Direct contact method of autoradiography was utilized in studying the distribution of exogenous C(14)-proline in Clonorchis sinensis, Eurytrema pancreaticum, Hymenolepis diminuta and Dipylidium caninum. The most distinct autoradiogram were obtained after 60 min of incubation, corresponding to the maximal absorption of C(14)-proline in these parasite. The radioactivitity of this labeled amino acid was chiefly concentrated in reproductive organs, especially egg-containing uterine tubules.
parasitology-helminth-trematoda-cestoda ; Clonorchis sinensis ; Eurytrema pancreaticum ; Hymenolepis diminuta ; Dipylidium caninum ; autoradiography ; C(14)-proline ; biochemistry ; amino acid

No abstract available.
Humans ; Lower Urinary Tract Symptoms* ; Prostate* ; Urethral Obstruction*

No abstract available.
Esophageal Achalasia*

The anthelminthic effect of phenylene-diisothiocyanate-(1,4)(=Jonit) was studied on the eighty three cases infected with Ancylostoma duodenale. For the evalution, the number of eggs per gram of feces on all these cases was calculated before treatment. The follow-up for the egg reduction was carried out over a period of four weeks. The sixty-seven cases were treated in dosage schedule of 3 x 100 mg every 12 hours. The cure rates - the rate of negative conversion of eggs - was 74.6 percent and the total egg reduction rate of 94.2% was obtained. The ten out of 14 cases treated in the dosage schedule of 2 x 100 mg every 12 hours showed 100% egg reduction and the cure rate was 71.4%. In this group. the total egg reduction rate of 78.6% was noted. In the dosage schedule of 2 x 50 mg every 12 hours the remainder, two out of total 83 cases showed 100% egg reduction. Side effects were observed as being mild, 51 cases (56.6%) were free of side reactions and the most frequently noted side effects were vertigo and diarrhea. From the above results, it is concluded that Jonit is an effective antheminthic against Ancylostoma duodenale and its effectiveness is quite equivalent to that of a known recommended anti-hookworm products.
parasitology-helminth-nematoda ; Ancylostoma duodenale ; chemotherapy ; phenylene-diisothiocyanate ; Jonit

Brain size is a useful parameter describing ontogenic character and function. Despite its potential contribution to functional study and diagnosis of disease, it has been hampered by poor assessment tools in vivo and postmortem changes. Recent development of medical imaging techniques such as MRI and CT enable us to understand brain structures in vivo. Many morphometirc studies of the brain has given us new insights in the field of functional neuroanatomy and neuropsychiatric diseases. In spite of these advances, volumetric data of normal Korean brain is not available yet. As an initial approach to Korean standard brain size, we measured the cerebellar volume between 20 and 80 years old Koreans. The MRI films free from lesions in brain was analyzed and measured by NIH image program. The Korean cerebellar volume were ranged between 86.2cm(3) and 141.3 cm(3) and average male cerebellum volume was significantly larger than that of female[male : 118.2+/-11.2cm(3)] > female : 108.0+/-9.6cm(3), P=0.1021E-07<0.05]. And we could not find volume change according to aging process. This is the first report on normal Korean cerebellar volume and the presence of gender difference in the Korean cerebellar volume. These data will be used for the standard useful in studying cerebellar function and cerebellum associated disorders in the future.
Aged, 80 and over ; Aging ; Brain ; Cerebellum ; Diagnosis ; Diagnostic Imaging ; Female ; Humans ; Magnetic Resonance Imaging* ; Male ; Neuroanatomy ; Postmortem Changes

Purpose: The purpose of this study was to investigate the relationship between social network characteristics, flow in class, communication skills, and problem-solving skills of nursing students in simulation. Methods: For this study a descriptive survey design was used. Participants were 100 nursing students who attended in 2 university and completed the self-report questionnaire. Data were collected from October 14 to December 6, 2019 and were analyzed with SPSS 26.0, AMOS 21.0 and Netminer 4 evaluation version. Results: It was confirmed that the task advice network centrality of nursing students fully mediates their communication skills and affects their problemsolving skills and that friendship network centrality completely mediates flow in class and communication skills, and affects problem-solving skills. Task advice network centrality, friendship network centrality, flow in class, and communication skills were found to explain problem solving skills by 51.8%. Conclusion In order to increase the problem-solving skills of nursing students in simulation nursing education, a strategy to improve their flow in class and communication skills is essential and it suggests the need to make it part of the curriculum. In addition, in order to increase the communication skills of nursing students, it is necessary to be careful when making a team to minimize the team members isolated within the team so that smooth interaction can occur.

Objectives: The aim of this study was to investigate the prevalence of hazardous drinking (HD) and its association with sociodemographic factors, smoking, social anxiety, self-esteem, and ego-resiliency in medical students. Methods: A total of 408 medical students were included in this study. Data were collected by self-administered questionnaire, and HD was assessed by Alcohol Use Disorder Identification Test (AUDIT). The HD and non-HD group were defined using the AUDIT score 10 for male and 6 for female as a cut-off, respectively. Multiple logistic regression analyses were carried out to examine the impact of sociodemographic factors, smoking, social anxiety, self-esteem, and ego-resiliency on HD. Results: A total of 192 participants (47.1%) were identified as having HD. Frequency of smoking and the severity of social anxiety were significantly higher in HD group than non-HD group. Meanwhile, the levels of self-esteem and egoresiliency were significantly lower than HD group than non-HD group. In multiple logistic regression, smoking was associated with a higher risk of HD, whereas ego-resiliency and age were associated with a lower risk of HD. Compared to the high level of subjective socioeconomic status, both middle and low level were associated with a lower risk of HD. Conclusions HD among medical students was quite common and associated with smoking, ego-resiliency, age, and level of subjective socioeconomic status. Strong efforts to improve smoking cessation and ego-resiliency, as well as education for HD in medical schools, is needed to reduce the harmful effects of alcohol.

Congenital lipoid adrenal hyperplasia is the most severe form of CAH, leading to impaired production of all steroid hormones including glucocorticoids, mineralocorticoid, and sex steroids. The affected individuals are all phenotypically female with a severe salt-losing syndrome that is fatal if steroid replacement is not begun immediately after birth. The lesion of this disorder has been suggested to be in the first step of steroidogenesis of conversion of cholesterol to pregnenolone by P450scc. Recently, molecular defect of this disease has been located in the transport of cholesterol into mitochondria due to defective regulatory protein called 'steroidogenic acute regulatory protein' while the enzyme P450scc itself is normal, differing from other types of congenital adrenal hyperplasia. We experienced 2 1/2 month old phenotypical girl who was admitted due to lethargic state and persistent vomiting with severe hyperkemia and hyponatremia. Blood levels of cortisol, aldosteron, and 17-OH progesteron were low and levels of ACTH, angiotensin, and plasma renin activity were high, urinary levels of 17-KS and 17-OHCH were low. The patient was found to have karyotype of 46, XY and has been being treated with predinisolone, fluorocortisol and sodium supplement in diet and doing well. The molecular study for P450scc gene and StAR gene of patient and family is in progress.
Adrenal Hyperplasia, Congenital ; Adrenocorticotropic Hormone ; Angiotensins ; Cholesterol ; Diet ; Female ; Glucocorticoids ; Humans ; Hydrocortisone ; Hyperplasia* ; Hyponatremia ; Karyotype ; Mitochondria ; Parturition ; Plasma ; Pregnenolone ; Renin ; Sodium ; Steroids ; Vomiting

PURPOSE: To report the visual outcome and to determine the stability of WIOL-CF(R) (GELMED, Praha, Czech Republic) hydrogel full-optics accommodative intraocular lens (IOL). METHODS: The present study evaluated 20 eyes of 10 patients who underwent routine cataract surgery and WIOL-CF(R) accommodative IOL implantation. Measurement included uncorrected/best corrected visual acuities (VA) at near and distant, degree of IOL decentration, degree of IOL tilting and anterior chamber depth on postoperative day 1, 1 month, 2 months, 6 months and 12 months. RESULTS: Result analysis was performed with 19 eyes of 10 patients, except for 1 complicated eye. At 12 months, the uncorrected distance VA of 11 eyes (57.9%) and 17 eyes (89.5%) were 20/25 and 20/40 or better, respectively. At 12 months, the uncorrected near VA of 12 eyes (63.2%) and 18 eyes (94.7%) were 20/25 and 20/40 or better, respectively. There was no statistically significant difference in anterior chamber depth (p > 0.05), IOL decentration (p > 0.05) and IOL tilting (p > 0.05) on postoperative day 1, 1 month, 2 months, 6 months and 12 months. CONCLUSIONS: The clinical results of cataract surgery with WIOL-CF were relatively satisfactory.
Anterior Chamber ; Cataract ; Eye ; Humans ; Hydrogel ; Lenses, Intraocular ; Visual Acuity

PURPOSE: To evaluate the effect of a capsular tension ring (CTR) on the tilting and decentration of intraocular lenses (IOLs) after cataract surgery. METHODS: Cataract surgery was performed on both eyes of twenty patients ranging from 57 to 75 years old. Forty eyes were divided into two groups based on whether or not a CTR (Lucid Korea, Korea) was implanted. Each patient received a CTR in one eye. All IOLs (MA60BM, Acrysof R , Alcon) were implanted into the capsular bag after a continuous curvilinear capsulorhexis smaller than the optic size of the IOL, and phacoemulsification was performed. The extent of tilting and decentration of the IOLs were measured with the EAS-1000 anterior eye segment analysis system at 7, 30, and 60 days after surgery. RESULTS: IOL decentration decreased to a statistically significant extent in the eyes implanted with both IOL and CTR, versus those with IOL only. The values of CTR+IOL group were: 0.38+/-0.16 mm at 7 days, 0.43+/-0.15 mm at 30 days, and 0.42+/-0.17 mm at 60 days. The IOL-only group values were: 0.49+/-0.11mm at 7 days, 0.53+/-0.14 mm at 30 days, and 0.57+/-0.16 mm at 60 days. IOL tilting also decreased significantly in the IOL+CTR group compared to the IOL-only group. The CTR+IOL values were: 2.22+/-0.46 degrees at 7 days, 2.36+/-0.50 degrees at 30 days, and 2.47+/- 0.40 degrees at 60 days. The IOL-only group values were: 3.14+/-0.65 degrees at 7 days, 2.91+/-0.67 degrees at 30 days, and 3.06+/-0.56 degrees at 60 days. CONCLUSIONS: These results indicate that the CTR reduces undesirable post-surgical movement of the IOL for at least 60 days.
Aged ; Anterior Eye Segment ; Capsulorhexis ; Cataract* ; Humans ; Korea ; Lenses, Intraocular* ; Phacoemulsification