1.Successful management of pheochromocytoma in early pregnancy.
Bo In JUNG ; Jae Woong CHOI ; Yeon Sun KIM ; Jin Iee CHUNG ; Moon Ho KANG
Journal of Korean Society of Endocrinology 1991;6(2):179-186
No abstract available.
Pheochromocytoma*
;
Pregnancy*
2.Correlation of tri-ponderal mass index with insulin-like growth factor-I and insulin-like growth factor binding protein-3 in children and adolescents
Iee Ho CHOI ; Sun-Young KIM ; Minsun KIM
Annals of Pediatric Endocrinology & Metabolism 2024;29(4):258-265
Purpose:
We aimed to investigate the relationship between the tri-ponderal mass index (TMI), a new indirect measure of fat mass, and insulin-like growth factor (IGF)-I/IGF binding protein (IGFBP)-3.
Methods:
The study included 1,630 children and adolescents who visited Jeonbuk National University Children's Hospital. Each patient’s medical record was retrospectively reviewed for age, sex, height, weight, body mass index (BMI), TMI, and IGF-1 and IGFBP-3 levels. Study participants were divided by sex and then categorized by age, BMI, and TMI. Finally, the correlations of TMI with IGF-1 level, IGF-1 standard deviation score (SDS), IGFBP-3 level, IGFBP-3 SDS, and IGF-1/IGFBP-3 ratio were investigated.
Results:
All participants were <19 years of age. BMI correlated with IGF-1 and IGFBP-3 levels in both sexes; however, the relationship with TMI differed by sex. TMI correlated with IGF-1 and IGFBP-3 SDS in boys and with IGF-1, IGFBP-3, and IGFBP-3 SDS in girls across all ages. In boys, BMI and TMI significantly correlated with IGF-1, IGF-1 SDS, IGFBP-3, IGFBP-3 SDS, and the IGF-1/IGFBP-3 ratio in the normal-weight group. TMI also correlated with IGF-1, IGFBP-3, and IGFBP-3 SDS in the overweight group. In girls, BMI significantly correlated with IGF-1, IGF-1 SDS, IGFBP-3, IGFBP-3 SDS, and the IGF-1/IGFBP-3 ratio in the normal-weight group and with IGFBP-3 and IGFBP-3 SDS in the overweight group, while TMI correlated with IGF-1, IGF-1 SDS, and the IGF-1/IGFBP-3 ratio in the normal-weight group; with IGF-1, IGFBP-3, and IGFBP-3 SDS in the overweight group; and with IGFBP-3 SDS in the obese group.
Conclusion
TMI may more strongly correlate with IGFBP-3 level than BMI in overweight boys and with IGFBP-3 SDS in overweight and obese girls. The correlation of IGFBP-3 SDS with TMI may be helpful for evaluating weight status in adolescent girls.
3.Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury.
Iee Ho CHOI ; Pyoung Han HWANG ; Sam Im CHOI ; Dae Yeol LEE ; Min Sun KIM
Journal of Korean Medical Science 2016;31(9):1499-1502
Prompt malaria diagnosis is crucial so antimalarial drugs and supportive care can then be rapidly initiated. A 15-year-old boy who had traveled to Africa (South Africa, Kenya, and Nigeria between January 3 and 25, 2011) presented with fever persisting over 5 days, headache, diarrhea, and dysuria, approximately 17 days after his return from the journey. Urinalysis showed pyuria and hematuria. Blood examination showed hemolytic anemia, thrombocytopenia, disseminated intravascular coagulation, and hyperbilirubinemia. Plasmapheresis and hemodialysis were performed for 19 hospital days. Falciparum malaria was then confirmed by peripheral blood smear, and antimalarial medications were initiated. The patient's condition and laboratory results were quickly normalized. We report a case of severe acute renal failure associated with delayed diagnosis of falciparum malaria, and primary use of supportive treatment rather than antimalarial medicine. The present case suggests that early diagnosis and treatment is important because untreated tropical malaria can be associated with severe acute renal failure and fatality. Physicians must be alert for correct diagnosis and proper management of imported tropical malaria when patients have travel history of endemic areas.
Acute Kidney Injury*
;
Adolescent
;
Africa
;
Anemia, Hemolytic
;
Antimalarials
;
Delayed Diagnosis*
;
Diagnosis
;
Diarrhea
;
Disseminated Intravascular Coagulation
;
Dysuria
;
Early Diagnosis
;
Fever
;
Headache
;
Hematuria
;
Humans
;
Hyperbilirubinemia
;
Kenya
;
Malaria*
;
Male
;
Nigeria
;
Plasmapheresis
;
Plasmodium falciparum
;
Pyuria
;
Renal Dialysis
;
Renal Insufficiency
;
Thrombocytopenia
;
Urinalysis
4.Clinical and Laboratory Characteristics of Pediatric Diabetic Ketoacidosis: A Single-Center Study.
Iee Ho CHOI ; Min Sun KIM ; Pyoung Han HWANG ; Dae Yeol LEE
Journal of Korean Diabetes 2017;18(3):193-204
BACKGROUND: Diabetic ketoacidosis (DKA) is an acute complication of pediatric type 1 diabetes mellitus (T1DM). We aimed to determine the risk factors and clinical characteristics of children and adolescents with DKA. METHODS: We retrospectively evaluated 59 episodes of DKA in 43 patients who were hospitalized for DKA between January 2006 and December 2015. DKA was classified as mild, moderate, or severe, according to patient history of DKA. The clinical and laboratory characteristics of these subgroups were compared. RESULTS: The average patient age was 11.98 ± 4.40 years (range, 1.3~17.9 years). Moderate episodes were the most common, with 21 episodes (35.6%), followed by 19 severe (32.2%) and 19 mild episodes (32.2%). Significant differences were observed between the subgroups regarding their characteristics of aggravated. Severe DKA episodes were more often observed during the winter season. Recurrent DKA cases were determined in 31 episodes (52.5%) who were significantly older, had higher body mass index, and lower serum C-peptide levels than the newly diagnosed DKA group. Female patients experienced severe and moderate cases more frequently (P = 0.041), which included two deaths. Only blood glucose levels were significantly higher in these fatal cases (P = 0.022). CONCLUSION: Even among the patients who had previously experienced DKA and older children with low serum C-peptide levels, there was no reduction in the severity of DKA. We recommend that patients with DKA be carefully treated and continuously informed regarding the importance of maintaining proper blood glucose levels, regardless of their previous history of DKA, age, or regularity of insulin therapy.
Adolescent
;
Blood Glucose
;
Body Mass Index
;
C-Peptide
;
Child
;
Diabetes Mellitus
;
Diabetes Mellitus, Type 1
;
Diabetic Ketoacidosis*
;
Female
;
Humans
;
Insulin
;
Retrospective Studies
;
Risk Factors
;
Seasons
5.A case of metastatic atypical carcinoid tumor of appendix: treatment with combination chemotherapy.
Sang Ho MOON ; Su Jung LEE ; Hun Ho SONG ; Young Iee PARK ; Bong Soo KIM ; Young Hee CHOI ; Young Eui PARK
Korean Journal of Medicine 2003;65(Suppl 3):S872-S876
Carcinoid tumor is the most commen tumor of appendix. Metastases from the appendecial carcinoid tumor is rare, and the prognosis of metastatic appendecial carcinoid tumors are closely related to the histologic findings. Atypical, aggressive metastatic carcinoid tumors shows poor prognosis. We experienced a case of atypical aggressive carcinoid tumor of appendix with metastasis. We treated her with combination chemotherapy, etoposide and cisplatin, and achieved partial remission. The duration of remission was 5 months, and survival duration was 19 months. To the best of our knowledge, this is the first case of atypical appendiceal carcinoid tumor with distant metastasis in Korea, so we report this case and the result of chemotherapy.
Appendix*
;
Carcinoid Tumor*
;
Cisplatin
;
Drug Therapy
;
Drug Therapy, Combination*
;
Etoposide
;
Korea
;
Neoplasm Metastasis
;
Prognosis
6.Growth inhibitory effect of mulberry leaf extract on Streptococcus mutans in vitro.
Eun Ju JUNG ; Choong Ho CHOI ; Jeong Iee CHOI ; Jeong Keun LEE ; Seong Soog JEONG ; Myung Ok HA ; Young Nam PARK ; Suk Jin HONG
Journal of Korean Academy of Oral Health 2012;36(1):26-31
No abstract available.
Morus
;
Streptococcus
;
Streptococcus mutans
7.A Case of Autoimmune Hemolytic Anemia Associated with an Ovarian Teratoma.
Ickkeun KIM ; Jue Yong LEE ; Jung Hye KWON ; Joo Young JUNG ; Hun Ho SONG ; Young Iee PARK ; Eusun RO ; Kyung Chan CHOI
Journal of Korean Medical Science 2006;21(2):365-367
Autoimmune hemolytic anemia associated with an ovarian teratoma is a very rare disease. However, treating teratoma is the only method to cure the hemolytic anemia, so it is necessary to include ovarian teratoma in the differential diagnosis of autoimmune hemolytic anemia. We report herein on a case of a young adult patient who had severe autoimmune hemolytic anemia that was induced by an ovarian teratoma. A 25-yr-old woman complained of general weakness and dizziness for 1 week. The hemoglobin level was 4.2 g/dL, and the direct and indirect antiglobulin tests were all positive. The abdominal computed tomography scan revealed a huge left ovarian mass, and this indicated a teratoma. She was refractory to corticosteroid therapy; however, after surgical resection of the ovarian mass, the hemoglobin level and the reticulocyte count were gradually normalized. The mass was well encapsulated and contained hair and teeth. She was diagnosed as having autoimmune hemolytic anemia associated with an ovarian teratoma. To the best of our knowledge, this is the first such a case to be reported in Korea.
Teratoma/*complications/diagnosis/surgery
;
Ovarian Neoplasms/*complications/diagnosis/surgery
;
Humans
;
Female
;
Diagnosis, Differential
;
Blood Transfusion
;
Anemia, Hemolytic, Autoimmune/diagnosis/*etiology/therapy
;
Adult
;
Adrenal Cortex Hormones/therapeutic use
8.Clinical features of tsutsugamushi disease in Chuncheon.
Ho Gwon LEE ; Seul Ki MIN ; Seung Jin KONG ; Su Jung LEE ; Hun Ho SONG ; Jong Woo YOON ; Myung Goo LEE ; Dong Hoon SHIN ; Sung Ha KANG ; Jeong Yeol LEE ; Young Iee PARK ; Moon Gi CHOI
Korean Journal of Medicine 2005;69(2):190-196
BACKGROUND: Tsutsugamushi disease is an acute febrile disease in Korea. Some patients with tsutsugamushi disease have severe illness, which needs care in intensive care unit, and may die due to the disease. We analyzed the cases with tsutsugamushi disease who lived in Chuncheon and neighboring communities to find out clinical manifestations, laboratory findings especially in severe cases. METHODS: We reviewed the clinical records of the 81 cases who were diagnosed as tsutsugamushi in Chuncheon Sacred Heart Hospital from April, 1997 to December, 2002. We analyzed the clinical and laboratory findings of the 81 cases, and the treatment results of 79 cases who recieved the treatment in this hospital. We also compared the characteristics of the patients between admission to general ward and intensive care unit (ICU). RESULTS: Seventy three cases developed the disease in autumn. Seventy cases had fever. 58 cases had eschar in their bodies. With the doxycycline treatment, forty five cases subsided the fever within 48 hours, but in 13 cases, fever continued after 5 days of treatment. Twenty five cases were admitted to ICU, 8 cases among them were treated with ventilator, 3 cases died due to the multi-organ failure. When we compared the clinical characteristics of the patients admitted to ICU with those to general wards, leukocyte count, the level of BUN and creatinine were higher, the albumin level was lower in ICU patients than those of general ward patients. CONCLUSION: Tsutsugamushi disease can progress to severe disease, and be fatal to the patients. So it is necessary to diagnose early and treat carefully. We suggest that leukocyte count, BUN, creatinine, or albumin can be used to predict the prognosis.
Creatinine
;
Doxycycline
;
Fever
;
Gangwon-do*
;
Heart
;
Humans
;
Intensive Care Units
;
Korea
;
Leukocyte Count
;
Orientia tsutsugamushi
;
Patients' Rooms
;
Prognosis
;
Scrub Typhus*
;
Ventilators, Mechanical
9.Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea.
Soo Jeong CHO ; Il Ju CHOI ; Chan Gyoo KIM ; Jong Yeul LEE ; Myeong Cherl KOOK ; Moon Woo SEONG ; Sook Ryun PARK ; Jong Seok LEE ; Young Woo KIM ; Keun Won RYU ; Jun Ho LEE ; Byung Ho NAM ; Young Iee PARK
Gut and Liver 2010;4(4):466-474
BACKGROUND/AIMS: To evaluate the association between Helicobacter pylori (H. pylori) infection and gastric cancer (GC) according to tumor subtype in Korea. METHODS: H. pylori status was determined serologically using the enzyme-linked immunosorbent assay. In total, 2,819 patients with GC and 562 healthy controls were studied. A logistic regression method was used after adjusting for possible confounders. RESULTS: The prevalence of H. pylori infection was significantly higher in the GC patients (84.7%) than in the controls (66.7%) (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.46-3.97). The adjusted OR was significantly higher in H. pylori-infected patients aged <60 years (OR, 4.69; 95% CI, 3.44-6.38) than in those aged > or =60 years (OR, 1.48; 95% CI, 0.88-2.46; p<0.001). Subgroup analyses revealed no differences in seroprevalence between early gastric cancer (84.8%; OR, 3.01; 95% CI, 2.27-4.01) and advanced gastric cancer (84.6%; OR, 2.94; 95% CI, 2.24-3.85), cardia cancer (83.8%; OR, 2.98; 95% CI, 2.16-4.02) and noncardia cancer (84.8%; OR, 3.17; 95% CI, 2.48-4.04), and differentiated carcinoma (82.7%; OR, 2.99; 95% CI, 2.21-4.04) and undifferentiated carcinoma (86.8%; OR, 3.05; 95% CI, 2.32-4.00). CONCLUSIONS: The seroprevalence of H. pylori was higher in GC patients than in healthy controls, especially in younger patients. H. pylori infection is associated with GC, regardless of the tumor location, stage, or differentiation.
Aged
;
Carcinoma
;
Cardia
;
Enzyme-Linked Immunosorbent Assay
;
Helicobacter
;
Helicobacter pylori
;
Humans
;
Korea
;
Logistic Models
;
Odds Ratio
;
Prevalence
;
Seroepidemiologic Studies
;
Stomach Neoplasms
10.Effect of a Proton Pump Inhibitor on Tumor Bleeding Prevention in Unresectable Gastric Cancer Patients: a Double-Blind, Randomized, Placebo-Controlled Trial.
Young Il KIM ; Mi Jung KIM ; Sook Ryun PARK ; Hark Kyun KIM ; Soo Jeong CHO ; Jong Yeul LEE ; Chan Gyoo KIM ; Gwang Ha KIM ; Moo In PARK ; Byung Ho NAM ; Young Iee PARK ; Il Ju CHOI
Journal of Gastric Cancer 2017;17(2):120-131
PURPOSE: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. MATERIALS AND METHODS: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS). RESULTS: This study initially planned to enroll 394 patients, but prematurely ended due to low recruitment rate. Overall, 127 patients were included in the analyses: 64 in the lansoprazole group and 63 in the placebo group. During the median follow-up of 6.4 months, tumor bleeding rates were 7.8% and 9.5%, in the lansoprazole and placebo groups, respectively, with the cumulative bleeding incidence not statistically different between the groups (P=0.515, Gray's test). However, during the initial 4 months, 4 placebo-treated patients developed tumor bleeding, whereas there were no bleeding events in the lansoprazole-treated patients (P=0.041, Gray's test). There was no difference in the proportion of patients who required transfusion between the groups. The OS between the lansoprazole (11.7 months) and the placebo (11.0 months) groups was not statistically different (P=0.610). Study drug-related serious adverse event or bleeding-related death did not occur. CONCLUSIONS: Treating patients with inoperable gastric cancer with lansoprazole did not significantly reduce the incidence of tumor bleeding. However, further studies are needed to evaluate whether lansoprazole can prevent tumor bleeding during earlier phases of chemotherapy (ClinicalTrial.gov, identifier No. NCT02150447).
Drug Therapy
;
Follow-Up Studies
;
Hemorrhage*
;
Humans
;
Incidence
;
Lansoprazole
;
Primary Prevention
;
Prospective Studies
;
Proton Pump Inhibitors
;
Proton Pumps*
;
Protons*
;
Stomach Neoplasms*