1.Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies.
Muhammad SADIQ ; Iftikhar AHMAD ; Jamila SHUJA ; Zubair AHMAD ; Riyasat AHMED ; Khushnaseeb AHMAD
Brain Tumor Research and Treatment 2017;5(2):120-126
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm²) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i.e., within 24 hours of surgery). Histopathological examination revealed neoplastic lesion exhibiting perivascular pseudo-rosettes with centrally hyalinized blood vessel and focal nuclear pleomorphism. Immunohistochemistry staining illustrated reactivity for glial fibrillary acidic protein and integrase interactor 1 (INI-1). These features rendered the diagnosis of astroblastoma. A comprehensive review of the current literature to summarize the clinicopathological and radiological characteristics, prognostic factors and current treatment strategies of astroblastomas is also presented. Our study would expand the pool of this uncommon tumor towards its better understanding and optimal treatment.
Adolescent
;
Blood Vessels
;
Brain
;
Brain Neoplasms
;
Craniotomy
;
Diagnosis
;
Female*
;
Glial Fibrillary Acidic Protein
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Headache
;
Humans
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Hyalin
;
Immunohistochemistry
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Integrases
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Magnetic Resonance Imaging
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Neoplasms, Neuroepithelial*
2.Role of anticoagulation with apixaban in left‑sided atrial tachycardias
Fraz Ahmed BAIG ; Muhammad Syed ANWAR ; Muhammad Firdous KHAN ; Aroon KUMAR ; F. N. U. MUSKAN ; Jiyanth PARKASH ; Ali KARIM ; Iftikhar AHMED ; Waheed AKHTAR ; Jahanzeb MALIK
International Journal of Arrhythmia 2024;25(2):10-
Background:
Atrial tachycardia poses challenges in patient management due to the associated risks of stroke and systemic embolism. While anticoagulation is recommended in atrial fibrillation (AF), its role in atrial tachycardia remains less defined. This prospective study aimed to evaluate the efficacy and safety of apixaban, a direct oral anticoagulant, in individuals diagnosed with left-sided atrial tachycardias.
Methods:
Patients diagnosed with left-sided atrial tachycardia (n = 439) were observed over 3 years. Baseline characteristics, medication regimens, and clinical outcomes were assessed. Apixaban-treated individuals (n = 213) received standard or reduced dosages, while the control group (n = 226) received standard care. Primary outcomes included stroke, systemic embolism, bleeding, and mortality rates.
Results:
Baseline characteristics were comparable between groups. The apixaban cohort showed a lower incidence of stroke (7.0% vs. 9.3%, p = 0.027) and decreased all-cause mortality (11.7% vs. 12.8%, p = 0.012) compared to controls.No significant differences were found in major bleeding or systemic embolization between groups.
Conclusion
Apixaban demonstrated a potential benefit in reducing stroke and mortality rates in patients with leftsided atrial tachycardia. While requiring further validation, these findings suggest a potential role for apixaban in anticoagulation strategies for atrial tachycardia management.