Ketosis-prone diabetes includes heterogeneous disease groups characterized by provoked or unprovoked ketoacidosis (ketosis), with a typical phenotype of autoimmune type 1 diabetes. As the incidence of obesity and type 2 diabetes is universally increasing, the rate of type 2 diabetes in diabetic ketoacidosis in children and adolescents is exptected to increase rapidly. The clinical presentation of atypical ketoacidosis with type 2 diabetes has been reported mostly in adults. We recently experienced a case of a 10-year-old obese girl with new-onset type 2 diabetes who initially presented with severe diabetic ketoacidosis, and introduce it with literature reviews.
Adolescent ; Adult ; Child ; Diabetes Mellitus, Type 2 ; Diabetic Ketoacidosis ; Humans ; Incidence ; Ketosis ; Obesity ; Phenotype

Ketosis-prone diabetes includes heterogeneous disease groups characterized by provoked or unprovoked ketoacidosis (ketosis), with a typical phenotype of autoimmune type 1 diabetes. As the incidence of obesity and type 2 diabetes is universally increasing, the rate of type 2 diabetes in diabetic ketoacidosis in children and adolescents is exptected to increase rapidly. The clinical presentation of atypical ketoacidosis with type 2 diabetes has been reported mostly in adults. We recently experienced a case of a 10-year-old obese girl with new-onset type 2 diabetes who initially presented with severe diabetic ketoacidosis, and introduce it with literature reviews.
Adolescent ; Adult ; Child ; Diabetes Mellitus, Type 2 ; Diabetic Ketoacidosis ; Humans ; Incidence ; Ketosis ; Obesity ; Phenotype

Purpose: This study was done clarify the concept of illness acceptance in patients with chronic disease. Methods: This study was conducted using a hybrid model of concept analysis that consists of three phases. In the theoretical phase, a working definition was formulated through a systematic review. In the fieldwork phase, five participants who had diabetes or hypertension for at least one year were interviewed. In the third phase, the results were combined in the final analysis. Results: There are three phases of accepting an illness: experiencing the limits, disease management, and designing new life. At the experience of the limits and disease management stages, the attributes of physical, psychological and social domains were derived, but at the stage of designing their new life, integrated attributes of these three domains were derived. Conclusion Illness acceptance of chronic disease was defined as a continuous and dynamic process in three phases. First, patients experience limitations due to the disease, such as physical illness, psychological instability, and difficulty performing social roles. Second, patients manage the disease by engaging in self-management, psychological coping strategies, and establishing social support. Third, patients design their new life by seeking better health-related quality of life and integrating the illness into their everyday life. However, patients experienced negative changes when disease management was not performed properly. The fact that illness acceptance could be cyclic means the difference between illness and loss/death acceptance. Nurse should develop and provide an integrated nursing intervention that is appropriate for phases of illness acceptance.

No abstract available.
Aged* ; Arm* ; Histiocytoma, Malignant Fibrous ; Humans

No abstract available.
Graft vs Host Disease* ; Liver Transplantation*

No abstract available.
Hand* ; Hyperpigmentation* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*

No abstract available.
Humans ; Telangiectasis

Carcinoma of the uterine cervix is a common malignancy for women in Korea. It frequently metastasizes to the lungs, bone, or liver, but cutaneous metastasis is rare, with a reported incidence of only 1.3%. In cases of cutaneous metastasis, the lesions present in the forms of nodules, ulcers, or plaques, and are generally located in the abdominal wall, vulva, anterior chest wall, lower extremities, and upper extremities. Here, we describe a case of a 64-year-old woman diagnosed with cutaneous metastases from squamous cell carcinoma of the uterine cervix on both flanks, lower abdominal wall, and both inguinal areas, three years after receiving chemoradiation therapy. At presentation, the primary carcinoma had been resolved completely. Histological and immunohistochemical findings revealed intact epidermis and infiltration of tumor cells in the dermis, which showed positivity for cytokeratin 5/6, cytokeratin 7, and tumor protein 63, consistent with metastatic squamous cell carcinoma of the uterine cervix.
Abdominal Wall ; Carcinoma, Squamous Cell* ; Cervix Uteri* ; Dermis ; Epidermis ; Female ; Humans ; Incidence ; Keratin-7 ; Keratins ; Korea ; Liver ; Lower Extremity ; Lung ; Middle Aged ; Neoplasm Metastasis* ; Thoracic Wall ; Ulcer ; Upper Extremity ; Uterine Cervical Neoplasms ; Vulva

No abstract available.
Child, Preschool* ; Female* ; Humans ; Nevus, Pigmented*

Chrysin is a 5,7-dihydroxyflavone and was recently shown to potently inhibit enterovirus 71 (EV71) by suppressing viral 3C protease (3Cpro) activity. In the current study, we investigated whether chrysin also shows antiviral activity against coxsackievirus B3 (CVB3), which belongs to the same genus (Enterovirus) as EV71, and assessed its ability to prevent the resulting acute pancreatitis and myocarditis. We found that chrysin showed antiviral activity against CVB3 at 10 muM, but exhibited mild cellular cytotoxicity at 50 muM, prompting us to synthesize derivatives of chrysin to increase the antiviral activity and reduce its cytotoxicity. Among four 4-substituted benzyl derivatives derived from C(5) benzyl-protected derivatives 7, 9-11 had significant antiviral activity and showed the most potent activity against CVB3 with low cytotoxicity in Vero cells. Intraperitoneal injection of CVB3 in BALB/c mice with 1x106 TCID50 (50% tissue culture infective dose) of CVB3 induced acute pancreatitis with ablation of acinar cells and increased serum CXCL1 levels, whereas the daily administration of 9 for 5 days significantly alleviated the pancreatic inflammation and reduced the elevation in serum CXCL1 levels. Collectively, we assessed the anti-CVB3 activities of chrysin and its derivatives, and found that among 4-substituted benzyl derivatives, 9 exhibited the highest activity against CVB3 in vivo, and protected mice from CVB3-induced pancreatic damage, simultaneously lowering serum CXCL1 levels.
Acinar Cells ; Animals ; Enterovirus ; Inflammation ; Injections, Intraperitoneal ; Mice ; Myocarditis ; Pancreatitis ; Vero Cells