1.A Clinical Observation on Meningitis in Infancy and Childhiid.
Jin Kyu PARK ; Eui Hyung KIM ; Tae Ju HWANG
Journal of the Korean Pediatric Society 1984;27(6):554-562
No abstract available.
Meningitis*
2.A Case of Macular Displacement after Surgical Reattachment of a Rhegmatogenous Retinal Detachment Induced with Penetrating Injury.
Tae Kwann PARK ; Dong Hee KIM ; Hyung Woo KWAK
Journal of the Korean Ophthalmological Society 2000;41(12):2755-2760
No Abstract Available.
Retinal Detachment*
;
Retinaldehyde*
3.Expression of Prostatic Carcinoma Oncogene PTI - 1 in Prostatic Carcinoma , Prostatic Intraepithelial Neoplasia and Benign Prostatic Hyperplasia Using in situ PCR .
Tae Jin LEE ; Eon Sub PARK ; Jae Hyung YOO
Journal of the Korean Cancer Association 2000;32(1):136-147
PURPOSE: Prostatic tumor induced gene-1 (PTI-1) is a mutated human EF-la and putative prostatic carcinoma tumor-inducing oncogene, that is differently expressed in prostatic cancer and benign prostatic hyperplasia. And, it is more sensitive marker than prostate- specific antigen (PSA) for detecting human prostate cancer in the bloodstream. This study invastigated the expression of PTI-1 in paraffin embedded tissue of prostatic carcinoma, prostatic intraepithelial neoplasia, and benign prostatic hyperplasia using in situ PCR. MATERIALS AND METHODS: we evaluated expression of PTI-1 in prostatic carcinoma with prostatic intraepithelial neoplasia (PIN) of 32 cases, benign hyperplasia of 20 cases, high grade transitional cell carcinoma of 10 cases and colon cancer of 10 cases for control group. Also, the immunohistochemical staining for PSA was performed to comparison with clinical value of PSA. RESULTS: The serum level of PSA was closely related to stage and Gleason score (p < 0.05). However, the results of immunohistochemical stains were variable to stage and Gleason score. PTI-1 using in situ PCR expressed in 50% of prostatic carcinoma, 41% of prostatic intraepithelial neoplasia, 10% of benign hyperplasia and colon cancer (p < 0.05). No expression is observed in transitional cell carcinoma. In prostatic carcinoma, PTI-1 expressed in 43.8% (7/16) of stage II, 50.0% (5/10) of stage III, and 66.7% (4/6) of stage IV (p<0.05). In PIN, expression of PTI-1 was similar to prostatic carcinoma (p<0.05). CONCLUSION: PTI-1 represented a relatively sensitive marker for prostatic carcinoma and PIN, indicator of prostatic carcinoma progression.
Carcinoma, Transitional Cell
;
Colonic Neoplasms
;
Coloring Agents
;
Humans
;
Hyperplasia
;
Neoplasm Grading
;
Oncogenes*
;
Paraffin
;
Polymerase Chain Reaction*
;
Prostatic Hyperplasia*
;
Prostatic Intraepithelial Neoplasia*
;
Prostatic Neoplasms
4.Radiologic evaluation of globus symptom
Tae Sub CHUNG ; Jong Tae LEE ; Hyung Sik YOO ; Jung Ho SUH ; Ki Whang KIM ; Tae Young JANG ; In Yong PARK
Journal of the Korean Radiological Society 1986;22(6):999-1004
The globus symptom is a condition in which a patient, often middle aged women, complains of a lump andchocking sensation in the throat, Functional disturbance of the cricopharyngeal muscle, rendering it incapable ofrelaxing during swallowing, has long been recognized as a cause of globus symptom and dysphagia. We wanted to findout how often and to what extent distrubed relaxation of the cricopharyngeal muscle can be seen in patients withglobus symptom with routine examination and video esophagogram. The results were as follows: 1. Male : femaleratio was 1:2.4. 2. Globus symptom was most frequent in the age group between 30-39 of female. 3. Organic lesionswere seen in 43.6%(24 Pts) of globus patients. 4. Cricopharyngeal muscle was visualized in 29.1%(16Pts), esophageal diverticulum in 3.6%(2 Pts) and degenerative spondylosis in 3.6%(2 Pts). 5. Incidence of visualizationof cricopharyngeal muscle were higher in male group (50%) than female one (20.5%). 6. Cricopharyngeal muscle wasmost frequently visualized on early swallowing phase(12/16 Pts).
Deglutition
;
Deglutition Disorders
;
Diverticulum, Esophageal
;
Female
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Pharynx
;
Relaxation
;
Sensation
;
Spondylosis
5.The Study of High Frequence Hearing Loss in Pilots.
Il Joong PARK ; Jae Beom PARK ; Tae Hyung MIN
Korean Journal of Aerospace and Environmental Medicine 2003;13(1):13-18
BACKGROUND: Hearing loss is associated with environmental noises. Not only the strength of the noise but also the exposure time of that seems important. We investigated to find the factors associated with hearing loss in pilots. METHOD: For the anlysis of hearing loss in pilots in the air force, we performed an audiometiric test on 563 pilots from 2000 to 2001 and analysed the results. REUSLT: The type of aircraft or regiment is not associated with hearing loss. The age, tenure and total flight time are the factors associated with hearing loss, especially in the high frequency zone. The flight time in the recent six months is shown not to be associated with hearing loss which means an exposure to noise in a longer term is important. In this study, the hearing threshold increased at 6,000 Hz regardless of age. CONCLUSION: The reason may be due to the noise environment of pilots. Therefore an additional study about pilots' normal limits of hearing threshold at 6,000 Hz and clinical meanings of that is necessary.
Aircraft
;
Hearing Loss*
;
Hearing*
;
Noise
6.A Case of Malignant Acanthosis Nigricans Associated with Gastric Adenocarcinoma.
Hyung Geun PARK ; Seong Min PARK ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1989;27(3):316-319
A 51-year-old female had disseminated, symmetrically distributed, brownish black pigmentation and papillary hypertrophy on the intertriginous and flexural areas for 6 months, and gastric adenocarcinoma was confirmed during the evaluation of internal malignancy, The cutaneous finding of acanthosis nigricans was a significant cutaneous marker of internal malignancy in this case.
Acanthosis Nigricans*
;
Adenocarcinoma*
;
Female
;
Humans
;
Hypertrophy
;
Middle Aged
;
Pigmentation
7.Ureteroscopic Management of Large Distal Ureteral Stones.
Hyung Keun PARK ; Sang Hyeon CHEON ; Hong Sik KIM ; Sang Uk CHUNG ; Tae Han PARK
Korean Journal of Urology 2000;41(10):1234-1238
No abstract available.
Ureter*
8.Morphometric Study for Muscular and Microvascular Remodeling of Left Ventricular Free Wall and Interventricular Septum in Hypertrophic Cardiomyopathy.
Young Jik LEE ; Hyung Suk KIM ; Jong Tae PARK ; Chang Soo PARK
Korean Journal of Pathology 1999;33(9):675-683
Hypertrophic cardiomyopathy (HCMP) is characterized myofiber hypertrophy and structural remodeling with changes in the proportion of the muscular, vascular, and interstitial compartments. A study was done to determine the structural remodeling patterns and the role of microvasculature of hearts in HCMP. Forty-two postmortem hearts were analyzed including 14 from patients who died of HCMP (group 1), 8 patients with HCMP but who died from extracardiac causes (group 2), 10 patients with ischemic heart disease (group 3), and 10 normal adult hearts (group 4). Macro- and microscopic examination, immunohistochemical study using CD34 antibody, and morphometric studies using image analyzer were performed. Mean cardiac weight and wall thickness were significantly higher in the HCMP group. Myocardial hypertrophy, and a variety of myocardial disarray and fibrosis involved the whole area of the left ventricles with HCMP. The percentage areas of microvessels were 6.40 0.7 in group 1, 5.90 0.6 in group 2, 4.98 0.3 in group 3, 4.85 0.4 in group 4, respectively, and the numbers of microvessels were 198.0 20.7 in group 1, 230.0 22.3 in group 2, 211.7 11.2 in group 3, and 236.4 11.4 in group 4, respectively (mean SE). The percentage area of microvessels was significantly higher in group 1 than in other groups. However, the number of microvessels in that group was lower than in the other groups, although it was statistically insignificant. Since flow-dependent vasodilation is preserved in HCMP, we considered flow-dependent vasodilation the cause of the discrepancy between the area and the number of microvessels. Ischemic changes observed in chronic HCMP and related heart failure were considesed to be due to the relative deficiency of the coronary flow compared to the increasing cardiac mass.
Adult
;
Cardiomyopathy, Hypertrophic*
;
Fibrosis
;
Heart
;
Heart Failure
;
Heart Ventricles
;
Humans
;
Hypertrophy
;
Microvessels
;
Myocardial Ischemia
;
Vasodilation
9.Immunohistochemical Analysis of TGF-beta Expression and Angiogenesis in Infiltrating Duct Carcinoma of the Breast.
Tae Jin LEE ; Nam Bok CHO ; Eun Sub PARK ; Jae Hyung YOO ; Sung Jun PARK
Korean Journal of Pathology 1996;30(7):557-569
Forty cases of infiltrating duct carcinoma of the breast were examined immunohistochemically for expression of TGF-beta and angiogenesis in order to analyze significant correlation with prognostic parameters including tumor size, axillary lymph node metastasis, clinical stage, histologic grade, estrogen receptor and progesterone receptor status. The TGF-beta expression was observed in tumors center and advancing edges of tumors. To determine microvessel density for angiogenesis, we stained endothelial cells for Factor VIII related antigen and counted microvessel within tumor. The results were as follows: 1) The strong immunohistochemical expression of TGF-beta and higher counts of microvessels were observed in advancing edges of tumors (p<0.05). 2) The TGF-beta expression in the advancing edges of tumors was closely related to clinical stage and presence of axillary lymph node metastasis (p<0.05). 3) The mean microvessel counts were significantly higher in tumors from patients with axillary lymph node metastasis and increased with increasing clinical stage (p<0.05). 4) The TGF-beta expression was not related to histologic grade, estrogen receptor and progesterone receptor status(p>0.05). Therefore, the results suggested that the TGF-beta expression and angiogenesis in infiltrating duct carcinoma of the breast may play an important part in prognostic factors, closely related to the lymph node metastasis and clinical stage.
Neoplasm Metastasis
10.A Case of Fetal Nuchal Cystic Hygroma.
Yung Ha CHOI ; Chung Ok PARK ; Wan Seok PARK ; Tae Hyung LEE ; Sung Ho LEE
Yeungnam University Journal of Medicine 1989;6(1):165-169
Fetal cystic hygroma is a rare congenital malformation of the lymphatic system appearing as a single or multiloculated fluid-filled cavity, most often in the neck. A case of fetal nuchal cystic hygroma was diagnosed by Ultrasonography at 22 weeks of gestation and the diagnosis was confirmed at autopsy. We present the case with a brief review of literature.
Autopsy
;
Diagnosis
;
Lymphangioma, Cystic*
;
Lymphatic System
;
Neck
;
Pregnancy
;
Ultrasonography