1.A study on the relationship between HBeAg and hepatitis B virus DNAamong healthy HBsAg carries.
Yoo Sik HAHM ; Hai Rim SHIN ; Hyung Jong PARK ; Sung Ryul KIM
Korean Journal of Epidemiology 1992;14(1):48-58
No abstract available.
Hepatitis B e Antigens*
;
Hepatitis B Surface Antigens*
;
Hepatitis B virus*
;
Hepatitis B*
;
Hepatitis*
2.Reliability and Validity of the Korean Version of Obsessive-Compulsive Inventory-Revised in a Non-clinical Sample.
Joon Suk LIM ; Se Joo KIM ; Woo Taek JEON ; Kyung Ryul CHA ; Joon Hyung PARK ; Chan Hyung KIM
Yonsei Medical Journal 2008;49(6):909-916
PURPOSE: The reliability and validity of a Korean version of the Obsessive-Compulsive-Inventory-Revised (OCI-R) was examined in non-clinical student samples. MATERIALS AND METHODS: The Korean version of OCI-R was administered to a total of 228 Korean college students. The Maudsley Obsessive Compulsive Inventory (MOCI), Beck's Depression Inventory (BDI), and Beck's Anxiety Inventory (BAI) were administered to 228 students. RESULTS: The total and each of subscale of the Korean OCI-R demonstrated excellent internal consistency, good test-retest reliability, moderate convergent validity and good divergent validity. CONCLUSION: It was concluded that the Korean version of the OCI-R has strong psychometric properties as the original version.
Female
;
Humans
;
Korea
;
Male
;
Obsessive-Compulsive Disorder/*diagnosis
;
*Psychological Tests/statistics & numerical data
;
Psychometrics
;
Questionnaires
;
Reproducibility of Results
;
Young Adult
3.Lung Transplantation for Chronic Humidifier Disinfectant-Associated Lung Injury.
Won Young KIM ; So Woon KIM ; Kyung Wook JO ; Sae Hoon CHOI ; Hyung Ryul KIM ; Yong Hee KIM ; Dong Kwan KIM ; Seung Il PARK ; Sang Bum HONG
Korean Journal of Critical Care Medicine 2016;31(2):146-151
In the spring of 2011, a cluster of lung injuries caused by humidifier disinfectant (HD) usage were reported in Korea. Many patients required mechanical ventilation, extracorporeal membrane oxygenation, and even lung transplantation (LTPL). However, the long-term course of HD-associated lung injury remains unclear because the majority of survivors recovered normal lung function. Here we report a 33-year-old woman who underwent LTPL approximately four years after severe HD-associated lung injury. The patient was initially admitted to the intensive care unit and was supported by a high-flow nasal cannula. Although she had been discharged, she was recurrently admitted to our hospital due to progressive lung fibrosis and a persistent decline in lung function. Finally, sequential double LTPL was successfully performed, and the patient's clinical and radiological findings showed significant improvement. Therefore, we conclude that LTPL can be a therapeutic option for patients with chronic inhalation injury.
Adult
;
Catheters
;
Disinfectants
;
Extracorporeal Membrane Oxygenation
;
Female
;
Fibrosis
;
Humans
;
Humidifiers*
;
Inhalation
;
Inhalation Exposure
;
Intensive Care Units
;
Korea
;
Lung Injury*
;
Lung Transplantation*
;
Lung*
;
Oxygen Inhalation Therapy
;
Respiration, Artificial
;
Survivors
4.Transradial Stenting of an Anomalous Right Coronary Artery Originating from the Left Sinus of Valsalva.
Kwang Soo CHA ; Dong Joo KEUM ; Hyung Ryul PARK ; Bong Keun KIM ; Moo Hyun KIM ; Young Dae KIM ; Jong Seong KIM
Korean Circulation Journal 1998;28(12):2056-2060
Anomalous right coronary artery arising from the left sinus of Valsalva is rare, but not protected from ather-osclerotic disease. Major factor determining successful angioplasty is the selection of the appropriate guiding catheter to provide optimal coaxial backup support. We report the first case of successful transradial stenting of an anomalous right coronary artery originating from the left sinus of Valsalva.
Angioplasty
;
Catheters
;
Coronary Vessels*
;
Sinus of Valsalva*
;
Stents*
5.Lung Transplantation in Acute Respiratory Distress Syndrome Caused by Influenza Pneumonia.
Youjin CHANG ; Sang Oh LEE ; Tae Sun SHIM ; Sae Hoon CHOI ; Hyung Ryul KIM ; Yong Hee KIM ; Dong Kwan KIM ; Seung Il PARK ; Sang Bum HONG
Korean Journal of Critical Care Medicine 2015;30(3):196-201
Severe acute respiratory distress syndrome (ARDS) is a life-threatening disease with a high mortality rate. Although many therapeutic trials have been performed for improving the mortality of severe ARDS, limited strategies have demonstrated better outcomes. Recently, advanced rescue therapies such as extracorporeal membrane oxygenation (ECMO) made it possible to consider lung transplantation (LTPL) in patients with ARDS, but data is insufficient. We report a 62-year-old man who underwent LTPL due to ARDS with no underlying lung disease. He was admitted to the hospital due to influenza A pneumonia-induced ARDS. Although he was supported by ECMO, he progressively deteriorated. We judged that his lungs were irreversibly damaged and decided he needed to undergo LTPL. Finally, bilateral sequential double-lung transplantation was successfully performed. He has since been alive for three years. Conclusively, we demonstrate that LTPL can be a therapeutic option in patients with severe ARDS refractory to conventional therapies.
Extracorporeal Membrane Oxygenation
;
Humans
;
Influenza, Human*
;
Lung Diseases
;
Lung Transplantation*
;
Lung*
;
Middle Aged
;
Mortality
;
Pneumonia*
;
Respiratory Distress Syndrome, Adult*
6.Effect of Adrenomedullin on Proliferation and Mitogen-Activated Protein Kinase Activity in Osteosarcoma Cell Lines (MG63, U2OS).
Jung Ryul KIM ; Byung Wan CHOI ; Jong Hyuk PARK ; Kyu Hyung KIM
The Journal of the Korean Orthopaedic Association 2008;43(6):775-782
PURPOSE: The aims investigated how how human osteosarcoma cell proliferation and the MAP kinases cascade are regulated, in the MG63 and U2OS human osteosarcoma cell lines after stimulating them with adrenomedullin (AM) with particular focus on extracellular signal-regulated kinase 1/2 (ERK 1 and 2) activation. MATERIALS AND METHODS: A cell proliferation assay was used to examined the effects of AM on the osteosarcoma cell lines (MG63 and U2OS). The effects of AM on ERK1/2 were examed by Western blot analysis. The roles of ERK 1/2 in the AM-induced proliferative signaling pathways in the two cell types were examed using PD98059, a selective inhibitor of the mitogen activated protein-ERK kinase (MEK) pathway. RESULTS: The addition of AM to the medium containing the osteosarcoma MG63 and U2OS cells induced proliferation in a dose-dependent manner. AM strongly activated ERK 1/2 mediated cell proliferation signaling, which was prevented using PD98059. CONCLUSION: These results suggest that AM plays an important role in the proliferation of human osteosarcoma MG63 and U2OS cells, and ERK kinase pathway plays a signal transduction role in AM treated human osteosarcoma MG63 and U2OS cell lines.
Adrenomedullin
;
Blotting, Western
;
Cell Line
;
Cell Proliferation
;
Flavonoids
;
Humans
;
Osteosarcoma
;
Phosphotransferases
;
Protein Kinases
;
Signal Transduction
7.Two Cases of Adrenal Cysts Assessed by Endoscopic Ultrasound-Guided Fine Needle Aspiration for Diagnostic and Therapeutic Purposes.
Hyung Hun KIM ; Jung Hwan LEE ; Sang Ryul LEE ; Su Yeon LEE ; Young Il PARK ; Soo Hyung RYU ; You Sun KIM ; Jeong Seop MOON
Korean Journal of Gastrointestinal Endoscopy 2010;40(2):97-101
Adrenal cyst is a rare disease and its incidence rate is about 0.06~0.18%. Many cases of adrenal cysts are diagnosed incidentally. Surgical excision is generally performed to rule out malignancy when an adrenal cyst is detected. However, a reviewing the overall cases revealed that only 7% of adrenal cysts were malignant or potentially malignant. Thus, it has been suggested to observe an asymptomatic simple benign cyst after aspiration. From this point of view, it is necessary to perform a functional hormonal test and fine needle aspiration cytology for investigating the nature of adrenal cysts. Adrenal cyst drainage can be performed when surgical resection is not indicated. Computed tomography or ultrasonography guided percutaneous aspiration and drainage has been performed, but linear endoscopic ultrasound has not yet been used for this purpose. We have performed endoscopic ultrasound guided fine needle aspiration of adrenal cysts for cytologic and hormonal examination and endoscopic ultrasound guided adrenal cyst drainage, and we report here on our experiences with this technique.
Biopsy, Fine-Needle
;
Drainage
;
Endoscopic Ultrasound-Guided Fine Needle Aspiration
;
Incidence
;
Rare Diseases
8.A Case of Endoscopic Ultrasound Guided Cholangiography with Antegrade Drainage.
Sang Ryul LEE ; Jung Hwan LEE ; Su Yeon LEE ; Hyung Hun KIM ; Jong Hyeok PARK ; Soo Hyung RYU ; You Sun KIM ; Jeong Seop MOON
Korean Journal of Gastrointestinal Endoscopy 2009;39(4):252-256
An 84-year-old woman presented with obstructive jaundice due to unresectable gallbladder cancer with a left renal cell carcinoma. Endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD) were unsuccessful because of tumor obstruction of the duodenal bulb, right hepatic duct and distal common bile duct. Endoscopic ultrasound (EUS)-guided biliary drainage with a transgastric approach was performed. A guide-wire was passed through the biliary obstruction and was successfully advanced into the duodenum via the ampulla. The procedure was completed in an antegrade fashion. The obstructed biliary system was successfully decompressed by the insertion of a biliary covered metal stent through the malignant stricture. There were no complications related to the use of this procedure.
Aged, 80 and over
;
Biliary Tract
;
Carcinoma, Renal Cell
;
Cholangiography
;
Cholangiopancreatography, Endoscopic Retrograde
;
Common Bile Duct
;
Constriction, Pathologic
;
Drainage
;
Duodenum
;
Female
;
Gallbladder Neoplasms
;
Hepatic Duct, Common
;
Humans
;
Jaundice
;
Jaundice, Obstructive
;
Stents
9.The Usefulness of Endoscopic Ultrasonography in the Diagnosis of Choledocholithiasis without Common Bile Duct Dilatation.
Sang Ryul LEE ; Jung Hwan LEE ; Su Yeon LEE ; Hyung Hun KIM ; Jong Hyeok PARK ; Soo Hyung RYU ; You Sun KIM ; Jeong Seop MOON
The Korean Journal of Gastroenterology 2010;56(2):97-102
BACKGROUND/AIMS: Endoscopic retrograde cholangiopancreatography (ERCP) is the most accurate modality in diagnosis of choledocholithiasis. However, it carries some complications. Endoscopic ultrasonography (EUS) is less invasive than ERCP and used for the diagnosis of choledocholithiasis. Recent studies showed that a usefulness of EUS for the diagnosis of small choledocholithiasis without common bile duct (CBD) dilatation. For such a reason, ERCP is being replaced by EUS in the diagnosis of bile duct stones. The aim of this study was to investigate the accuracy of EUS for the diagnosis of choledocholithiasis without CBD dilatation. METHODS: A total of 66 patients with suspected choledocholithiasis without CBD dilatation were enrolled. EUS were performed in all cases within 48 hours after computed tomography (CT) or ultrasonography (US). Final diagnosis was obtained by ERCP or clinical course (minimum 6 months follow-up). We analyzed the accuracy of US, CT, and EUS, respectively. RESULTS: CT and US were performed in 51 and 15 cases, respectively. CBD stones were detected in 23 (35%) patients by ERCP. EUS showed 100% sensitivity, 95% specificity, 92% positive predictive value, and 100% negative predictive value for identifying CBD stones. CT or US showed 26%, 93%, 67%, and 70%, respectively. There were no EUS-related complications. CONCLUSIONS: EUS was more effective than CT or US and as accurate as ERCP for the diagnosis of small choledocholithiasis without CBD dilatation. Thus, EUS may help to avoid unnecessary diagnostic ERCP and its complication.
Adult
;
Aged
;
Aged, 80 and over
;
Choledocholithiasis/pathology/*ultrasonography
;
Common Bile Duct Diseases/diagnosis
;
Diagnosis, Differential
;
Dilatation, Pathologic/diagnosis
;
*Endosonography
;
Female
;
Gallstones/ultrasonography
;
Humans
;
Male
;
Middle Aged
;
Sensitivity and Specificity
;
Tomography, X-Ray Computed
10.A Case of Gastroduodenal Crohn's Disease Mistaken for a Gastric Malignancy.
Byung Ryul CHOI ; Chang Soo KIM ; Jae Hoon KIM ; Dong Ho OH ; Joon Hyung DOH ; Chang Hyung LEE ; Ho Gak KIM ; Jung Dong BAE ; Mi Ok PARK
Korean Journal of Gastrointestinal Endoscopy 1999;19(5):817-822
Gastroduodenal Crohn's Disease (CD), which is uncommon in adults, involves the gastric antrum and proximal duodenum in most cases, and results in epigastric pain, weight loss, and gastric outlet obstruction, raising initial suspicion that it may be peptic ulcer disease or a malignancy. On upper endoscopy, aphthous ulcers are typical in the early stages but linear or stellate ulcers with a cobblestone appearance and luminal narrowing can be found in advanced diseases. Multiple mucosal biopsies are helpful for diagnosis despite the fact that granulomas are seen in less than one third of all cases. Gastroduodenal CD requires oral sulfasalazine therapy or systemic corticosteroid therapy in advanced cases. A case of gastroduodenal CD in a 37-year-old man admitted with epigastric pain, anorexia, vomiting and weight loss is herein reported. Malignancy was suspected as a result of the patient's clinical manifestations and endoscopic findings. An endoscopic biopsy revealed an active inflammation in the mucosa and lamina propria. The patient's condition improved with oral sulfasalazine and prednisolone therapy.
Adult
;
Anorexia
;
Biopsy
;
Crohn Disease*
;
Diagnosis
;
Duodenum
;
Endoscopy
;
Gastric Outlet Obstruction
;
Granuloma
;
Humans
;
Inflammation
;
Mucous Membrane
;
Peptic Ulcer
;
Phenobarbital
;
Prednisolone
;
Pyloric Antrum
;
Stomatitis, Aphthous
;
Sulfasalazine
;
Ulcer
;
Vomiting
;
Weight Loss