1.Primary Malignant Lymphoma of the Liver: Report of a case.
Soo Kyong CHUNG ; Chang Suck KANG ; Won Il KIM ; Sang In SHIM ; Sun Moo KIM
Korean Journal of Pathology 1987;21(4):285-290
Primary extranodal lymphoma of the liver is very rare, approximately thirty-one cases having been reported in the literature. We report one case of primary malignant lymphoma of the liver in a 26-year-old female, who was presented with palpable abdominal mass on the epigastrium for about 40 days. Laboratory findings revealed no specific abnormalities. Peripheral lymph nodes or spleen were not palpable. An abdominal ultrasonogram revealed a huge mass involving the entire left lobe of the liver. Left lateral segmentectomy of the liver was done. The resected lateral portion of left lobe of the liver showed a large solitary mass, 12 cm in the greatest dimension, with a yellowish gray fleshy solid cut surface. Though light microscopic feature was compatible with primary malignant lymphoma, diffuse large cell type, intermediate grade by the working formulation, undifferentiated carcinomas including hepatocellular carcinoma, plasmacytoma, and pleomorphic sarcomas could not be completely ruled out. Thus, marker studies and electron microscopic examination were performed. Immunoperoxidase stains for common leukocyte antigen was positive, and the Leder stain for myeloid granule was negative. Electron microscopic stuids revealed findings of neoplastic lymphoid cells, consistent with malignant lymphoma. Primary lymphoma of the liver has only rarely been reported, and its natural history is unclear. Many of the reported cases have been large cell lymphomas, as in this case.
Female
;
Humans
;
Carcinoma, Hepatocellular
2.The effect of inductive chemotheraphy with FAC regimen on breast cancer.
Eil Sung CHANG ; Young Il KIM ; Seung Moo NOH ; Jin Sun BAE ; Ki Sub SON
Journal of the Korean Surgical Society 1993;44(4):520-527
No abstract available.
Breast Neoplasms*
;
Breast*
3.Espihageal Atresia with Tracheoesophageal Fistula and Other Multiple Congenital Anomalies: An autopsy case.
Mee Soo CHANG ; Hye Ju AN ; Kyo Young LEE ; Won Il KIM ; Sang In SHIM ; Sun Moo KIM
Korean Journal of Pathology 1989;23(1):145-148
We experienced an autopsy case of esophageal atresia with tracheoesophageal fistula and other multiple congenital anomalies in a 4 days old male infant. Esophageal atresia with tracheoesophageal fistula was type C by Gross Classification. Combined anomalies were malrotation of left kidney, one left accessory renal artery form right renal artery and one left accessory renal vein from right renal vein, duodenal atresia and annular pancreas. Until now, the esophageal atresia with tracheoesophageal fistula and other multiple congenital anomalies (7 congenital anomalies) are not reported in the korean literature, except our case. Our autopsy case, it suggests that esophageal atresia with tracheoesophageal fistula has often close relation-ship with other multiple congenital anomalies.
Infant
;
Male
;
Female
;
Humans
4.An experimental study for the evaluation of hemopoietic effects of 9 medicinal plants used in herbal drugs.
Mi Kyung CHUNG ; Ok Kyung KIM ; Il Moo CHANG ; Myung Hee PARK ; Sang In KIM
Korean Journal of Hematology 1993;28(2):285-297
No abstract available.
Plants, Medicinal*
5.Complications in spinal cord injured patients.
Young Moo NA ; Chang Il PARK ; Saeil CHUN ; Jung Soon SHIN
Journal of the Korean Academy of Rehabilitation Medicine 1991;15(1):12-21
No abstract available.
Humans
;
Spinal Cord*
6.Therapeutic efficacy of trimetazidine on angina pectoris.
Moo Hyun KIM ; Il PARK ; Jung Ha PARK ; Sun Taek KIM ; Chang Ho YANG ; Jong Seong KIM
Korean Circulation Journal 1993;23(3):461-467
BACKGROUND: Trimetazidine 1(2, 3, 4 trimethoxybenzyl)-piperazine dihydrochloride has shown improved exercise tolerance and delayed ischemic threshold in patients with effort angina. But, unlike other classical antianginal drugs, it netiher reduces oxygen consumption nor increases the blood supply. Its effects could be attributed to protection of the myocardial cell function during ischemia, preventing the fall of ATP, reducing intracellular acidosis and subsequently preventing the accumulation of sodium and calcium in the myocyte. METHODS: We investigated the antianginal efficacy of trimetazidine(Vastinan) in 36 patients(22 males, 14 females, mean age of 56.5 year) who had positive exercise stress test among those with typical effort anginal symptoms from Feb, 1992 to Oct, 1992. These patients received 60mg trimetazidine per day(20mg tid) for 1 month and then exercise stress test, routine hematologic examination and urinalysis were performed at the beginning and at the end of therapeutic examination and urinalysis were performed at the beginning and at the end of therapeutic period. The results were as follows. RESULTS: In exercise parameters, there were 19.2% increase in total work, 30.3% increase in exercise duration and 13% shortening in the normalization time of depressed ST-segment and these were no significant change in hemodynamic parameters(heart rate, blood pressure and maximum Rpp(rate pressure product)(p>0.05). The characters of chest pain were changed in the 19 patients, complete disappearance in 4 patients, reduction of intensity or frequency in 12 patients and aggravation in 3 patients. 2 patients complained of mild epigastric discomfort. There were no significant changes in hematologic findings and urinalysis. CONCLUSIONS: Trimetazidine 60mg per day was efficient in patients with angina and more observations are necessary in assessing the long-term therapeutic efficacy and side effects of this drug.
Acidosis
;
Adenosine Triphosphate
;
Angina Pectoris*
;
Blood Pressure
;
Calcium
;
Chest Pain
;
Exercise Test
;
Exercise Tolerance
;
Female
;
Hemodynamics
;
Humans
;
Ischemia
;
Male
;
Muscle Cells
;
Oxygen Consumption
;
Sodium
;
Trimetazidine*
;
Urinalysis
7.Accuracy of 18F FDG PET after Surgery and Radiotherapy in Head and Neck Cancers.
Weon Il YANG ; Chang Woon CHOI ; Yong Sik LEE ; Byeung Il KIM ; Jae Sung LEE ; Sang Moo LIM ; Yoon Sang SHIM ; Sung Woon HONG
Korean Journal of Nuclear Medicine 1999;33(6):466-474
PURPOSE: The purpose of this study was to evaluate the diagnostic accuracy of [18F]FDG PET in the diagnosis of recurrent head and neck cancer after the completion of surgery and radiotherapy in patients with head and neck cancers. MATERIALS AND METHODS: In fifty-nine patients with head and neck cancers, whole body [18F]FDG PET studies were performed. According to the different therapeutic modalities, patients were divided into four groups (Group I; pre-treatment, Group II; surgery, Group III; radiotherapy, Group IV; both surgery and radiotherapy). [18F]FDG PET images were compared with clinical, CT and histopathologic findings. RESULTS: For detection of metastatic lymph nodes in 14 patients of pre-treatment group (group I), the sensitivity and specificity of PET were 100% (10/10) and 75% (3/4), and those of CT were 80% (8/10) and 100% (4/4). For detection of recurrence in 45 patients of post-treatment group, overall sensitivity and specificity of PET were 96.2% (25/26) and 78.9% (15/19) [(100% and 75% in group II, 80% and 50% in group III, and 100% and 100% in group IV)] without significant difference from pre-treatment group (p>0.1). In detecting recurrence, the sensitivity and specificity of [18F]FDG PET were 90.9% (10/11) and 20% (1/5) in 16 patients who underwent [18F]FDG PET within 2 months after the completion of treatment. The specificity of these patients was significantly lower than that of 29 patients (100% of sensitivity and specificity) who underwent [18F]FDG PET 2 months after treatment (p<0.05). CONCLUSION: [18F]FDG PET is an accurate diagnostic modality for the detection of recurrence in head and neck cancer. Post-therapy [18F]FDG PET should be obtained at least 2 months after the completion of surgery or radiotherapy.
Diagnosis
;
Head and Neck Neoplasms
;
Head*
;
Humans
;
Lymph Nodes
;
Neck*
;
Radiotherapy*
;
Recurrence
;
Sensitivity and Specificity
8.Radiation Absorbed Dose Measurement after I-131 Metaiodobenzylguanidine Treatment in a patient with Pheochromycytoma.
Weon Il YANG ; Byeung Il KIM ; Jae Sung LEE ; Jeong Rim LEE ; Chang Woon CHOI ; Sang Moo LIM ; Sung Woon HONG
Korean Journal of Nuclear Medicine 1999;33(4):422-429
PURPOSE: The measurement of radiation absorbed dose is useful to predict the response after I-131 labeled metaiodobenzylguanidine (MIBG) therapy and determine therapy dose in patients with unresectable or malignant pheochromocytoma. We estimated the absorbed dose in tumor tissue after high dose I-131 MIBG in a patient with pheochromocytoma using a gamma camera and Medical Internal Radiation Dose (MIRD) formula. MATERIALS AND METHODS: A 64-year old female patient with pheochromocytoma who had multiple metastases of mediastinum, right kidney and periaortic lymph nodes, received 74 GBq (200 mCi) of I-131 MIBG. We obtained anterior and posterior images at 0.5, 16, 24, 64 and 145 hours after treatment. Two standard sources of 37 and 74 MBq of I-131 were imaged simultaneously. Cummulated I-131 MIBG uptake in tumor tissue was calculated after the correction of background activity, attenuation, system sensitivity and count loss at a high count rate. RESULTS: The calculated absorbed radiation dose was 32-63 Gy/ 74 GBq, which was lower than the known dose for tumor remission (150-200 Gy). Follow-up studies at 1 month showed minimally reduced tumor size on computed tomography, and mildly reduced I-131 MIBG uptake. CONCLUSION: We estimated radiation absorbed dose after therapeutic I-131 MIBG using a gamma camera and MIRD formula, which can be peformed in a clinical nuclear medicine laboratory. Our RESULTS suggest that the measurement of radiation absorbed dose in I-131 MIBG therapy is feasible as a routine clinical practice that can guide further treatment plan. The accuracy of dose measurement and correlation with clinical outcome should be evaluated further.
3-Iodobenzylguanidine
;
Female
;
Follow-Up Studies
;
Gamma Cameras
;
Humans
;
Kidney
;
Lymph Nodes
;
Mediastinum
;
Middle Aged
;
Neoplasm Metastasis
;
Nuclear Medicine
;
Pheochromocytoma
9.Findings of F - 18 FDG Whole Body PET in Patients with Stomach Cancer.
Byung Il KIM ; Jong Inn LEE ; Won Il YANG ; Jae Sung LEE ; Gi Jeong CHEON ; Chang Woon CHOI ; Sang Moo LIM ; Sung Woon HONG
Korean Journal of Nuclear Medicine 2001;35(5):301-312
No abstract available.
Humans
;
Stomach Neoplasms*
;
Stomach*
10.The Usefulness of F-18-FDG PET and The Effect of Scan Protocol in Diagnosis of Intraocular Tumors.
Seong Woon HONG ; Chang Woon CHOI ; Sang Moo LIM ; Tae Won LEE ; Jae Sung LEE ; Weon Il YANG ; Byeung Il KIM ; Min Kyeung SIM
Korean Journal of Nuclear Medicine 1999;33(5):439-451
PURPOSE: It is important to differentiate malignant from benign lesions of intraocular masses in choosing therapeutic plan. Biopsy of intraocular tumor is not recommended due to the risk of visual damage. We evaluated the usefulness of F-18-FDG PET imaging in diagnosing intraocular neoplasms. MATERIALS AND METHODS: F-l8-FDG PET scan was performed in 13 patients (15 lesions) suspected to have malignant intraocular tumors. There were 3 benign lesions (retinal detachment, choroidal effusion and hemorrhage) and 10 patients with 12 malignant lesions (3 melanomas, 7 retinoblastomas and 2 metastatic cancers). Regional eye images (256*256 and 128*128 matrices) were obtained with or without attenuation correction. Whole body scan was also performed in eight patients (3 benign and 6 malignant lesions). RESULTS: All malignant lesions were visualized while all benign lesions were not visualized. The mean peak standardized uptake value (SUV) of malignant lesions was 2.64+/-0.57 g/ml. There was no correlations between peak SUV and tumor volume. Two large malignant lesions (>1000 mm3 ) showed hot uptake on whole body scan. But two medium-sized lesions (100-l000 mm3) looked faint and two small (<100 mm3) lesions were not visualized. The images reconstructed with 256*256 matrix showed lesions more clearly than those with 128X128 matrix. CONCLUSION: F-18-FDG PET scan is highly sensitivity in detecting malignant intraocular tumor. For the evaluation of small-sized intraocular lesions, whole body scan is not appropriate because of low sensitivity. A regional scan with sufficient acquisition time is recommended for that purpose. Image reconstruction in matrix size of 256*256 produced clearer images than the ones in 128X128, but it does not affect the diagnostic sensitivity.
Biopsy
;
Choroid
;
Diagnosis*
;
Humans
;
Image Processing, Computer-Assisted
;
Melanoma
;
Orbital Neoplasms
;
Positron-Emission Tomography
;
Retinoblastoma
;
Tumor Burden
;
Whole Body Imaging