A formulation of pellet containing ibuprofen was carried out using Avicel, lactose as exipients. The obtained pellets were coated with EC to prolong the drug release. An ibuprofen sustained release capsule was prepared by filling coated pellet into the capsule shell.
Ibuprofen ; Delayed-Action Preparations

Full Spectrum Quantification technique gained fast, accurate results without extraction. This conforms to analysis of drug samples on the market. Results proved the method was accurate and has the acceptable reproducibility
Acetaminophen ; Ibuprofen ; Tablets

OBJECTIVE: Ibuprofen, a nonsteroidal anti-inflammatory drug, is poorly soluble leading to its slow systemic absorption. This study aimed to optimize the formulation of an ibuprofen hydrogel-based matrix tablet to improve its dissolution for better oral bioavailability.

METHODS: Raw material of ibuprofen was subjected to quality control test and compatibility test with the excipients. Six trial formulations were performed, with polyethylene glycol (PEG) 6000 as the matrix for the first three trial formulations and carbopol for the remaining trial formulations. Finished product quality control (FPQC) tests were conducted to choose the best formulations to be compared against the marketed products using comparative dissolution and stability studies.

RESULTS: Among the trial formulations, Formulation 3 and Formulation 4 displayed highly satisfactory results from FPQC. The results of disintegration tests, comparative dissolution, and stability studies suggested carbopol as the better polymer over PEG 6000 which made Formulation 4 as the best.

CONCLUSION: Based on the percent drug release and similarity factor, it was concluded that the formulation optimized in this study was considered to be similar with the standard liquigel.

PURPOSE: The National Institute of Health (NIH) category III Chronic Nonbacterial Prostatitis/Chronic Pelvic Pain Syndromes (CPPS) are common disorders. However, there has been no consensus on how treatment should be planned for these patients. The purpose of this trial was to compare the efficacy of tamsulosin and ibuprofen in the treatment of CPPS patients. MATERIALS AND METHODS: Between June 2001 and May 2002, 117 patients were diagnosed, in our department, as noninflammatory CPPS (Category IIIb). The study comprised of 63 patients who were randomly placed into three groups as follows: group 1 tamsulosin, group 2 ibuprofen and group 3, both tamsulosin and ibuprofen. The tamsulosin and ibuprofen, or both, were given to the respective groups for 12 weeks. The NIH chronic prostatitis symptom index (NIH-CPSI) and uroflowmetry were evaluated both before and after the treatment. RESULTS: Before the treatment, the CPSI of the 40 patients who received tamsulosin was 18.43+/-6.60, and after was 13.00+/-6.07. For the ibuprofen group, the CPSI value before the treatment was 18.00+/-5.81, and after was 17.07+/-5.36. In the tamsulosin group, the difference between the pre- and post treatment CPSI values was statistically significant (p<0.001). Conversely, in the ibuprofen group, the difference was insignificant (p=0.106). After the treatment, the difference between the tamsulosin and ibuprofen groups was also statistically significant (p=0.039). The mean maximal urinary flow rate (Qmax) before the treatment in all patients was 15.49+/-4.82ml/sec. A significant increase in the Qmax was obtained in the tamsulosin group. CONCLUSIONS: Tamsulosin appeared effective for treating patients with noninflammatory CPPS. However, it was concluded that a 12 week treatment period was insufficient.
Consensus ; Humans ; Ibuprofen ; Pelvic Pain* ; Prostatitis

Chromatography, Gas ; methods ; Humans ; Ibuprofen ; blood

Although various analgesics have been administrated for postoperative pain control, postoperative pain has not been adequately controlled . The purpose of this study was to evaluate the effects and patient's satisfaction of Myprodol(R)(combination analgesics with codeine, ibuprofen, paracetamol) compared to Acetamionphen and placebo drug after periodontal surgery and dental implant surgery. We studied 98 cases of outpatients which were composed of 67 cases of flap operation(which separated to 3 groups: Placebo group(n=25), Myprodol(R) group(n=22), Acetaminophen group(n=20)) and 21 cases of dental implant surgery(which separated to 3 groups : Placebo group(n=10), Myprodol(R) group(n=12), Acetaminophen group(n=9)). We evaluated the postoperative pain(Pain 1), Pain after first drug administraion(Pain 2), the degrees of pain reduction(pain 3), patient's satisfaction for drug, and side-effects. We obtained following results; 1. In Pain 1, making a comparison among groups, there was no significant difference in both cases of flap operation-group and dental implant surgery-group 2. In Pain 2, establishing a comparison among groups, there was no significant difference in flap operationgroup, but significant difference was seen between placebo group and Myprodol(R) group in cases of dental implant surgery group(P<0.05). 3. In Pain 3, making a comparison among groups, Myprodol(R) group showed significant differences compared to placebo group and Acetaminophen group in both cases of flap operation group and dental implant surgery group(P<0.05). 4. In patient's satisfactory score, making a comparison among groups, there were significant differences between placebo group and Myprodol(R) group in cases of flap operation group and between Myprodol(R) group and Acetaminophen group in cases of dental implant surgery group(P<0.05). 5. Making a comparison in side-dffect, no significant differrence was seen. Our conclusion is that Myprodol(R) is a effective oral analgesics to the patients who underwent periodontal surgery or implant surgery for it's synergism among three dugs.
Acetaminophen ; Analgesics ; Codeine ; Dental Implants* ; Humans ; Ibuprofen ; Outpatients ; Pain, Postoperative

An antral web is an extremely rare gastric anomaly that disturbs the gastric outlet. The onset of symptoms will depend on the diameter of the aperture. Obstructive symptoms may not occur when the aperture is >l centimeter in diameter. If the aperture is larger than 1 cm without significant symptoms, conservative treatment is sufficient. A case of an antral web with an ulcer and vomiting in a 7-year-old boy who received ibuprofen for 2 days is presented. The patient became symptom-free after medical treatment.
Carbamates ; Child ; Humans ; Ibuprofen ; Organometallic Compounds ; Stomach Ulcer ; Ulcer ; Vomiting

Background:The failure of medical treatment for closure of the ductus arteriosus in very premature is still high (41%). Objectives:This study aims to evaluate the response of ductus arteriosus by color doppler ultrasound in premature infants treated with ibuprofen. Subjects and method:A pilot study was conducted at neonatal intensive care patients on 8 prernatures. The mean birth weight was 825 g (640g - 1190g) and gestational average age of 27.4 weeks of amenorrhea with respiratory distress with ductus arteriosus significantly. The average size was 1.9\xb10.3mm. Intervention: Children received the first dose of Ibuprofen 10mg/kg/day at age from 35 to 54 hours of life, and then 5mg/kg/day after 2 doses. Results:The outcome measure of the size of the ductus arteriosus was performed before each dose of Ibuprofen and 6 hours and 12 hours after each dose. At least three different measures has been taken every echocardiographie. 4 ways of evolution kinetics of turnover: 1: ductus arteriosus ferrne rapidly for 12 early hours of 1st dose (2 patients). 2nd: ductus arteriosus after 3rd dose (3 patients). 3rd: ductus arteriosus quickly after first 12 hours of 1st dose and then reopened (1 patient). 4th: ductus arteriosus not ferrne (2 patients). The size of sales decreased significantly 6 hours and 12 hours after the 1st dose of the 1st prernatures cure in 7 (87%) whatever the final outcome (p<0.05). Conclusion:The different responses from one individual to another led us to consider a Echo guide personalized therapy. A further research should be carried out to find a protocol for better value.
Ductus Arteriosus/ pathology ; Ibuprofen/ therapeutic use ; Ultrasonography ; Doppler ; Infant ; Premature

A chiral high-performance liquid chromatography method was developed for the simultaneous determination of ibuprofen enantiomers in dog plasma. It was used to study the pharmacokinetics in the Beagle dog after intravenous administration of racemic-ibuprofen, S-ibuprofen and R-ibuprofen. Ketoprofen was chosen as the internal standard. After a simple precipitation using methanol as the precipitating solvent, both analytes and IS were separated on a Kromasil 100-5CHI-TBB chiral column (250 mm x4.6 mm, 5 μm) with isocratic elution using acetonitrile - 20 mmol x L(-1) phosphate buffer (pH 3.0, containing 5% methanol) (6 : 4) as the mobile phase. The detection wavelength was 220 nm. Liner calibration curves for both of the ibuprofen enantiomers were over the concentration range from 0.5 to 50 μg x mL(-1) with a lower limit of quantification of 0.5 μg x mL(-1), the accuracies were all in standard ranges. The intra- and inter- assay precisions were all below 7%. The recovery rate was 93.1% to 100.4%. The experiments proved that the method was simple, rapid and sensitive. It can be used in the quantitative determination of ibuprofen enantiomers in dog plasma. The method was used to determine the concentration of ibuprofen enantiomers in Beagle dog plasma after a single intravenous administration of racemic-ibuprofen, S-ibuprofen and R-ibuprofen (9 mg x kg(-1)) and the pharmacokinetics parameters were calculated based on the concentration-time curves. The C(max) of S-ibuprofen in Beagle dog plasma after a single intravenous administration of racemic-ibuprofen, S-ibuprofen and R-ibuprofen were 30.8 ± 4.7, 46.1 ± 5.9 and 20.0 ± 2.6 μg x mL(-1), respectively. In terms of the exposure of active ingredient, it revealed a significant difference between the administration of S-ibuprofen and the other two groups. The systematical R- to S- chiral inversion was discussed. Comparing the pharmacokinetic parameters at different doses, chiral inversion were 70.1% ± 36.6% and 76.4% ± 36.2%, respectively, after intravenous administration of racemic- and R-ibuprofen. This study provides a theoretical basis for the safety of ibuprofen formula of injection drug.
Animals ; Chromatography, High Pressure Liquid ; Dogs ; Ibuprofen ; blood ; pharmacokinetics ; Stereoisomerism

Acute generalized exanthematous pustulosis(AGEP) is a relatively rare exfoliative skin syndrome. It consists of a generalized eruption of pustules in response to medication or infection. Antibiotics are the most commonly implicated medications. Nonsteroidal anti-inflammatory drugs(NSAID) can also trigger AGEP. However, So far, a case of AGEP due to ibuprofen has not been reported in Korea. Therefore we report a case of acute generalized exanthematous pustulosis as a result of use of ibuprofen in a 10 years old female.
Acute Generalized Exanthematous Pustulosis* ; Anti-Bacterial Agents ; Child ; Female ; Humans ; Ibuprofen ; Korea ; Skin