Slipped femoral capital epiphysis is the condition in which the femoral head begins to slip gradually off the femoral neck. After first discription of Ambrose Pare(1572), the world literature has presented many cases, usually more than one hundred in each clinic. Its incidence in Korea, however, is extremely rare and particularly it is difficult to find out the report of typical case. The author reports here a typical case of billateral slipped femoral capital epiphysis in a 17 year old boy with symptom duration of 2 years on right side and 6 months on left side. Physical examination showed his body stature to be normal and his genital organs to have no abnormalities. However, both hips revealed severe pain and limited range of motion, especially in internal rotation and abduction, which restricted his normal gait. Operative reduction of epiphysio-cervical distorsion was successful in the left hip. After skeletal traction of the left hip, an anatomical repositioning by intraarticular wedge rection osteotomy was maintained by 3 Knowles pins. 3 months postoperatively he resumed partial weight bearing on his left hip with little pain and improved range of motion. Further restoration of function can reasonably be expected.
Epiphyses ; Femur Neck ; Gait ; Genitalia ; Head ; Hip ; Humans ; Incidence ; Korea ; Male ; Osteotomy ; Physical Examination ; Range of Motion, Articular ; Traction ; Weight-Bearing

Reconstruction nf torn cruciate ligament by using fascia lata, hamstring tendon and patellar tendon has been accompanied not infrequently with such complication as the avascular necrosis and/ or degeneration of the graft with eventual stretching. Normally the knee resists invaision by any tissue not covered by synovial membrane except the meniscus, which is a fibrocartilaginous structure and is not dependent on vascular supply, but is nourished by synovial fluid. The method using the meniscus in this procedure would be superior to the above methods would also entail less complication. In the two knee injuries, the patella and femur fracture in case 1 and the posterior dislocation in case 2, the torn posterior cruciate ligaments were reconstructed with torn lateral menisci. The results were good in both with normal stability.
Dislocations ; Fascia Lata ; Femur ; Knee ; Knee Injuries ; Ligaments ; Menisci, Tibial ; Methods ; Necrosis ; Patella ; Patellar Ligament ; Posterior Cruciate Ligament ; Synovial Fluid ; Synovial Membrane ; Tendons ; Transplants

Osteopathia Striata is a rare developmental abnormality characterized by striation of the skeleton, especially the metaphyses of the long bones. It has been seen on only a few occasions since it was first described by Voorhoeve in 1924. This case, a nine year old boy, showed well marked striation throughout bones of right lower extremity and pelvis and so justifies the title of paper.
Humans ; Lower Extremity ; Male ; Pelvis ; Skeleton

Congenital clasped thumb is an unusal condition characterized by the thumb being held tightly beneath the flexed fingers in such a way that it cannot escape for normal prehension. New-born infants frequently hold their thumbs beneath their flexed fingers. If the flexed thumb persists and normal independent action of the thumb does not develop third or fourth month after birth, congenital clasped thumb is suggested. It is the result of failure of normal developmenl of the muscles and tendinous structures that provide extension for the thumb and fingers at the metacarpophalangeal joint. The deformity also includes volar soft tissue contractures of digits in varying degrees of severity. Since first description of Zadek in 1934 for bilateral thumb extensor agenesis. total 48 cases of congenital clasped thumb have been reparted throughout the world. A case of bilateral congenital clasped thumb with bilateral calcaneo-varus deformity in one month-old boy was diagnosed and treatment with prospect of complete funtional recovery.
Congenital Abnormalities ; Contracture ; Fingers ; Humans ; Infant ; Male ; Metacarpophalangeal Joint ; Muscles ; Parturition ; Thumb ; United Nations

No abstract available.
T-Lymphocyte Subsets* ; Thyroid Diseases* ; Thyroid Gland*

No abstract available.
T-Lymphocyte Subsets* ; Thyroid Diseases* ; Thyroid Gland*

Recently, we found that the Korean traditional medicine could enhance the expression of some cytokine in murine bone marrow cell culture. To understand the mode of actions of the traditional medicine, we examined the pattern of protein phosphorylation in bone marrow cells treated with Korean traditional medicine. When bone marrow cells were treated with Korean traditional medicine, the phosphorylation of p45, p50, p84/p91 kinase was observed, and gene expression of TPO and SCF was related to p45 and p91. It had been reported that TPO, SCF, IL-3 and GM-CSF gene expression transmits signal through the JAK-STAT pathway. Molecular involvement of JAK-STAT in signal induced by Korean traditional medicine was analyzed by anti-JAK and anti-STAT-1 Ab. To analyze the transcriptional factor that promotes the cytokine gene expression by the stirnulation of Korean traditional medicine, GAS and NF-B binding activity was analyzed by EMSA. We found the increase in NF-B at SMT and BHT. Therefore, we conclude that the cytokine gene expression induced by Korean traditional medicine was mediated by the JAK-STAT pathway and by the combination of GAS and NF-kB.
Bone Marrow Cells ; Butylated Hydroxytoluene ; Gene Expression ; Granulocyte-Macrophage Colony-Stimulating Factor ; Hematopoiesis* ; Interleukin-3 ; Medicine, Korean Traditional* ; Medicine, Traditional ; NF-kappa B ; Phosphorylation ; Phosphotransferases ; Signal Transduction

The Korean traditional medicinal (KTM) herbs such as Angelicae gigantis, Rehmannia glutinosa, Paeoniae lactiflora, Cnidii officinale, Salviae miltiorrhizae, and Millettia reticulata, and prescribed formula Samultang, and Bohyultang improve the function of the hematopoietic system and nourishing the body to promote health. However, there are limited scientific background on the mode of action of these medicine. To understand the diverse actions following traditional medicine stimulation, we determined the production of hematopoietic cytokine, thrombopoietin, stem cell factor, and interleukin-3 (IL-3) in KlM treated bone marrow cells. When bone marrow cells were treated with KTM, the expression of hematopoietic cytokine were increased in RT-PCR and ELISA analysis. Furthermore, when the bone marrow cells were separated into adherent celis and suspension cells and were treated with KTM, we found the increase of TPO gene expressions in suspension cells. Meanwhile, other hematopoietic cytokine gene expression in bone marrow cells was higher as whole than when adherent cells and suspension cells was separated. Therefore, we could know the interaction of two cells that increases the cytokine expression. These results suggest that KTM has hematopoietic effects through increasing the production of cytokine.
Angelica ; Bone Marrow Cells ; Enzyme-Linked Immunosorbent Assay ; Gene Expression ; Hematopoiesis* ; Hematopoietic System ; Interleukin-3 ; Medicine, Korean Traditional* ; Medicine, Traditional ; Millettia ; Paeonia ; Rehmannia ; Salvia ; Stem Cell Factor ; Thrombopoietin

No abstract available.
Diagnosis*

Out of 3288 patients admitted National Leprosy Center in Sorok-do, could be selected 120 patients confirmed to have one or more plantar ulcers, whose frequency and localization form the basis of this clinical observation. 1. Of 120 patients, 32 had ulcers bilaterally, so that total 196 ulcers in 152 feet were subjected to study. 2. Male patients were approximately three times more frequent than female. Age range showed that 76(63.3%) of 120 patients were in their six and seven decade, and only three cases were under the third Decade. 3. The base of first metatarsal was the site with highest incidence of ulcer (28.6%), and the bases of all metarsals occupied 57.7% of all ulcers. The medial plantar and the heel were low in incidence. 4, Transverse division of the plantar surface revealed that ulcers were located predominantly in the forefoot part (64.8%), showing gradual decrease in the midfoot (27%) and the hindfoot region (8.2%) 5. Longitudinal section of the plantar surface into three compartments showed almost even distribution of ulcers, though the central ray showed slightly lower incidence than those of the medial and lateral ray. 6. Dynamic pressure triangle was found to be the site of preference, in which 100 ulcers(59%) of all was observed. 7. Non-lepromatous patients showed the higher rate of occurrence, in that they occupied 21.3% of all the patients, while 30.8% of 120 ulcer-patients were non-lepromatous type. 8. Of total 196 ulcers, those with history of more than ten years were 117(59.7%), and 18 of them had the history of more than 30 years.
Female ; Foot ; Foot Ulcer ; Heel ; Humans ; Incidence ; Leprosy ; Male ; Metatarsal Bones ; Ulcer