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This study analyzes the career trajectories of students from Jeonuigam in the late nineteenth centry Joseon dynasty, shedding light on its educational functions by focusing on individuals listed in the Jeonhamsaengdoan and Byeoncheonpalsean. The primary subject of this research, the Jeonhamsaengdoan, is a valuable resource for understanding the career paths of Jeonuigam students, containing enrollment information for 384 individuals. The Byeolcheonpalsean, introduced for the first time in this paper, provides information about an alternative method of enrollment known as ‘Byeolcheon’ for students entering Jeonuigam.The analysis of these individuals’ career paths reveals that many Jeonuigam students had overlapping enrollments in other technical institutions, such as Saekwon and Gwangsangam. This suggests that medical education was not limited to specific disciplines but was part of a broader educational framework. Moreover, the Seogyeong system allowed younger siblings to enroll alongside older ones, while the Byeolcheon system, which facilitated recommendations from other institutions, provided educational opportunities for families. These findings highlight the diverse methods in which medical and vocational education were conducted in the late nineteenth century Joseon dynasty.Approximately 66 percent of Jeonuigam students became medical officials, while others pursued careers in fields such as interpreting and various government roles, contributing to society in multiple ways. This study demonstrates that Jeonuigam was not solely focused on training medical personnel but was intricately linked to broader vocational education systems. Consequently, this study contributes to a historical understanding of medical education in the late Joseon period. Future studies should explore comparisons with Hyeminseo and Naeuiwon, changes in the social status of the middle class, and Jeonuigam’s role during the transition to modern medical systems.

This study analyzes the career trajectories of students from Jeonuigam in the late nineteenth centry Joseon dynasty, shedding light on its educational functions by focusing on individuals listed in the Jeonhamsaengdoan and Byeoncheonpalsean. The primary subject of this research, the Jeonhamsaengdoan, is a valuable resource for understanding the career paths of Jeonuigam students, containing enrollment information for 384 individuals. The Byeolcheonpalsean, introduced for the first time in this paper, provides information about an alternative method of enrollment known as ‘Byeolcheon’ for students entering Jeonuigam.The analysis of these individuals’ career paths reveals that many Jeonuigam students had overlapping enrollments in other technical institutions, such as Saekwon and Gwangsangam. This suggests that medical education was not limited to specific disciplines but was part of a broader educational framework. Moreover, the Seogyeong system allowed younger siblings to enroll alongside older ones, while the Byeolcheon system, which facilitated recommendations from other institutions, provided educational opportunities for families. These findings highlight the diverse methods in which medical and vocational education were conducted in the late nineteenth century Joseon dynasty.Approximately 66 percent of Jeonuigam students became medical officials, while others pursued careers in fields such as interpreting and various government roles, contributing to society in multiple ways. This study demonstrates that Jeonuigam was not solely focused on training medical personnel but was intricately linked to broader vocational education systems. Consequently, this study contributes to a historical understanding of medical education in the late Joseon period. Future studies should explore comparisons with Hyeminseo and Naeuiwon, changes in the social status of the middle class, and Jeonuigam’s role during the transition to modern medical systems.

This study analyzes the career trajectories of students from Jeonuigam in the late nineteenth centry Joseon dynasty, shedding light on its educational functions by focusing on individuals listed in the Jeonhamsaengdoan and Byeoncheonpalsean. The primary subject of this research, the Jeonhamsaengdoan, is a valuable resource for understanding the career paths of Jeonuigam students, containing enrollment information for 384 individuals. The Byeolcheonpalsean, introduced for the first time in this paper, provides information about an alternative method of enrollment known as ‘Byeolcheon’ for students entering Jeonuigam.The analysis of these individuals’ career paths reveals that many Jeonuigam students had overlapping enrollments in other technical institutions, such as Saekwon and Gwangsangam. This suggests that medical education was not limited to specific disciplines but was part of a broader educational framework. Moreover, the Seogyeong system allowed younger siblings to enroll alongside older ones, while the Byeolcheon system, which facilitated recommendations from other institutions, provided educational opportunities for families. These findings highlight the diverse methods in which medical and vocational education were conducted in the late nineteenth century Joseon dynasty.Approximately 66 percent of Jeonuigam students became medical officials, while others pursued careers in fields such as interpreting and various government roles, contributing to society in multiple ways. This study demonstrates that Jeonuigam was not solely focused on training medical personnel but was intricately linked to broader vocational education systems. Consequently, this study contributes to a historical understanding of medical education in the late Joseon period. Future studies should explore comparisons with Hyeminseo and Naeuiwon, changes in the social status of the middle class, and Jeonuigam’s role during the transition to modern medical systems.

This study analyzes the career trajectories of students from Jeonuigam in the late nineteenth centry Joseon dynasty, shedding light on its educational functions by focusing on individuals listed in the Jeonhamsaengdoan and Byeoncheonpalsean. The primary subject of this research, the Jeonhamsaengdoan, is a valuable resource for understanding the career paths of Jeonuigam students, containing enrollment information for 384 individuals. The Byeolcheonpalsean, introduced for the first time in this paper, provides information about an alternative method of enrollment known as ‘Byeolcheon’ for students entering Jeonuigam.The analysis of these individuals’ career paths reveals that many Jeonuigam students had overlapping enrollments in other technical institutions, such as Saekwon and Gwangsangam. This suggests that medical education was not limited to specific disciplines but was part of a broader educational framework. Moreover, the Seogyeong system allowed younger siblings to enroll alongside older ones, while the Byeolcheon system, which facilitated recommendations from other institutions, provided educational opportunities for families. These findings highlight the diverse methods in which medical and vocational education were conducted in the late nineteenth century Joseon dynasty.Approximately 66 percent of Jeonuigam students became medical officials, while others pursued careers in fields such as interpreting and various government roles, contributing to society in multiple ways. This study demonstrates that Jeonuigam was not solely focused on training medical personnel but was intricately linked to broader vocational education systems. Consequently, this study contributes to a historical understanding of medical education in the late Joseon period. Future studies should explore comparisons with Hyeminseo and Naeuiwon, changes in the social status of the middle class, and Jeonuigam’s role during the transition to modern medical systems.

BACKGROUND: Harassment means systemic and repeated unethical acts. Research on workplace harassment have been conducted widely and the NAQ-R has been widely used for the researches. But this tool, however the limitations in revealing differended in sub-factors depending on the culture and in reflecting that unique characteristics of the Koren society. So, The workplace harassment questionnaire for Korean finace and service workers has been developed to assess the level of personal harassment at work. This study aims to develop a tool to assess the level of personal harassment at work and to test its validity and reliability while examining specific characteristics of workplace harassment against finance and service workers in Korea. METHODS: The framework of survey was established based on literature review, focused-group interview for the Korean finance and service workers. To verify its reliability, Cronbach’s alpha coefficient was calculated; and to verify its validity, items and factors of the tool were analyzed. The correlation matrix analysis was examined to verify the tool’s convergent validity and discriminant validity. Structural validity was verified by checking statistical significance in relation to the BDI-K. RESULTS: Cronbach’s alpha coefficient of this survey was 0.93, which indicates a quite high level of reliability. To verify the appropriateness of this survey tool, its construct validity was examined through factor analysis. As a result of the factor analysis, 3 factors were extracted, explaining 56.5 % of the total variance. The loading values and communalities of the 20 items were 0.85 to 0.48 and 0.71 to 0.46. The convergent validity and discriminant validity were analyzed and rate of item discriminant validity was 100 %. Finally, for the concurrent validity, We examined the relationship between the WHI-KFSW and pschosocial stress by examining the correlation with the BDI-K. The results of chi-square test and multiple logistic analysis indicated that the correlation with the BDI-K was satatisctically significant. CONCLUSION: Workplace harassment in actual workplaces were investigated based on interviews, and the statistical analysis contributed to systematizing the types of actual workplace harassment. By statistical method, we developed the questionare, 20 items of 3 categories.
Humans ; Korea ; Methods ; Reproducibility of Results*

OBJECTIVES: The aim of this study was to investigate continuously on how a short-term family psychoeducation program for schizophrenia would change the emotional stress and the knowledge of the family members. METHODS: Subjects were the family members who participated in the short-term family psychoeducation program for schizophrenia. The participants were asked to fill out self-reporting forms for 3 times-before commencing the 6-week family education, immediately after completing the program, and 3 months after completing the program respectively. RESULTS: A total of 46 subjects participated, and 20 of them responded to all questionnaires. Three months after the completion of psychoeducation, depression and anxiety subscale score among the General Health Questionnaire-28 decreased by 2.60 (p=0.04) and 2.20 (p=0.04) respectively. In caregiver burden criterion, the score decreased by 9.45 (p=0.04) in 3 months after completing the education. In knowledge about schizophrenia test, the score increased by 2.60 score (p<0.001), and this result was maintained after 3 months. CONCLUSION: It was found that a short-term family education program for schizophrenia was effective not only in improving the knowledge on the disease but also in reducing anxiety and depression, and this effect was maintained immediately after the psychoeducation and so was it as time passed as well.
Anxiety ; Caregivers ; Depression ; Education ; Humans ; Surveys and Questionnaires ; Schizophrenia* ; Stress, Psychological

OBJECTIVES: Endodontically treated teeth with insufficient tooth structure are often restored with esthetic restorations. This study evaluated the cytotoxicity and biological effects of yttria partially stabilized zirconia (Y-TZP) blocks in combination with several dental cements. MATERIALS AND METHODS: Pairs of zirconia cylinders with medium alone or cemented with three types of dental cement including RelyX U200 (3M ESPE), FujiCEM 2 (GC), and Panavia F 2.0 (Kuraray) were incubated in medium for 14 days. The cytotoxicity of each supernatant was determined using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays on L929 fibroblasts and MC3T3-E1 osteoblasts. The levels of interleukin-6 (IL-6) mRNA were evaluated by reverse transcription polymerase chain reaction (RT-PCR), and IL-6 protein was evaluated by enzyme-linked immunosorbent assays (ELISA). The data were analyzed using one-way ANOVA and Tukey post-hoc tests. A p < 0.05 was considered statistically significant. RESULTS: The MTT assays showed that MC3T3-E1 osteoblasts were more susceptible to dental cements than L929 fibroblasts. The resin based dental cements increased IL-6 expression in L929 cells, but reduced IL-6 expression in MC3T3-E1 cells. CONCLUSIONS: Zirconia alone or blocks cemented with dental cement showed acceptable biocompatibilities. The results showed resin-modified glass-ionomer based cement less produced inflammatory cytokines than other self-adhesive resin-based cements. Furthermore, osteoblasts were more susceptible than fibroblasts to the biological effects of dental cement.
Cytokines ; Dental Cements* ; Enzyme-Linked Immunosorbent Assay ; Fibroblasts ; Interleukin-6 ; Osteoblasts ; Polymerase Chain Reaction ; Resin Cements ; Reverse Transcription ; RNA, Messenger ; Tooth

OBJECTIVE: Autophagy contributes to the clearance and recycling of macromolecules and organelles in response to stress. We previously reported that vitrified mouse oocytes show acute increases in autophagy during warming. Herein, we investigate the potential role of Atg7 in oocyte vitrification by using an oocyte-specific deletion model of the Atg7 gene, a crucial upstream gene in the autophagic pathway. METHODS: Oocyte-specific Atg7 deficient mice were generated by crossing Atg7 floxed mice and Zp3-Cre transgenic mice. The oocytes were vitrified-warmed and then subjected to in vitro fertilization and development. The rates of survival, fertilization, and development were assessed in the Atg7 deficient oocytes in comparison with the wildtype oocytes. Light chain 3 (LC3) immunofluorescence staining was performed to determine whether this method effectively evaluates the autophagy status of oocytes. RESULTS: The survival rate of vitrified-warmed Atg7(f/f);Zp3-Cre (Atg7(d/d)) metaphase II (MII) oocytes was not significantly different from that of the wildtype (Atg7(f/f)) oocytes. Fertilization and development in the Atg7(d/d) oocytes were significantly lower than the Atg7(f/f) oocytes, comparable to the Atg5d/d oocytes previously described. Notably, the developmental rate improved slightly in vitrified-warmed Atg7(d/d) MII oocytes when compared to fresh Atg7(d/d) oocytes. LC3 immunofluorescence staining showed that this method can be reliably used to assess autophagic activation in oocytes. CONCLUSION: We confirmed that the LC3-positive signal is nearly absent in Atg7(d/d) oocytes. While autophagy is induced during the warming process after vitrification of MII oocytes, the Atg7 gene is not essential for survival of vitrified-warmed oocytes. Thus, induction of autophagy during warming of vitrified MII oocytes seems to be a natural response to manage cold or other cellular stresses.
Animals ; Autophagy ; Fertilization ; Fertilization in Vitro* ; Fluorescent Antibody Technique ; Genes, vif ; Metaphase ; Mice* ; Mice, Transgenic ; Oocytes* ; Organelles ; Recycling ; Survival Rate ; Vitrification*

Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier function have been identified as the cause of atopic dermatitis. Loss-of-function mutation of filaggrin, a significant constituent of skin barrier, has been revealed as a cause for atopic dermatitis, and factors like enhanced protease activity, and decreased synthesis of the lipid lamellae especially ceramides also plays an important role in barrier dysfunction. Not only these genetic causes but also environmental factors are associated in barrier dysfunction, such as soap or detergents which increases skin pH, or proteases of dust mites or cockroaches which enhances epidermal barrier breakdown. Lately, skin barrier dysfunction is also thought to play an important role in the early stage of other allergic diseases such as asthma. Therefore, comprehension of the function of skin barrier can provide help in understanding various allergic diseases.
Asthma ; Ceramides ; Cockroaches ; Comprehension ; Dermatitis, Atopic ; Detergents ; Dust ; Hydrogen-Ion Concentration ; Intermediate Filament Proteins ; Mites ; Peptide Hydrolases ; Skin ; Skin Diseases ; Soaps