1.Electromyographic Studies of Obstetrical Palsy.
In Hee CHUNG ; Jung Soon SHIN ; Hyungnam MOON
Yonsei Medical Journal 1972;13(1):28-34
Electromyography and related electrodiagnostic techniques are being applied to clinical studies of neuromuscular diseases with increasing frequency and effectiveness. Four patients with obstetrical palsy were examined and followed up with electromyography. The findings from clinical observation and electromyographic studies were discussed in regard to the site of the lesion, prediction of prognosis and the degree of nerve regeneration. It is emphasized that findings provided by electromyographic examinations can not only contribute to accurate diagnosis, but also serve as a guide for selecting appropriate means of treatment with physical therapy for the patients with obstetrical palsy as well as to monitor progress, by doing a series of periodic examinations. Adler and Patterson(1967) reported that the incidence of Erb's palsy has remarkably decreased. From 1939 to 1962 they found only one hundred and twenty three cases instead of four hundred and ninety one cases in the period from 1928 to 1939 at the Hospital for Special Surgery. Statistics on obstetrical palsy due to the brachial plexus injury are not available in Korea. It is assumed however that its incidence here must also be decreased as the obstetric services have advanced significantly in recent years. The clinical picture of a brachial plexus palsy is dependent on the location of the pathology in the plexus and it is not easy to predict the prognosis without knowledge of the degree of injury. With electromyographic studies it is possible to detect the exact site of the lesion in the brachial plexus, the degree of injury and the progress of nerve regeneration. Therefore, it is a useful tool for making accurate diagnosis and prognosis and the findings provided by the electromyographic studies permit appropriate selection of treatment as the nerve regeneration takes place. Four cases of obstetrical palsy of the brachial plexus were referred to Severance Hospital for electromyographic examination and subsequent treatment from February to September 1972.
Child, Preschool
;
Electromyography*
;
Female
;
Human
;
Infant
;
Infant, Newborn
;
Male
;
Paralysis, Obstetric/diagnosis*
;
Paralysis, Obstetric/therapy
2.Electromyographic Studies of Obstetrical Palsy.
In Hee CHUNG ; Jung Soon SHIN ; Hyungnam MOON
Yonsei Medical Journal 1972;13(1):28-34
Electromyography and related electrodiagnostic techniques are being applied to clinical studies of neuromuscular diseases with increasing frequency and effectiveness. Four patients with obstetrical palsy were examined and followed up with electromyography. The findings from clinical observation and electromyographic studies were discussed in regard to the site of the lesion, prediction of prognosis and the degree of nerve regeneration. It is emphasized that findings provided by electromyographic examinations can not only contribute to accurate diagnosis, but also serve as a guide for selecting appropriate means of treatment with physical therapy for the patients with obstetrical palsy as well as to monitor progress, by doing a series of periodic examinations. Adler and Patterson(1967) reported that the incidence of Erb's palsy has remarkably decreased. From 1939 to 1962 they found only one hundred and twenty three cases instead of four hundred and ninety one cases in the period from 1928 to 1939 at the Hospital for Special Surgery. Statistics on obstetrical palsy due to the brachial plexus injury are not available in Korea. It is assumed however that its incidence here must also be decreased as the obstetric services have advanced significantly in recent years. The clinical picture of a brachial plexus palsy is dependent on the location of the pathology in the plexus and it is not easy to predict the prognosis without knowledge of the degree of injury. With electromyographic studies it is possible to detect the exact site of the lesion in the brachial plexus, the degree of injury and the progress of nerve regeneration. Therefore, it is a useful tool for making accurate diagnosis and prognosis and the findings provided by the electromyographic studies permit appropriate selection of treatment as the nerve regeneration takes place. Four cases of obstetrical palsy of the brachial plexus were referred to Severance Hospital for electromyographic examination and subsequent treatment from February to September 1972.
Child, Preschool
;
Electromyography*
;
Female
;
Human
;
Infant
;
Infant, Newborn
;
Male
;
Paralysis, Obstetric/diagnosis*
;
Paralysis, Obstetric/therapy
3.Tissue-specific expression and subcellular localization of ALADIN, the absence of which causes human triple A syndrome.
A Ri CHO ; Keum Jin YANG ; Yoonsun BAE ; Young Yil BAHK ; Eunmin KIM ; Hyungnam LEE ; Jeong Ki KIM ; Wonsang PARK ; Hyanshuk RHIM ; Soo Young CHOI ; Tsuneo IMANAKA ; Sungdae MOON ; Jongbok YOON ; Sungjoo Kim YOON
Experimental & Molecular Medicine 2009;41(6):381-386
Triple A syndrome is a rare genetic disorder caused by mutations in the achalasia-addisonianism-alacrima syndrome (AAAS) gene which encodes a tryptophan aspartic acid (WD) repeat-containing protein named alacrima-achalasia-adrenal insufficiency neurologic disorder (ALADIN). Northern blot analysis shows that the 2.1 kb AAAS mRNA is expressed in various tissues with stronger expression in testis and pancreas. We show that human ALADIN is a protein with an apparent molecular weight of 60 kDa, and expressed in the adrenal gland, pituitary gland and pancreas. Furthermore, biochemical analysis using anti-ALADIN antibody supports the previous finding of the localization of ALADIN in the nuclear membrane. The mutations S544G and S544X show that alteration of S544 residue affects correct targeting of ALADIN to the nuclear membrane.
Adrenal Insufficiency/*genetics
;
Antibodies/immunology
;
Cloning, Molecular
;
DNA, Complementary/genetics
;
Esophageal Achalasia/*genetics
;
Gene Expression Profiling
;
Hela Cells
;
Humans
;
Lacrimal Apparatus Diseases/*genetics
;
Mutagenesis, Site-Directed
;
Nerve Tissue Proteins/*analysis/*genetics/immunology
;
Nuclear Pore/chemistry
;
Nuclear Pore Complex Proteins/*analysis/*genetics/immunology
;
RNA, Messenger/analysis/genetics
;
Syndrome
;
Tissue Distribution