1.Remarkable Postmortem CT Findings in Forensic Autopsy.
Sookyoung LEE ; Jong Pil PARK ; Hohyeon GONG ; Sungjin CHO ; Hyungnam KOO ; Heon LEE ; Kyungmoo YANG ; Bongwoo LEE ; Nakeun CHUNG ; Hanyoung LEE ; Youngshik CHOI ; Joongseok SEO
Korean Journal of Legal Medicine 2014;38(3):103-112
Despite being a very new field, forensic imaging is rapidly being used in forensic medical practices around the world. Computed tomography images are being produced and used for many reasons. Forensic imaging is being used for preliminary examination of serious findings before a routine autopsy, as it might help to give positive proof in some cases. Some major preliminary findings, such as brain hemorrhage, cardiac tamponade, or aortic dissection, can then be substantiated with the results of the physical autopsy. Forensic imaging techniques may also provide additive evidence about the cause of death such as pneumothorax, ileus, gas embolism, and aspiration that are difficult to detect with the traditional surgical autopsy techniques. Forensic imaging is also proving useful outside the autopsy room; forensic anthropologists and odontologists are using images to help them determine the age, sex, and even lifestyle of human specimens. Finally, forensic images have also begun to function as a form of record keeping in complex cases.
Autopsy*
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Cardiac Tamponade
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Cause of Death
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Embolism, Air
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Humans
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Ileus
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Intracranial Hemorrhages
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Life Style
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Pneumothorax
2.Tissue-specific expression and subcellular localization of ALADIN, the absence of which causes human triple A syndrome.
A Ri CHO ; Keum Jin YANG ; Yoonsun BAE ; Young Yil BAHK ; Eunmin KIM ; Hyungnam LEE ; Jeong Ki KIM ; Wonsang PARK ; Hyanshuk RHIM ; Soo Young CHOI ; Tsuneo IMANAKA ; Sungdae MOON ; Jongbok YOON ; Sungjoo Kim YOON
Experimental & Molecular Medicine 2009;41(6):381-386
Triple A syndrome is a rare genetic disorder caused by mutations in the achalasia-addisonianism-alacrima syndrome (AAAS) gene which encodes a tryptophan aspartic acid (WD) repeat-containing protein named alacrima-achalasia-adrenal insufficiency neurologic disorder (ALADIN). Northern blot analysis shows that the 2.1 kb AAAS mRNA is expressed in various tissues with stronger expression in testis and pancreas. We show that human ALADIN is a protein with an apparent molecular weight of 60 kDa, and expressed in the adrenal gland, pituitary gland and pancreas. Furthermore, biochemical analysis using anti-ALADIN antibody supports the previous finding of the localization of ALADIN in the nuclear membrane. The mutations S544G and S544X show that alteration of S544 residue affects correct targeting of ALADIN to the nuclear membrane.
Adrenal Insufficiency/*genetics
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Antibodies/immunology
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Cloning, Molecular
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DNA, Complementary/genetics
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Esophageal Achalasia/*genetics
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Gene Expression Profiling
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Hela Cells
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Humans
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Lacrimal Apparatus Diseases/*genetics
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Mutagenesis, Site-Directed
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Nerve Tissue Proteins/*analysis/*genetics/immunology
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Nuclear Pore/chemistry
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Nuclear Pore Complex Proteins/*analysis/*genetics/immunology
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RNA, Messenger/analysis/genetics
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Syndrome
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Tissue Distribution