The detection of the tubercle bacilli is absolutely necessary to make definite diagnosis of patients with genitourinary tuberculosis. Recently it has been reported that the detection rate of tubercle bacilli from the patient's urine is decreasing because of abuse of the anti-tuberculous drugs and the resistance developed in the experimental animals such as mouse and guinea pig (Marks, 1972). Therefore the necessity of the development of better diagnostic methods has been mandatory. Recently it was reported that the Korean chipmunks(Tamias sibiricus asiaticus. Gmelin) are highly susceptible to tubercle bacilli (Chang et al., 1971). The specific objection of this study is to pursue the possibility of using the chipmunks for the early diagnosis of genitourinary tuberculosis. Twenty-four hour urines of 34 patients with suspected genitourinary tuberculosis were tested for tubercle bacilli with smear, culture, and inoculation ink chipmunks and mice intraperitoneally. The results are briefly summarized as follows: 1. 18 cases out of 34 patients with suspected genitourinary tuberculosis were confirmed to be positive by any means of stained smear, culture and animal inoculation. Of 18 proved genitourinary tuberculosis. 12 cases were confirmed by smear, culture and mouse inoculation, and on the other hand. 14 cases by chipmunks inoculation. 2. In the group of chipmunks inoculation, 8 cases were found to be positive on the 10th day and 14 cages on the 20th day. 3. These findings suggest that the period required for the detection of tubercle bacilli was shorter and the positive rate was higher than that of other animals and other methods. For the clinical applications of the Korean chipmunks as a diagnostic tools, further effort is considered to be necessary.
Animals ; Diagnosis ; Early Diagnosis ; Guinea Pigs ; Hand ; Humans ; Ink ; Mice ; Sciuridae* ; Tuberculosis*

No abstract available.
Hepatitis* ; Humans

Hemophilia, a genetically determined disorder, can be divided into hemophilia A and hemophilia B. Hemophilia A, defined as a sex-linked recessive trait hemorrhagic disease of males characterized by a deficiency of factor VIII occurs about seven times more frequently than hemophilia B which is characterized by a deficiency of factor IX. The complications resulting from hemophilia occurs in virtually every system. This paper is concerned with a rare complication of hemophilia, iliacus hematoma with femoral neuropathy. On case of spontaneous hemorrhage of iliacus muscle with femoral neuropathy in hemophilia was decompressed through a small incision with sump drainage under cover of AHF(Anti-hemophilic factor) concentrated plasma cryoperecipitate followed AHF replacement therapy.
Drainage ; Factor IX ; Factor VIII ; Femoral Neuropathy ; Hematoma ; Hemophilia A ; Hemophilia B ; Hemorrhage ; Humans ; Male ; Plasma

No abstract available.

PURPOSE: Although varicose veins are very common in adults, the mechanism of the disease has not been established. Degradation of the extracellular matrix is regulated by various matrix metallopreteinases (MMPs) and their inhibitors tissue inhibitor of metallaproteinase (TIMPs). This study was performed to analyse the relationship between venous wall degeneration and expression of these matrix proteinases. METHODS: Twelve great saphenous vein (GSV) segments from 7 patients without varicose veins (control) and 86 GSV segments from 18 patients (22 limbs) with varicose veins (C2,4,5EPASPR) were used for this study. Light microscopic examination was used in the evaluation of vein wall degeneration, immunohistochemistry and Western blotting for the expression of MMPs (MMP-1, MMP-2, MMP-9 and MMP-13) and TIMPs (TIMP-1 and TIMP-2), and zymography for gelatinolytic activity of MMP-2 and MMP-9 were performed. RESULTS: MMP-9 was more strongly expressed in the vein wall of both control and patient groups, especially in the endothelial cells and medial muscle layers and TIMP-2 followed. The expression of MMP-9 was closely related to the degree of venous wall degeneration. Activated MMP-2 and MMP-9 were observed in both groups and expressed more in the proximal GSV of the patients. In the Western blotting, the expression of MMP-9 and TIMP-1 were significantly higher than other MMPs and TIMP-2 in the patients with varicose veins. CONCLUSION: MMP-9 is much more expressed in the wall of degenerative veins. This matrix-degrading enzyme may play an important role in the degeneration of venous wall followed by its remodeling.
Adult ; Blotting, Western ; Endothelial Cells ; Extracellular Matrix ; Humans ; Immunohistochemistry ; Light ; Matrix Metalloproteinases ; Metalloproteases ; Muscles ; Saphenous Vein ; Tissue Inhibitor of Metalloproteinase-1 ; Tissue Inhibitor of Metalloproteinase-2 ; Varicose Veins ; Veins

OBJECTIVE: This study aimed to propose clinical guidelines for placing miniscrew implants using the results obtained from 3-dimensional analysis of maxillary anterior interdental alveolar bone by cone-beam computed tomography (CBCT). METHODS: By using CBCT data from 52 adult patients (17 men and 35 women; mean age, 27.9 years), alveolar bone were measured in 3 regions: between the maxillary central incisors (U1-U1), between the maxillary central incisor and maxillary lateral incisor (U1-U2), and between the maxillary lateral incisor and the canine (U2-U3). Cortical bone thickness, labio-palatal thickness, and interdental root distance were measured at 4 mm, 6 mm, and 8 mm apical to the interdental cementoenamel junction (ICEJ). RESULTS: The cortical bone thickness significantly increased from the U1-U1 region to the U2-U3 region (p < 0.05). The labio-palatal thickness was significantly less in the U1-U1 region (p < 0.05), and the interdental root distance was significantly less in the U1-U2 region (p < 0.05). CONCLUSIONS: The results of this study suggest that the interdental root regions U2-U3 and U1-U1 are the best sites for placing miniscrew implants into maxillary anterior alveolar bone.
Adult ; Cone-Beam Computed Tomography ; Female ; Humans ; Incisor ; Male ; Tooth Cervix

To evaluate the effectiveness of superselective transcatheter arterial embolization (STAE) for hepatocelluar carcinoma (HCC) with a mixture of ethanol and Lipiodol, STAE was done in 12 male patients with HCC. Three were diagnosed clinically with angiographic findings and elevated alphafetprotein levels and three were recurrent tumors after surgery. Sono-guided aspiration biopsy proved the diagnosis of hepatocellular carcinoma in another six patients. The tumor was a small single nodule (2-5cm in diameter) in 11 patients. In one patient, two nodules were found. Superselective catheterization was done using 3F Tracker catheter(Target Therapeutics USA) coaxially through 6F catheter into the feeding hepatic artery, usually the third order branch. One to four cc of 75% ethanol mixed with Lipiodol was infused under fluoroscopy immediately after imjection of 2% lidocaine. Immediate angiography and CT after 2 weeks were undertaken. Complete segmental or subsegmental devascularization including feeding arteries and tumor vascularities occurred in all patients. Follow-up angiography after 6 to 15 months revealed the tumor opacified by Lipiodol. The tumor decreased in 5 cases and recurrence was found in three patients. CT taken 2 weeks after STAE showed low density halo around the tumor in 5 cases. Subsequest segmentectomy in four patients revealed total or near total necrosis of the tumor and no evidence of damage in surrounding parenchyme. STAE for HCC with a mixture of ethanol and Lipiodol is an effective and safe measure for small HCC.
Angiography ; Arteries ; Biopsy, Needle ; Carcinoma, Hepatocellular* ; Catheterization ; Catheters ; Diagnosis ; Ethanol* ; Ethiodized Oil* ; Fluoroscopy ; Follow-Up Studies ; Hepatic Artery ; Humans ; Lidocaine ; Male ; Mastectomy, Segmental ; Necrosis ; Recurrence

Limb-Body Wall complex is a complicated with the essential features of neural-tube defects, body-wall disruption, and limb abnormalities. This complex should be distinguished from other body-wall defects including omphalocele and gastroschisis since the prognosis for limb-body wall is uniformly poor. We have experienced one case of limb-body wall complex in a 22-year-old primigravida, which is presented with a brief review of the literature.
Extremities ; Gastroschisis ; Hernia, Umbilical ; Humans ; Prognosis ; Young Adult

Transcatheter embolization using absolute ethanol is a widely used technic in interventional radiology. Butits mechanism of action and embolization effect on various infusion speed are poorly understood. Authors performedan experimental study in rabbits to doccument the effect of absolute ethanol onvarious infusion rate. The resultsare as follows; 1. In high speed infusion group(>0.1ml/sec. n=13), 11 cases showed peripheral obstruction and 2 cases showed central obstruction. 2. In low speed infusion group(<0.1ml/sec. n=12), 4 cases showed peripheralobstruction and 8 cases showed central obstruction (p<0.02). 3. On follow-up angiography performed 4 weeks later(n=8), no demonstrable significant differences are found between two groups.
Angiography ; Ethanol ; Follow-Up Studies ; Rabbits ; Radiology, Interventional ; Renal Artery

Radilogic findings in 30 patients with intestinal tubeculosis and 10 patients with intestinal Behcet'sdiseases, who had been diagnosed at seoul National University Hospital during the recent 5 years, were analysedretrospectively to evaluate the radiologic differential diagnosis of the two diseases. Intestinal tuberculosisseverely involved the cecum, the ileocecal valve, the distal ileum and colons, but Behcet's disease mainlyinvolved th distal ileum and infrequently the ileocecal valve and the cecum. The ulcers in tuberculosis wereusually multiple small barium collected areas among psuedopolyps on the contrary, those in Behcet's disease weremultiple, discrete, well marginated, geographic, ring-like deep penetrating or collar-button shaped. Intestinaltuberculosis tended to involved long segments of intestines, with severer mucosal irregularity and deformity ofthe ileocecal valve and the ascending colon in comparison with Behcet's disease. Mesenteric and/or peritonealinvolvment were accompanied in 1/3 cases of intestinal tuberculosis,a nd active pulmonary tuberculosis or pleuraleffusion also in 1/3 cases of intestinal tuberculosis.
Barium ; Cecum ; Colon ; Colon, Ascending ; Congenital Abnormalities ; Diagnosis, Differential ; Humans ; Ileocecal Valve ; Ileum ; Intestines ; Seoul ; Tuberculosis ; Tuberculosis, Pulmonary ; Ulcer