A group of chemicals that have proved to be frequent causes of allergic contact dermatitis from applied ingredients of the vehicle. Fisher (1971) testing with a vehicle tray of 15 chemicals in 100 patients with allergic contact dermatitis due to topically administered medications found 30 positive patch test reactions of patients and reported that most important sensitiiing chemicals are Ethylenediamine, Lanolin, Farabens, Phenylmercuric acid, and. propylene glycol monostearate. These chemicals have been recognized as such common sensitizers that they are nonincluded. in the standard patch test series by many countries. From the standpoint of allergenicity of topical preparations including topical medicaments and cosmetics, prevention and diagnostic procedures of dermatitis should be investigated extensively through the patch test studies. But, in our country, there has only a few investigation conceming the dermatitis from vehicle, particularly the medicaments and cosmetics. Therefore, author has tried to establish the vehicle tray fitted to our country according to the basic consideration used with the vehicle patch test tray of Fisher. 100 patients suspected of having allergic contct dermatitis due to topical medication or cosmetics were patch tested with a group of chemicals composed of substances commonly found in vehicles of current topical medications or cosmetics. There were many significant reactions to Ethylenediamine, Paraben, Lanolin, Sodium lauryl sulfate, Polyethylene glycol and Turpentine which play a significant role as solubilzer, antioxidants, emulsifieis, exirpients, preservatives, stabilizers, and surfactants. Author proposed that a group of chemicals should be patch tested on patients of allergic contact dermatitis for the establishmc,nt and development of the hypoallergenic topical medicaments or cosmetics.
Antioxidants ; Dermatitis ; Dermatitis, Allergic Contact* ; Humans ; Lanolin ; Patch Tests ; Polyethylene Glycols ; Propylene Glycol ; Sodium Dodecyl Sulfate ; Surface-Active Agents ; Turpentine

A case of Toxic epidermal necrolysis in 19 th years old man is presented. This patient has been suffering from erythematous patches and bullae over entire body including vesicles, erosions, and fissures on both lips since 2 days ago after taking some drugs (analgetics, aspirin, chloramphenicol, sulfisoxazole, erythromycine.) for treatment of tonsillitis. Furthermore, it is very difficult for us to say why the disease has occured. Toxic Epidermal Necrolysis (TEN) by talking drugs or Staphylococcal Scalded Skin Syndrpme (4S) by staphylococcus aurues because staphylococcus aureus was found on bacteriai culture from his throat swab. He was treated with corticosteroid, antibiotics and fluids for 20 days with good result. Literature was briefly reviewed.
Anti-Bacterial Agents ; Aspirin ; Chloramphenicol ; Humans ; Lip ; Palatine Tonsil ; Pharynx ; Skin ; Staphylococcus ; Staphylococcus aureus ; Stevens-Johnson Syndrome* ; Sulfisoxazole ; Tonsillitis

It has been well known for a long time that Rhus species are belonged botanically to same family called family Anacardacea and their allergenic components are identical because it contains 3-pentadecyl catechol. However, Mason (1954) and some investigators suggest the possibility that some individuals may be sensitive to a component of the oleoresin other than 3-pentadecyl catechol. By this suggestion, author performed the patch test on 138 individuals with 4 species of Korean Rhus tree (Rhus verniciflua, Rhus trichocarpa, Rhus javanica, and Rhus sylvestris.) and observed the incidence of latent sensitivity to dry leaves of Rhus trees and urushiol, The patch test results on sensitivity to Rhus verniciflua, Rhus trichocarpa, Rhus javanica, and Rhus sylvestris showed 35.50%, 27.53%, 21.01%. 28. 26%, and 29. 71% respectively and these results could make the suggestion that cross sensitivity between each Rhus trees are few and a certain specific antigenic component may be contained in every Rhus tree leaves. On animal experiment concerning the basic study for the extraction of Rhus tree antigen, author could easily sensitize the guinea pig with urushiol but couldn't challenge these animal with methanol aceton extract of Rhus leaves. From these findings, author proposed that Korean Rhus trees are different immunologically to poison ivy tree antigen and a certain specificities of antigeniciy contain in each Korean Rhus. But this postulation will need further experimental study as multiple step fractionation with Rhus tree.
Animal Experimentation ; Animals ; Guinea Pigs ; Humans ; Incidence ; Methanol ; Patch Tests ; Research Personnel ; Rhus* ; Toxicodendron ; Trees*

Demodicidosis is caused by the enormous infestation of 400 micron sized demodex folliculorum which normally exist, though in small number, in pilosebaceous unit. Its characteristic clinical feature is erythema and erythematous indurated papulopustular eruptions combined with itching and buming sensation. Microscopic examination of indurated pustule always reveals demodex folliculorum. Many authors have reported that demodicidosis aggravated by avoidance of using soap, long-term use of cosmetic cream, especially cold cream, topical or systemic use of corticosteroid. Our patiednts were housewives of 46,39, and 42 years old and presented characteristic clinical featurss and skin lesions by topical application of corsicosteroid for 1~2 years and were diagnosed as steroid acne. But simple microscopic examination reveled demodex folliculorum. We treated them with 5% sulfur lintment and soap and water cleansing of face with remarkable clinical improvement.
Acne Vulgaris ; Adult ; Erythema ; Humans ; Pruritus ; Sensation ; Skin ; Soaps ; Sulfur ; Water

No abstract available.

The solitary type of Koratoacanthoma is a common, rapidly growing, benign tumor with a natural history of spontaneous involution which was first described by Hutchinson in 1889. It was well known that this Keratoacanthoma is close resemblence to squamous cell carcinoma clinicallt & histopathology. The etiology of Kertoacanthoma is ucertain but it have been associated with many exogenous factors, including sun exposure, occupational exposure to heat and trauma, and tar and with autoimmune etiology and viral infection. We experienced 2 cases of soitary type of Keratoacantoma with typical clinical and histopathologic findings which presented on the pubic area and forehead but had no predisposing factors of Keratoacanthoma. The one was 66-year-old woman who had been a history of proritic, rapidly growing tumor on Mons Pubis since about 6 months ago. The another one was 40 year-old male who had been a history of asymromatic, growing tomor on forehead since about 3 months ago. In the H-E stained sections, there were horn filled invagination, dyskeratotic cell, horn pearl in the epidermis and an inflammatory infiltration in dermis. Diagnosis was cinfirmedby the clinical and histopatholigical pictures. The former was treated by electrocautery after simple excision and the latter by curretage and electrodesiccation.
Adult ; Aged ; Animals ; Carcinoma, Squamous Cell ; Causality ; Dermis ; Diagnosis ; Electrocoagulation ; Epidermis ; Female ; Forehead ; Horns ; Hot Temperature ; Humans ; Keratoacanthoma* ; Male ; Natural History ; Occupational Exposure ; Solar System

Epidermolysis bullosa Dystrophica is rare, chronic non-mflammatory mechanobullous disease of hereditary trait, which easily produces bulIa by minor trauma or spontaneousIy. The lesions usually appears from birth or in infant involving especially lower leg, hand, foot and lea,ds to erosive, hemorrhagic bulla, secondary infection, pruritus and scar formation and sometimes deformity of nails and cicatrical alopecia. It sometimes involves oral mucosa, esophagus, eye, tooth, bone, respiratory system, anus and vagina. This disease has rare tendency for carcinogenesis from cicatrical Iesions. These manifestations are more severe in recessive type than in dominant type. We had observed 5 cases of EBD at Ewha Womans University Hospital from Sept. 1975. to Jul. 1976. Among 5 cases, 4 cases occurred from birth, 1 case occurred at age l. Skin lesivns were hand, foot, knee area in all 5 cases. Head, face were involved in 2 cases. Arm, leg, trunk, buttock were involved in 3 cases. In skin manifestations, bulla, erosive bulla, secondary infection, scar formation, pruritus, nail deformity, positive Nikolsky sign were observed in all 5 cases. Hemorrhagic bulla, miliaria. were presented, in 1 case, alopecia in 2 cases. Aggrevated season were summer in 4 cases, spring in 1 case, HistologicalIy, microscopic observation, after H@-E stain, revealed hyperkeratosis in 3 cases, acanthosis in 2 cases, partial atrophy in 1 case, partial ulcer in 1 case, snbepidermal bulla in 5 cases, chronic nonspecific inflamma- tory cell infiltration of upper dermis in 3 cases, fibrosis of lower dermis in 1 case.
Alopecia ; Anal Canal ; Arm ; Atrophy ; Buttocks ; Carcinogenesis ; Cicatrix ; Coinfection ; Congenital Abnormalities ; Dermis ; Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Esophagus ; Female ; Fibrosis ; Foot ; Hand ; Head ; Humans ; Infant ; Knee ; Leg ; Miliaria ; Mouth Mucosa ; Parturition ; Pruritus ; Respiratory System ; Seasons ; Skin ; Skin Manifestations ; Tooth ; Ulcer ; Vagina

Malignant melanoma is a tumor arising within the melanocyte system of the skin, eyes and juxtacutaneous mucous membrane. Tbrough the lymphatic channel developed early metastasis and regional lymphade- nopzthy developed. Malignant melanoma may arise on apparently normal skin, in a junction nevua, rareh in a compound nevus and extremeIy rarely in an intradermaI nevus and 20% of total incidence of malignant melanoma are preceded by a nevocellular nevus. A 41 year-old male patient who had multiple, pea to walnut sized, black colored. nodules developing on entire body visited our Dermto. dept. About one year ago, solitary black colored nodule arose from preexisting pigmented nevus which had been from 20 yrs ago on Rt. ant. axillary area and then nodule remcved by wide exeision and regional lymphadenectomy at a Hosp. 2 months after surgical operation, multiple pea to walnut sized, black colored nodules has developed on entire body. There was no lymphadenopathy on entire body. In H-E & Fontana-Masson stain, numerous bizzarre large cells with hyperchromatic variable sized melanin pigments are seen in the dermis and subcutaneous tissues Mitotic figutes are present. Diagnosis was confirmed by the clinical and histological feature. The patient was treated with BCG waccination(4*10^6-8*10^6 live organisms weekly) by altemately intralesional inj, on the lesion and subcuraneous inj. on both shoulder during 6wks and has been in follow-up.
Adult ; Ants ; Dermis ; Diagnosis ; Follow-Up Studies ; Humans ; Incidence ; Juglans ; Lymph Node Excision ; Lymphatic Diseases ; Male ; Melanins ; Melanocytes ; Melanoma* ; Mucous Membrane ; Mycobacterium bovis ; Neoplasm Metastasis ; Nevus ; Nevus, Pigmented* ; Peas ; Shoulder ; Skin ; Subcutaneous Tissue

Erythema dyschromicum perstans is a cutaneous pigmentary dermatosis of unknown etiology chararcterizd by asymptomatic macules of an ashy gray color which was first presented by Ramirez. We reported a case of Erythema dyschromicum perstans in 57 year old female patient. The skin lesion were characterized by the presence of discreated or confluented bluish-gray colored pigrnentation on the lateral surface of hoth upper extremities. Histologically, the lesion showed hydropic degeneration of the epidermis witb in continence of pigmcnt and an apperence of malanin-hearing macrophages in upper dermis which are compatible with Erythema dyschromicum perstans.
Dermis ; Epidermis ; Erythema* ; Female ; Humans ; Macrophages ; Middle Aged ; Skin ; Skin Diseases ; Upper Extremity

Urticaria pigmentosa is a manifestation of mastocytosis characterized by persistent pigmented cutaneous lesions of various size that tend to urticate upon mechanical or chemical irritation, The disease is most common in ehildren and skin lesions after appear within 1 or 2 months of birth. Urticaria pigmentosa in children begins with disseminated eruption (buIlou type) or with a solitary tumor or nodule(solitary type). One case. of solitary type and one case of bullous type are reported in this paper. The one case is a solitary type of urticaria pigmentosa in 1 1/2 years old male who had dark brownish pigmented nodule(2.5 1cm) on right hack since 1 year ago. Tie other is a bullous type of urticaria pigmentousa in 6 months old male who had generalizcd. bulla, hemorragic bulla with crust & millium since 4 months ago. Dignosis was confirmed by histologic findings in which showed infiltration of mast cells in upper nr entire dermis arui rnetachromatic granules in mast cell on toluidine blue stain. Literature were reviewed briefly.
Child ; Dermis ; Humans ; Infant ; Male ; Mast Cells ; Mastocytosis ; Parturition ; Skin ; Tolonium Chloride ; Urticaria Pigmentosa* ; Urticaria*