The purpose of this study is to evaluate the antibacterial effects of two liquid fluoride materials on Streptococcus mutans (S. mutans). Riva star aqua™ (SDI, Bayswater, Australia), which consists of silver fluoride (AgF, step 1) and potassium iodide (KI, step 2), and Fluor protector® (FP; Ivoclar Vivadent, Liechtenstein) were used for experimental groups. Experimental groups were divided into 4 groups : AgF, KI, AgF + KI and FP. For the positive control (PC) group, ampicillin was used, and the negative control group (NC) did not receive any additional treatment. Each group was divided into 30 and 50 µL groups by volume of liquid and applied to flat-coated S. mutans. The diameter of the zone of inhibition was measured. The PC and AgF groups showed larger diameters than other materials (p < 0.05), and the AgF group showed no significant difference from the PC group in the 50 µL group (p > 0.05). The FP group showed larger diameters than the AgF + KI group in the 30 µL (p = 0.009). The KI group did not show significant difference from the NC group (p > 0.05). AgF is comparable to ampicillin in antibacterial effects on S. mutans, and better than FP.

Objectives: One of the main causes of tooth loss in Korea is dental caries, a chronic disease affecting individuals of all ages worldwide. The average decayed, missing, and filled teeth (DMFT) index, a measure of the caries experience of the population, has been stagnating in Korea for a number of years. The purpose of this study was to investigate the pattern of caries prevalence by tooth type, and to identify the characteristics and risk factors of the specific affected caries (SaC) and significant caries (SiC) groups in Korea’s 12-year-old children. Data were obtained from the 2018 Children’s Oral Health Survey. Methods: Data from a total of 22,303 subjects were included in the study. We grouped the data according to two DMFT-related indices, the SaC index, which includes all subjects who have experienced a carious lesion, and the SiC index, which includes the top one-third of the population by DMFT. We then analyzed the sociodemographic variables and oral health behaviors seen in these groups. Results: The average DMFT index for all the 12-year-old children was 1.89, and that of those in the SaC and SiC groups was 3.37 and 4.86, respectively. The teeth that were found to be most likely to develop caries were the mandibular and maxillary first molars, and the tooth associated with the highest mean DMFT index was the mandibular first premolar. Among the variables analyzed, perceived oral health status was the most influential variable in the SaC and SiC groups, followed by gender, and then the presence or absence of calculus. Household income was not a statistically significant variable. Conclusions The results of this study revealed the characteristics common to 12-year-old children who are vulnerable to caries. This will provide valuable information when planning dental disease management projects.

No abstract available.
Cyclosporine* ; Pityriasis Rubra Pilaris* ; Pityriasis*

Purpose: The aim of this study was to determine the reliability and validity of the metacognition rating scale (MCRS), which is a revised version of the existing metacognition questionnaire (MCQ) with anger and anxiety added. Methods: A survey was conducted on 591 nursing students at colleges in North and South Gyeongsang Provinces, South Korea. The collected data were processed for the reliability and validity of the MCRS through Cronbach’s ⍺ and confirmatory factor analysis using SPSS 26.0. Results: Cronbach’s ⍺ for the reliability of MCRS was calculated at .88, .86, .77, .74, and .66 for five subfactors. Among the five subfactors, the first, second, third, and fifth factors showed high correlation in each of six items. Factor 4 was highly correlated in 5 out of 6 questions. Conclusion The data confirm that the MCQ revised to include anger and anxiety is both reliable and valid for nursing students. Therefore, this scale can be used to identify the maladaptive metacognition of nursing students in stressful situations.

Purpose: The aim of this study was to determine the reliability and validity of the metacognition rating scale (MCRS), which is a revised version of the existing metacognition questionnaire (MCQ) with anger and anxiety added. Methods: A survey was conducted on 591 nursing students at colleges in North and South Gyeongsang Provinces, South Korea. The collected data were processed for the reliability and validity of the MCRS through Cronbach’s ⍺ and confirmatory factor analysis using SPSS 26.0. Results: Cronbach’s ⍺ for the reliability of MCRS was calculated at .88, .86, .77, .74, and .66 for five subfactors. Among the five subfactors, the first, second, third, and fifth factors showed high correlation in each of six items. Factor 4 was highly correlated in 5 out of 6 questions. Conclusion The data confirm that the MCQ revised to include anger and anxiety is both reliable and valid for nursing students. Therefore, this scale can be used to identify the maladaptive metacognition of nursing students in stressful situations.

The indications for total elbow replacement arthroplasty (TERA) include rheumatoid arthritis, degenerative arthritis, acute fracture, nonunion, malunion, posttraumatic arthritis, tumor, and chronic instability. With the development of designs and the increasing use of TERA, more periprosthetic fractures are occurring. On the other hand, there is less data on periprosthetic fractures after TERA because TERA is a relatively rare procedure. Thus, a careful review of the previous literature and appropriate selection of surgical indications are essential for achieving a satisfactory outcome, which should be accompanied by precise surgery as planned. This article presents the causes, risk factors, classification, and principles of treatment of periprosthetic fractures after TERA.

Primary bone marrow lymphomas are infrequent. We report a case of primary bone marrow T-cell lymphoma in a 33-year old patient who has been treated as a hypocellular marrow. There was no enlarged lymph nodes or organomegaly. The peripheral blood smears showed several lymphoid atypical cells. The bone marrow biopsy revealed markedly increased cellularity and disclosed malignant lymphoma, diffuse, large-cell, immunoblastic type The lymphoma cells disclosed positive reaction in leukocyte common antigen (CD45) and UCHL-1 (CD45RO) antibodies which is compatible with a T-cell phenotype. The patient was received allogeneic bone marrow transplantation.
Adult ; Anemia, Aplastic* ; Antibodies ; Antigens, CD45 ; Biopsy ; Bone Marrow Transplantation ; Bone Marrow* ; Humans ; Lymph Nodes ; Lymphoma* ; Lymphoma, T-Cell ; Phenotype ; T-Lymphocytes

Background: With the increase in meals at home due to coronavirus disease 2019 (COVID-19), the pattern and incidence of enteritis seemed to change. Some types of enteritis, such as Campylobacter enteritis, appear to have increased. Our study aimed to evaluate the change in the trend of enteritis, especially Campylobacter enteritis, before COVID-19 (2016– 2019) and at the present time during COVID-19 in South Korea. Methods: We analyzed data from the Health Insurance Review and Assessment Service. From 2016 to 2020, the International Classification of Diseases codes related to enteritis were examined to distinguish bacterial and viral enteritis and the trends of each were analyzed.The aspects of enteritis, before and after the COVID-19 outbreak, were compared. Results: Both bacterial and viral enteritis declined in all age groups from 2016 to 2020 (P< 0.001). In 2020, the reduction rate of viral enteritis was higher than that of bacterial enteritis. However, unlike other causes of enteritis, even after COVID-19, Campylobacter enteritis increased in all age groups. An increase of Campylobacter enteritis in 2020 was particularly noticeable in children and adolescents. The prevalence of viral and bacterial enteritis was higher in urban areas than in rural areas (P < 0.001). Campylobacter enteritis was more common in the rural areas (P< 0.001). Conclusion Although the prevalence of bacterial and viral enteritis have decreased in COVID-19, Campylobacter enteritis has increased in all age groups and in rural areas compared to urban areas. Recognizing that the trend of Campylobacter enteritis before and during COVID-19 is helpful for future public health measures and interventions.

Dioscoreae Rhizome (DR) has been used in traditional medicine to treat numerous diseases and is reported to have anti-diabetes and anti-tumor activities. To identify a bioactive traditional medicine with anti-inflammatory activity of a water extract of DR (EDR), we determined the mRNA and protein levels of proinflammatory cytokines in macrophages through RT-PCR and western blot analysis and performed a FACS analysis for measuring surface molecules. EDR dose-dependently decreased the production of NO and pro-inflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and PGE2, as well as mRNA levels of iNOS, COX-2, and pro-inflammatory cytokines, as determined by western blot and RT-PCR analysis, respectively. The expression of co-stimulatory molecules such as B7-1 and B7-2 was also reduced by EDR. Furthermore, activation of the nuclear transcription factor, NF-kappaB, but not that of IL-4 and IL-10, in macrophages was inhibited by EDR. These results show that EDR decreased pro-inflammatory cytokines via inhibition of NF-kappaB-dependent inflammatory protein level, suggesting that EDR could be a useful immunomodulatory agent for treating immunological diseases.
Blotting, Western ; Cytokines ; Dinoprostone ; Dioscorea ; Immune System Diseases ; Inflammation ; Interleukin-10 ; Interleukin-4 ; Interleukin-6 ; Macrophages ; Medicine, Traditional ; NF-kappa B ; Rhizome ; RNA, Messenger ; Transcription Factors ; Tumor Necrosis Factor-alpha ; Water

Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic mice; however, the role of the gut microbiota in ameliorating efficacy of QDMC remains unclear. We investigated the effect of QDMC on the gut microbiota in a type 2 diabetic aged mouse model that was administered a high-fat diet. Proinflammatory (TNF-α and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine levels in the fat were normalized via oral administration of QDMC, and relative abundances of Bacteroides, Butyricimonas, Ruminococcus, and Mucispirillum were simultaneously significantly increased. The abundance of these bacteria was correlated to the expression levels of cytokines. Our findings suggest that the immunomodulatory activity of QDMC is partly mediated by the altered gut microbiota composition.