The importance of facet joint asymmetry has been debated as a cause of the low back pain and sciatica. And many studies have been proposed about the relationship between facet joint angle or facet joint asymmetry and the development of the disc degeneration or disc herniation. In the diagnosis of the spinal disorder, we have been used mainly myelogram and computed tomography. Several years ago, more advancement has been achieved by use of magnetic resonance image (MRI). Author studied the relationship between the facet joint angle and facet joint asymmetry and the development of the herniated nucleus pulposis (HNP) or spinal stenosis by comparision of the facet joint angle and facet joint asymmetry in each groups. Author reviewed the patients who were diagnosed as HNP or spinal stenosis with computerized tomography (CT) or MRI and treated with operative method at the department of orthopaedic surgery, Dong-A University Hospital. Facet joint angles were measured on the mid-disc cut, which was parallel to the inferior vertebral end-plate of the superior vertebra. The angles were measured by a midsagittal line through the disc and intersecting lines formed by conneqting the two end points of each facet. Facet joint asymmetry was determined by the difference between right and left facet joint angles. The results were compared between each groups and comparison group and statistical analysis was performed with the Kruskal- Wallis test in 95% confidence interval. The patients had only one level involved and had no other spinal disorder. 85 cases of HNP (central in 35 cases and lateral in 50 cases) and 50 cases of spinal stenosis were evaluated. The results were as follows: l. At the level of L4-5, the mean facet joint angles (+/-SD) were 42.50+/-5.52 (Rt.), 46.71+/-9.68 (Lt.) in central HNP, 40.91+/-9.11 (Rt.), 41.23+/-8.51 (Lt.) in lateral HNP, 37.77+/-11.41 (Rt.), 37.95+/-11.91 (Lt.) in spinal stenosis and 42.38+/-5.07 (Rt.), 41.25+/-5.85 (Lt.) in control group. 2. At the level of LS-S1, the mean facet joint angles were 48.83+/-5.64 (Rt.), 48.17+/-4.62 (Lt.) in central HNP, 52.20+/-11.30 (Rt.), 51.60+/-9.06 (Lt.) in lateral HNP, 42.67+/-8.89 (Rt.), 43.50+/- 9.85 (Lt.) in spinal stenosis and 43.91+/-7.88 (Rt.), 43.76+/-7.81 (Lt.) in control group. 3. At the level of L4-5, the mean facet asymmery was 6.35+/-6.04 in central HNP, 6.95+/-6.76 in lateral HNP, 6.47+/-5.56 in spinal stenosis and 4.31+/-5.42 in control group. 4. At the level of L5-S1, the mean facet asymmetry was 4.95+/-5.18 in central HNP, 4.72+/-5.25 in lateral HNP, 5.50+/-4.83 in spinal stenosis and 4.42+/-4.96 in control group. In conclusion, there were no statistically significant relationships between the magnitude of the facet joint angle and development of the HNP and spinal stenosis, and between the facet asymmetry and development of the HNP and stenosis.
Constriction, Pathologic ; Diagnosis ; Humans ; Intervertebral Disc Degeneration ; Low Back Pain ; Magnetic Resonance Imaging ; Sciatica ; Spinal Stenosis* ; Spine* ; Zygapophyseal Joint*

No abstract available.
Pyelonephritis, Xanthogranulomatous*

No abstract available.
Pyelonephritis, Xanthogranulomatous*

To evaluate the relapse pattern and long-term stabilities depanding on surgical methods following orthognathic surgery of Cl III patients, the author selected 24 subjects(10 male, 14 female) operated by SSRO and 26 subjects(10 male, 16 female) operated by IVRO. Each subject took four lateral cephalograms: just before surgery(Tl), within 48hrs after surgery(T2), 4-8 wks after surgery(T3), 6 month or more after surgery(T4), and the landmarks were digitized. The differences of relapse patterns in each interval between two groups were compared and the significance of correlation among the variables of each group was tested The obtained results are as follows; 1. Horizontal early relapse was forward movement of mandible in SSRO group, as compared to the backward movement in IVRO group, and there was a statistical significance between the two groups. 2. Vertical early and late relapses were decreases in anterior facial height in both groups and there was no statistical significance between the two groups. 3. There was a statistical significance in negative correlation between mandibular hornontal late relapse and surgical change of articular angle in SSRO group. 4, There was a statistical significance in negative correlation between amount of mandibular set-back and mandibular horizontal early relapse in both groups.
Humans ; Male ; Mandible ; Orthognathic Surgery* ; Recurrence*

The purpose of this study is to evaluate the correlation between the operative indications and the MRI findings in the herniated lumbar disc. We reviewed the lumbar spine MRI and medical records in the 158 patients of the herniated lumbar disc which were removed by open discectomy. We assessed the herniated lumbar disc in the MRI by the Steinmetz s classification and the operative findings with postoperative results at least 6 months. 170 levels of the operated lumbar discs in these patients consisted of protruded discs in 41 levels, extruded subligamentous discs in 91 levels, extruded transligamentous discs in 27 levels, sequestered discs in 11 levels. We recognized especially in the operated protruded discs that were combined with the lateral recess stenosis in most cases. Postoperatively, 139 patients (88%) had excellent and good results. We concluded that the clinical operative indications were correlated with the cases which were more severe than extruded subligamentous discs or protruded discs combined with lateral recess stenosis in MRI findings.
Classification ; Constriction, Pathologic ; Diskectomy* ; Humans ; Magnetic Resonance Imaging* ; Medical Records ; Spine

No abstract available.
Female ; Humans ; Leukemia, Promyelocytic, Acute* ; Pregnant Women*

No abstract available.

PURPOSE: Cytolethal distending toxin (CDT) is a family of heat-labile cytotoxins produced by several gram-negative mucosa-associated pathogens, including Aggregatibacter actinomycetemcomitans. CDT is well known to be capable of inducing growth arrest, morphological alterations, and eventually death in various cells. CDT belongs to a tripartite AB2 toxin (CdtB: the enzymatic A subunit ; CdtA and CdtC: the heterodimeric B subunit). Previous studies proposed that CdtA and CdtC together bind to a cell surface receptor and glycolipids act as a receptor for A. actinomycetemcomitans CDT (AaCDT). In this study, recombinant CdtA and CdtC proteins of AaCDT were co-expressed in a bacterial expression system and tested for their affinity for GM1 ganglioside. METHODS: The genes for CdtA and CdtC from A. actinomycetemcomitans Y4 were utilized to construct the expression vectors, pRSET-cdtA and pET28a-cdtC. Both CdtA and CdtC proteins were expressed in Escherichia coli BL21(DE3) and then purified using hexahistidine (His6) tag. The identity of purified protein was confirmed by anti-His6 antibody and monoclonal anti-CdtA antibody. Furthermore, the affinity of recombinant protein to GM1 ganglioside was checked through ELISA. RESULTS: Recombinant CdtA and CdtC proteins were expressed as soluble proteins and reacted to anti-His6 and monoclonal anti-CdtA antibodies. ELISA revealed that purified soluble CdtA-CdtC protein bound to GM1 ganglioside, while CdtA alone did not. CONCLUSIONS: Co-expression of CdtA and CdtC proteins enhanced the solubility of the proteins in E. coli, leading to convenient preparation of active CdtA-CdtC, a critical material for the study of AaCDT pathogenesis.
Antibodies ; Bacterial Toxins ; Cytotoxins ; Edetic Acid ; Enzyme-Linked Immunosorbent Assay ; Escherichia coli ; Glycolipids ; Histidine ; Humans ; Oligopeptides ; Proteins ; Solubility

Although pulmonary artery aneurysms are a rare vascular anomaly, they are seen in a wide variety of conditions, such as congenital heart disease, infection, trauma, pulmonary hypertension, cystic medial necrosis and generalized vasculitis. To our knowledge, mycotic aneurysms caused by pulmonary actinomycosis have not been reported in the radiologic literature. Herein, a case of pulmonary actinomycosis complicated by mycotic aneurysm is presented. On CT scans, this case showed focal aneurysmal dilatation of a peripheral pulmonary artery within necrotizing pneumonia of the right lower lobe, which was successfully treated with transcatheter embolization using wire coils.
Actinomycosis/*complications ; Aged ; Aneurysm, Infected/*etiology/*radiography/therapy ; Embolization, Therapeutic ; Human ; Male ; Pneumonia, Bacterial/*complications ; *Pulmonary Artery ; Treatment Outcome

Neonatal diabetes mellitus (NDM) is defined as hyperglycemia that presents clinical symptoms within the first month of life and requires insulin therapy to maintain euglycemia. The diabetic condition may be transient, permanent, or transient with recurrence later in life. NDM is a rare clinical disorder. Three cases of NDM have been reported in Korea so far. We experienced two cases of NDM in twin brothers who were born with small for gestational ages. Their HLA typings were DR9 and DR14, and insulin autoantibody, islet cell antibody, GAD-reactive autoantibody, and insulin receptor antibody were not found. The genetic analysis with polymorphic DNA markers for chromosome 6 indicated paternal uniparental isodisomy.
Chromosomes, Human, Pair 6 ; Diabetes Mellitus* ; Genetic Markers ; Gestational Age ; Histocompatibility Testing ; Humans ; Hyperglycemia ; Insulin ; Islets of Langerhans ; Korea ; Receptor, Insulin ; Recurrence ; Siblings* ; Twins* ; Uniparental Disomy