1.Combination Chemotherapy with High Dose Cisplatin - Cyclophosphamide in Primary Epithelial Ovarian Cancer.
Jeong Sup YUN ; Ha Jeong KIM ; Sung Kyoo JANG ; Ki Hyung KIM ; Man Soo YOON
Korean Journal of Gynecologic Oncology and Colposcopy 2001;12(1):12-22
OBJECTIVE: The purpose of this study was to evaluate the therapeutic efficacy and toxicity of high dose cisplatin-cyclophosphamide combination chemotherapy on patients with primary epithelial ovarian cancer. METHODS: A review of 63 patients previously diagnosed as primary epithelial ovarian cancer after initial operation and histology at Pusan National University Hospital from Jul. 1993 to Jun, 1997 was performed. Patients were received the combination chemotherapy including cisplatin 100mg/m2/day and cyclophosphamide 750mg/m2/day, repeated 6 cycles every 4 weeks. The mean age was 48 years old, and previous surgical procedures were total abdominal hysterectomy and bilateral salpingo-oophorectomy with omentectomy. The patients were classified into FIGO stage and pathologic results. RESULTS: The clinical response rate was 100% in the FIGO stage Ic patients with PC combination chemotherapy, 100% in stage II, 53.5% in stage III, and 25% in stage IV. The overall response rate was 69.8%. The 3-year survival rate according to the treatment groups was 93.3% in stage Ic group, 60% in stage II, 50% in stage III and 0% in stage IV. The mean survival duration was 34.6 months. Hematologic toxicities in cisplatin-cyclophosphamide chemotherapy were neutropenia and anemia. Nausea and vomiting were the most common side effects and occurred in 96.8%. Most of the toxicities were grade 1 and 2. CONCLUSION: The combination chemotherapy with cisplatin-cyclophosphamide is relatively safe and effective method in the treatment of primary epithelial ovarian cancer.
Anemia
;
Busan
;
Cisplatin*
;
Cyclophosphamide*
;
Drug Therapy
;
Drug Therapy, Combination*
;
Humans
;
Hysterectomy
;
Middle Aged
;
Nausea
;
Neutropenia
;
Ovarian Neoplasms*
;
Survival Rate
;
Vomiting
2.A case of bilateral polycystic kidney diagnosed prenatally by ultrasonography.
Byung Soo KIM ; Jung Gyu LEE ; Kil Hyung LEE ; Sung Ki HONG ; Man Jong LEE ; Ha Jong JANG
Korean Journal of Obstetrics and Gynecology 1993;36(7):1016-1020
No abstract available.
Polycystic Kidney Diseases*
;
Ultrasonography*
3.Peripheral Vascular Disease in Patients with Significant Coronary Artery Disease.
Dong Hun CHOI ; Jong Won HA ; Won Heum SHIM ; Moon Hyung LEE ; June KWAN ; Si Hoon PARK ; Yang Soo JANG
Korean Circulation Journal 1995;25(2):477-482
BACKGROUND: Although it is known that patients wth peripheral vascular disease are at high risk for coronary arterial disease, however, it has not been determined that patients with coronary artery disease(CAD) correlates with peripheral vascular disease(PVD). This study was designed to determine the prevalence and clinical characteristics of peripheral vascular disease(PVD) in patients with coronary artery disease(CAD). METHODS: A total of one hundred seventy-eight patients with CAD confirmed by coronary angiogram(145 male, age 58.5+/-10.1) were included in this study from February 1992 to May 1994. Coronary and peripheral angiograms were performed in all patients and the patients were divided into two groups; patients with PVD dand patients without PVD. Clinical characteristics were compared between two groups. RESULTS: Peripheral vascular disease was present in 49 patients(27.5%) among 178 CAD patients. The mean age of patients with PVD was significantly older than that of patients without PVD. The hypertension was statistically significant difference between two groups(P<0.05). There were no major differences in the number of risk factors or number of stenotic coronary arteries in patients with and without PVD. CONCLUSION: The prevalence of PVD in patients with CAD was high and it is reasonable to state that most common risk factors for coronary and peripheral atherosclerosis were age, hypertension and obesity.
Atherosclerosis
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Humans
;
Hypertension
;
Male
;
Obesity
;
Peripheral Vascular Diseases*
;
Prevalence
;
Risk Factors
4.a comparative study of hysterosalpingography and laparoscopy in assessment of tubal patency in infertile women.
Yoon Jung RHA ; Gil Hyung LEE ; Jung Gyoo LEE ; Seung Jin OH ; Ha Jong JANG ; Se Jun HAN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2857-2862
No abstract available.
Female
;
Humans
;
Hysterosalpingography*
;
Laparoscopy*
5.Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study.
Eun Jin JANG ; Young Kyun LEE ; Hyung Jin CHOI ; Yong Chan HA ; Sunmee JANG ; Chan Soo SHIN ; Nam Han CHO
Journal of Bone Metabolism 2016;23(1):34-39
BACKGROUND: Fracture-risk assessment tool (FRAX) using just clinical risk factors of osteoporosis has been developed to estimate individual risk of osteoporotic fractures. We developed prediction model of fracture risk using bone mineral density (BMD) as well as clinical risk factors in Korean, and assessed the validity of the final model. METHODS: To develop and validate an osteoporotic FRAX, a total of 768 Korean men and women aged 50 to 90 years were followed for 7 years in a community-based cohort study. BMD as well as clinical risk factors for osteoporotic fracture including age, sex, body mass index, history of fragility fracture, family history of fracture, smoking status, alcohol intake, use of oral glucocorticoid, rheumatoid arthritis, and other causes of secondary osteoporosis were assessed biannually. RESULTS: During the follow-up period, 86 osteoporotic fractures identified (36 in men and 50 in women). The developed prediction models showed high discriminatory power and had goodness of fit. CONCLUSIONS: The developed a Korean specific prediction model for osteoporotic fractures can be easily used as a screening tool to identify individual with high risk of osteoporotic fracture. Further studies for validation are required to confirm the clinical feasibility in general Korean population.
Arthritis, Rheumatoid
;
Body Mass Index
;
Bone Density*
;
Cohort Studies*
;
Female
;
Follow-Up Studies
;
Humans
;
Korea
;
Male
;
Mass Screening
;
Osteoporosis
;
Osteoporotic Fractures*
;
Risk Assessment*
;
Risk Factors
;
Smoke
;
Smoking
6.Growth conditions and biotypes of gardnerella vaginalis.
Jung Gyu LEE ; Kil Hyung LEE ; Byung Soo KIM ; Ha Jong JANG ; Se Joon HAN ; Nam Woong YANG ; Sung Hee SHIN
Korean Journal of Obstetrics and Gynecology 1993;36(6):837-846
No abstract available.
Gardnerella vaginalis*
;
Gardnerella*
7.Acromegaly improved with sandostatin LAR treatment.
Young Ju LEE ; Hyun Chul JO ; Seung Hyung HA ; Ji Wong JANG ; Jong Hwa KIM ; Heung Kon HWANG
Korean Journal of Medicine 2007;73(6):643-646
Cardiovascular disease is the most frequent cause of death in patients with acromegaly. Recently, long-term treatment with a somatostatin analogue (Sandostatin LAR) has been shown to be effective in controlling growth hormone (GH) and insulin like growth factor-1 (IGF-1) hypersecretion in most patients with acromegaly. Along with the effectiveness in the hormone profile, Sandostatin LAR has been reported to be effective for tumor mass shrinkage and clinical symptom improvement. We have encountered a female acromeglic patient with severe dilated cardiomyopathy and the patient was treated with Sandostatin LAR After treatment for 12 months, as seen by follow up echocardiography, the overall cardiac function was significantly improved. We report the case with a review of the literature.
Acromegaly*
;
Cardiomyopathy, Dilated
;
Cardiovascular Diseases
;
Cause of Death
;
Echocardiography
;
Female
;
Follow-Up Studies
;
Growth Hormone
;
Humans
;
Insulin
;
Octreotide*
;
Somatostatin
8.Deep Vein Thrombosis and Pulmonary Embolism in the 8th Week of Pregnancy.
Sung Hyung HA ; Rak Kyeong CHOI ; Ji Won JANG ; Dal Soo LIM ; Hweung Kon HWANG ; Young Moo RO
Korean Circulation Journal 2007;37(3):130-133
A 29-year-old woman in her 8th week of pregnancy was referred to our hospital for swelling in the lower extremities, rapid onset of dyspnea (1 hr) and pre-syncope. Severe right ventricular dysfunction and moderate pulmonary hypertension were detected using 2-dimentional Doppler echocardiography. In addition, left calf vein and proximal thromboses were detected by venous compression ultrasound imaging. After successful thrombolytic treatment, the patient quickly recovered and was discharged from hospital on subcutaneous low-molecular-weight heparin. She delivered a normal, healthy infant at full-term (40 weeks).
Adult
;
Dyspnea
;
Echocardiography, Doppler
;
Female
;
Heparin, Low-Molecular-Weight
;
Humans
;
Hypertension, Pulmonary
;
Infant
;
Lower Extremity
;
Pregnancy*
;
Pulmonary Embolism*
;
Thrombolytic Therapy
;
Thrombosis
;
Ultrasonography
;
Veins
;
Venous Thrombosis*
;
Ventricular Dysfunction, Right
9.Isolated Left Coronary Ostial Stenosis in Korea.
Bon Kwon KOO ; Moon Hyung LEE ; Yang Soo JANG ; Jong Won HA ; Choong Won GOH ; Won Heum SHIM ; Seung Yun CHO ; Kyung Jong YOO ; Meyun Shick KANG
Korean Circulation Journal 1996;26(6):1144-1151
BACKGROUND: We studied clinical and angiographic findings of 16 Korean patients who had isolated laft coronary ostial steonsis and compared them with those of the patients with non-ostial left main stenosis. The aim of this study is to find the characteristics of the patients with isolated left voronary ostial stenosis. METHODS: Medical records and coronary angiograms were reviewed. We divided the patients with left main stenosis into four groups by lesion location and associated lesion. Clinical and angiographic findings of each group were compared. RESULTS: Twenty four patients(0.15%) had left coronary ostial stenosis and among them sixteen patients(0.1) had an isolated lesion. Their mean age was 48 years and 62% were female. Only 6 patients had coronary risk factors. Two patients were diagnosed as having Takayasu's srteritis. At treadmill exercise test, 7 out of 11 patients lhowed positive results at stage I. Eight patients had undergone surgical treatment. Comoared with the patients who had non-ostial left main stenosis, left ostial group showed lower mean age, female preponderance and lower incidence of coronary risk factors. There was no difference in the results of treadmill exercise test and hemodynamic parameters. CONCLUSION: Isolated left coronary ostial stenosis in Korea also predominantly occured in young female patients who had less risk factors as previous reports. But the incidence of this lesion and nonatherosclerotic origin seemed to be higher. And most of the patients with the left coronary ostial stenosis had isolated ostial stenosis.
Constriction, Pathologic*
;
Exercise Test
;
Female
;
Hemodynamics
;
Humans
;
Incidence
;
Korea*
;
Medical Records
;
Risk Factors
10.Isolated Left Coronary Ostial Stenosis in Korea.
Bon Kwon KOO ; Moon Hyung LEE ; Yang Soo JANG ; Jong Won HA ; Choong Won GOH ; Won Heum SHIM ; Seung Yun CHO ; Kyung Jong YOO ; Meyun Shick KANG
Korean Circulation Journal 1996;26(6):1144-1151
BACKGROUND: We studied clinical and angiographic findings of 16 Korean patients who had isolated laft coronary ostial steonsis and compared them with those of the patients with non-ostial left main stenosis. The aim of this study is to find the characteristics of the patients with isolated left voronary ostial stenosis. METHODS: Medical records and coronary angiograms were reviewed. We divided the patients with left main stenosis into four groups by lesion location and associated lesion. Clinical and angiographic findings of each group were compared. RESULTS: Twenty four patients(0.15%) had left coronary ostial stenosis and among them sixteen patients(0.1) had an isolated lesion. Their mean age was 48 years and 62% were female. Only 6 patients had coronary risk factors. Two patients were diagnosed as having Takayasu's srteritis. At treadmill exercise test, 7 out of 11 patients lhowed positive results at stage I. Eight patients had undergone surgical treatment. Comoared with the patients who had non-ostial left main stenosis, left ostial group showed lower mean age, female preponderance and lower incidence of coronary risk factors. There was no difference in the results of treadmill exercise test and hemodynamic parameters. CONCLUSION: Isolated left coronary ostial stenosis in Korea also predominantly occured in young female patients who had less risk factors as previous reports. But the incidence of this lesion and nonatherosclerotic origin seemed to be higher. And most of the patients with the left coronary ostial stenosis had isolated ostial stenosis.
Constriction, Pathologic*
;
Exercise Test
;
Female
;
Hemodynamics
;
Humans
;
Incidence
;
Korea*
;
Medical Records
;
Risk Factors