PURPOSE: Benign prostate hyperplasia(BPH) can be treated with alpha1-adrenergic blocker that relaxes prostate smooth muscle or 5 alpha-reductase inhibitor that reduces serum dirtydrotestosterone. The efficacy of the combination of 5 alpha -reductase inhibitor(finasteride) and alpha1-adrenergic blocker(doxazosin) was evaluated in patients with benign prostate hyperplasia. MATERIALS AND METHODS: Eighty five patients with BPH was treated and followed over 6 months and divided into three groups: Group 1(doxazosin 3mg/day), Group 2(finasteride 5mg) and Group 3(combination of both drugs). Initially, all patients were evaluated by international Prostatic Symptom Score(IPSS: irritative, obstructive, sum, life quality), uroflowmetry, residual urine, serum prostate specific antigen(PSA) and prostate weight by transrectal ultrasonography. IPSS, uroflowmetry and complications were evaluated every month. Residual urine and PSA were assessed at every 3 months, prostate weight at every 6 months. RESULTS: In Group 1 and 3, IPSS were more decreased than In Group 2 immediately(p < 0.001). In Group 1 and 3, maximal flow rate was more increased than in group 2 immediately(p < 0.001). There was no difference of mean change of residual urine among three group. In Group 2 and 3, serum prostate specific antigen and prostate weight were more decreased than in Group 1 (p < 0.001). CONCLUSIONS: In medical treatment of BPH, the combination therapy of alpha1-adrenergic blocker and 5alpha-reductase inhibitor shows early symptomatic improvement and decreased prostate weight without significant complications.
Cholestenone 5 alpha-Reductase ; Humans ; Hyperplasia* ; Muscle, Smooth ; Prostate* ; Prostate-Specific Antigen ; Ultrasonography

A kidney containing more than 1,000ml fluid in its collecting system is generally defined as giant hydronephrosis. The clinical manifestations of giant hydronephrosis are indistinct. The patient seems to seek medical help late due to tolerable symptoms and particularly in the state of poor economic condition. We present a giant hydronephrosis of contents of 60 liters associated with ureteropelvic junction stricture on a 43-year-old woman. The final diagnosis was performed by exploration of abdomen and nephrectomy was done.
Abdomen ; Adult ; Constriction, Pathologic ; Diagnosis ; Female ; Humans ; Hydronephrosis* ; Kidney ; Nephrectomy

To investigate relationship between alpha1-acrenoceptors and nicardipine, an 1,4-dihydropyridine calcium antagonist, effects of nicardipine, on phenylephrinne(PE)-induced vasoconstriction in isolated arterial rings and pressor response of rabbits were observed. In normal physiological salt solution(NPSS), 35mM KCI produced persistent contractions of thoracic aorta and carotid artery and the contractions were dose-dependently inhoboted by cumulative admini-stration of nicardipine in the range of doses from 10(-10)M to 10(-4)M, IC50s of nicardipine in the thoracic aorta and carotid artery were 3.3x10(-7)M and 4.6x10(-7)M, respectively and there was no difference between both values. Constant contractions induced by 10(-5)M PE in both rings were inhibited by the same doses of nicardipine in a dose-dependent fashion. The IC50s were 2.8x10(-4)M in thoracic aorta and 2.9x10(-5)M in carotid artery respectively, and the former was about 10 times greater than the latter. In Ca2+ free PSS, KCI did not produce any contractionn. Though constant and reproducible in NPSS, PE-induced contraction was transient and not reproducible in Ca2+ free PSS. The contraction in both rings were weakened to about 70% of those in NPSS. Pretreatment with nicardipine in the range of doses from 10-8M to 10-5M hardly affected the PE-induced contraction and the largest dose 10(-4)M slightly inhibited the contraction. Intravenous injection of nicardipine 10 to 1000microg/kg decreased blood pressure and heart rate of rabbits in a dose-dependent manner. The % decrease of heart rate was much smaller in comparison with the %decrease of blood presseure. Pressor effect of 30microg/kg PE was dose-dependently inhibited after treatment with nicardipine 10 to 1000microg/kg and ID50 was 314microg/kg(6.1x10(-7)mole/kg). Above results suggest that nicardipine blocks extracellulr Ca2+ influx by membrane depolarization and in a part by alpha1-adrenceptors, then relaxes arterial smooth muscles in rabbits.
Aorta, Thoracic ; Blood Pressure ; Calcium ; Carotid Arteries ; Heart Rate ; Inhibitory Concentration 50 ; Injections, Intravenous ; Membranes ; Muscle, Smooth ; Nicardipine* ; Rabbits ; Vasoconstriction

The principle of surgery of the parotid gland is adequate removal of the tumor with functional and anatomical preservation of all blanches of the facial nerve. There are two main surgical approaches to superficial or total conservative parotidectomy. Anterior approach and posterior approach. Preliminary identification of the main trunk of the facial nerve is probably the most favoured techniques, but identification of the peripheral blanches of the facial nerve, with subsequent Proximal dissection to the main trunk, is long established but less popular technique. We have prospectively experienced the low incidence of facial nerve damage in series of 55 conservative parotidectomies performed using the anterior approach. The techniques employed is described with a deport of results obtained in the belief that this approach warrants greater popularity and saute technique.
Facial Nerve ; Incidence ; Parotid Gland ; Prospective Studies

Lymphoma of the prostate is exceedingly rare. Much more common than primary lymphoma of the prostate id secondary involvement of malignant lymphomas originating at other sites. A variety of treatments have bee n used, including prostatectomy, radiotherapy or combinations of chemotherapy and radiotherapy. Generally, the prognosis is very poor, and there is currently no consensus regarding treatment. We report on a patient with T-cell lymphoma who presented with symptoms of bladder neck obstruction. The patient has been asymptomatic and under complete remission after completion of doxorubicin-based chemotherapy for 2 cycles.
Bees ; Consensus ; Drug Therapy ; Drug Therapy, Combination* ; Humans ; Lymphoma ; Lymphoma, T-Cell* ; Prognosis ; Prostate* ; Prostatectomy ; Radiotherapy ; T-Lymphocytes* ; Urinary Bladder Neck Obstruction

Pheochromocytoma is one of the surgically curable hypertensive syndrome and may arise wherever chromaffin cells are located. A case of a left large adrenal pheochromocytoma developed in a 49 year old male is presented with brief review of literatures.
Chromaffin Cells ; Humans ; Male ; Middle Aged ; Pheochromocytoma*

A clinical evaluation was made on 59 patients with posterior urethral injury treated in the Department of Urology, Chonnam University Hospital, during the period from January 1980 to December 1986. The results were as follows : 1. Of 157 patients with urethral injuries among 2,932 urological in-patients during the period, 59 sustained posterior urethral injury. These age ranged from 6 to 68 years. 2. The most common cause of posterior urethral injury was traffic accident(59.3%) which is followed by industrial accident(27.1%), falling down(10.2%), iatrogenic(1.7%) and inflammatory(1.7%) in decreasing order. 3. The managements were transperineal end-to-end anastomosis in 28 patients, primary urethral realignment with interlocking sounds in 12, indwelling of Foley catheter in 8, pull-through procedure in 3, cystostomy only in 4, transpubic urethroplasty in 3 and scrotal skin inlay urethroplasty in 1. 4. Of the 28 cases treated with delayed transperineal end-to end anastomosis, postoperative urethral stricture developed in 12(42.9%), impotence in 2(7.1%), incontinence in 2(7.1%) and urethrocutaneous fistula in 1(3.6%). 5. Of the 12 cases treated with primary urethral realignment, urethral stricture developed in 7(58.3%), impotence in 1(8.3%), incontinence in 1(8.3%) and epididymitis in 1(8.3%).
Catheters ; Constriction, Pathologic ; Cystostomy ; Epididymitis ; Erectile Dysfunction ; Fistula ; Humans ; Inlays ; Jeollanam-do ; Male ; Skin ; Urethral Stricture ; Urology

No Abstract available.
Cross Infection* ; Korea*

Testicular biopsy is an important tool in the diagnosis and management of male infertility. The increasing use of this procedure has permitted a rational classification of the testicular lesion responsible for infertility and provide an intelligent basis for the institution of corrective measures or the withholding of therapy in cases in which the biopsy indicates a hopeless prognosis for fertility. The testicular biopsy findings of 48 azoospermia cases were evaluated in aspects of testicular size and past history. The following results were obtained. 1. The biopsy findings of 8 cases with normal sized testes and no nodules of both epididymimides and vasa deferens were normal in 4 cases, germinal aplasia in 2 cases, maturation arrest in 1 case and hypospermatogenesis in 1 case. 2. The biopsy findings of 23 cases with small sized testes and no nodules of both epididymides and vasa deferens were germinal aplasia in 13 cases, generalized fibrosis in 6 cases, maturation arrest in 3 cases and hypospermatogenesis in 1 case. 3. The past history of 17 cases with normal sized testes and bilateral induration of epididymides of vasa deferens revealed nonspecific epididymitis in 6 cases, tuberculous epididymides in 6 cases, tuberculous epididymitis in 5 cases, vasectomy in 5 cases and trauma of scrotum in 1 case. The biopsy findings of these cases were normal in 10 cases, hypospermatogenesis in 3 cases, testicular blockage in 3 cases and atrophy in 1 case.
Atrophy ; Azoospermia* ; Biopsy* ; Classification ; Diagnosis ; Epididymitis ; Fertility ; Fibrosis ; Humans ; Infertility ; Infertility, Male ; Male ; Oligospermia ; Prognosis ; Scrotum ; Testis ; Vasectomy

No abstract available.
Chronic Pain* ; Electroacupuncture* ; Needles* ; Syringes*