1.Peritoneal Dialysis.
Korean Journal of Medicine 2014;86(2):138-141
More than thirty years after its introduction as a modality of renal replacement therapy (RRT), peritoneal dialysis (PD) has now become an established form of RRT. There were 70,211 patients receiving RRT at the end of 2,012 in Korea, and PD accounted for 10.8% of them. The rate for PD patients per million population has grown by 24% during the past 10 years. In this paper, physiology of peritoneal dialysis, assessment of peritoneal membrane transport function, updated target of solute removal, and potential complications of peritoneal dialysis will be discussed.
Humans
;
Korea
;
Membranes
;
Peritoneal Dialysis*
;
Physiology
;
Renal Replacement Therapy
2.Peritoneal Dialysis.
Korean Journal of Medicine 2014;86(2):138-141
More than thirty years after its introduction as a modality of renal replacement therapy (RRT), peritoneal dialysis (PD) has now become an established form of RRT. There were 70,211 patients receiving RRT at the end of 2,012 in Korea, and PD accounted for 10.8% of them. The rate for PD patients per million population has grown by 24% during the past 10 years. In this paper, physiology of peritoneal dialysis, assessment of peritoneal membrane transport function, updated target of solute removal, and potential complications of peritoneal dialysis will be discussed.
Humans
;
Korea
;
Membranes
;
Peritoneal Dialysis*
;
Physiology
;
Renal Replacement Therapy
3.Clinical Usefulness of Low Calcium Dialysate in Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients.
Hyunjin NOH ; Sug Kyun SHIN ; Shin Wook KANG ; Kyu Hun CHOI ; Dae Suk HAN ; Ho Yung LEE
Korean Journal of Nephrology 1998;17(5):779-785
Hypercalcemia is a common complication in CAPD patients treated with calcium-containing phosphate binders and using the standard dialysate (SCD) calcium concentration of 3.5mEq/L. We performed a retrospective study in 25 CAPD patients to determine whether a low calcium dialysate (LCD) containing 2.5mEq/L calcium would reduce the incidence of hypercalemia with adequate control of serum inorganic phosphate levels and diminish the need to use aluminum-containing phosphate binders. All patients had previously used SCD before converting to LCD. The incidence of hypercalcemia (more than 2 episodes of corrected serum calcium > or = 10.5mg/dL) tended to be lower after converting to LCDl 0.27 (0-2.76) vs. 0 (0-1.97) episodes/patient-yearl. Intact PTH level increased from 38.8 (0.1-1599.3)pg/mL to 70.6 (9.5-1540.0)pg/mL after conversion, but there was no statistical sifnificance. Serum calcium, inorganic phosphate, alkaline phosphatase and bicarbonate levels did not change after converting to LCD. We were able to reduce aluminum hydroxide dosagel 1.09 (0-10.88) vs. 0 (0-3.26)g/day/patientl and increase calcium carbonate dosage (1.95 0.92 vs. 2.98 2.14g/day/ patient) after conversion significantly (P<0.05). The frequency of peritonitis was similar in LCD and SCD period. In conclusion, low calcium dialysate is useful in diminishing aluminum-containing phosphate binder dosage and increasing calcium carbonate dosage to maintain a similar phosphate value. Its effects on renal osteodystrophy remain to be assessed.
Alkaline Phosphatase
;
Aluminum Hydroxide
;
Calcium Carbonate
;
Calcium*
;
Humans
;
Hypercalcemia
;
Incidence
;
Kidney Failure, Chronic
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Peritonitis
;
Renal Osteodystrophy
;
Retrospective Studies
4.The authors' reply: Letter to the Editor: Cardiac arrest caused by nafamostat mesilate: Kounis syndrome in the dialysis room?.
Kidney Research and Clinical Practice 2017;36(1):107-107
No abstract available.
Dialysis*
;
Heart Arrest*
;
Mesylates*
5.Acute Eosinophilic Pneumonia Associated with Amitriptyline in a Hemodialysis Patient.
Hyunjin NOH ; Young Kyu LEE ; Shin Wook KANG ; Kyu Hun CHOI ; Dae Suk HAN ; Ho Yung LEE
Yonsei Medical Journal 2001;42(3):357-359
Drugs are well known causes of eosinophilic lung disease. In many patients, drug-induced eosinophilic lung disease presents with transient eosinophilic infiltrates that disappear after discontinuation of the drug. Some patients, however, experience a fulminant, acute eosinophilia-like disease. Recently, we experienced a case of amitriptyline-associated acute eosinophilic pneumonia with respiratory failure in a diabetic hemodialysis patient. Eight days after treatment with amitriptyline, sudden fever, chill, dry cough and dyspnea developed. Subsequently, multiple patch consolidations appeared on the chest radiographs. Bronchoalveolar lavage (BAL), established a diagnosis of acute eosinophilic pneumonia. After immediate discontinuation of amitriptyline, a rapid clinical and radiological improvement was observed. The present case indicates that the possibility of acute eosinophilic pneumonia should be fully considered in dialysis patients developing unexplained respiratory symptoms while on amitriptyline therapy.
Acute Disease
;
Adult
;
Amitriptyline/*adverse effects
;
Antidepressive Agents, Tricyclic/*adverse effects
;
Female
;
Human
;
Pulmonary Eosinophilia/*etiology
;
*Renal Dialysis
6.Inducible Nitric Oxide Synthase (iNOS) is Increased in Diabetic Rat Glomeruli: Role of Angiotensin II (AII).
Kyu Hun CHOI ; Hyunjin NOH ; Bum Seok KIM ; Shin Wook KANG ; Dae Suk HAN ; Ho Yung LEE
Korean Journal of Nephrology 2003;22(4):366-373
BACKGROUND: This study was designed to examine whether iNOS pathway is pathologically altered in experimental diabetic nephropathy and whether therapy with ACE inhibitor (imidapril: I) or angiotensin II type 1 receptor (AT1) blocker (L-158, 809: L) ameliorates these changes. METHODS: Male SD rats were injected with diluent (control: C) or streptozotocin. Diabetic (D) rats were then randomized to receive vehicle, I (2 mg/ kg/d) or L (1 mg/kg/d) by gavage. At the end of the 12-week treatment, rats underwent either a 4 hour placebo or an intraperitoneal LPS (2 mg/kg) challenge. Inducible NOS mRNA and protein were measured by RT-PCR and Western blot in isolated glomeruli. RESULTS: Systolic blood pressure and urinary protein excretion increased significantly in D rats compared with C. The basal expression of iNOS mRNA was increased in D rats compared with that of C, whereas there was no significant difference in the level of protein. Upon LPS stimulation, the iNOS mRNA and protein expression was significantly elevated in D rats. In D rats, this up-regulation of LPS-stimulated iNOS expression was equally ameliorated by both I and L in mRNA and protein levels. CONCLUSION: LPS-stimulated glomerular iNOS expression was enhanced in diabetic nephropathy, and the activation of angiotensin II may play a role in this enhancement.
Angiotensin II*
;
Angiotensins*
;
Animals
;
Blood Pressure
;
Blotting, Western
;
Diabetic Nephropathies
;
Humans
;
Male
;
Nitric Oxide Synthase Type II*
;
Rats*
;
Receptor, Angiotensin, Type 1
;
RNA, Messenger
;
Streptozocin
;
Up-Regulation
7.A Case of Atypical Gitelman's Syndrome with Normomagnesemia and Normal Magnesium Excretion.
Jin Seok JEON ; Young Min KIM ; Hyunjin NOH ; Dong Cheol HAN
Korean Journal of Nephrology 2004;23(4):626-629
Gitelman's sydnrome is a heritable renal disorder characterized by hypomagnesemia, hypokalemia and hypocalciuria. As compared to those with Bartter's syndrome, reduced urinary excretion of calcium and magesium wasting are essential features of Gitelman's syndrome. Interestingly, we have experienced a case of 32-year old man with a mixed type of Gitelman's syndrome and Bartter's syndrome, which includes normomagnesemia, normal renal magnesium excretion, and hypocalciuria. Herein we report the case of atypical Gitelman's syndrome with brief review of related literature.
Adult
;
Bartter Syndrome
;
Calcium
;
Gitelman Syndrome*
;
Humans
;
Hypokalemia
;
Magnesium*
8.Transplantation of a Horseshoe Kidney Found During Harvest Operation of a Cadaveric Donor: A Case Report.
Sangchul YUN ; Hee Doo WOO ; Seung Whan DOO ; Soon Hyo KWON ; Hyunjin NOH ; Dan SONG
Journal of Korean Medical Science 2014;29(8):1166-1169
A 34-yr-old female was diagnosed as being brain dead. Preoperative ultrasound revealed no abnormal focal lesions. However, the horseshoe kidney was identified during organ harvest. En bloc nephrectomy was performed. The kidney was divided at the midline of isthmus. The divided right kidney was discarded due to numerous arteries and veins. The divided left kidney was transplanted. After declamping, the kidney was well perfused and started clearing. Resistive index was 0.72. Glomerular filtration ratio was 84.69 mL/min on postoperative day 14. The horseshoe kidney can be successfully transplanted and could be a good solution for the shortage of organ donors.
Adult
;
Cadaver
;
Female
;
Humans
;
Kidney/*abnormalities/ultrasonography
;
Kidney Failure, Chronic/diagnosis/*therapy
;
Kidney Transplantation/*methods
;
*Tissue Donors
;
Tissue and Organ Harvesting/*methods
;
Treatment Outcome
9.Transplantation of a Horseshoe Kidney Found During Harvest Operation of a Cadaveric Donor: A Case Report.
Sangchul YUN ; Hee Doo WOO ; Seung Whan DOO ; Soon Hyo KWON ; Hyunjin NOH ; Dan SONG
Journal of Korean Medical Science 2014;29(8):1166-1169
A 34-yr-old female was diagnosed as being brain dead. Preoperative ultrasound revealed no abnormal focal lesions. However, the horseshoe kidney was identified during organ harvest. En bloc nephrectomy was performed. The kidney was divided at the midline of isthmus. The divided right kidney was discarded due to numerous arteries and veins. The divided left kidney was transplanted. After declamping, the kidney was well perfused and started clearing. Resistive index was 0.72. Glomerular filtration ratio was 84.69 mL/min on postoperative day 14. The horseshoe kidney can be successfully transplanted and could be a good solution for the shortage of organ donors.
Adult
;
Cadaver
;
Female
;
Humans
;
Kidney/*abnormalities/ultrasonography
;
Kidney Failure, Chronic/diagnosis/*therapy
;
Kidney Transplantation/*methods
;
*Tissue Donors
;
Tissue and Organ Harvesting/*methods
;
Treatment Outcome
10.Relationship between duration of hospital-acquired acute kidney injury and mortality: a prospective observational study.
Jinyoung YOO ; Ji Sung LEE ; Jiyeon LEE ; Jin Seok JEON ; Hyunjin NOH ; Dong Cheol HAN ; Soon Hyo KWON
The Korean Journal of Internal Medicine 2015;30(2):205-211
BACKGROUND/AIMS: New definitions of acute kidney injury (AKI) have recently emerged. Some studies have suggested that duration of AKI is an additional predictive parameter for mortality. Here, we evaluated whether AKI duration was predictive of long-term mortality in patients with hospital-acquired acute kidney injury (HAAKI). METHODS: We prospectively enrolled patients who developed HAAKI at an urban university hospital, from September 2007 to August 2008 and followed them until December 2011. Patients were divided into two groups by duration of the AKI (1 to 5 days vs. > or = 6 days), and long-term mortality was compared. RESULTS: HAAKI developed in 1.2% of patients during the enrollment period. The median follow-up period was 240 days (interquartile range, 53 to 1,428). In 42.3% of patients (n = 52), the AKI lasted 1 to 5 days, while it lasted > or = 6 days in 57.7% (n = 71). Survival analysis showed that a longer duration of AKI increased the risk of death. Long-term survival was significantly different in the two groups. CONCLUSIONS: The duration of AKI influenced mortality rates in hospitalized patients. Thus, AKI duration is a parameter affecting mortality in HAAKI.
Acute Kidney Injury/diagnosis/etiology/*mortality/therapy
;
Aged
;
Female
;
*Hospitalization
;
Hospitals, University
;
Humans
;
Kaplan-Meier Estimate
;
Male
;
Middle Aged
;
Prognosis
;
Proportional Hazards Models
;
Prospective Studies
;
Republic of Korea
;
Risk Factors
;
Time Factors