1.DNA analysis of squamous cell carcinoma and basal cell carcinoma of the skin using flow cytometry.
Korean Journal of Dermatology 1991;29(3):384-390
DNA flow cytometric analysis was performed on paraffin-embedded tissue from 10 cases of squamous cell eareinoma (SCC) and 10 cases of basal cell carcinoma(BCC). These results were applicable to do a better prognosis in BCC than SCC. In 10 cases of SCC, the DNA index was 1.34 and aneuploidy was identified in 9. In 10 cases of BCC, the DNA index was 1.30 and aneuploidy was identified in 6.
Aneuploidy
;
Carcinoma, Basal Cell*
;
Carcinoma, Squamous Cell*
;
DNA*
;
Flow Cytometry*
;
Prognosis
;
Skin*
2.Usefulness of 99mTc-MDP Bone Scintigraphy for Assessing Vascular Ingrowth on Hydroxyapatite Ocular Implant.
Bong Joo KANG ; Hyung Sun SOHN
Korean Journal of Nuclear Medicine 1999;33(6):484-492
PURPOSE: This study was to evaluate the clinical usefulness of 99mTc-MDP bone scintigraphy for assessing vascular ingrowth into the ocular implants after enucleation or evisceration. MATERIALS AND METHODS: Twenty-four patients (M:F=7:17, mean age: 36 years), who buried a coralline hydroxyapatite after uncomplicated enucleation or evisceration surgery were studied. Dynamic and static scintigraphy on the orbit fossa were obtained after injection of 740 MBq 99mTc-MDP to evaluate the status of vascularization. The study was performed from the 3 to 33 weeks after surgery. According to the visual analysis, activity greater than nasal bridge was graded as 4, equal to the nasal bridge as 3, less than nasal bridge but greater than normal orbit as 2, greater than normal orbit but less than grade 2 as 1. Uptake ratio was also calculated by measuring the implants activity (H) and contralateral orbit activity (N). Grading score and uptake ratio were compared with clinical outcome of vascularization. Additionally, we also analyzed the vascularization status as time lapse between primary surgery and scintigraphic study and surgical methods. RESULTS: Twenty-one patients who had bone scintigraphy at 11 weeks after surgery showed increased uptake above grade 2 and greater H/N ratio than 1.56. Of these, 19 patients who had drilling surgery for permanent peg application showed adequate bleeding during the procedure. The activity grade and uptake ratio were inversely correlated with vascular ingrowth. Higher than grade 2 or greater than 1.56 in H/N ratio seemed to be an indicator for better prognosis. Accomplishment of vascularization was not affected by the surgical way such as enucleation or evisceration. CONCLUSION: 99mTc-MDP bone scintigraphy can be a useful method to evaluate the vascularized status of implants. Adequate time for 99mTc-MDP bone scintigraphy may be 11-20 weeks after enucleation or evisceration.
Durapatite*
;
Hemorrhage
;
Humans
;
Orbit
;
Prognosis
;
Radionuclide Imaging*
;
Technetium Tc 99m Medronate*
3.A Case of Muscular Sarcoidosis diagnosed by Gallium-67 Scintigraphy and Magnetic Resonance Imaging.
Hyung Sun SOHN ; Euy Neyng KIM
Korean Journal of Nuclear Medicine 1999;33(6):543-548
Gallium-67 scintigraphy is helpful in the assessment of active extrapulmonary sarcoidosis. Muscular involvement of sarcoidosis is often asymptomatic or nonspecific, and laboratory examinations do not provide convincing evidence of muscular involvement. We report a case of muscular sarcoidosis, which was detected by gallium-67 scintigraphy. In a patient who was suffering from fever and arthralgia of knee joint, gallium-67 scintigraphy showed mediastinal and hilar involvement of sarcoidosis with unexpected extensive muscular uptake. Magenetic resonance imaging revealed the detailed depiction of intramuscular infiltration of sarcoid granuloma. Gallium-67 scintigraphy is useful in detecting inflammatory muscular involvement of sarcoidosis as well as other multiorgan involvement.
Arthralgia
;
Fever
;
Granuloma
;
Humans
;
Knee Joint
;
Magnetic Resonance Imaging*
;
Radionuclide Imaging*
;
Sarcoidosis*
4.Surgical Treatment of 100 Patients of Osmidrosis.
Chang Hwa LEE ; Hyung Sun SOHN ; Seok Don PARK
Korean Journal of Dermatology 1988;26(6):861-866
One hundred patients of osmidrosis were treated by surgical procedure at the Department of Dermatology, Wonkwang University Hospital. The methods of operative treatment were elliptical excision for 37(74), bipedicle incision with apocrine glancl undercutting for 14(28), and single incision wit.h apocrine gland undercutt,ing for 49 (98). The results were summarized as follows : 1. Of the 74 axillae treated by elliptical excision, one occurred recurrence, and 1.7 showed complication, hematoma in 6, infection and delayed union in 4, each necrosis and severe scar in one each, 2. Of the 28 axillae treated by bipedicle incision with apocrine gland undercutting, 6 showed complication; hematoma in 4, infection and delayed union in one each 3. Of t..he 98 axillae treated by single incision with apocrine gland undercutting, 5 showed complication, hematoma in 3, infection and delayed union in one each In conclusion, single incision with apocrine gland undercutting was found to be more excellent compared with the other surgical methods.
Apocrine Glands
;
Axilla
;
Cicatrix
;
Dermatology
;
Hematoma
;
Humans
;
Necrosis
;
Recurrence
5.A Case of Subcutaneous Dermoid Cyst.
Sang Yong KIM ; Hyung Sun SOHN ; Seok Don PARK
Korean Journal of Dermatology 1989;27(3):329-333
A 18-year-old male patient presented with the skin colored, dome-shaped, soft, movable mass in his left retroauriculr region. The mass has slowly increased in size since birth. Histopathologic exarnination revealed sebaceous gland, eccrine gland and crosssectioned hair in the surrounding tissue, hair shaft projected into the lumen, and laminated horny material in the cyst. Transitional zone between stratified squarnous epithelium and the wall lined by histiocytes showed homogenous degenerative change. After surgical removal of the lesion, no recurrence was observed during 15 months of follow-up.
Adolescent
;
Dermoid Cyst*
;
Eccrine Glands
;
Epithelium
;
Follow-Up Studies
;
Hair
;
Histiocytes
;
Humans
;
Male
;
Parturition
;
Recurrence
;
Sebaceous Glands
;
Skin
6.Quantitative Ga-67 Scintigraphy in patients with Silicosis: Comparison with Chest X-ray and Pulmonary Function.
Kwang Hyun SHIN ; Hyung Sun SOHN ; Yong An CHUNG
Korean Journal of Nuclear Medicine 1999;33(4):381-387
PURPOSE:The International Labor Organization (ILO) has established an international standard for chest X-ray diagnosis of pneumoconiosis since 1980. However, there is a need for improved diagnosis and staging in occupational disease. We evaluated Ga-67 citrate scintigraphy quantitatively and correlated the scintigraphic findings with pulmonary function tests and chest X-ray result. MATERIALS AND METHODS: Twenty-five patients underwent whole body scintigraphy with additional chest and abdomen images 48 hrs after intravenous injection of 185 MBq of Ga-67 citrate. Ten normal controls were also studied. Regions of interest (ROI) were drawn on the posterior image to measure counts from the liver and lungs (Lung/Liver Ratio). RESULTS: L/L ratio according to the stages of chest X-ray classification were as follows; stage 0 (normal, n=10): 0.3948+/-0.0692, stage 1 (n=10): 0.5763+/-0.1837, stage 2 (n=11): 0.6849+/-0.1459, stage 3 (n=4): 0.9913+/-0.0712. There was a significant correlation between the scintigraphic L/L ratio and the X-ray stage (r=0.618, p<0.05). However, no significant correlation between L/L ratio and pulmonary function tests were observed (p>0.05). CONCLUSION: Quantitative Ga-67 scintigraphy can be a useful method for staging of silicosis. However, it is not a method to assess pulmonary functional impairment.
Abdomen
;
Citric Acid
;
Classification
;
Diagnosis
;
Humans
;
Injections, Intravenous
;
Liver
;
Lung
;
Occupational Diseases
;
Pneumoconiosis
;
Radionuclide Imaging*
;
Respiratory Function Tests
;
Silicosis*
;
Thorax*
7.Effect of Hydrogen Ion Concentration on the Growth of Vibrio vulnificus.
Seok Don PARK ; Hyung Sun SOHN ; Jung Woon KO
Korean Journal of Dermatology 1986;24(3):354-357
Using the 8 strains of Vibrio vulnificus isolated from the patients with primary sepsis, the viability of Vibrio vulnificus were studied in the various range of hydrogen ion concentration. The opitimal pH range of growth was 7-9, and survived between pH 3. 6 and 12. 5 when incubated at 37C for one hour.
Humans
;
Hydrogen*
;
Hydrogen-Ion Concentration*
;
Protons*
;
Sepsis
;
Vibrio vulnificus*
;
Vibrio*
8.A Case of Piezogenic Pedal Papules.
Sang Yong KIM ; Chang Hwa LEE ; Hyung Sun SOHN
Korean Journal of Dermatology 1988;26(5):680-683
No abstract available.
9.A Case of Eosinophilic Cellulitis.
Chang Hwa LEE ; Sang Yong KIM ; Hyung Sun SOHN
Korean Journal of Dermatology 1988;26(2):231-235
We report a 44-year-old female patient with Eosinophilic cellulitis who had developed pruritic erythematous plaque on the right lower abdomen since two months ago. The blood eosinophil count was 2,066/mm at first visit. This lesion responded well to cortieosteroid therapy. However new erythematous swelling reappeared on the left lower abdomen and left inner thigh 3 months after the first treatment. A biopsy specimen taken from an erythematous plaque showed many flame figures and diffuse infiltration of eosinophils and histiocytes in the lower dermis and subcutaneous fat tissue.
Abdomen
;
Adult
;
Biopsy
;
Cellulitis*
;
Dermis
;
Eosinophils*
;
Female
;
Histiocytes
;
Humans
;
Subcutaneous Fat
;
Thigh
10.A Case of Generalized Normolipemic Plane Xanthoma.
Jang Won SEO ; Dong Lim KIM ; Hyung Sun SOHN
Korean Journal of Dermatology 1990;28(6):794-798
We report a case of generalized plane xanthoma which showed no-rmolipoproteinemia and was not associated with unerlying disorders or other type of xanthomas. A 48-year-old female has noticed well defined, slightly elevated, yellowish plaques which occurred on the periorbital areas, sides of the neck, scapular areas, anterior chest, buttocks and lower extremities for 3 years. Biopsy specimen taken from the neck showed perivascular accumulations of foam cells in the upper and mid dermis. Paper electrophoresis didn't, show elevation of any lipoprotein.
Biopsy
;
Buttocks
;
Dermis
;
Electrophoresis, Paper
;
Female
;
Foam Cells
;
Humans
;
Lipoproteins
;
Lower Extremity
;
Middle Aged
;
Neck
;
Thorax
;
Xanthomatosis*