No abstract available.
Ammonium Compounds* ; Ammonium Sulfate* ; Animals ; Bromodeoxyuridine* ; CHO Cells* ; Chromosome Aberrations* ; Cricetinae ; Humans ; Siblings* ; Sister Chromatid Exchange*

The treatment of tibial shaft fracture has become one of the most controversial subjects in orthopedic surgery. Comminuted, segmental and rotationally unstable fractures or bone defect at fraction site have problems of the fixation. The interlocking nail solve these problems. We have experienced 8 cases of the tibial shaft fractures treated with interlocking nail from 1986 to 1988. Authors analyzed these cases and out own clinical study. The results were as follows. 1. The average bone union rate was about 15 weeks. 2. The interval between operation and crutch walking was 4.3 weeks. 3. The merits of this operation were the short hospitalization and early adaptation of social activity. 4. The advantage is be able to do early ambulation without following muscular atrophy or joint stiffness. 5. The results were assessed on clinical examination and radiographic appearance by Hamza et al. An excellent results were 7 cases and good result was 1 case.
Clinical Study ; Early Ambulation ; Hospitalization ; Joints ; Muscular Atrophy ; Orthopedics ; Walking

No abstract available.

No abstract available.
Cytogenetics* ; Korea* ; Oncogenes* ; Stomach Neoplasms*

No abstract available.
Blotting, Southern*

One hundred and twenty seven patients with uterine cervical carcinoma underwent computed tomography(CT) and magnetic resonance(MR) imaging, followed by surgical exploration. MR imaging was superior to CT in visualization of the tumor, for parametrial evaluation, and for tumor staging. MR imaging had an accuracy of 74% in the assessment of thickness of cervical stromal invasion. The accuracy rates for parametrial evaluation were 78% for CT and 88% for MR imaging. The overall accuracy rates for tumor staging were 68% for CT and 80% for MR imaging. The accuracy rates for pelvic lymph node evaluation were 82% for CT and 85% for MR imaging. Our findings suggest that MR imaging is supperior to CT in preoperative staging of uterine cervical carcinoma.
Humans ; Lymph Nodes ; Magnetic Resonance Imaging* ; Neoplasm Staging

Alcohol influences the neuroadaptation of brain cells where receptors and enzymes like protein kinase C (PKC) exist. Naltrexone acts on opioid receptors. However, other mechanisms of action remain unknown. We prepared SH-SY5Y neuroblastoma cells, and fed them with 150 mM ethanol for 72 h followed by treatment with naltrexone for 24 h. We performed microarray analysis and reverse transcriptase-polymerase chain reaction. Our results showed that PKC epsilon increased 1.90 times and showed an overall decreasing pattern as time increased. Phosphorylated ERK also increased 2.0 times according to the change of PKC epsilon. Integrin alpha7 increased 2.32 times and showed an increasing pattern as time increased. In conclusion, naltrexone influences PKC epsilon neuronal signaling system and endothelial adhesion molecule integrin alpha7 in addition to the well-known opioid system.
Antigens, CD/*metabolism ; Cell Line, Tumor ; Comparative Study ; DNA, Complementary/genetics ; Humans ; Integrin alpha Chains/*metabolism ; Naltrexone/*pharmacology ; *Neuroblastoma/enzymology/metabolism/pathology ; Oligonucleotide Array Sequence Analysis ; Protein Kinase C-epsilon/*metabolism ; Research Support, Non-U.S. Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors

PURPOSE: To determine the features of hepatic adenomatous hyperplasia using different imaging modalities. MATERIALS AND METHODS: Twenty-two patients with 29 adenomatous hyperplastic nodules of the liver (0.9-3.1 cm) underwent sonography (29 lesions), CT (24 lesions), angiography (11 lesions), MR (12 lesions), and Lipiodol CT(seven lesions). Each lesion was analyzed for echogenicity, attenuation, vascularity, signal intensity, and Lipiodol uptake. RESULTS: On sonograms, echogenicity was high in 16, low in 11, and iso- in 2 of 29 lesions. On contrast enhanced CT scans, attenuation was high in 4, low in 14, and iso- in 6 of 24 lesions. On hepatic angiograms, vascularity of lesions was avascular in 9 and slightly vascular in 2 of 11 lesions. On MR images, signal intensity was high in 11 and iso- in 1 of 12 lesions on T1-weighted MRI, and iso- in 7, and low in 5 of 12 lesions on T2-weighted MRI. On iodized-oil CT scans, retention of Lipiodol was present in 3 and absent in 4 of seven lesions. CONCLUSION: Common imaging findings of adenomatous hyperplasia of the liver are high echogenicity on sonography, low attenuation on CT, hypovascularity on angiography, high signal intensity on T1-weighted MRI, and iso- or low signal intensity on T2-weighted MRI.
Angiography ; Ethiodized Oil ; Humans ; Hyperplasia* ; Liver* ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed

OBJECTIVES: The aim of this prospective study is to investigate predictors estimating relapse in Korean alcohol-dependent patients using variables like alcohol history, drinking craving, treatment motivation and insight. METHODS: Alcohol dependent patients(N=48) who completed questionnaires about sociodemographic variables and drinking history, Timeline Follow-Back(TLFB), Obsessive-Compulsive Drinking Scale(OCSD), Alcohol Urge Questionnaire(AUQ), Pennsylvania Alcohol Craving Scale(PACS), University of Rhode Island Change Assessment(URICA), Hanil Alcohol Insight Scale(HAIS) were followed-up for 24weeks. Subjects who drank heavily(5 standard drinking or more/day) or were not followed up anymore were classified as the relapse group. We used logistic regression analysis with backward elimination of SPSS PC+11.5 to investigate relapse estimate predictors. RESULTS: Average drinking amount per drinking day for last 1 year and HAIS score were predictors of relapse in alcohol-dependent patients. CONCLUSIONS: Our findings suggest that therapist should give more attention to alcohol-dependent patients who had more drinks per drinking day for last 1 year and had lower insight level.
Alcoholism ; Drinking ; Follow-Up Studies* ; Humans ; Logistic Models ; Motivation ; Pennsylvania ; Prospective Studies ; Recurrence* ; Rhode Island

PURPOSE: Kikuchi-Fujimoto disease (KFD) is a benign disease, which is characterized by a cervical lymphadenopathy with fever, and it often mimics malignant lymphoma (ML). 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a powerful imaging modality for the diagnosis, staging and monitoring of ML, with the limitations including the nonspecific FDG uptake in infectious or inflammatory processes. This study compared clinical manifestations and PET/CT findings between KFD and ML patients. METHODS: We retrospectively reviewed the medical records of 23 patients with KFD and 33 patients with ML, diagnosed histopathologically, between January 2000 and May 2013 at the Department of Pediatrics, Yeungnam University Medical Center. Among them, we analyzed the clinical manifestations, laboratory findings and characteristics, and the amount of 18F-FDG uptake between 8 KFD and 9 ML patients who had 18F-FDG PET/CT. RESULTS: The 18F-FDG PET/CT maximum standardized uptake values (SUVmax) ranged from 8.3 to 22.5 (mean, 12.0) in KFDs, and from 5.8 to 34.3 (mean, 15.9) in MLs. There were no significant differences in SUVmax between KFDs and MLs. 18F-FDG PET/CT with ML patients showed hot uptakes in the extranodal organs, such as bone marrow, small bowel, thymus, kidney, orbit and pleura. However, none of the KFD cases showed extranodal uptake (P<0.001). 18F-FDG PET/CT findings of KFD with nodal involvement only were indistinguishable from those of ML. CONCLUSION: Patients who had extranodal involvement on PET/CT were more likely to have malignancy than KFD.
Academic Medical Centers ; Bone Marrow ; Child* ; Diagnosis ; Electrons ; Fever ; Fluorodeoxyglucose F18 ; Histiocytic Necrotizing Lymphadenitis* ; Humans ; Kidney ; Lymphatic Diseases ; Lymphoma* ; Medical Records ; Orbit ; Pediatrics ; Pleura ; Positron-Emission Tomography ; Positron-Emission Tomography and Computed Tomography* ; Retrospective Studies ; Thymus Gland