and infertility-related quality of life was explained 56.6% by the variables. CONCLUSION: It is suggested to highlight the importance of the infertility-related quality of life and to develop and execute the nursing intervention program for enhancing resilience and decreasing infertility stress of infertility women in infertility clinics.
Female ; Humans ; Infertility ; Nursing ; Quality of Life

PURPOSE: Asthma inhalation therapy is important for the treatment of childhood asthma. Therefore, it is necessary to educate patients on the correct inhalation techniques. The purpose of this study was to determine the effectiveness and necessity of educating patients on the correct inhalation techniques. METHODS: A total of 86 patients with bronchial asthma and who were over 7 years old were enrolled and educated on handling inhaler devices for 2 years. The inhaler devices used were the diskus (n=27), turbuhaler (n=12) and metered dose inhaler with a spacer (n=47). Trained pharmacists provided the education. Four steps (breathing out prior to inhalation, inhalation, holding the breath, exhaling slowly) that were critical for handling each device were evaluated and each step was scored as good, fair or poor. We evaluated the symptom score (daytime cough, nighttime cough, sleep disturbance and limitation of activity) and lung function before treatment and 4 weeks later. RESULTS: Over 90.0% of the diskus users performed fair to good in each step. The symptom score and lung function at 4 weeks later after education were significantly improved (P=0.000). The turbuhaler users all performed fair to good on each step. The symptom score was significantly improved (P<0.005), but the lung function was not difference. Over 95% of the users of a metered dose inhaler with a spacer performed moderate to good on each step. The symptom score and lung function were significantly improved (P<0.05). CONCLUSION: The structured, detailed education on inhaler devices by trained specialists was very important for performing correct inhalation therapy to control asthma, and repeated education might be also necessary.
Asthma ; Cough ; Exhalation ; Handling (Psychology) ; Humans ; Inhalation ; Lung ; Metered Dose Inhalers ; Nebulizers and Vaporizers ; Pharmacists ; Respiratory Therapy ; Specialization

OBJECTIVE: This study was performed to determine whether large loop excision of the transformation zone (LLETZ) affects the outcome of pregnancy after 20 weeks gestation. METHODS: In a retrospective case control study 20 women who had undergone large loop excision of the transformation zone and were subsequently delivered at Ilsin Christian Hospital were identified between 1991 and 2003. 40 controls were identified and matched for age and parity from women delivered immediately before and after index cases. Maternal factors were analyzed such as pregnancy gestation, use of oxytocin, analgesia, whether labor was induced, mode of delivery, length of labor, estimated blood loss and birth weight of previous delivery. Perinatal outcome measured fetal weight and admission to the neonatal unit. RESULTS: There was no significant difference between the women who had undergone LLETZ and the controls except women delivered after LLETZ had increased rate of emergency cesarean section and amount of blood loss. CONCLUSION: Previous studies investigating pregnancy outcome after LLETZ have been generally reassuring and this study also have no difference. However, in this study women who were delivered after LLETZ had slight increased rate of emergency cesarean section, this may be related to adverse obstetrical history (recurrent abortion, infertility etc.). However socioepidemiological factors were not controlled and the small number of case groups were included, so larger controlled studies will be necessary to confirm this findings.
Analgesia ; Birth Weight ; Case-Control Studies ; Cervix Uteri* ; Cesarean Section ; Emergencies ; Female ; Fetal Weight ; Humans ; Infertility ; Oxytocin ; Parity ; Pregnancy ; Pregnancy Outcome* ; Pregnancy* ; Retrospective Studies

Endometrial cancer is increasing in South Korea. In young women, endometrial cancer can be treated by progestins for preserving fertility. We experienced a successful case of twin pregnancy after conservative therapy of endometrial cancer with Megestrol acetate. Ovulation induction and intrauterine insemination was done. A brief review of related literature was done.
Endometrial Neoplasms* ; Female ; Fertility ; Humans ; Insemination ; Korea ; Megestrol Acetate ; Ovulation Induction ; Pregnancy ; Pregnancy, Twin* ; Progestins ; Twins*

OBJECTIVE: The HCV seroprevalence rate and the vertical transmission rate in Korean pregnancy women have not been determined until now. The purpose of this study is to estimate the prevalence of anti- HCV in pregnant women and vertical transmission rate to assess the role of antenatal screening of HCV and the necessity of following babies from anti-HCV positive mothers. METHODS: We reviewed the medical records of 21,639 patients who delivered at Ilsin Christian hospital from January 2000 to October 2003. The HbsAg, HbsAb, anti-HCV, HIV test were performed in their 1st trimester of pregnancy and the HCV RNA test was performed by RT-PCR in samples positive for anti-HCV. 38 babies born to anti-HCV positive mothers were tested for anti-HCV and those who were positive anti-HCV were also tested for HCV RNA by PCR. RESULTS: The positive rate of anti-HCV in pregnant women was 0.42% (90/21,639) and that of HCV RNA was 57% (51/90). The positive rate of anti-HCV was 26.3% (10/38) and the result of HCV RNA test was all negative in babies whose mothes were positive for anti-HCV. CONCLUSION: The prevalence of anti-HCV in pregnant women who delivered at our hospital seems to be higher than that in the Korean young adult man and it is similar with the whole world prevalence rate. The prevalence of anti-HCV of babies born to HCV PCR positive mothers was higher than that born to HCV PCR negative mothers. None of anti-HCV positive babies was HCV RNA positive. With this, we conclude that the vertical transmission as the transmission route of HCV infection is negligible but routine screening for HCV is acceptable to pregnant women.
Female ; Hepatitis B Surface Antigens ; HIV ; Humans ; Mass Screening ; Medical Records ; Mothers ; Moths ; Polymerase Chain Reaction ; Pregnancy ; Pregnant Women* ; Prenatal Diagnosis ; Prevalence* ; RNA ; Seroepidemiologic Studies ; Young Adult

A neonate may incur liver injury during spontaneous delivery. The liver is the organ most likely to be injured during the birth process. Breech presentation and manipulation are the most common causes of hepatic trauma. However, hepatic hemorrhage can occur in any infant, regardless of size and the type of delivery. Infants with subcapsular hemorrhage are usually asymptomatic at birth, and gross hepatic rupture from these lesions is unusual. In patient with primary rupture, major bleeding takes place immediately, explaining the high percentage of neonatal deaths with massive liver rupture. If subcapsular hemorrhage remain intracapsular with spontaneous resolution, the only treatment needed in subcapsular hemorrhage may be transfusion. We experienced one case of neonatal subcapsular hemorrhage with persistent hyperbilirubinemia. We report this case with the brief review of related literature.
Breech Presentation ; Female ; Hematoma* ; Hemorrhage ; Humans ; Hyperbilirubinemia ; Hyperbilirubinemia, Neonatal* ; Infant ; Infant, Newborn ; Liver ; Parturition ; Pregnancy ; Rupture

The prenatal diagnosis of spina bifida includes the combined use of maternal serum alpha-fetoprotein (MSAFP) screening and fetal sonography. On ultrasonogram, spina bifida is characterizd by visualization of the spinal defect and associated cranial abnomalities: the Lemon sign, the Banana sign, ventriculomegaly, small biparietal diameter, and obliteration of the cisterna magna. We should now be able to rely on ultrasound as the main technique for diagnosis of spina bifida when MSAFP is elevated. Recently, we have experienced three cases of spina bifida diagnosed with meningomyelocele, lemon sign, banana sign and ventriculomegaly on ultrasonogram at respectively 18+3, 18, and 18+6 weeks of gestation. We present these cases with a brief review of literatures.
alpha-Fetoproteins ; Cisterna Magna ; Diagnosis ; Mass Screening ; Meningomyelocele ; Musa ; Pregnancy ; Prenatal Diagnosis ; Spinal Dysraphism* ; Ultrasonography*