1.Mutations of p53 tumor suppressor gene in human lung cancer cell lines.
Weon Seon HONG ; Seok Il HONG ; Dong Soon LEE ; Young Sook SON ; Choon Taek LEE
Tuberculosis and Respiratory Diseases 1993;40(6):653-658
No abstract available.
Cell Line*
;
Genes, Tumor Suppressor*
;
Humans*
;
Lung Neoplasms*
;
Lung*
2.A Case of Midbrain Hemorrhage Presenting as Bilateral Ptosis with Diurnal Fluctuation.
Journal of the Korean Neurological Association 2000;18(3):326-329
A 54 year-old woman presented with bilateral fatigable blepharoptosis with diurnal fluctuation and diplopia for 10 days. She had a 3 year history of hypertension and showed symptoms of bilateral ptosis, supranuclear upward gaze palsy, and vertical diplopia with the pupils promptly constricting to light. Bell's phenomenon and vertical oculocephalic responses were intact but an impaired convergence was noted in both eyes. A intramuscular neostigmine test was negative. T1 and T2-wighted MRI of the brain showed a small round high signal intensity lesion in the periaqueductal gray (PAG) region. Therefore, she was diagnosed with a midbrain ptosis due to midbrain hemorrhage. The PAG lesion was suggested as contributing to the fatigable blepharoptosis and supranuclear upward gaze palsy in the patient. We recommend that patients with clinical features of myasthenia limited to the ocular muscles and, having risk factors for cerebrovascular disease, be thoroughly evaluated for intracranial lesions if warranted.
Blepharoptosis
;
Brain
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Diplopia
;
Female
;
Hemorrhage*
;
Humans
;
Hypertension
;
Magnetic Resonance Imaging
;
Mesencephalon*
;
Middle Aged
;
Muscles
;
Neostigmine
;
Paralysis
;
Periaqueductal Gray
;
Pupil
;
Risk Factors
3.Usefulness of Occipital EEG Spectral Profile in the Differential Diagnosis of Alzheimer Type and Vascular Dementia.
Seung Han SUK ; Il Hong SON ; Yong Tae KWAK
Journal of the Korean Neurological Association 2000;18(3):292-297
BACKGROUND: Alzhiemeranjx disease (AD) and vascular dementia (VD) are common types of dementia. As a result of the development of new specific agents for AD, and because vascular dementia is a potentially preventable dementia, differentiating these diseases is of great importance. The role of EEG spectral analysis in the differential diagnosis between Alzheimer type and vascular dementia is still controversial. Since there have been few studies concerning the differential diagnosis of dementia by EEG, the present study has focused on this aspect. Usefulness of EEG in differen-tial diagnosis of dementia will be elucidated by clarifying relationship between type of dementia and spectral profile of EEG. METHODS: We analyzed the power spectra taken from 16 derivations and spectral profile was constructed by averaging twenty 2 sec epochs in three study groups (normal controls, AD and VD). Spectral profile was divided into three groups; (I) type A, showing a dominant 6.5-12 Hz peak (ii) type B, lacking a dominant peak in the 6.5-12 Hz (iii) type C, corresponding to a flat, low voltage, spectrum. To elucidate the relationship between spectral profile and other factors including diagnosis, statistical test was done. RESULTS: (1) In AD, type C profile was statistically more prevalent than in VD and type A profile was reversed. (2) In AD, Mini-Mental State Examination (MMSE) score was statistically lower in type C profile. (3) Spectral profile was not associated with age, age of symptom onset, and symptom duration. CONCLUSIONS: This study suggested that spectral profile is a useful tool for the differential diagnosis of dementia (AD and VD) and correlated with the severity of disease in AD.
Dementia
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Dementia, Vascular*
;
Diagnosis
;
Diagnosis, Differential*
;
Electroencephalography*
4.Clinical Studies on Congenitally Corrected Transposition of the Great Arteries.
Byong Kwan SON ; Chung Il NOH ; Jung Yun CHOI ; Yong Soo YUN ; Chang Yee HONG
Journal of the Korean Pediatric Society 1986;29(3):55-63
No abstract available.
Arteries*
5.Capsular polysaccharide typing of domestic mastitis-causing Staphylococcus aureus strains and its potential exploration of bovine mastitis vaccine developmen. I. capsular polysaccharide typing, isolation and purification of the strains.
Hong Ryul HAN ; Son Il PAK ; Seung Won KANG ; Woo Seog JONG ; Cheol Jong YOUN
Journal of Veterinary Science 2000;1(1):53-60
One hundred seven isolates of Staphylococcus aureus from bovine mastitis were investigated for colony morphology in serum-soft agar (SSA), autoagglutination in salt, and capsular serotype. Capsular polysaccharide (CP) was purified and quantified from the extracts of clinical isolates. Overall, 89 isolates (83.2%) were diffuse in the SSA, without any difference in the proportion of diffuse colony between type 5 and type 8 strains. Some strains exhibited compact colonies in the SSA and expressed CP as determined by an enzyme-linked immunosorbent assay, indicating that compact morphology does not exclude encapsulation. The majority of the strains (11/12) showed autoagglutination in the salt aggregation test. The serotype 336 accounted for 46.7% of the isolates followed by serotype 5 (12.1%) and serotype 8 (12.1%). Particularly, twenty-six (24.3%) isolates reacted with two serotypes; 7 for type 8/336 and 19 for type 5/336. Five isolates (4.7%) were nontypeable with monoclonal antibodies specific for CP serotype 5, 8, or 336. The CP concentration in culture supernatants varied with the serotypes, and the total amount of CP produced by cells grown in a liquid medium was much less than that produced by cells grown on a solid medium. The Western blotting indicated that the CP bands of S. aureus serotype 5 and 8 were ranged in the molecular mass of 58-84 kilodalton (kDa), with additional bands in the region of approximately >or= 48 or
6.A Case of 4P-Syndrome.
Hong Kyu LEE ; Sung Sik LEE ; Soon Il LEE ; Young Seok LEE ; Kweon Ha SON
Journal of the Korean Pediatric Society 1988;31(10):1366-1370
No abstract available.
7.Urinary Biomarkers for Neurodegenerative Diseases
Won gi SEOL ; Hye jung KIM ; Il hong SON
Experimental Neurobiology 2020;29(5):325-333
Global incidence of neurodegenerative diseases (NDDs) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) is rapidly increasing, but the diagnosis of these diseases at their early stage is challenging. Therefore, the availability of reproducible and reliable biomarkers to diagnose such diseases is more critical than ever. In addition, biomarkers could be used not only to diagnose diseases but also to monitor the development of disease therapeutics. Urine is an excellent biofluid that can be utilized as a source of biomarker to diagnose not only several renal diseases but also other diseases because of its abundance in invasive sampling. However, urine was conventionally regarded as inappropriate as a source of biomarker for neurodegenerative diseases because it is anatomically distant from the central nervous system (CNS), a major pathologic site of NDD, in comparison to other biofluids such as cerebrospinal fluid (CSF) and plasma. However, recent studies have suggested that urine could be utilized as a source of NDD biomarker if an appropriate marker is predetermined by metabolomic and proteomic approaches in urine and other samples. In this review, we summarize such studies related to NDD.
8.Peripheral blood lymphocyte subsets in patients with stomach cancer.
Weon Seon HONG ; Young Il MIN ; Young Sook SON ; Seok Il HONG
Journal of Korean Medical Science 1995;10(3):164-168
The present study was conducted in order to investigate the immunologic alterations alongside the numerical changes in peripheral blood lymphocytes(PBL) and their subsets in stomach cancer patients. Lymphocyte surface markers were determined in 85 stomach cancer patients and 49 controls by indirect immunofluorescence technique using monoclonal antibodies. Monoclonal antibodies used were Leu 2a(CD8, suppressor/cytotoxic T cells), Leu 3a(CD4, inducer/helper T cells), Leu 4(CD3, pan T reagent), Leu 11(CD16, natural killer cells) and Leu 12(CD19, B cells). The numbers of PBL, CD3+, CD4+, CD8+, CD16+ and CD19+ cells significantly decreased and the CD4: CD8 value increased in 85 patients with stomach cancer compared to those in controls(p < 0.01). In stage I(n = 17), neither PBL, their subsets nor the CD4: CD8 value were significantly different from those of the controls. In stage II(n = 17), the numbers of PBL, CD3+, CD4+ and CD8+ cells decreased(p < 0.01). In stage III(n = 24) and IV(n = 27), PBL and all subsets measured decreased(p < 0.01). The CD4: CD8 value showed significant increases in stages III and IV(p < 0.01), because the CD8+ cells decreased to a greater extent than did the CD4+ cells. The results demonstrating that the lymphocyte subsets are depressed differentially with the stage suggest that host immunity is impaired with the progression of stomach cancer.
Adult
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Age Distribution
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Aged
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Antigens, CD19/analysis
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Antigens, CD3/analysis
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CD4-Positive T-Lymphocytes/cytology
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CD8-Positive T-Lymphocytes/cytology
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Female
;
Human
;
Lymphocyte Count
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Lymphocyte Subsets/chemistry/*immunology
;
Male
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Middle Age
;
Receptors, IgG/analysis
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Sex Distribution
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Stomach Neoplasms/blood/*immunologym
9.A case of multiple endocrine neoplasia type 3.
Kun Ho YOON ; Soon Jip YOO ; Hyun Sik SON ; Moo Il KANG ; Kwan Soo HONG ; Kwang Woo LEE ; Ho Young SON ; Sung Ku KANG
Journal of Korean Society of Endocrinology 1991;6(3):282-286
No abstract available.
Multiple Endocrine Neoplasia*
10.Male pseudohermaphroditism due to 17alpha-hydroxylase deficiency.
Hyun Shik SON ; Yong Seog OH ; Soon Jip YOO ; Kun Ho YOON ; Moo Il KANG ; Kwan Soo HONG ; Kwang Woo LEE ; Ho Young SON ; Sung Ku KANG
Journal of Korean Society of Endocrinology 1992;7(2):153-159
No abstract available.
46, XY Disorders of Sex Development*
;
Humans
;
Male*