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Hyung In YANG ; Dong Soo LEE ; Sung Chul KIM ; Sang Kyun BAE ; Chang Woon CHOI ; June Key CHUNG ; Suhnggwon KIM ; Myung Chul LEE ; Jung Sang LEE ; Chang Soon KOH

Korean Journal of Nuclear Medicine 1992;26(2):312-317

8.Effects of Simvastatin Alone or Combined With Ramipril on Nitric Oxide Bioactivity and Inflammation Markers in Hypercholesterolemic Patients.

Ji Won SON ; Kwang Kon KOH ; Seung Min YOU ; Woun Seok RYU ; Jeong Yeal AHN ; Han Gyu KIM ; Dae Sung KIM ; Hyung Sik KIM ; Kyu Jin OH ; Eak Kyun SHIN

Korean Circulation Journal 2003;33(11):1053-1059

BACKGROUND AND OBJECTIVES: Because the mechanisms of the biological effects of statin and antiotensin converting enzyme inhibitor therapies differ, the vascular responses to these therapies were studied in hypercholesterolemic patients. MATERIALS AND METHODS: Simvastatin, 20 mg, placebo or ramipril, 10 mg, were administered daily for 2 months, with a 2 month washout, to 32 hypercholesterolemic patients. This was a randomized, double-blind, placebo-controlled, crossover in design study. RESULTS: Simvastatin alone, or in combination with ramipril, significantly changed the lipoproteins, and improved the percentage of the flow-mediated dilator response to hyperemia by 46+/-48% and by 59+/-66%, respectively, relative to the baseline measurements (both p<0.001). The plasma malondialdehyde levels were reduced, relative to baseline measurements, by 6+/-57% (p=0.045) and 13+/-47% (p=0.045 and p<0.001, respectively) and plasma levels of monocyte chemoattractant protein-1 by 3+/-27% and by 9+/-16%, respectively (p=0.113 and p=0.001, respectively). The C-reactive protein were also reduced, relative to baseline measurements, by 17+/-75% and by 17+/-37%, respectively (p=0.003 and p=0.001, respectively). However, simvastatin combined with ramipril changed, to a greater extent, but was statistically insignificant, the percentage of the flow-mediated dilator response to hyperemia, and the plasma monocyte chemoattractant protein-1 levels, than simvastatin alone. CONCLUSION: Compared with simvastatin alone, the addition of ramipril improved the endothelial function to greater extent, but was statistically insignificant, in hypercholes-terolemic patients.
C-Reactive Protein ; Chemokine CCL2 ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hyperemia ; Inflammation* ; Lipoproteins ; Malondialdehyde ; Nitric Oxide* ; Plasma ; Ramipril* ; Simvastatin*

9.Absolute renal 99mTc-DMSA uptake and renal scan in children with vesicoureteral reflux.

Sang Kyun BAE ; Dong Soo LEE ; Hyung In YANG ; Chang Woon CHOI ; June Key CHUNG ; Myung Chul LEE ; Chang Soon KOH ; Yong CHOI ; Gwang Myung KIM ; Hwang CHOI ; Kyung Mo YEON

Korean Journal of Nuclear Medicine 1992;26(2):327-332

10.Comparison between myocardial perfusion and function in rest state in coronary artery disease.

Chang Woon CHOI ; Dong Soo LEE ; Sang Eun KIM ; Sang Kyun BAE ; Hyung In YANG ; June Key CHUNG ; Myoung Mook LEE ; Myung Chul LEE ; Young Bae PARK ; Jung Don SEO ; Young Woo LEE ; Chang Soon KOH

Korean Journal of Nuclear Medicine 1992;26(2):265-273

1.A gastroesophageal cyst in the posterior mediastinum.

2.Absent perfusion and nonvisualization by renal scintigraphy in a case of transplant kidney.

3.Radionuclide cisternography of arachnoid cyst.

4.Captopril 99mTc-DTPA renal scintigraphy in diagnosis of renovascular hypertension.

5.The effect and side effect of dipyridamole in myocardial SPECT.

6.Gallium and 99mTc-antigranulocyte antibody scan in lymphoma.

7.Facioscapulohumeral Muscular Dystrophy Confirmedby D4Z4 Analysis.

8.Effects of Simvastatin Alone or Combined With Ramipril on Nitric Oxide Bioactivity and Inflammation Markers in Hypercholesterolemic Patients.

9.Absolute renal 99mTc-DMSA uptake and renal scan in children with vesicoureteral reflux.

10.Comparison between myocardial perfusion and function in rest state in coronary artery disease.

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