1.Diagnostic Accuracy in Endoscopic Gastric Biopsy - Part 1. Analysis of preoperative gastric biopsies in 236 cases with neoplastic lesions based on gastretomy and histotopographic investigation.
Korean Journal of Gastrointestinal Endoscopy 1983;3(1):10-16
Two hundreds and forty six preoperative endoseopic gastric biopsies from 236 conaecutive cases were subjected to the retrospective analyais of diagnostic accuracy among 597 tumor- bearing gastrectomy specimens confirmed by extended histotopographic investigations during a period of 1980 to 1981 at Seoul National University Hospital. The overall diagnostic accuracy of endoscopic gastric biopsy was 93.1% with 0.8% false positivity and 3.5% of false negative caaes; of those, the concordance rate of preoperative biopsy diagnosis based on the histotopographic investigation of the gastrectomy remained in 85.5%, whereas 75% of diagnostic discrepancy wae reaulted from inappropriate biopsy sampling or failure of neoplastic tissue obtainability; and the rest of 25% was mostly false negative cases. (continue...)
Biopsy*
;
Diagnosis
;
Gastrectomy
;
Retrospective Studies
;
Seoul
2.Effect of sialadenectomy or administration of epidermal growth factor on initiation of hepatoma in rat.
Journal of the Korean Cancer Association 1993;25(2):196-201
No abstract available.
Animals
;
Carcinoma, Hepatocellular*
;
Epidermal Growth Factor*
;
Rats*
3.Cystandenoma and Primary Cystadenocarcinoma of the Liver.
Korean Journal of Pathology 1989;23(2):263-268
Primary cystic neoplasia of the liver is rare. We report a cystadenoma with mesenchymal stroma (CMS) and a cystadenocarcinoma, and make a review of literature with particular reference to their histogenesis. The CMS has many similarities to the ovarian mucinous cystadenoma; occurring almost exlusively in female, being lined by mucus-secreting epithelial cells, and containing dense ovarian-like stroma. These features suggest that CMS may arise from the ectopic ovarian tissue within the liver. Cystadenocarcinoma may have its origin in CMS or cystadenoma without mesenchymal stroma of CMS. Cholangiocarcinoma arising from the congenital hepatic cysts can be differentiated only when it contains benign epithelia.
Female
;
Humans
;
Cysts
4.A Case of 5 alpha-reductase Deficiency in Infancy.
Journal of Korean Society of Pediatric Endocrinology 1998;3(1):96-101
5 alpha-reductase deficiency resulting in male pseudohermaphroditism is a rare disease characterized by clitoral-like phallus, bifid scrotum, urogenital sinus, testis cited in labioscrotal folds. Evaluation of plasma T/DHT ratios in infancy, particularly after hCG stimulation of the testes and elevated urinary tetrahydrocortisol (THF) to 5 alpha-tetrahydrocortisol(5 alpha-THF) ratios provide a valuable dianostic test for 5 alpha-reductase deficiency. We report one case of 5 alpha-reductase deficiency who were presented with ambiguous genitalia and elevated T/DHT ratio before and after hCG stimulation.
46, XY Disorders of Sex Development
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Cholestenone 5 alpha-Reductase*
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Disorders of Sex Development
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Plasma
;
Rare Diseases
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Scrotum
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Testis
;
Tetrahydrocortisol
5.A Study of the noise level in hospital and the Count-Measure against the noise.
Korean Journal of Preventive Medicine 1973;6(1):43-49
In this study noise source in a ward at four general hospitals in Seoul area has investigated and analysed. The degree of reaction against noise by 171 randomly has also been examined. The results of the study have shown that the source of noise is the speakers of wired broadcasting or from visiting guests in two hospitals located in residential area. The patients at the two other hospitals located at commercial site have been suffered more from traffic noise, However, because of their separated living at hospital from their ordinary houselife, sixty on percent of the inpatients have wished a music sound of around 60 dB (A). After having considered the results of the investigation and wishes of the inpatients, following suggestions have been made: 1. Reduce the number of guests or their length of stay. 2. Wired bodadcasting system should be substitued by sireless one, or if it's unavoidable, it should be used in office rooms only. 3. Since the stops and starts of vehicles induce much noise, Seoul City Government be requested to prepare an appropriate administrative measure for the vehicles around hospital area and ti should prevent the establishment of new hospitals along high way site. 4. By using earphone, inpatients can choose a wireless channel according to each individual's taste. This through the masking effect, would cover up the noise source. 5. Rooms along the streets should be utilized as offices, otherwise double windows should be set up for inpatient's wards.
Hospitals, General
;
Humans
;
Inpatients
;
Length of Stay
;
Local Government
;
Masks
;
Music
;
Noise*
;
Seoul
6.Nesidioblastosis in Neonate with Persistent Hyperinsulinemic Hypoglycemia.
Il Tae WHANG ; Ho Seong KIM ; Ho Seong HAN
Journal of Korean Society of Pediatric Endocrinology 1998;3(2):231-236
Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia of infancy(PHHI) or familial hyperinsulinsm, is the most common cause of recurrent severe hypoglycemia in infancy. It is an autosomal recessive disorder characterized by irregular insulin secretion leading to inappropriately raised plasma insulin concentration compared to blood glucose levels. Recently, mutations in the sulfonylurea receptor(SUR) have been described in association with PHHI. The mainstay of medical treatment is glucose infusion and diazoxide or long acting somatostatin. If medical treatment fails in preventing hypoglycemia, near total pancreatectomy is recommended. We report one case of nesidioblastosis cured by near total pancreatectomy with brief review of literatures.
Blood Glucose
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Congenital Hyperinsulinism*
;
Diazoxide
;
Glucose
;
Humans
;
Hypoglycemia
;
Infant, Newborn*
;
Insulin
;
Nesidioblastosis*
;
Pancreatectomy
;
Plasma
;
Somatostatin
7.Expression of BrdU and C-Ha-ras in Experimentally Induced Enzyme Altered Foci of the Liver and Hepatocellular Carcinoma.
Myung Sook KIM ; Woo Ho KIM ; Yong Il KIM
Korean Journal of Pathology 1994;28(6):584-595
For sequential phenotypic changes including enzyme altered hepatocytic foci, hyperplastic nodules, hepatocellular adenomas and carcinomas were produced in Sprague-Dawley rats by Solt-Farber method (administration of diethylnitrosamine and acetylaminofluorene (AAF), and partial hepatectomy). The immunohistochemical expressions of glutathione S transferase P (GST-P) and bromodeoxyuridine (BrdU) were assessed for selective proliferative activity in the enzyme altered foci and the subsequently developed lesions by double immunohistochemical staining technique. Immunoreactive areas against GSTP gradually increase from early period of carciogenesis. BrdU labeling in such areas remained high during the first week. but decreased thereafter. BrdU labeling index remained low in the GSTP negative area throughout the experimental period. This suggests that cells in the enzyme altered foci keep away from the suppressor effect of AAF in contrast to the normal cells in which their growth are inhibited by AAF. BrdU labeling index remained very low in both hyperplastic nodule and adenoma which were prevalent during the mid-experimental period, but increase markedly in carcinoma. The long period of low BrdU labeling index seems to correspond to the "slowly growing step of persistent nodule" during hepatocarcinogenesis. The differentiation index, a ratio of S phase fraction between GSTP positive and negative areas, was low in adenoma-developing period and high in carcinoma-developing period. C-Ha-ras p21 was not expressed in foci of enzyme altered hepatocyte and hyperplasia, but highly positive in carcinoma. This indicates that the c-Ha-ras may involve the late step of hepatocarcinogenesis.
Rats
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Animals
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Adenoma
;
Carcinoma, Hepatocellular
8.Silver-binding nucleolus organizer regions in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal tumors and adjacent mucosa in rats.
Woo Ho KIM ; Yong Il KIM ; Jin Pok KIM
Journal of the Korean Cancer Association 1991;23(4):701-707
No abstract available.
Animals
;
Mucous Membrane*
;
Nucleolus Organizer Region*
;
Rats*
9.Computerization of Surgical Pathology Reporting and Data Storage by Automatic Coding System using Personal Computer.
Woo Ho KIM ; Jeong Wook SEO ; Yong Il KIM
Korean Journal of Pathology 1989;23(4):410-415
The authors developed a computer program for use in report printing as well as data storage and retrieval system at the surgical pathology and its efficacy was evaluated at the Department of Pathology, Seoul National University Hospital. This program used IBM PC XT and was written in DBASE III plus language. The main features of the program included an automatic coding and decoding of the diagnosis, automatic searching of the previous biopsy during gross dictation, powerful word processing function and flexibility of the program. The data storage was carried out during the typewriting of the report, so that the typist's workload became markedly reduced. Two kinds of data files wer stored in the hard disk ; the temporary file contained full informations and the permanent file contained the core data only. Searching of a specific case was performed by pathology accession number, chart number, patient's name or by SNOMED code within a second. All the cases were arranged by copied to the diskette during the daily service automatically, with which data were easily restored in case of hard disk failure. The advantages of this program using a persosnal computer were discussed with comparison to those of larger computer system. Based on the experience of 8 months usage in Seoul National University, we assume that this program gives a sufficient solution to the surgical pathology service of many institutes where a large computer system with well designed software is not available yet.
Biopsy
10.Heterotopic Enchondral Ossification in Metastatic Colonic Adenocarcinoma: A case report .
So Yeon PARK ; Yong Il KIM ; Woo Ho KIM
Korean Journal of Pathology 2000;34(7):531-533
Calcification and ossification of colon cancer is frequently encountered, especially in the mucinous carcinoma. However, cartilage formation or enchondral ossification has rarely been described in human colon cancer. This report describes a case of a 59-year-old man with retroperitoneal metastasis of mucinous adenocarcinoma of colon, which showed a widespread heterotopic ossification through membranous or enchondral ossification. The ossification appeared in apposition to tumor cell nests and in the organized mucin pool. In our knowledge, this is the first case showing enchondral ossification in gastrointestinal carcinoma in Korea.
Adenocarcinoma*
;
Adenocarcinoma, Mucinous
;
Cartilage
;
Colon*
;
Colonic Neoplasms
;
Humans
;
Korea
;
Middle Aged
;
Mucins
;
Neoplasm Metastasis
;
Ossification, Heterotopic