No abstract available.
Dyspnea* ; Humans

PURPOSE: Analyzing of the causes of childhood death will provide us with the basis to understand prevalent diseases and to make the best possible health plan according to the studies. The National Statistical Office (NSO) of Korea has released an annual report of nationwide death. However, it could have underestimated the death toll of children because of delayed or missing reports of infants who died during the neonatal period. The death reports by pediatricians at hospitals could compensate for the dropped number of infantile death reported by the NSO. METHODS: We collected the death records for children under 15 years of age from the 136 secondary or tertiary referral hospitals over the country from January 1 through December 31, 1995. Then we tried to make a compilation of the records from both the NSO and our committee to finalize the cause of death. RESULTS: According to the records of the 136 hospitals, the total number of childhood death was 3,900 in 1995, including 1,790 deaths in the first 28 days of life. Most deaths occurred in the hospital (89.0%), which were confirmed either by a pediatrician (6.2%) or by a pediatric resident (58.8%). We were compiling 6,735 deaths according to the NSO and 3,415 of our own, with 846 overlaps. Seventeen deaths recorded by the NSO occurred in the first 6 days of life, compared to 1,292 from our own. After the first year, 4,762 deaths recorded by the NSO and 790 of ours were observed. CONCLUSION: The death records from hospitals could be enough to compensate for the dropped number of neonatal deaths recorded by the NSO, depicting more accurately the real pattern of death for Korean children in 1995.
Cause of Death* ; Child* ; Death Certificates ; Humans ; Infant ; Korea ; Tertiary Care Centers

PURPOSE: Analyzing of the causes of childhood death will provide us with the basis to understand prevalent diseases and to make the best possible health plan according to the studies. The National Statistical Office (NSO) of Korea has released an annual report of nationwide death. However, it could have underestimated the death toll of children because of delayed or missing reports of infants who died during the neonatal period. The death reports by pediatricians at hospitals could compensate for the dropped number of infantile death reported by the NSO. METHODS: We collected the death records for children under 15 years of age from the 136 secondary or tertiary referral hospitals over the country from January 1 through December 31, 1995. Then we tried to make a compilation of the records from both the NSO and our committee to finalize the cause of death. RESULTS: According to the records of the 136 hospitals, the total number of childhood death was 3,900 in 1995, including 1,790 deaths in the first 28 days of life. Most deaths occurred in the hospital (89.0%), which were confirmed either by a pediatrician (6.2%) or by a pediatric resident (58.8%). We were compiling 6,735 deaths according to the NSO and 3,415 of our own, with 846 overlaps. Seventeen deaths recorded by the NSO occurred in the first 6 days of life, compared to 1,292 from our own. After the first year, 4,762 deaths recorded by the NSO and 790 of ours were observed. CONCLUSION: The death records from hospitals could be enough to compensate for the dropped number of neonatal deaths recorded by the NSO, depicting more accurately the real pattern of death for Korean children in 1995.
Cause of Death* ; Child* ; Death Certificates ; Humans ; Infant ; Korea ; Tertiary Care Centers

To find out the predictors of nocturnal arterial oxygen desaturation in patients with respiratory diseases, transcutaneous oxygen saturation(StcO2) monitoring studies using a pulse oximeter were performed during sleep in 20 patients. StcO2 was decreased more than 4% from the baseline value in 18 patients(90%) and more than 10%('Desaturator') in 8(40%). Five of the seven patients(71.4%) with awake PaO2<60mmHg and three of the thirteen patients(23.1%) with awake PaO2≥60mmHg were 'desaturators'. The awake PaO2/FIO2 and PaO2/PAO2 could distinguish 'desaturator' from 'nondesaturator, and PaO2, SaO2 or StcO2 could not. These results suggest that the nocturnal oxygen desaturation depends on the severity of the underlying disease rather than the baseline PaO2. Anthropomorphic and lung function factors could not separate between 'desaturator' and 'non-desaturator', and about a quarter of patients with a wake PaO2≥60mmHg developed significant desaturation. Therefore, it is necessary to monitor the nocturnal arterial oxygen saturation in patients with respiratory diseases regardless of their severity of airflow obstruction or awake PaO2.
Humans ; Lung ; Oxygen*

Ideal charateristics of soft tissue fillers include longevity, biocompatibility, low adverse event profile and a reasonable cost. Radiesse(R) have many advantage as the desirable properties of facial filler. Authors introduce Radiesse(R) was recently introduced as a facial filler agent. Radiesse(R) was injected to 81 male and female patients in the study, using 27G fine needle. The age range of the patients was 22 to 48 years. The injected areas were nasal root, tip, nasolabial folds and jaw. We measured patient satisfaction scale during the period of follow up 2 to 6 months. The scale of satisfaction was good to excellent in 69 cases of 81 cases and fair in 9 cases of 81 cases. Patients satisfaction was poor in only 3 cases. Patients were observed no systemic effects but minimal adverse events which are leakage, nodule and subclinical inflammation. Radiesse(R) was highly effective, long lasting material for facial soft tissue augmentation. If a precise injection technique were applied, Radiesse(R) can be a very good option for real volumetric facial soft tissue augmentation.
Female ; Male ; Humans

BACKGROUND: ASV is a closed-loop ventilation system that guarantees a user-set minimum per-minute volume in intubated patients, whether paralyzed or with spontaneous breathing. Here, we tested the effects of ASV onrespiratory mechanics and compared them with volume-controlled ventilation (VCV). METHODS: Thirteen patients meeting the criteria for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) were enrolled. All patients were paralyzed to eliminate spontaneous breathing. We started with VCV (VCV1), then used ASV followed by VCV modes (VCV2), maintaining minute volume as much as that of VCV1. RESULTS: During ASV, compared with VCV1, the inspiratory and expiratory tidal volumes and expiratory resistance increased. Conversely, the total respiratory rate and maximum pressure decreased. No changes in the arterial blood gases, heart rate, or mean systemic pressure were noted during the trial. CONCLUSIONS: In ALI/ARDS patients, although no differences were observed in the arterial blood gas analysis between the two modes, ASV provided better respiratory mechanics in terms of peak airway pressure and tidal volume than VCV.
Acute Lung Injury ; Blood Gas Analysis ; Gases ; Heart Rate ; Humans ; Lung ; Mechanics ; Respiration ; Respiratory Mechanics ; Respiratory Rate ; Tidal Volume ; Ventilation

BACKGROUND: There is little data on the 3 year prognosis and quality of life of patients on long-term (>72 hour) mechanical ventilation in a medical intensive care unit (MICU). METHODS: Patients with long-term mechanical ventilation from May 2003 through July 2003 in MICU of Asan Medical Center, Seoul were enrolled in this studay. The survival rates were observed prospectively at 1, 3, 6, 12, 24, 36 months, and the quality of life of survivor was measured at 12 months by using Short Form 36 (SF-36). RESULTS: The survival rate at 1, 3, 6, 12, 24 and 36 months was 54.8% (40/73), 39.7% (29/73), 30.1% (22/73), 20.5% (15/73), 18.3% (13/71) and 16.9% (12/71), respectively. There was a similar survival rate regardless of the diseases that required mechanical ventilation. A neoplasm or chronic liver disease had a worse survival rate than chronic lung or kidney disease (p>0.05). Each SF-36 domain except for the Role-emotional was inferior to the general population. CONCLUSIONS: The survival rate of patients with mechanical ventilation more than 72 hours is decreases continuously until 12 months but is relatively constant from 12 to 36 months. In these patients quality of life is also decrased.
Chungcheongnam-do ; Humans ; Intensive Care Units* ; Critical Care* ; Kidney Diseases ; Liver Diseases ; Lung ; Prognosis* ; Prospective Studies ; Quality of Life ; Respiration, Artificial* ; Seoul ; Survival Rate ; Survivors

BACKGROUND: Even though two-month rifampicin (RMP, R) and pyrazinamide (PZA, P) treatment has some advantages over isoniazid (INH, H) treatment for latent tuberculosis infection (LTBI), it was withdrawn from the list of treatment regimens for LTBI because of reported cases of severe hepatotoxicity. The purpose of this study was to estimate the frequency of hepatotoxicity of RMP and PZA treatment excluding INH in a Korean population. METHOD: TIn order to recruit patients who were prescribed RMP and PZA excluding INH, 256 INH-resistant tuberculosis patients were investigated through retrospective medical record analysis. A standard four-drug regimen was changed to a RMP/PZA-containing regimen excluding INH in 64 patients (RZ+ group). In the same study period, 146 patients who were prescribed an INH/RMP/PZA-containing standard regimen were randomly selected as a control (HRZ+ group). Clinical characteristics including liver diseases and the frequency of drug-induced hepatitis were compared between the RZ+ and HRZ+ groups. RESULT: The mean age of patients in the RZ+ group was 50.2 (+/-16.2) and the male-to-female ratio was 36:28. The frequency of underlying liver diseases was 10.9% (7/64), which was not significantly different from that of the HRZ+ group (4.1%, 6/146). Even though the treatment duration of RZ+ (5.5 +/- 4.8 months) was longer that than that of HRZ+ (2.7 +/- 2.3 months), the frequency of toxic hepatitis was not significantly different between RZ+ and HRZ+ groups, 3.5% (2/57) and 7.1% (10/140), respectively. CONCLUSION: Hepatotoxicity was mild and occurred in a minor proportion of patients in a Korean population prescribed an RMP/PZA-containing regimen. A future prospective study including more patients is needed.
Drug-Induced Liver Injury ; Humans ; Isoniazid* ; Latent Tuberculosis ; Liver Diseases ; Medical Records ; Pyrazinamide* ; Retrospective Studies ; Rifampin* ; Tin ; Tuberculosis

BACKGROUND: Even though two-month rifampicin (RMP, R) and pyrazinamide (PZA, P) treatment has some advantages over isoniazid (INH, H) treatment for latent tuberculosis infection (LTBI), it was withdrawn from the list of treatment regimens for LTBI because of reported cases of severe hepatotoxicity. The purpose of this study was to estimate the frequency of hepatotoxicity of RMP and PZA treatment excluding INH in a Korean population. METHOD: TIn order to recruit patients who were prescribed RMP and PZA excluding INH, 256 INH-resistant tuberculosis patients were investigated through retrospective medical record analysis. A standard four-drug regimen was changed to a RMP/PZA-containing regimen excluding INH in 64 patients (RZ+ group). In the same study period, 146 patients who were prescribed an INH/RMP/PZA-containing standard regimen were randomly selected as a control (HRZ+ group). Clinical characteristics including liver diseases and the frequency of drug-induced hepatitis were compared between the RZ+ and HRZ+ groups. RESULT: The mean age of patients in the RZ+ group was 50.2 (+/-16.2) and the male-to-female ratio was 36:28. The frequency of underlying liver diseases was 10.9% (7/64), which was not significantly different from that of the HRZ+ group (4.1%, 6/146). Even though the treatment duration of RZ+ (5.5 +/- 4.8 months) was longer that than that of HRZ+ (2.7 +/- 2.3 months), the frequency of toxic hepatitis was not significantly different between RZ+ and HRZ+ groups, 3.5% (2/57) and 7.1% (10/140), respectively. CONCLUSION: Hepatotoxicity was mild and occurred in a minor proportion of patients in a Korean population prescribed an RMP/PZA-containing regimen. A future prospective study including more patients is needed.
Drug-Induced Liver Injury ; Humans ; Isoniazid* ; Latent Tuberculosis ; Liver Diseases ; Medical Records ; Pyrazinamide* ; Retrospective Studies ; Rifampin* ; Tin ; Tuberculosis