1.Significance of Serum CA 125 and CA 15-3 Levels in Patients with Ovarian Tumor.
Korean Journal of Gynecologic Oncology and Colposcopy 1994;5(1):36-44
The concentration of the turnor markera CA 125 and CA 15-3 in serum of patients with ovarian tumors was quantitated to test if there is a diacrimination between benign and malignant ovariam tumors. In the study of 96 patients, 76 benign ovarian tumniors and 20 malignant ovarian tummors, the sensitivity of the preoperatiue serurn CA 125 level (>35U/ml) in cletezting malignant tumor was 75%, spicificity 78%, positive predictive value 47% engative predictive value 92%, diagnostic efficacy 77%. The sensitivit,y of the preopratiue aerum CA 15-3 level (>20U/ml) was 30%, specilicity 99%, positive prdictive value 86%, negative prodictive value 84%, deagnostic value 84%. In the elevation of CA 125 alone and both Ca 125 and 15-3 concentration, the positivity and false positivity were 70%,11% and 25%, 1% in the doagnosis of malignant ovarian tumor respectuvely. Therefore our results suggest that additional measurement of CA 15-3 is more helful than measure ment of CA 125 alone in descriminating benign from malignant ovarian tumors by increasing the specificity.
Humans
;
Sensitivity and Specificity
;
Weights and Measures
2.An Immunohistochemical Study for the ras and neu Oncoprotein and Epidermal Growth Factor Receptor in the Uterine Cervical Carcinoma.
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(1):43-55
To evaluate the expression of ras, neu oncoprotein a.nd epidermal growth factor receptor (EGFR) on uterine cervieal carcinoma, imimunohistochemieal staining was performed on 9 cases of dysplasia, 39 cases of careinoma in situ(CIS), 32 cases of microinvasive earcinoma(WIC) and 60 cases of frankly invasive carrinoma(FIC). The results obtained were as follows: Ras p21 protein was positive in 29.5% of total cases, and it was very low in dysplasia lesion(12. 5%) and CLS(17.9%) while it was high in MIC(31.3%) and FIC(38.9%). In CIS, parabasal cell type showed positive reaction in only 8.7%, but pleomorpkic type showed 60.0% positivity. Invasive carcinoma showed no significant differences between histolegic types. Expression of neu protein was very high in caneerous group(around 95%) and slight,ly lower in dysp]asia(75.0%). No differences were found depending on histologic types and stages. EGFR was expressed in 51.8% of total cases; 12.5% of dysplasia; 54.2% of all cases of carcinoma. Keratinizing type of CIS showed highest positive reaction(90,0%), of which tendency were also noted in keratinizing type of i.nvasvie cinoma(76.2%). The results suggested that ras and EGFR could be used as a factor of prognostic value.
Epidermal Growth Factor*
;
Receptor, Epidermal Growth Factor*
3.A Case of Incontinentia Pigmenti (Bloch - Sulzberger type) in Male.
Korean Journal of Dermatology 1982;20(3):487-491
No abstract available.
Humans
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Incontinentia Pigmenti*
;
Male*
4.A Case of Baso-Squamous Cell Carcinoma.
Korean Journal of Dermatology 1980;18(6):619-623
A 67 year-old male patient had butterfly-shaped ulcer with oozing on the face since 25 years ago. Histopathologically the lesion showed basal cell and squamous cell carcinoma. He received skin graft after surgical excision and showed no evidence of recurrence or metastasis for over six months.
Aged
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Carcinoma, Squamous Cell
;
Humans
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Male
;
Neoplasm Metastasis
;
Recurrence
;
Skin
;
Transplants
;
Ulcer
5.Hereditary Hemorrhagic Telangiectasia in a Family.
Korean Journal of Dermatology 1990;28(6):826-830
We report three cases of hereditary hemorrhagic telangiectasia in one family. The punctiform, spider-like and nodular telangieectatic lesions were presented in these all patients, the father, son an daughter. But nevus flammeus-like lesion which was the unusual manifestation of hereditary hemorrhagic telangiectasia was noticed on daughters chest. There were no abnormal laboratory findings and no evidence of systemic disease. Histological findings showed only dilated telangiectatic blood vessels in the upper dermis.
Blood Vessels
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Dermis
;
Fathers
;
Humans
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Nevus
;
Nuclear Family
;
Telangiectasia, Hereditary Hemorrhagic*
;
Thorax
6.A Clinical Study of 12 Cases of Sarcoma of the Uterus.
Korean Journal of Gynecologic Oncology and Colposcopy 2000;11(4):404-410
OBJECTIVE: Sarcoma of uterus is originated from uterine muscles and/or connective tissues and rare and most lethal of all primary uterine tumors. The purpose of this study was to evaluate the clinical outcome of 12 patients diagnosed primary uterine sarcoma at the Department of Obstetrics and Gynecology in Kyungpook National University Hospital between 1984 and 1998 for 15 years. METHODS: After review of chart in twelve patients, data including clinical and histologic findings, treatment and outcome were analysed. RESULTS: The most common histologic finding was leiomyosarcoma(6cases, 50%) and the age of patients ranged 24 to 69 years and the average age was 43.25 years and two patients were nulliparous. The most common sign was abnormal uterine or vaginal bleeding(48%), and pelvic cavity or vaginal mass(16%), pelvic pain(16%), no symptom(16%), in order of frequency. The distribution by FIGO clinical stage was four cases(33%) for stage I, one case (8%) for stageII, one case(8%) for stage III, six cases (50%) for stage N. The nine cases received hysterectomy with or without BSO. Two cases received myomectomy to preserve fertility. The mean follow-up duration was 39.6 months. CONCLUSION: Uterine sarcoma is an uncommon and aggressive tumors with a poor prognosis. Leiomyosarcoma is the most frequent histologic type(50%). Stage I uterine sarcoma with or without adjuvant chemotherapy has better prognosis than other stages.
Animals
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Chemotherapy, Adjuvant
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Connective Tissue
;
Female
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Fertility
;
Follow-Up Studies
;
Gyeongsangbuk-do
;
Gynecology
;
Humans
;
Hysterectomy
;
Leiomyosarcoma
;
Mice
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Myometrium
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Obstetrics
;
Prognosis
;
Sarcoma*
;
Uterus*
7.A Case of Ritter's Disease.
Korean Journal of Dermatology 1971;9(3):61-64
The authors observed and treated a case of Ritter's disease, 1 month old male child, and admitted with complaint of generalized exfoliation followed by spontaneous erythema and blister on face, trunk and intertriginous areas for 3 days. The patient was treated with antibiotics and steroid-antibiotic ointment, and was discharged on 10th day after admission with cleared up of lesions.
Anti-Bacterial Agents
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Blister
;
Child
;
Erythema
;
Humans
;
Infant, Newborn
;
Male
;
Staphylococcal Scalded Skin Syndrome*
8.A case of necrotizing enterocolitis associated with cow and soy milk intolerance.
Sang Soo ROH ; Young Il PARK ; Sang Il LEE
Journal of the Korean Pediatric Society 1992;35(6):862-866
No abstract available.
Enterocolitis, Necrotizing*
;
Soy Milk*
9.Mechanisms of HPV-16-induced Transformation in Human Epithelial Cells in Culture.
Heon Soo LEE ; Jae Ho YANG ; Il Soo PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(4):298-307
Human epithelial cell line immortalized by Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 via calcium-phosphate method. Subsequently, 8 clonal cell lines were obtained after G418 selection. Among these clonal cells, clonal cell-4(C-4) and clonal cell-6(G-6) showed increases of tumorigenic cellular properties such as saturation density, soft agar colony formation and cell aggregation. Morphological alteration such as appearane of foci was observed on these two clones after passage 6 and 7(50 to 55 days after transfection). When clonal cells and control cells were treated with MNNG(0.01ug/ml), both C-4 and C-6 showed increases of tumorigenic cellular properties and the level of increase was much more elevated as compared to clonal cells prior to MNNG treatment. Appearance of foci formation was observed in C-4 and C-6 after passage-6. After passage-8, control cells and all clonal cells showed morphological alterations. It seems that treatment of cells containing HPV-16 DNA with MNNG increases tumorigenic properties of the cells and expedite morphological transformations. (continue)
Agar
;
Cell Aggregation
;
Cell Line
;
Clone Cells
;
DNA
;
Epithelial Cells*
;
Human papillomavirus 16
;
Humans*
;
Methylnitronitrosoguanidine
;
Plasmids
10.Hepatic Changes Resembling the Indian Childhood Cirrhosis in an IgM anti-CMV Positive Infant.
Soo Im CHOI ; Chan Il PARK ; Ki Sup CHUNG
Korean Journal of Pathology 1987;21(2):90-93
This is to describe a neonatal hepatitis with pericellular hepatic fibrosis and Mallory bodies in a sero-positive infant for IgM anti-CMV. A necropsy of the liver revealed severe heaptocellular swelling with many intracytoplasmic hyaline bodies, pronounced fibrosis of a creeping type, bile stasis with ductular proliferation, and the lack of parenchymal regeneration. These microscopical changes of the liver resembled those of Indian Childhood Cirrhosis (ICC). In the present case the patient's serum IgM anti-CMV is the only clue for the etiological diagnosis.
Infant
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Child
;
Male
;
Female
;
Infant, Newborn
;
Humans