No abstract available.

In order to evaluate the genotoxic hazard among workers potentially exposed to low level petrochemical substances, the analyses of micronuclei (MN) and sister chromatid exchanges (SCEs) in lymphocytes were performed in 46 male workers (as exposed group) and 46 nonexposed subjects (as control group). Mean frequencies of MN and SCEs (respectively, 12.9/1000 cells and 6.5/cell) in exposed group were very significantly higher than those (10.2/1000 cells and 5.4/cell) in control group. And there were also significant differences in mean frequencies of MN and SCEs adjusted for age, employment duration, smoking, and drinking between two groups. Median frequencies of MN and SCEs in exposed group were very significantly higher than those in control group. Frequencies of SCEs were higher in smokers than in non-smoker. Frequencies of MN in smokers, however, were similiar to those of non-smoker. Interaction between exposure and smoking on MN and SCEs induction was not observed. The results suggest that there is genotoxic hazard in high risk group like workers handling carcinogens in petrochemical plants and the analyses of MN and SCEs are useful biomarkers for the exposure to hazard substances even at the level below the exposure limit.
Biological Markers ; Carcinogens ; Drinking ; Employment ; Humans ; Lymphocytes ; Male ; Sister Chromatid Exchange ; Smoke ; Smoking

No abstract available.
Alopecia* ; Hair* ; Humans ; Male* ; Tissue Expansion*

Licensure, credentialling and academic institutions are seeking new innovative approaches to the assessment of professional competence. Central to these recent initiatives is the need to determine standards of performance, which separated the competent from the non-competent candidate. The goal of this study is to introduce the criterion referenced standard-setting methods to medical Schools. The authors used Angoff and Jaeger method, which are the simplest absolute standard setting methods. In this study, the cut-off score estimated by Jaeger method was higher than that of Angoff method.
Humans ; Licensure ; Professional Competence ; Schools, Medical

No abstract available.
Bone Marrow* ; Histiocytes* ; Niemann-Pick Diseases*

No abstract available.
Asthma*

It has been generally assum d that eccrine poroma arises from acrosyringium, the epidermal sweat duct unit. Eccrine poroma mainly involves the non hairy surfaces of the skin, but it has also been found on hair-bearing areas. One of the characteristics of this structure is absence of melanocytes and melanin granules arnong its cells. However a complete absence of melanocytes and melanin granules in eccrine poroma is not invariable and a few reports of such an occurrence have been presented. The authors report herein a case of unusual and rare eccrine poroma. The eccrine poroma had melanin pigment and melanocytes, was pedunculated and occurred on the parietal scalp which was the unusual site of involvement. The eccrine poroma was also combined with a pedunculated congenital melanocytic nevus on the supraauricular scalp.
Melanins ; Melanocytes ; Nevus, Pigmented* ; Poroma* ; Rabeprazole ; Scalp* ; Skin ; Sweat

Necrolytic migratory erythema is a rare, distinctive, necrotizing cutaneous eruption usually associated with glucagonoma, an alpha-cell tumor of the pancreas. Other clinical features include ane- mia, diabetes mellitus and weight loss. However, it also occurrs without the pancreatic glucagonoma. So this rare condition is called pseudoglucagonoma syndrome, and has been described in association with chronic hepatic diseases, malabsorption with villous atrophy, chronic pancreatitis, celiac sprue, hypoproteinemia and odontogenic infection. We report a case of pseudoglucagonoma syndrome induced by malnutrition without glucagonoma. A 28-year-old Korean female was referred to our department complaining of multiple erythematous, desquamative, crusted and erosive patches on the extremities, and diffuse scalp alopecia for 5 years. She also had perianal erosion, angular cheilitis without glossitis, amenorrhea, axillary and pubic hair loss, and weight loss. Six years previously she had had Whipples operation for a pancreatic solid and papillary neoplasm. The laboratory data showed hypoalbuminemia, essential fatty acid deficiency, diabetes mellitus and slightly high levels of zinc and glucagon. A skin biopsy showed irregular acanthosis, epidermal edema and pallor, dyskeratosis, areas of superficial epidermal necrosis and vascular dilatation of the papillary dermis. The patient improved dramatically after intravenous hyperalimentation and oral intake of mediurn chain triglyceride. For 2.5 years she has taken medium-chain triglycerides without any other treatment, and no side effects on recurrence has been observed.
Adult ; Alopecia ; Amenorrhea ; Atrophy ; Biopsy ; Celiac Disease ; Cheilitis ; Dermis ; Diabetes Mellitus ; Dilatation ; Edema ; Extremities ; Female ; Glossitis ; Glucagon ; Glucagonoma ; Hair ; Humans ; Hypoalbuminemia ; Hypoproteinemia ; Malnutrition ; Necrolytic Migratory Erythema* ; Necrosis ; Pallor ; Pancreas ; Pancreatitis, Chronic ; Parenteral Nutrition, Total ; Recurrence ; Scalp ; Skin ; Triglycerides* ; Weight Loss ; Zinc

No abstract available.
Knee* ; Ligaments*

BACKGROUND: The umbilicus is a simple scar that obliterates the portal through which the omphalomesenteric duct connected the primitive gut to the yolk sac; through which the intestine was expelled prior to its rotation; through which passed the umbilical arteries and vein; at which the allantosis attached to the early urinary bladder; and at which the umbilical cord that carried these structures was fused to the body wall. The umbilicus is situated at the level of L3 to L4 in the midline of the abdomen. It's shape, size, and configuration vary greatly related to age and sex. Deramtoses of the umbilicus are umbilical hernia, congenital abnormalities, granulomas, omphalith, infections, eczema and tumors. OBJECTIVE: The purpose of this study was to examine the umbilical shape and size related to age and sex and diseases of the umbilicus. METHODS: During a 6-month-period from May to October, 1998, 420 person's umbilical shapes and size were examined with regard to age and sex. The diseases of the umbilicus were evaluated, too. RESULTS & CONCLUSIONS: 1. The mean vertical diameter of the umbilicus is 1.89+/-0.65cm and the mean transverse diameter is 1.98+/-0.86cm. The mean diameter of umbilicus in women(vertical: 1.98+/-0.73cm, transverse: 2.07+/-0.99cm) is larger than the mean diameter of umbilicus in men(vertical: 1.80+-0.53cm, transverse: 1.89+/-0.66cm)(p<0.05). 2. The vertical diameter of umbilicus in both sexes showed increasing aspect until the 30-39 year old group, and the transverse diameter of umbilicus in both sexes showed increasing aspect until the 40-49 year old group. 3. The shapes of umbilicus were divided into the protruded type and the depressed type. Most of our cases showed the depressed type. The protruded types were more in the 0-9 year old group(23%) than other year old groups. The shapes of umbilicus were divided into the round type and the elliptical type, too. The elliptical type(transverse diameter>vertical diameter) is more than the elliptical type(vertical diameter>transverse diameter) in men, and the elliptical type(vertical diameter>transverse diameter) is more than the elliptical type(transverse diameter>vertical diameter) in women. 4. The diseases of the umbilicus are allergic contact dermatitis(6 cases), pityriasis rosea(5 cases), psoriasis(3 cases), scabies(3 cases), rhus dermatitis(2 cases), pemphigus(2 cases), drug eruption(1 case), and insect bite(1 case).
Abdomen ; Cicatrix ; Congenital Abnormalities ; Eczema ; Female ; Gastrula ; Granuloma ; Hernia, Umbilical ; Humans ; Insects ; Intestines ; Male ; Pityriasis ; Rhus ; Umbilical Arteries ; Umbilical Cord ; Umbilicus ; Urinary Bladder ; Veins ; Vitelline Duct ; Yolk Sac