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OBJECTIVE: To evaluate the colonic motility and nutrients intake in children with spastic cerebral palsy (CP) and to compare the results with those of normal children. METHOD: Thirty-eight children with spastic CP were participated in this study. They took the radioopaque markers for 3 successive days. Then, abdominal X-ray was taken on the fourth day. Total and segmental colon transits were estimated by the simplified assessment of a single-film technique by Metcalf et al. The amounts of nutrients intake for 3 days were recorded and nutritional factors were analyzed by ESHA Food Processor. Then, daily intakes of the nutrients were compared with Recommended Dietary Allowance of the Korean Nutrition Society. RESULTS: Total and segmental colon transit time were more than 2 times delayed in children with spastic CP as compared with those of normal controls. Total colon transit time was significantly prolonged in quadriplegic and non-ambulatory children (p<0.05). On the evaluation of daily nutrients intake, most of nutritional factors were inadequate in children with spastic CP. CONCLUSION: The children with spastic CP had the problems in colonic motility and nutritional intake. Also, delayed colon transit time was significantly related with poor mobility. Therefore, early intervention for these problems will be required in spastic CP, especially quadriplegic and non-ambulatory children.
Cerebral Palsy* ; Child* ; Colon* ; Early Intervention (Education) ; Humans ; Muscle Spasticity* ; Recommended Dietary Allowances

10.Expression of Mutant p53 and MAGE-3 Gene Products in Esophageal Squamous Cell Carcinoma.

Sung Rae CHO ; Il Chong YANG ; Chung Seok LEE ; Do Hwan CHUN ; Hee Kyung CHANG

The Korean Journal of Thoracic and Cardiovascular Surgery 2001;34(1):64-71

BACKGROUND: Despite recent advances in multimodality therapy, the prognosis for invasive esophageal cancer is poor, with five years survival rate generally below 10%. Therefore, immunotherapy is considered as one of the new therapeutic modality in esophageal cancer. However, expression of tumor specific antigen in tumor tissue should be necessary for immunotherapy of tumor. This study is to clarify that mutant p53 protein and MAGE-3 gene product is expressed in esophageal cancer specifically and they can be played a role of prognostic factors in esophageal cancer. MATERIAL AND METHOD: Expression of mutant p53 protein and MAGE-3 gene products in formalin fixed, paraffin embedded samples of 79 patients with primary squamous cell carcinoma of the esophagus, who undewent esophageal resection, were analyzed immunohistochemically with DO-7 monoclonal antibody and anti- MAGE-3 antibody. Twenty cases of esophageal normal mucosa and 20 cases of leiomyoma which is a benign tumor of esophagus, were used as control groups. Immunoreactivities of mutant p53 and MAGE-3 gene product in esophageal cancer tissues were analyzed and the relationships between immunoreactivity of mutant p53 protein, MAGE-3 gene product and AJCC stage of esophageal cancer were determined by the Chi-square test. RESULT: Positive immunoreactivity of mutant p53 and MAGE-3 gene product were each of 41/79(51.9%), 48/79(60.8%) in esophageal cancer tissue, but 0% in normal mucosa and leiomyoma of esophagus(p<0.001). Both immunoreactivity of mutant p53 and MAGE-3 gene products were not related to AJCC stage of esophageal cancer(p=0.193, p=0.452). There was not correlation between expression of mutant p53 protein and MAGE-3 gene product in esophageal cancer(p=0.697). CONCLUSION: Mutant p53 and MAGE-gene product cannot be a prognostic factor in squamous cell carcinoma of esophagus, but mutant p53 and MAGE-3 gene product is expressed in squamous cell carcinoma of the esophagus specifically, so esophageal cancer can be target for cytotoxic T lymphocyte in anticancer immunotherapy.
Carcinoma, Squamous Cell* ; Esophageal Neoplasms ; Esophagus ; Formaldehyde ; Humans ; Immunotherapy ; Leiomyoma ; Lymphocytes ; Mucous Membrane ; Paraffin ; Prognosis ; Survival Rate

1.Renal transplantation in CsA-treated patients aged 50 years and older.

2.Causes of death after kidney transplantation, 1979 to 1991.

3.Multivariate and univariate analyses of risk factors affecting graft survival of 700 primary living donor renal transplants based on Yonsei Medical Center Experience.

4.Experimental study of biomechanical charateristics of anterior talofibular ligament.

5.Usefullness of duplex deppler ultrasonography in renal allograft patient for the evaluation of renal dysfunction.

6.Treatment of steroid-resistant acute rejection after renal allograft.

7.Myopathy with Congenital Fiber Type Disproportion (CFTD): A case report .

8.Whole blood cyclosporine measurement by fluorescence polarization immunoassay.

9.Assessment of Colonic Motility and Nutrients Intake in Children with Spastic Cerebral Palsy.

10.Expression of Mutant p53 and MAGE-3 Gene Products in Esophageal Squamous Cell Carcinoma.

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