No abstract available.
Aneurysm* ; Hydrocephalus*

The authors report a very unusual case of ruptured aneurysm by direct vessel invasion of anaplastic oligodendroglioma (WHO grade III) confirmed by histopathological examinations. As local invasion is the hallmark of malignant gliomas, malignant glial tumors invade neighboring structure and often cause microscopic endothelial proliferation, telangiectasias in small arteriols, but direct arterial invasion by glioma is very rare. Possible mechanisms of intracranial aneurysm development by glioma are thought to be related to the close proximity to the tumor, perivascular basement membrane breakage due to high tumor pressure and increased regional blood flow through the feeding artery of tumor. The aneurysm and tumor were treated in a single operation simultaneously.
Aneurysm ; Aneurysm, Ruptured ; Anterior Cerebral Artery* ; Arteries ; Basement Membrane ; Glioma ; Intracranial Aneurysm* ; Oligodendroglioma* ; Regional Blood Flow ; Rupture* ; Telangiectasis

The chest X-ray findings of 20 cases of pulmonary opportunistic infections were analyzed according tocausative agents. The results we as follows; 1. Final diagnoses of 20 cases of opportunistic infections weretuberculosis in 6 cases, pneumocystis carinii pneumonia in 5 cases, bacterial infection in 7 cases, and fungalinfection in 2 cases. 2. The underlying diseases were leukemia in 6 cases, kidney transplantation in 6 cases,lymphoma in 3 cases, nephrotic syndrome in 1 case, nasopharyngeal cancer in 1 case, multiple myeloma in 1 case,agranulocytosis in 1 case, and hypogammaglobulinemia in 1 case. 3. In tuberculosis, all the 6 cases showed severemanifestations such as miliary tuberculosis, tuberculous pneumonia, moderately advanced tuberculosis andtuberculous pericarditis. 4. In pneumocystis carinii pneumonia, the most frequent findings were bilateral alveolardensities and peripheral field of the lung was saved in most cases. 5. In 2 cases of fungal infections bilatarealmultiple cavitary nodules were noted. 6. In cases of bacterial infection there were more cases of gram negativeinfection than gram positive and 2 cases of pseudomonas revealed bilateral multiple cavitary nodules.
Agammaglobulinemia ; Bacterial Infections ; Diagnosis ; Kidney Transplantation ; Leukemia ; Lung ; Multiple Myeloma ; Nasopharyngeal Neoplasms ; Nephrotic Syndrome ; Opportunistic Infections ; Pericarditis ; Pneumonia ; Pneumonia, Pneumocystis ; Pseudomonas ; Thorax ; Tuberculosis ; Tuberculosis, Miliary

No abstract available.
Sinusitis*

Purpose: This study aimed to compare a dynamic neuromuscular training program with a static neuromuscular training program for taekwondo players. Methods: This study design was a randomized control trial. Three high school taekwondo teams (taekwondo neuromuscular training [TNT] group, 22; Get Set group, 17; and control group, 24) participated in the study. Get Set group performed a program focused on the static movement, and TNT group performed a program which was modified Get Set to dynamic movement. Control group maintained the existing taekwondo training without any intervention. The intervention group performed 15-minute training three times a week for 6 weeks. Dynamic Postural Stability Index (DPSI) and time-to-boundary test (TTB) tests were performed before and after 6 weeks of training. Results: As a result of DPSI, an interaction effect was observed only in the anterior/posterior stability index of the dominant leg of the TNT and Get Set groups (p＜0.05). However, there was no difference between the TNT and the Get Set groups.As a result of TTB analysis, no statistical effect was observed in all variables of the dominant and non-dominant legs. Conclusion As a result of conducting 6-week dynamic and static neuromuscular training for taekwondo athletes, the effect of training was found in both the intervention group. However, differences in training effects between groups could not be proved. Therefore, it is necessary to clearly confirm the difference between the two training through long-term follow-up studies.

Recently, the efficacy of immuno-oncologic agents for advanced hepatocellular carcinoma (HCC) has been proven in several trials. In particular, atezolizumab with bevacizumab (AteBeva), as a first-line therapy for advanced HCC, has shown tremendous advances in the IMBrave150 study. However, second or third-line therapy after treatment failure with AteBeva has not been firmly established. Moreover, clinicians have continued their attempts at multidisciplinary treatment that includes other systemic therapy and radiotherapy (RT). Here, we report a case that showed a near complete response (CR) of lung metastasis to nivolumab with ipilimumab therapy after achieving a near CR of intrahepatic tumor using sorafenib and RT in a patient with advanced HCC who had experienced treatment failure of AteBeva.

BACKGROUND: Unlike that of adults, depression of adolescents need screening because learning ability, physical growth and social adaptation are seriously affected. But Beck Depression Inventory(BDI), the assessment tool for adults, is generally used for adolescents as well because only few are available. The purpose of this study is to examine the reliability of a Korean version of BDI(K-BDI) as a screening instrument of adolescent depression. METHODS: From May 1, 1998 to June 1, 1998 we visited two high schools (one male, one coeducation) in Sungnam city and K-BDI questionnaires were given. The subjects were 1,107 high school students. This study was to evaluate the reliability of BDI and to find out factor structure through analysis. RESULTS: The sex distribution of subjects was 929(83.9%) males and 178(16.1%) females. Cronbach's internal consistency and Spearman-Brown split half correlation coefficient was 0.85, 0.86, respectively, in the male group, 0.74, 0.86, respectively, in the female group and 0.85, 0.86, respectively,in the total group. By principal axis factoring, 4 factors were extracted. Which were factorI:Negative Self Attitude, factorII:Performance Difficulty, factorIII:Guilty and Psychomotor Retardation, and factorIV:Somatic Symptom. All of the correlations between total BDI score and the individual items showed positive correlation(P<0.001). Average BDI score and prevalence rate was 11.7+/-7.24, 11.4%, respectively, in the male group, 18.51+/-6.65, 34.8%, respectively, in the female group and 12.85+/-7.56, 15.2%, respectively, in the total group. CONCLUSION: The results suggest that the K-BDI is a reliable tool in adolescence. Therefore, it may be used as a screening tool for adolescent depression.
Adolescent* ; Adult ; Axis, Cervical Vertebra ; Depression* ; Female ; Gyeonggi-do ; Humans ; Learning ; Male ; Mass Screening ; Prevalence ; Sex Distribution ; Surveys and Questionnaires

Diabetes is a common medical condition in hospitalized patients and is associated with increased requirement for operation and increased postoperative morbidity and mortality. The stress of surgery induces catabolic changes that alter glucose and lipid levels, as well as protein metabolism. Persistent hyperglycemia can lead to ketoacidosis in type I diabetic patients or hyperosmolar syndrome in type 2 diabetic patients. Also, hyperglycemia is a risk factor for endothelial dysfunction, impaired immunity, wound healing and embolism. The ultimate goal in the management of diabetic patients is to optimize glucose control through monitoring, fluid replacement and use of insulin.
Diabetes Mellitus ; Embolism ; Glucose ; Humans ; Hyperglycemia ; Insulin ; Ketosis ; Risk Factors ; Wound Healing

PURPOSE: Non-metastatic colorectal cancer patients with diabetes have poor overall survival than those without diabetes. However, the effect of hyperglycemia on survival after diagnosis of metastatic colorectal cancer (CRC) has not been assessed. Therefore, we assessed the impact of hyperglycemia on the survival and infection-related adverse events (AEs) in patients with metastatic CRC. MATERIALS AND METHODS: We reviewed the records of 206 patients with newly diagnosed metastatic CRC who were treated with palliative chemotherapy from March 2000 to December 2012 at Chungbuk National University Hospital. The mean glucose level of each patient was calculated using all available glucose results. RESULTS: The mean glucose levels ranged between 76.8 and 303.5 mg/dL, and patients were categorized into quartiles in accordance to their mean glucose level: group 1 (< 106.7 mg/dL), group 2 (106.7-117.2 mg/dL), group 3 (117.3-142.6 mg/dL), and group 4 (> 142.6 mg/dL). The median overall survival for patients in groups 1, 2, 3, and 4 were 22.6, 20.1, 18.9, and 17.9 months, respectively; however, this difference was not statistically significant (p=0.643). Compared with patients in group 1, those in groups 2, 3, and 4 were at a higher risk of infection-related AEs, according to a multivariate analysis (p=0.002). CONCLUSION: Hyperglycemia was not associated with shorter survival; however, it was associated with infection-related AEs in patients with newly diagnosed metastatic CRC receiving palliative chemotherapy.
Chungcheongbuk-do ; Colorectal Neoplasms* ; Diagnosis ; Drug Therapy* ; Glucose ; Humans ; Hyperglycemia* ; Multivariate Analysis

PURPOSE: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that can increase adhesion molecule expression on monocytes and produce superoxide anions. Hyperglycemia induces MCP-1 production in vascular endothelial cells and retinal pigmented epithelial cells, and has been implicated as a causal factor in the facilitation of vascular complications in diabetes. In the present study, we evaluated the association of a single nucleotide polymorphism (SNP) in the MCP-1 gene with proliferative diabetic retinopathy (PDR) in a Korean population with type 2 diabetes. MATERIALS AND METHODS: We conducted a case-control study, which enrolled 590 subjects with type 2 diabetes, and SNP genotyping of c.2518A/G in the MCP-1 gene was performed using polymerase chain reaction followed by digestion with PvuII restriction enzyme. RESULTS: The prevalence of c.2518A/G polymorphism in diabetic patients was 13.2% (A/A), 47.1% (A/G) and 39.7% (G/G). In patients with diabetic retinopathy, the prevalence of PDR was significantly higher (p=0.009) in diabetic subjects with the c.2518A/A genotype (35.9%; n=78) compared to those with either the A/G or G/G genotype (22.3%, n=512). The prevalence of any other micro and macro-complications, including nephropathy and cerebrovascular events, were not different according to the c.2518A/G genotype. CONCLUSION: Our new genetic findings suggest that the c.2518A/A genotype in MCP-1 could be used as a susceptibility gene to predispose Koreans exhibiting type 2 diabetes for the development of PDR.
Aged ; Case-Control Studies ; Chemokine CCL2/*genetics ; Diabetes Mellitus, Type 2/*complications ; Diabetic Retinopathy/etiology/*genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; *Polymorphism, Single Nucleotide ; Republic of Korea