1.Evaluation of the development of high risk low birth weight infants using bayley developmental test.
Chul LEE ; Yil Seob LEE ; Hyung Rae CHO ; Dong Kwan HAN
Journal of the Korean Pediatric Society 1993;36(1):38-48
Forty two high risk low birth weight infants who had been admitted in neonatal intensive care unit at Yongdong Severance Hospital from August 1987 to July 1990 and followed up in the high risk infants follow-up clinic were studied for evaluation of their development using the Bayley develop-mental test at the age of 9 month(corrected age). The results obtaincd were as follows: 1) Their Mental Developmental Index(MDI)and Psychomotor Developmental Index(PDD)were 99.4+/-12.8 and 101.8+/-16.6 MDI and PDI in birth weight 1000~1500 gm group were 95.3+/-9.8 and 99.3+/-14.3 and the indexes in birth weight 1500~2500gm group were 102.2+/-14.3 and 103.5+/-17.9. 2) There is no statistical significant relationship between the results of Bayley scales and birth weight, cranial ultrasonographic finding, APGAR score, ventilator care and neonatal seizure. However, the MDI was significantly lower in small for gestational age group than appropriate gestational age group. 3) The body weight, height and head circumference measured at the age of 9 month, at the same time when Baylcy developmcntal test was performed, were 45.0+/-29.6, 40.2+/-25.7 and 46.2+/-26.8percentile of Korean Pediatric Growth Standard(1985).
Apgar Score
;
Birth Weight
;
Body Weight
;
Follow-Up Studies
;
Gestational Age
;
Head
;
Humans
;
Infant*
;
Infant, Low Birth Weight*
;
Infant, Newborn
;
Intensive Care, Neonatal
;
Seizures
;
Ventilators, Mechanical
;
Weights and Measures
2.A clinical survey of tongue cancer.
Seung Hwan LEE ; Kyung Rae KIM ; Chyl Won PARK ; Hyung Seok LEE ; Sun Kon KIM ; Jeung Yop HAN
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(6):1299-1306
No abstract available.
Tongue Neoplasms*
;
Tongue*
3.Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis.
Hyung Rae LEE ; Tae Young HAN ; Sook Ja SON ; June Hyunkyung LEE
Annals of Dermatology 2011;23(4):536-538
Disseminated superficial actinic porokeratosis (DSAP) consists of multiple annular, hyperkeratotic lesions that have a bilateral distribution on sun-exposed areas, particularly the extremities. DSAPs have a wider distribution than porokeratosis of Mibelli and usually develop during the 3rd or 4th decade of life. Squamous cell carcinoma that arises in the classical type of porokeratosis of Mibelli is well-documented, but there are only a few reports of squamous cell carcinoma in DSAP. Here, we describe a 62-year-old man with DSAP who developed squamous cell carcinoma on his right forearm.
Carcinoma, Squamous Cell
;
Extremities
;
Forearm
;
Humans
;
Middle Aged
;
Porokeratosis
4.Clinical Experience in the Treatment of Port-Wine Stains with Blebs.
Hyung Rae LEE ; Tae Young HAN ; Young Gull KIM ; June Hyunkyung LEE
Annals of Dermatology 2012;24(3):306-310
BACKGROUND: The current modality of choice for the treatment of Port-wine stains (PWS) is laser photocoagulation. Laser therapy for the treatment of PWS, especially with a pulsed dye laser (PDL), has been proven safe and effective; however, because penetration of the PDL is too shallow for an effective ablation of the blebs, treatment of blebbed PWS, using PDL, may be insufficient. OBJECTIVE: We demonstrated the clinical efficacy of a 1,064 nm long pulsed Nd:YAG laser with contact cooling device for blebbed PWS. METHODS: Twenty one patients with blebbed PWS (Fitzpatrick skin types II-V) underwent a treatment, using a 1,064 nm long pulsed Nd:YAG laser with a contact cooling device at 8-week intervals. Treatments were done using 5~6 mm spot sizes at 20~30 ms and 95~170 J/cm2. Laser parameters were adjusted in order to meet the needs of each individual patient's lesions. RESULTS: All subjects tolerated the treatments well, and showed clinical improvement from blebs. Of the 21 patients, 18 of them experienced either moderate or excellent response. CONCLUSION: Use of a 1,064 nm long pulsed Nd:YAG laser results in a greater depth of vascular coagulation. A 1,064 nm long pulsed Nd:YAG laser with contact cooling device may be regarded as a promising therapeutic option for the treatment of blebbed PWS.
Blister
;
Humans
;
Laser Therapy
;
Lasers, Dye
;
Light Coagulation
;
Port-Wine Stain
;
Skin
5.Accuracy of References in Journal of the Korean Pediatric Society and Journals of the Korean Pediatric Subspecialty Societies and Citation Pattern Analysis.
Gil Ho CHO ; Mi Kyung LEE ; Man Yong HAN ; Young Rae KIM ; Seo Jung KIM ; Kyu Hyung LEE
Journal of the Korean Pediatric Society 2002;45(11):1325-1331
PURPOSE: We tried to check the accuracy of references in the Journal of the Korean Pediatric Society and Journals of the Korean Pediatric Subspecialty Societies. We also wanted to know the citation patterns of authors by analyzing the frequency of cited materials. METHODS: Three journals were randomly selected from the 2000 issues of Journal of the Korean Pediatric Society and nine journals were selected mainly from the second half of 2000 issues of each Journal of the Korean Pediatric Subspecialty Societies for the study. Then the accuracy of references was checked with Medline. Journals before 1964, books, and journals which were not written in English were used only in the citation pattern analysis. RESULTS: Author errors were the most common(21.3%) among the reference elements. The next was title errors, followed by page errors, journal errors, volume errors and year errors. Total average error rate was 34.7% and we were unable to find journals in 89 cases(2.2%). The journal of the Korean Society of Neonatology had the lowest error rate(17.4%) and the journal of the Korean Pediatric Cardiology Society had the highest error rate(53.2%). The reference journals which were published and quoted in the most recent three years were only 612 cases(15%). Foreign journals were selected as reference(78.4%) more than domestic journals; The Journal of the Korean Pediatric Society was the most frequently cited reference(43.3%) among domestic journals. CONCLUSION: Authors are ultimately responsible for the accuracy of references and they should check the reference list with responsibility. Hopefully, authors also will have to use more domestic journals and recent journals.
Cardiology
;
Neonatology
6.Primary Papular Xanthoma in an Infant.
Hyung Rae LEE ; June Hyunkyung LEE ; Sook ja SON ; Tae Young HAN
Korean Journal of Dermatology 2012;50(2):163-166
Papular xanthoma is one of the clinicopathologic variants of normolipemic cutaneous non-Langerhans cell histiocytosis. It is a very rare condition that is characterized by non-confluent, yellowish papules located on the face, trunk and mucous membranes with no internal involvement. It has been predominantly reported in adults but childhood cases were also recently seen. We report a typical case of papular xanthoma in a 14-month-old boy who presented numerous yellow-brown papules on the face, arm and buttock. On histologic findings, it showed typical features of papular xanthoma.
Adult
;
Arm
;
Buttocks
;
Histiocytosis
;
Humans
;
Infant
;
Mucous Membrane
;
Xanthomatosis
7.Correlation of Left Ventricular Ejection Fraction Measured by Echocardiography and Contrast Cineangiography.
Jee Young OH ; Gil Ja SHIN ; Si Hoon PARK ; Woo Hyung LEE ; Han Rae CHO
Korean Journal of Medicine 1997;52(5):624-630
OBJECTIVE: Left ventricular ejection fraction is an important clinical variable with respect to diagnosis, treatment and prognosis in various cardiovascular diseases. Measurement of left ventricular ejection fraction is performed by three commonly used methods, M-mode and two dimensional echocardiography, radionuclide angiography and contrast cineangiography. We compared echocardiographic and contrast cinean-giographic ejection fraction by correlation coefficiency to determine the accuracy of echocardiography determined ejection fraction at our institution and to assess the agreement of left ventricular ejection fraction between two methods. METHODS: We measured left ventricular ejection fraction by M-mode, two-dimensional echocardiography and contrast cineangiography in 144 cases of normal and cardiovascular heart disease patients from September 1993 to April 1995 in the cardiology division of Ewha Womans University hospital. The echocar-diography and contraat cineangiography were performed within 7 days of each other. RESULTS: M-mode echocardiographic ejection fraction correlated with contrast cineangiographic ejection fraction (r=0.7841). M-mode echocardiographic ejection fraction corrected with two-dimensional echocardiography in the presence of regional wall motion abnormality correlated with contrast cineangiographic ejection fraction (r=0.8149). By agreement analysis, the difference of mean of ejection fraction measured by M-mode echocardiography and contrast cineangiography was within 95% confidence limits. The mean was 4.08% and the standard deviation was 8.29%. The difference of mean of ejection fraction corrected by two-dimensional echocardiography and contrast cineangiography was within 95% confidence limits. The mean was -3.19% and the standard deviation was 7.74% CONCLUSION: The values of left ventricular ejection fraction by echocardiography showed good correlation with those of contrast cineangiographic ejection fraction, Therefore, echocardiography would be a useful tool as contrast cineangiography in evaluating the left ventricular function.
Cardiology
;
Cardiovascular Diseases
;
Cineangiography*
;
Diagnosis
;
Echocardiography*
;
Female
;
Heart Diseases
;
Humans
;
Prognosis
;
Radionuclide Angiography
;
Stroke Volume*
;
Ventricular Function, Left
8.A Pigmented Follicular Cyst of the Axilla with Atypical Distribution.
Hyung Rae LEE ; Tae Young HAN ; Sook Ja SON ; Hyunkyung LEE
Korean Journal of Dermatology 2011;49(10):955-956
A pigmented follicular cyst typically presents as an asymptomatic, solitary papule on head and neck in adult men. The histologic features of pigmented follicular cysts are cross-sectioned, terminally-differentiated hair shafts in an epidermal cyst. There are no sebaceous lobules or other appendages within the wall or in close proximity. We herein report a case of pigmented follicular cyst of the axilla in a 31-year-old man.
Adult
;
Axilla
;
Epidermal Cyst
;
Follicular Cyst
;
Hair
;
Head
;
Humans
;
Male
;
Neck
9.Immunohistochemical Study on the Expression of Laminin-5 in the Oral Cavity and Oropharyngeal Squamous Cell Carcinoma.
Hyung Seok LEE ; Kyung TAE ; Hye Kyung PARK ; Jang Hee HAN ; Seok Hyun CHO ; Kyung Rae KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2002;45(12):1179-1183
BACKGROUND AND OBJECTIVES: Laminins are extracellular matrix proteins localized mainly in basement membranes. Currently there are at least ten different laminin chains and 11 heterotrimetric laminin variants. Laminin-5 is a heterotrimeric basement membrane molecule (alpha3beta3gamma2). It serves as an important adhesion protein for epithelial cells and it also plays an important role in cell migration during tumor invasion and tissue remodeling. This study was designed to investigate the relationship between laminin-5 expression and clinicopathologic variables in oral cavity and oropharynx squamous cell carcinomas using immunohistochemistry. MATERIALS AND METHOD: The expression of the laminin-5 around tumor cells was determined in 32 oral cavity and oropharyngeal carcinomas by immunohistochmical staining with antibody against laminin-5gamma2 chain. RESULTS: Statistical analysis showed that the frequency of laminin-5gamma2 chain expression was correlated with the lymph node metastasis (p<0.05). The poor differentiation of tumor cells, the large tumor size, advanced overall stage and the deep tumor invasion showed high expression of laminin-5, although it was not significant statistically. CONCLUSION: These results suggest that overexpression of laminin-5 in oral cavity and oropharyngeal squamous cell carcinoma might be a biomarker that can predict cervical lymph node metastasis.
Basement Membrane
;
Carcinoma, Squamous Cell*
;
Cell Movement
;
Epithelial Cells
;
Extracellular Matrix Proteins
;
Immunohistochemistry
;
Laminin
;
Lymph Nodes
;
Mouth*
;
Neoplasm Metastasis
;
Oropharynx
10.Synergistic effects of drug and aerobic exercise on endothelial function and epicardial fat thickness in patients with hypertension and dyslipidemia
Eun-Ah JO ; Shan-Shan WU ; Hyung-Rae HAN ; Jung-Jun PARK ; Jung-Ho HEO
Kosin Medical Journal 2025;40(1):31-40
Background:
Aerobic exercise training and drug therapy are well-established interventions for the prevention and treatment of hypertension and dyslipidemia. We investigated the synergistic effects of aerobic exercise and olmesartan/rosuvastatin on epicardial fat thickness (EFT) and endothelial function in patients with hypertension and dyslipidemia.
Methods:
A sample of 75 participants with hypertension and dyslipidemia was evaluated for multifactorial cardiovascular risk at baseline and at 6 months of intervention according to anthropometric and hemodynamic components, lipid profile, glycemia, brachial artery flow-mediated dilation (FMD), and EFT. After 3 months of drug therapy only, participants were allocated to one of three conditions: treadmill (n=22), exergame (n=29), or control (n=24).
Results:
After 12 weeks of drug therapy only, systolic and diastolic blood pressure (3% and 2%, both p<0.05), total cholesterol (6.3%, p<0.01), low-density lipoprotein cholesterol (4.9%, p<0.05), triglycerides (11.1%, p<0.05), fasting blood glucose (10.2%, p<0.01), and glycosylated hemoglobin (3%, p<0.01) were significantly reduced. After 12 weeks of combined aerobic exercise and drug therapy, both the treadmill and exergame groups showed a significant improvement in FMD (both p<0.001) and reduction in EFT (both p<0.001). Systolic and diastolic blood pressures decreased in the treadmill group only (1.9% and 2.7%, respectively, p<0.05).
Conclusions
Incorporating aerobic exercise into drug therapy regimens can yield synergistic effects, particularly in improving endothelial function and reducing EFT, providing a comprehensive approach to managing cardiovascular risk in patients with hypertension and dyslipidemia.