1.Vascular Endocrinology-New Scope of Endocrinology.
Journal of Korean Society of Endocrinology 2000;15(4-5):468-478
No Abstract Available.
Endocrinology*
2.An update on the drug therapy of diabetes mellitus.
Journal of the Korean Academy of Family Medicine 2002;23(2):141-150
No abstract available.
Diabetes Mellitus*
;
Drug Therapy*
3.Effects of Ca2+ Channel Blockers on Expression of L-type Voltage Dependent Ca2+ Channels in Vascular Smooth Muscle Cells Obtained from the Aorta of Diabetic Rats.
Journal of the Korean Geriatrics Society 2003;7(2):95-100
BACKGROUND: The proliferation of vascular smooth muscle cells(VSMCs) is an important process in the pathogenesis of atherosclerosis. VSMCs proliferation is closedly related to the cytosolic calcium flux via L-type voltage dependent calcium channel. OBJECTIVES: To investigate the role of cytosolic Ca2+ in the proliferation of VSMCs. METHODS: The proliferation of aortic vascular smooth muscle cells of streptozotocin induced diabetic rats, acquired by enzymatic method. Cell counting, and calcium agonists(Bay K 8644 10(-6)M) or calcium antagonists(verapamil 10(-6)M). Cytosolic calcium ion was measured with Fura 2 method. Calcium channel gene expression was detected with RT-PCR method. RESULTS: VSMCs of diabetic rats were more proliferated than those of nondiabetic ones. Bay K 8644 enhanced VSMCs proliferation of both groups. Verapamil blocked the incremental effects induced by Bay K 8644. Expression of calcium channel gene was enhanced by Bay K 8644 and was reversed by vera- pamil. CONCLUSION: The enhanced proliferation of VSMCs is associated with the increment in cytosolic calcium, which is accompli shed through the expression of L-type voltage dependent calcium channel.
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
;
Animals
;
Aorta*
;
Atherosclerosis
;
Calcium
;
Calcium Channels
;
Cell Count
;
Cytosol
;
Fura-2
;
Gene Expression
;
Muscle, Smooth, Vascular*
;
Rats*
;
Streptozocin
;
Verapamil
4.Progeria Syndrome.
Journal of the Korean Geriatrics Society 2002;6(3):177-182
No abstract available.
Progeria*
5.Aging and endorcine system.
Journal of Korean Society of Endocrinology 1993;8(1):1-5
No abstract available.
Aging*
6.Endocrinologic Aspects of Aging.
Journal of the Korean Geriatrics Society 1998;2(2):18-29
No abstract available.
Aging*
7.Role of Cytosolic Calcium Ion and Expression of Proliferation Responsive Gene of Cultured Medial Smooth Muscle Cells Obtained from rat Aortas with Atherosclerotic Changes Induced by High Cholesterol Feeding.
Journal of the Korean Geriatrics Society 2000;4(4):251-256
BACKGROUND: Vascular smooth muscle cells (VSMCs) proliferation is an important process in the pathogenesis of atherosclerosis. VSMCs proliferation is closedly related to the cytosolic calcium flux via L-type voltage dependent calcium channel. OBJECTIVES: To investigate the role of cytosolic Ca(2+) in the proliferation of VSMCs. METHODS: The proliferation of aortic vascular smooth muscle cells of rats(1% cholesterol diet fed rats and general diet fed ones), acquired by enzymatic method. Cell counting, and calcium agonists(Bay K 8644 10(-6)M) or calcium antagonists(verapamil 10(-6)M). Cytosolic calcium ion was measured with Fura 2 method. Calcium channel gene expresssion was detected with RT-PCR method. RESULTS: Masson Trichrome staining shows more disturbed cell lining, more VSMCs, more degenerated media, more collagen laydown, and more adventitial fat in the aorta of cholesterol-fed rats than in that of general diet-fed ones. VSMCs of cholesterol fed-rats were moreproliferated than those of general diet fed-ones. Bay K 8644 enhanced VSMCs proliferation of both groups. Verapamil blocked the incremental effects induced by Bay K 8644. Expression of calcium channel gene was enhanced by Bay K 8644 and was reversed by verapamil. CONCLUSION: The enhanced proliferation of atherosclerotic VSMCs is associated with the increment in cytosolic calcium, which is accomplshed through the expression of L-type voltage dependent calcium channel.
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
;
Animals
;
Aorta*
;
Atherosclerosis
;
Calcium Channels
;
Calcium*
;
Cell Count
;
Cholesterol*
;
Collagen
;
Cytosol*
;
Diet
;
Fura-2
;
Muscle, Smooth*
;
Muscle, Smooth, Vascular
;
Myocytes, Smooth Muscle*
;
Rats*
;
Verapamil
8.Growth of Diabetic Arterial SMC is Greater than that of Normal SMC.
Journal of the Korean Geriatrics Society 1999;3(1):15-18
No abstract available.
9.Diabetes mellitus in the elderly.
Journal of the Korean Academy of Family Medicine 1999;20(4):314-320
No abstract available.
Aged*
;
Diabetes Mellitus*
;
Humans
10.Constipation and Weakness.
Journal of the Korean Medical Association 1998;41(8):867-870
No abstract available.
Constipation*