No abstract available.
Leiomyoma*

White rabbits weighing about 2kg, divided in 2 groups: the first group is administered with 5 mg, of testosterone propionate and second group administered with 50mg. The animals are killed after one, two and three weeks of administration from each group. Pituitary gland, thymus, adrenal gland and testis are removed and cut into thin preparation followed by staining with homatoxylin-eosin and van Gieson. The slides are examined microscopically and the results are as follows: 1) The chief cells and basophilic cells of anterior lobe of pituitary gland showed slight degeneration alone with vascular dilatation and congestion. s a whole, the group of massive dose revealed more severe degeneration than in the other group. 2) Thymus manifested marked congestion and severe hemorrhage, interlobular connective tissue proliferation and atrophic change in the cortex and medulla with fatty degeneration. In the group administered with massive dose, the changes are more remarkable. 3) In the adrenal gland, whole layers of cortex revealed cloudy swelling and hyaline degeneration. The cells of zona reticularis showed marked congestion. In the massive dose group, these changes are slightly more emphasized. 4) In the testis, germ cells and Sertoli cells are undergoing cloudy swelling and thickening of the basement membrane, and decreased spermatogenesis. In the group of massive dose, the changes are more prominent.
Adrenal Glands* ; Animals ; Basement Membrane ; Basophils ; Connective Tissue ; Dilatation ; Estrogens, Conjugated (USP) ; Germ Cells ; Hemorrhage ; Hyalin ; Pituitary Gland ; Pituitary Gland, Anterior* ; Rabbits ; Sertoli Cells ; Spermatogenesis ; Testis* ; Testosterone Propionate ; Testosterone* ; Thymus Gland* ; Zona Reticularis

No abstract available.
Candida* ; Esophagitis* ; HIV Infections* ; HIV* ; Humans

No abstract available.
Anemia, Aplastic*

Aortoesophageal fistula is an uncommon and fatal complication after surgery of aortic aneurysm. A case of aortoesophageal fistula as a complication of synthetis patch aortoplasty for mycotic aneurysm of descending thoracic aorta is described. After 3 months since patch aortoplasty for mycotic aneurysm of descending thoracic aorta this patient visited the emergency room due to melena and hematemesis. After gastrofiberoscopy and computed tomography the patient was taken ot the operating room. The surgical intervention was performed in two steps. Median sternotomy and midline laparotomy were made. Hemashield's Dacron(16mm) bypass between ascending thoracic aorta and infra-renal abdominal aorta was established first. Through the posterolateral thoracotomy false aneurysm and previous Hemashield's Dacron patch of descending aorta were resected. The two ends of the aorta were sutured and esophageal fistula was repaired. The esophageal suture line and the stumps were covered with omental graft. Thirty months later the patient has had no difficulty referable to the aortic surgery.
Aneurysm, False ; Aneurysm, Infected* ; Aorta ; Aorta, Abdominal ; Aorta, Thoracic* ; Aortic Aneurysm ; Emergency Service, Hospital ; Esophageal Fistula ; Fistula* ; Hematemesis ; Humans ; Laparotomy ; Melena ; Operating Rooms ; Polyethylene Terephthalates ; Sternotomy ; Sutures ; Thoracotomy ; Transplants

No abstract available.
Kidney Transplantation* ; Pregnancy*

BACKGROUND: In Korea, the prevalence of tuberculosis and hepatitis is high, and combined therapy with rifampicin and pyrazinamide is used in tuberculosis, so drug induced hepatitis is not only problem of tuberculosis therapy but also cause of treatment failure. However most of recent reports on drug induced hepatitis during antituberculosis medication have dealt with its pathogenesis and have stressed the biochemical, and histopathological aspects of the disorder, whereas this study was designed primarily to provide information on the clinical features. METHOD: The subjects of study were 1414 patients treated with antituberculosis drugs on the department of chest medicine at National Medical Center during the 5-year 6-month period from January 1, 1988, to June 30, 1993. Retrospective analysis of clinical features for the 29 patients who developed drug induced hepatitis was done. RESULTS: 1) The incidence of antituberculosis drug induced hepatitis was 2.1%. 2) Male to female ratio of antituberculosis drug induced hepatitis was 2:1, but case rates among males and females were not significantly different. 3) Rates of drug induced hepatitis according to age distribution shows the most common incidence between 35 to 49 year old age group, but rates among groups of age were not significantly different. 4) Drug induced hepatitis was most common in the case of moderate advanced Pulmonary tuberculosis(rate is 2.78%), but rates among types of tuberculosis were not significantly different. 5) 18 cases(62%) of antituberculosis drug induced hepatitis patients had no signs or symptoms. In remaining cases, they were nausea, vomiting, jaundice, hepatomegaly, icteric sclera, right upper quadrant -tenderness in order 6) 22 cases(76%) of antituberculosis drug induced hepatitis cases had occurred within the first month. 7) The duration of abnormal liver function was 28±5(Mean±SD), ranged from 5 days to 180 days. 8) One case of antituberculosis drug induced hepatitis died. 9) The levels of abnormal GOT ranged from 64 to 1055U/L and GPT from 68 to 931U/L. CONCLUSION: There are no decided predisposing factors of antituberculosis drug induced hepatitis, so it should be done biochemical monitoring as week as close monitoring for overt signs or symptoms of hepatitis to avoid the development of irreversible hepatic reaction, especially at the treatment of the first month.
Age Distribution ; Causality ; Female ; Hepatitis* ; Hepatomegaly ; Humans ; Incidence ; Jaundice ; Korea ; Liver ; Male ; Nausea ; Prevalence ; Pyrazinamide ; Retrospective Studies ; Rifampin ; Sclera ; Thorax ; Treatment Failure ; Tuberculosis ; Vomiting

Recently, there is a increasing tendency in microvascular free flap reconstruction. But microvascular free flap transfer requires much time in mastering the suture technique as well as long operation time. Moreover it carrys the risk for thrombosis and total flap failure. So, these factors have inspired the need for quicker and easier methods for microvascular anastomosis. Since the Nakayama`s experimental work on ring-pin anastomotic device, many experimental and clinical works on mechanical anastomosis system have been developed. Authors have tried 3M microvascular anastomotic device in 25 cases of free flap transfer for the last 3 years. The results are as follows: 1) Mean follow-up period was 5.2 months. 2) Mean time for the vein anastomosis was 5.5 minutes. 3) Survival rate of the flap was 100 %. We got a conclusion that 3M microvascular coupling device can be a safe, fast and reliable adjunct for soft and friable venous microvascular anastomosis.
Follow-Up Studies ; Free Tissue Flaps* ; Survival Rate ; Suture Techniques ; Thrombosis ; Veins

Recently, there is a increasing tendency in microvascular free flap reconstruction. But microvascular free flap transfer requires much time in mastering the suture technique as well as long operation time. Moreover it carrys the risk for thrombosis and total flap failure. So, these factors have inspired the need for quicker and easier methods for microvascular anastomosis. Since the Nakayama`s experimental work on ring-pin anastomotic device, many experimental and clinical works on mechanical anastomosis system have been developed. Authors have tried 3M microvascular anastomotic device in 25 cases of free flap transfer for the last 3 years. The results are as follows: 1) Mean follow-up period was 5.2 months. 2) Mean time for the vein anastomosis was 5.5 minutes. 3) Survival rate of the flap was 100 %. We got a conclusion that 3M microvascular coupling device can be a safe, fast and reliable adjunct for soft and friable venous microvascular anastomosis.
Follow-Up Studies ; Free Tissue Flaps* ; Survival Rate ; Suture Techniques ; Thrombosis ; Veins

BACKGROUND AND OBJECTIVES: The purpose of this study was to investigate the familial correlation and heritability of the LDL cholesterol level through a segregation analysis. SUBJECTS AND METHODS: This study was based on the data from 9,884 Korean individuals, ascertained as pedigrees, who had participated in the 1998 and 2001 Korean National Health & Nutrition Examination Survey. The subjects of the segregation analysis were 3,613 Korean with more than five family members. RESULTS: The LDL cholesterol level revealed a strong familial correlation among spouses, parental-offspring and siblings; a low correlation with spouses, but a high correlation with parental-offspring and siblings. The heritability of the LDL cholesterol level was 37.3%, when controlled for age, age2, gender, age x gender, waist circumference, smoking, alcohol drinking, exercise and education. After the segregation analysis, models of the major gene effects were rejected in the general population. However, the Mendelian dominant and co-dominant models were found in high risk families. CONCLUSION: In conclusion, the randomly ascertained Korean families of this study showed strong familial aggregation in the LDL cholesterol level. This suggested that variations in the level of LDL cholesterol may be influenced by a major gene effect.
Alcohol Drinking ; Cholesterol, LDL ; Education ; Humans ; Siblings ; Smoke ; Smoking ; Spouses ; Waist Circumference