No Abstract Available.
Retinal Detachment* ; Retinaldehyde*

PURPOSE: To evaluate the relation between recovery of visual function and microperimetric fixation area in eyes with idiophthic macular hole after vitrectomy. METHODS: We used SLO (Scanning laser microscope, Rodenstock, Germany) microperimetry to examine foveal retinal function and fixation area in 14 eyes with idiopathic macular hole following pars plana vitrectomy. The relation between those preoperative and postoperative best corrected visual acuity and fixation area was studied. RESULTS: The macular hole size was correlated with preoperative visual acuity (p=0.026) and the closure of hole was related to the size of fixation area (p=0.003). The postoperative visual acuity was related to symptom duration before the vitrectomy (p=0.03), but not related to preoperative macular hole size. The fixation area correlated with the postoperative best corected visual acuity (p=0.043) and the direction of movement was variable. In most eyes, fixation area was located above the horizontal meridian. CONCLUSIONS: The fixation area was correlated with postoperative visual acuity and we think functional macular hole closure as well as anatomical closure were useful parameter of the success of macular hole surgery.
Ophthalmoscopes* ; Retinal Perforations* ; Retinaldehyde ; Visual Acuity ; Vitrectomy*

Proliferative vitreoretinopathy (PVR) is a main cause of failure in retinal reattachment surgery. There have been many studies about the inhibition of proliferative vitreoretinophthy with several drugs. Authors investigated the inhibitory effect of proliferative vitreoretinopathy and retinal toxicity with various concentration of daunorubicin after intravitreal injection into the eyes of the pigmented rabbit. 7 pigment rabbit (11eyes) were used as subjects. After lensectomy and vitrectomy, control group was injected dermal fibroblast and F-BSS, and treatment group was injected dermal fibroblast and 5, 10, 15, 30 nmol Daunorubicin. At two weeks after intravitreal injection, both group were enucleated and examined with gross finding, light--microscopy, and electronmicroscopy. In all control group, proliferative vitreoretinopathy was found, but only preretinal membrane formation was found in 5, 10 nmol Daunorubicin injected group. In 15 nmol Daunorubicin injected group, the retina structure was preserved normally. In 30 nmol Daunorubicin injected group, the retinal outer segment was degenerated in microscopic finding. These results show that Daunorubicin has a potent effect on proliferative vitreoretinopathy, especially in 15 nmol, but retinal toxicity is suspected in marethan 30 nmol.
Daunorubicin* ; Fibroblasts ; Intravitreal Injections ; Membranes ; Retina ; Retinal Photoreceptor Cell Outer Segment ; Retinaldehyde ; Vitrectomy ; Vitreoretinopathy, Proliferative*

Solitary choroidal tuberculoma is a rare ocular tuberculosis, a form of secondary infection derived through the blood-stream from some focus of infection elsewhere in the body, characterized by gradual growing until it resembles a tumor projecting into the cavity of eye. Authors experienced a case of a solitary choroidal tuberculoma. A brief review of literature is described.
Choroid* ; Coinfection ; Tuberculoma* ; Tuberculosis, Ocular

Electrical conductivity of eyeball replaced with vitreous substitutes were also measured in both the non-enucleated and enucleated eye. The study of correlation between the electroretinogram and conductivity of eyeball to be replaced with vitreous substitutes was also evaluated. The electrical conductivity of each vitreous replacement was shown 74.5% in vitreous, 77.5% in saline, 100% in air and silicone oil respectively relative to standard material -1.5 battery, 100%. There was no difference of conductivity between the enucleated eye and non-enucleated eye. There were no correlation between the ERG amplitude and conductivity. As a result of experiments, the decrease in amplitude is suggested as a damage of retina by manipulation and surgery rather than decrease of conductivity with vitreous replacements.
Electric Conductivity* ; Rabbits* ; Retina ; Silicone Oils

Bacterial endogenous endophthalmitis is a rare, but devastating complication of septicemia.It has occurred in the process of systemic infection and its underlying conditions are Diabetes Mellitus, advanced liver disease and immunosuppressive state or drug abuse. Klebsiella endogenous endophthalmitis is especially rapidly progressive and visual outcome is typically poor. To evaluate the clinical aspect of this disease, particularly predisposing factors, causative microorganism, outcome of therapeutic modality and initial time of therapy, we performed a retrospective study on 9 eyes of 9 patients who had been treated with this diagnosis from September 1988 to January 1999 at Kyung-Hee Medical Center. Mean time between the onset of disease and the initiation of therapy was 4.33 days. Underlying systemic diasease consist of Daibetes Mellitus, advanced liver disease and chronic renal failure [5 patients:DM with advanced liver disease, 3 patients:DM alone, 1 patient:DM with CRF].The visual outcome was poor but it turned out better in two patients compared with initial visual acuity, no change in one patient and worse in six patients. We found that Diabetes Mellitus and advanced liver disease were leading underlying predisposing factors of Klebsiella Pneumoniae and visual outcome was poor despite the various intensive treatments.High index of suspicion and aggressive diagnostic and therapeutic approach might improve visual outcome.
Causality ; Diabetes Mellitus ; Diagnosis ; Endophthalmitis* ; Humans ; Kidney Failure, Chronic ; Klebsiella ; Klebsiella pneumoniae ; Liver Diseases ; Retrospective Studies ; Substance-Related Disorders ; Visual Acuity

The authors investigated the possibility of transplantion of cultured retinal pigment epithelial cell to normal pigmented rabbit retina. Focal retinal detachment was made in the pigment rabbit retina, and the cultured RPE cells were injected into subretinal space. The neural retina spontaneously rettached withim 6 days. At 4 weeks after tranplantation, eyes were enucleated and examined with light-microscopy and electron-microscopy. The transplanted RPE cells were proliferated with multilayer in electronmicroscopic finding, and the tight-junction was found between proliferative RPE cells. The outer segment and nucleus of photoreceptor cell were well preserved in microscopic finding. As a result, the cultured RPE cells can be sucessfully transplanted to normal pigmented rabbit retina, and photoreceptor cell was not changed after transplantation.
Epithelial Cells ; Photoreceptor Cells ; Retina ; Retinal Detachment ; Retinal Pigment Epithelium* ; Retinaldehyde*

We have attempted to measure parafoveal retinal acuity directly on the exact retinal locus, while observing the retinal image in real time using the scanning laser ophthalmoscope(SLO 101, Rodenstock, Munish, Germany). By the SLO Visumetry software(Rodenstock v. 3.0), thirty eyes of healthy volunteers were examined in 20degrees image field. Using Snellen E as stimulus, the examination was performed from the fovea by the radial pattern. The maximal retinal distance point, which responded to stimulus, was recorded by the pixel, and the distance(mm) from the fovea was calculated by the Bennett formula. The maximum distance from the fovea at the given stimulus size was achieved as follows: 0.32+/-0.01mmat the 15 x15 arc of minute(0.333), 0.63+/-0.01mm at the 17 x17 arc of minute(0.294), 1.05+/-0.03 mmat 20 x 20 arc of minute(0.25), and 1.44+/-0.0 5 mmat the 23 x23 arc of minute(0.217). It was also revealed that the horizontal maximal distance from fovea at given stimulus size was statistically superior to the vertical maximal distance(p<0.05). In conclusion we were able to establish the normal range of parafoveal retinal acuity in healthy volunteers. It may serve as the baseline for subsequent study of retinal pathology and functional evaluation as well as its treatment.
Healthy Volunteers* ; Pathology ; Reference Values ; Retinaldehyde* ; Visual Acuity*

In the condition of diabetic retinopathy, the vascular changes are localized primarily in the retinal capillaries and are presumed to promote angiogenesis. To investigate the change of retinal blood flow velocities and morphological parameters in diabetic retinopathy, we measured perifoveal capillary blood velocities(v) and the size of foveal avascular zones(FAZ). Thirteen patients with diabetic maculopathy and nine healthy volunteers were included in this study. The scanning laser technique in conjunction with an image analysing system were used to assess the morphological and hemodynamic changes in diabetic retinopathy. Diabetic maculopathy group showed a slower capillary blood velocity than normal group(2.44+/-0.39mm/sec vs2.75+/-0.61 mm/sec, p>0.18). The foveal avascular zone was significantly larger in diabetic maculopathy group than in normal group(313.5+/-64.6micrometervs. 238.9+/-93.8micrometer, p<0.05). This results indicate that the retinal microcirculation is altered in diabetic patients compared with healthy subjects. These alterations may be due to the change of the capillary wall and blood viscosity in diabetic patients. The determination of these parameters can be utilized in monitoring the progress of diabetic maculopathy.
Blood Flow Velocity ; Blood Viscosity ; Capillaries ; Diabetic Retinopathy ; Healthy Volunteers ; Hemodynamics ; Humans ; Microcirculation ; Retinaldehyde

VEPs weie recorded in 222 cases of different disease groups and in 42cases of the control group using a Nicolet CA 1000 system. The latency time of N1, P1, N2, and P2 from the prominent surface peak and the P1-N2 amplitude at full field pattern reversal VEP. The score of each disease group was compared with those of the control group. The results are as follows; 1. Functional amblyopia, optic neuritis, and optic nerve atrophy patients presented a significant derrease in amplitude in comparison to normal subiects. 2. In the P1 implicit time, optic neuritis, and optic nerve atrophy patients presented a marked delay. Functional amblyopia patients presented a moderate delay while other disease group patients presented normal to mild delays. 3. More than half of the optic neuritis and optic nerve atrophy patients presented a detraction of the P1 wave form.
Adolescent ; Adult ; Amblyopia/*diagnosis ; Brain Diseases/*diagnosis ; Child ; Diagnosis, Differential ; *Evoked Potentials, Visual ; Humans ; Middle Aged ; Optic Atrophy/*diagnosis ; Optic Neuritis/*diagnosis ; Time Factors