This study was undertaken to investigate the effect of premedicants, diazepam and atropine sulfate in ten surgical patients by determining human plasma thyroxine levels. Tetrasorb-125 was utilized as a kit which offers a method for quantitative measurement of total circulating serum thyroxine. The plasma thyroxine level before administration of premedicants was 11. 16+/-2. 45ug/100ml and at 60 minutes after administration of premedicants. it was 11. 3+/-2. 73ug/100ml so that clinical significance of the result was absent. The number of male and female patients was 3 and 7, mean age 40. 1+/-9. 82 and average body weight 56. 1+/-4. 01kg. Consequently there was no significant change in human plasma thyroxine during one hour :of premedication.
Atropine* ; Body Weight ; Diazepam* ; Female ; Humans* ; Male ; Plasma* ; Premedication ; Thyroxine*

A male patient with atrial fibrillation aged 74 years underwent an operation for benign hypertropic prostate under spinal anesthesia. Post-operatively he suffered from convulsions but was discharged without sequlae on the 1Sth post-operative day. The causes of symptcnmatic fits include hypoxia in general, cerebral edema, embolus hyperpyrexia, drugs, hypoglycemia, hypocalcemia and concomitant diseases including cerebrovascular accidents. Probably a combination of some of these factors caused have caused post-operative or post-spinal anesthesia convulsions.
Anesthesia* ; Anesthesia, Spinal ; Anoxia ; Atrial Fibrillation* ; Brain Edema ; Embolism ; Humans ; Hypocalcemia ; Hypoglycemia ; Male ; Prostate ; Seizures* ; Stroke

This study was undertaken to investigate the effect of premedieants, diazepam and atropine sulfate in ten surgical patients by determining human plasma insulin. Also Insulin-Riakit was utilized as a kit for the detertrmination of insulin levels in the blood by radioimmunoassay (double antibody system). The plasma insulin level before administration of premedicants was 1:1. 1+/-1. 55 um/mL and 12. 6+/-2. 02um/ml. at 60 minutes after administration of premedicants so that the clinical significance of the results was absent. Sex ratio between male and female patients was 1: 1, mean age 39. 2+/-12. 1 and average body weight(kg) 55. 5+/-58.3. Consequently, there was no significant change in plasma insulin one hour after premedication and its result was within normal limits.
Atropine* ; Diazepam* ; Female ; Humans* ; Insulin ; Male ; Plasma* ; Premedication ; Radioimmunoassay ; Sex Ratio

This study was undertaken to investigate the effect of premedicants, diazepam and atropine sulfate in twenty surgical patients by measuring the Human Plasma Renin Acitivty. RENIN. RIA(Radioimmunoassay K for Angiotensin I) was utilized and the renin activity was expressed as the release of angiotenain I, ng. per ml. of plasma per hour. The sex ratio between male and female patients was 11:9, mean age 38,95+/-13.16 and average body weight 55.5+/-8.20kg. The value of the human plasma renin activity before administration of premedicants was 2.05+/-0.95ng/ml/hr. and at 60 minutes after administration of premedicante it was 2.21+/-0.82ng/ml/hr., and it's result was within normal limits. Consequently there was no significant change statistically in human plasma renin activity after one hour of premedications.
Angiotensins ; Atropine* ; Body Weight ; Diazepam ; Female ; Humans* ; Male ; Plasma* ; Premedication ; Renin* ; Sex Ratio

This study was performed to investigate the effects of nitrous oxide-narcotic anesthesia (Nitrous oxide-pethidine HCI-muscle relaxant) and surgery on plasma aldosterons level in surgical patients and the aldosterone level in plasma was measured by the Abbott Laboratorie's Aldosterone RIA Kit. Average body weights and ages of subjects were 58.1+/-6.45(kg) and 43.8+/-11.55(yrs) respectively. Mean control aldosterone level in plasma was 121.3+/-58.66I(pg/ml) (mean +/- SE) but it gradually rose during anesthesia and surgery. The mean plasma aldosterone level rose to 232.7+/-40.06(pg/ml) (p<0.005) at 90 minutes after the start of surgery, and therefore, it was a significantly higher value than that of the control.
Aldosterone* ; Anesthesia* ; Body Weight ; Humans ; Plasma*