2.Internet of Things-Based Behavioral Intervention for Older Adults with Major Depressive Disorder: Preliminary Study
Hyo Jin HAN ; Chang Hyung HONG ; Jae Hoon KIM ; Hyun Woong ROH ; Sang Joon SON
Journal of Korean Geriatric Psychiatry 2019;23(1):14-19
OBJECTIVE: To assess the effectiveness of Internet of Things (IoT)-based behavioral intervention for reducing depressive symptom of older adults with major depressive disorder. METHODS: A 12-week randomized cross-over controlled study was conducted at community mental health center. We recruited 39 participants with major depressive disorder aged 60 years or older. As a multidomain intervention, four evidence-based therapeutic factors (physical activity, healthy diet, social activity, and emotional regulation) were approached. To maintain motivation of participants, we applied contingency management using IoT device based on operant conditioning theory. RESULTS: The primary outcome was change of depressive symptom measured by Montgomery-Asberg Depression Rating Scale (MADRS). Mixed-effect model compared the effectiveness of intervention and usual care management (intervention by time and period interaction, p=0.017). And during the study period consisting of a total of visit 8, significant group difference was shown in post hoc test at visit 4 (MADRS score of intervention group : MADRS score of control group=7.7±3.4 : 21.1±11.5, p=0.008). CONCLUSION: Community-implementable IoT-based behavioral intervention resulted in greater reduction of depressive symptom of elderly with major depressive disorder.
Adult
;
Aged
;
Conditioning, Operant
;
Depression
;
Depressive Disorder, Major
;
Diet
;
Humans
;
Internet
;
Mental Health
;
Motivation
3.The Brain-MR Studies in the Brain Death Patient: Report of 3 Cases: The Utility of the Anesthetic Mapleson Circuit-F System.
Ji Yun PARK ; Tae Woong KIM ; Hyung Geun OH ; Kwang Ik YANG ; Hyung Kook PARK ; Hak Jae ROH ; Dushin JEONG
Journal of the Korean Neurological Association 2008;26(1):42-45
Brain-MR studies are sensitive to intracranial ischemia and vascular flow. However, brain MR study for brain death is clinically limited because keeping the ventilation is difficult during study. In our hospital, three 'brain death patients' brain-MR studies were performed under the anesthetic Mapleson's circuit-F system. Three patients' clinical states were not changed after the studies. We confirmed that brain herniation, absent intracranial flow void, no intracranial contrast enhancement, poor gray/white matter differentiation, and prominent nasal enhancement findings. The value of brain-MR study for brain death may be possible.
Brain
;
Brain Death
;
Ischemia
;
Ventilation
4.Seroepidemiology of Hepatitis Viruses and Hepatitis B Genotypes of Female Marriage Immigrants in Korea.
Jae Cheol KWON ; Hye Young CHANG ; Oh Young KWON ; Ji Hoon PARK ; In Soo OH ; Hyung Joon KIM ; Jun Hyung LEE ; Ha Jung ROH ; Hyun Woong LEE
Yonsei Medical Journal 2018;59(9):1072-1078
PURPOSE: The Korean society has moved rapidly toward becoming a multicultural society. This study aimed to estimate the seroprevalence of hepatitis viruses and investigate hepatitis B virus (HBV) genotypic diversity in female marriage immigrants. MATERIALS AND METHODS: Screening program was conducted at support centers for multicultural families in 21 administrative districts in Korea between July 2011 and January 2017. A total of 963 female marriage immigrants were included in this study. Blood samples were tested for hepatitis viral markers and HBV genotype. RESULTS: Subjects' median age was 33 years (20–40 years), and they originated from nine countries including Vietnam (n=422, 43.8%), China (n=311, 32.3%), the Philippines (n=85, 8.8%), Cambodia (n=58, 6.0%), and Japan (n=39, 4.0%). About 30% (n=288) of subjects required hepatitis A vaccination. HBsAg positive rate was 5.4% (n=52). Positive HBsAg results were the highest in subjects from Southeast Asia (6.6%, n=38). Anti-HBs positive rate was 60.4% (n=582). About 34% (n=329) of subjects who were negative for anti-HBs and HBsAg required HBV vaccinations. Genotypes B and C were found in 54.6% (n=12) and 45.4% (n=10) of the 22 subjects with HBV, in whom genotypes were tested. Eight (0.8%) subjects were positive for anti-HCV. Positive anti-HCV results were the highest in subjects from Central Asia (7.9%, n=3). CONCLUSION: Testing for hepatitis viral marker (hepatitis A virus IgG and HBsAg/anti-HBs) is needed for female marriage immigrants. Especially, HBV genotype B is different from genotype C of Koreans. Therefore, interest and attention to vaccination programs for female marriage immigrants are necessary for both clinicians and public health institutes.
Academies and Institutes
;
Asia
;
Asia, Southeastern
;
Biomarkers
;
Cambodia
;
China
;
Emigrants and Immigrants*
;
Female*
;
Genotype*
;
Hepatitis A
;
Hepatitis B Surface Antigens
;
Hepatitis B virus
;
Hepatitis B*
;
Hepatitis Viruses*
;
Hepatitis*
;
Humans
;
Immunoglobulin G
;
Japan
;
Korea*
;
Marriage*
;
Mass Screening
;
Philippines
;
Prevalence
;
Public Health
;
Seroepidemiologic Studies
;
Vaccination
;
Vietnam
5.A Case of Miliary Tuberculosis in a Patient with Behcet's Disease and Uveitis Receiving Infliximab.
Jung Wan YOO ; Jae Hyung ROH ; Jin Wook PARK ; Yong Giun KIM ; Ji Woong JANG ; Soo Young NA ; Tae Sun SHIM
Tuberculosis and Respiratory Diseases 2009;67(5):454-457
Infliximab, a TNF-alpha antagonist, has been used to treat refractory rheumatoid arthritis, ankylosing spondylitis, Crohn's disease and Behcet's disease. Tuberculosis (TB) is a well-known opportunistic infection in patients receiving infliximab. Therefore, patients should be screened and treated for latent or active TB infection before being administered infliximab. Recently, we encountered a case of military TB during infliximab therapy in a patient suffering from Behcet's disease and uveitis. We report this case with a review of the relevant literature.
Antibodies, Monoclonal
;
Arthritis, Rheumatoid
;
Crohn Disease
;
Humans
;
Military Personnel
;
Opportunistic Infections
;
Spondylitis, Ankylosing
;
Stress, Psychological
;
Tuberculosis
;
Tuberculosis, Miliary
;
Tumor Necrosis Factor-alpha
;
Uveitis
;
Infliximab
6.A Case of Miliary Tuberculosis in a Patient with Behcet's Disease and Uveitis Receiving Infliximab.
Jung Wan YOO ; Jae Hyung ROH ; Jin Wook PARK ; Yong Giun KIM ; Ji Woong JANG ; Soo Young NA ; Tae Sun SHIM
Tuberculosis and Respiratory Diseases 2009;67(5):454-457
Infliximab, a TNF-alpha antagonist, has been used to treat refractory rheumatoid arthritis, ankylosing spondylitis, Crohn's disease and Behcet's disease. Tuberculosis (TB) is a well-known opportunistic infection in patients receiving infliximab. Therefore, patients should be screened and treated for latent or active TB infection before being administered infliximab. Recently, we encountered a case of military TB during infliximab therapy in a patient suffering from Behcet's disease and uveitis. We report this case with a review of the relevant literature.
Antibodies, Monoclonal
;
Arthritis, Rheumatoid
;
Crohn Disease
;
Humans
;
Military Personnel
;
Opportunistic Infections
;
Spondylitis, Ankylosing
;
Stress, Psychological
;
Tuberculosis
;
Tuberculosis, Miliary
;
Tumor Necrosis Factor-alpha
;
Uveitis
;
Infliximab
7.Chronic Post-traumatic Inflammatory Tenosynovitis of the Finger Joint.
Youn Moo HEO ; Sang Bum KIM ; Jae Young ROH ; Won Ki PARK ; Hyung Tak OH ; Jin Woong YI
Journal of the Korean Society for Surgery of the Hand 2010;15(1):8-14
PURPOSE: Chronic inflammatory tenosynovitis (CITS) involving the finger joint after trauma has been rarely reported. This study reports the surgical results of ten patients with CITS. MATERIALS AND METHODS: From March 2007 to June 2009, ten patients with pain, swelling and limitation of motion of the finger were diagnosed as CITS. All patients had a history of direct injury. The operation was performed at a mean of 6.6 months after the onset of symptom. Average range of motion was 54 degrees in five patients with CITS of the metacarpophalangeal joint and was 44 degrees in five patients with that of the proximal interphalangeal joint. The mean follow-up duration was 15 months. Two of ten patints showed the involvement of the bone. Tenosynovectomy was performed and four patients required volar and dorsal double incisions. In cases of the bony invasion, multiple drilling and curettage was done. RESULTS: Postoperatively, all patients showed improvement of pain and swelling and did not show recurrence. The magnetic resonance image was carried out in all patients and showed the inflammatory changes of the tendosynovium and joint capsule. Culture and PCR test for tuberculosis showed negative findings in all cases. However, anti-tuberculosis chemotheraphy for nine months was applied to three patients who showed caseous necrosis or rice body in biopsy. The mean range of motion was 66 degrees in metacarpophalangeal joint and 53 degrees in proximal interphalangeal joint. CONCLUSIONS: Magnetic resonance image appears helpful in the diagnosis and the treatment of CITS which involved the joint of hand and the operative treatment can improve the symptoms and clinical outcomes.
Biopsy
;
Curettage
;
Finger Joint
;
Fingers
;
Follow-Up Studies
;
Hand
;
Humans
;
Joint Capsule
;
Joints
;
Magnetic Resonance Spectroscopy
;
Mandrillus
;
Metacarpophalangeal Joint
;
Necrosis
;
Polymerase Chain Reaction
;
Range of Motion, Articular
;
Recurrence
;
Tenosynovitis
;
Tuberculosis
8.The Relationship between Temporal Discounting and Well-Being in the Elderly.
Seok Joo HONG ; Ki Jung CHANG ; Hyun Woong ROH ; Jai Sung NOH ; Young Ki CHUNG ; Ki Young LIM ; Chang Hyung HONG ; Sang Joon SON
Journal of Korean Geriatric Psychiatry 2016;20(1):33-37
OBJECTIVE: This study aims to examine association of temporal discounting with well-being of Korean community-dwelling elderly. METHODS: The subjects of this research were 4,373 community-dwelling older persons without dementia. Each subject was administered the questionnaires regarding the socio-demographic characteristics, temporal discounting which was measured using standard questions in which participants were asked to choose between an immediate, smaller payment and a delayed, larger one. Outcome variable is Korean version of the World Health Organization Five Well-Being Index (WHO-5). Statistical analyses including the Pearson's correlation test and logistic regression were performed in this study. RESULTS: At baseline, temporal discounting was negatively associated with WHO-5 in the Pearson's correlation test (r=-0.04, p=0.006). In a adjusted model for confounding variables, temporal discounting was negatively associated with WHO-5 [odd ratio (95% confidence interval)=0.57 (0.35–0.92), p=0.021]. CONCLUSION: Elderly individual with a higher temporal discounting (which indicates impulsivity) may have a lower quality of life.
Aged*
;
Confounding Factors (Epidemiology)
;
Dementia
;
Humans
;
Logistic Models
;
Quality of Life
;
World Health Organization
9.Association between Alcohol Use Disorder and Cognitive Function According to Gender in the Elderly.
Dong Soo KIM ; Ki Jung CHANG ; Chang Hyung HONG ; Hyun Woong ROH ; Jai Sung NOH ; Young Ki CHUNG ; Ki Young LIM ; Mi JANG ; Sang Joon SON
Journal of Korean Geriatric Psychiatry 2016;20(1):20-24
OBJECTIVE: This study aims to investigate the association between alcohol use disorder and cognition in Korean community-dwelling elderly, especially the gender-specific difference. METHODS: Data obtained from 1,141 subjects (976 men and 165 women) aged above 60 years was analyzed from the Gwangju Dementia and Mild Cognitive Impairment Study. All subjects completed the study questionnaire including demographic characteristics, history of current and past illnesses, drug history, Korean Mini-Mental State Examination (K-MMSE), and cut down, annoyed, guilty feelings, eye-opener (CAGE), Short Form of Geriatric Depression Scale-Korean version (SGDS-K). RESULTS: Of the 1,141 subjects (mean age 72.17±6.20, mean educational level 6.50±4.48), 267 demonstrated alcohol use disorder (23.40%) and 874 were non-alcohol use disorder (76.60%). The mean of K-MMSE for alcohol use disorder group was 23.23±4.99, and for non-alcohol use disorder group was 23.70±3.94. When alcohol use disorder is accompanying, the decrement of K-MMSE score was 3.07 for female, and 0.35 for male. And we confirmed the interactive effect on K-MMSE score between sex and alcohol use disorder after adjusting for age, education level, depression (F=5.798, p=0.016). CONCLUSION: In conclusion, our study demonstrates an association between alcohol use disorder and cognitive impairment by gender in the elderly.
Aged*
;
Alcohols
;
Cognition
;
Dementia
;
Depression
;
Education
;
Female
;
Gwangju
;
Humans
;
Male
;
Mild Cognitive Impairment
10.Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis.
Chang Youl LEE ; Jeong Hee JEON ; Hyung Jung KIM ; Dong Hwan SHIN ; Tae Woong ROH ; Chul Min AHN ; Yoon Soo CHANG
The Korean Journal of Internal Medicine 2008;23(3):116-120
BACKGROUND/AIMS: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial. METHODS: Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R. RESULTS: The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance. CONCLUSIONS: We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.
Adult
;
Aged
;
Aged, 80 and over
;
Animals
;
Carcinoma, Non-Small-Cell Lung/*immunology/mortality/pathology
;
Female
;
Humans
;
Immunohistochemistry
;
Insulin-Like Growth Factor I/*biosynthesis
;
Male
;
Mice
;
Middle Aged
;
Neoplasm Metastasis
;
Neoplasm Staging
;
Prognosis
;
Receptor, IGF Type 1/*biosynthesis