We report a case of Mondor's disease, or superficial thrombophlebitis of the chest wall, which occured in a 35-year-old female after a mild blunt trauma of the right chest wall. She had 0.3 × 25 cm, firm, tender, bifurcated cord-like lesions on the right chest and upper abdomen for two weeks. The histopathologic findings corresponded to the “thrombus organization” stage of Mondor's disease, characterized by numerous small areas of recanalization with marked surrounding fibrosis. The patient was treated with non-steroidal antiinflammatory drugs and warm compresses. Within 7 weeks, the cord-like lesions virtually disappeared.
Abdomen ; Adult ; Female ; Fibrosis ; Humans ; Thoracic Wall ; Thorax ; Thrombophlebitis

We report a case of eosinophilic pustular folliculitis in a 18-year-old woman who had numerous mild pruritic erythematous plaques with follicular papules and pustules covering almost her whole body. Histopathologically intrafollicular, perifollicular and perivascular eosinophilic infiltrates were present with mild spongiosis. The blocd eosinophil count was 9%. The patient responded well to systemic administration of corticosteroid and dapsoni.
Adolescent ; Eosinophils* ; Female ; Folliculitis* ; Humans

In order to evaluate the pathogenicity of Korean strains of Trichomonas vaginalis, an experimental inoculation of T. vaginalis into mouse peritoneal cavity was performed. Fifteen strains of T. vaginalis were selected from 53 infected cases and were cultured axenically in Roiron-Rattner medium at 37C for 48 hours. Each strain, at the dose of 0.5 ml of 1x10(6)/ml trichomonads, was inoculated intraperitoneally to a group of 10 mice, respectively. A total of 15 groups, consisted of 150 mice, were sacrificed on the 8th day of inoculation, and then they were thoroughly examined for the detection of the lesion. The results obtained in present study were summarized as follows: Prior to inoculation, the positive rates in 2 kinds of media cultivating T. vaginalis were compared. In Johnson's CPLM medium, 65 percent of positive rate was obtained, and 94.2 percent of positive rate, the better result, was shown in the culture of Roiron-Rattner medium. Overall death rate of 150 inoculated mice was 7.3 percent (range 0-40 percent), and 7 strains (46.7 percent) out of 15 inoculated strains were proved as fatal strain. The intraperitoneal lesions produced by the inoculation of T. vaginalis were observed in the liver (20 percent), intestinal wall and mesentery (14 percent), peritoneal wall (9.3 percent), wall of the stomach (6.0 percent), and the spleen (5.3 percent) of 150 inoculated mice. Occasionally, the lesions were also found in the pancreas and wall of the urinary bladder. In 11.3 percent of inoculated mice, purulent ascites with living trichomonads could be seen. Thirteen strains (86.7 percent) out of the 15 inoculated strains produced the T. vaginalis-associated pathological lesions. On the histopathological investigation of those lesions, intraperitoneal inoculation was characterzed by a necrotizing granulomatous inflammation, i.e., acutely necrotizing process with areas of encircling granuloma formation. Numerous free lying trichomonads were seen along the expanding margin of the lesion. Where there were free trichomonads, the reaction was usually of necrotizing. And these organisms directly eroded the vascular wall and often provoked thrombosis. From the above findings, it is considered that the Korean strains of T. vaginalis are highly pathogenic.
parasitology-protozoa-Trichomonas vaginalis ; pathogenesis ; mouse ; granuloma ; necrosis ; Roiron-Rattner medium ; Johnson's CPLM medium

The present experimental study was undertaken to observe the chronological change of the worm structure of Clonorchis sinensis and the pathological findings of the liver when this fluke was inoculated to the mouse intraperitoneally. The recovery rate, survival rate, location and size of the inoculated worms as well as the pathological changes of the liver were investigated for the comparison among the groups of mice, classified by number of worms and the duration of experiment. The results obtained were summarized as follows: The recovery and survival rates of the worms decreased especially 28 days after the inoculation. Most of worms (90.l percent) were collected from the peritoneal cavity and some of worms were found tightly adherent to the capsules of the liver, spleen, stomach, intestine and diaphragm. There were no worms recovered penetrated in the parenchymes of these organs. The mean worm size after inoculation was smaller than that before inoculation. At the 10th day after the inoculation, the shrinkage of posterior portion of the worm body was observed. Remarkable atrophy in the reproductive organs of the worm, such as spermatheca, testes, vitelline glands and ovary was frequently observed at the 10th day of inoculation. Histopathologically the liver failed to show any parasitic worm inside the intrahepatic biliary system. However, multiple well formed egg-containing granulomas were present along the liver capsule. These necrotic granulomas were occasionally found under the fibrotic liver capsule. Focal necrosis and focal phlebitis together with vascular dilatation were prominent features seen in the liver. The bile duct in the liver showed mild dilation of the lumen, flattening of epithelial cells and periductal small round cell infiltration. Neither adenomatous hyperplasia nor portal fibrosis was seen in the whole experimental groups. Foci of intralobular micro-granulomas were found in some experimental animals. The worms recovered in the capsule of the liver were degenerated and necrotized. Usually, there were remarkable capsulitis and granuloma formation around the eggs.
parasitology-helminth-trematoda ; Clonorchis sinensis ; pathology ; liver ; spleen ; stomach ; intestine ; diaphragm ; granuoma ; peritoneal cavity

BACKGROUND: Squamous cell caircinoma(SCC) often shows acantholysis as a result of degenerative changes of neoplastic cells. Regurding the acantholytic changes of SCC most textbooks and literature describe the acantholysis-associated tubular or alveolar structures, which are diagnostic features of adenoid SCC. But the acantholytic changes of SCC are not always assaciated with tubular or alveolar structres. The general and detailed histologic features of acantholysis of SCC have not been reported. OBJECTIVE: We analyzed the histologic features of acantholysis of SCC . MEHTODS: Twenty six biopsy specimens from 26 patients with SCC were studied for the distributions and sites of acantholysis such as lefts and tubular or alveolar structurs on routine histologic staining. RESULTS: All 26 biopsy specimens showed acantholysis in their tumors ocal acantholysis was found in 12 cases, and diffuse, widesprcad acantholysis was found in 14 cascs. The foci of acantholysis were in the surface epidermis in 9 cases, in the follicular wall in 5 cases, and in both the surface epidermis and the follicuar wall in 12 cases. The types of acantholytic cells were either dyskeratotic cells or non-dyskeratotic squamous cells. Tuthular or alveolar structures were found in 5 cases. Clefts were found in 12 cases, one in the subcomealarea, the other 11 were within tumor mases, and one of them showed Darier-like feature with papillary projections of neoplastic cells into thc lumens. CONCLUSION: The acantholytic hanges of the SCC are more comrr on y found than expected. The acantholytic changes involve not only dyskeratotic cells but also non-dysL eratotic cells and often show glandular structures and clefts.
Acantholysis* ; Adenoids ; Biopsy ; Carcinoma, Squamous Cell* ; Dronabinol ; Epidermis ; Humans

No abstract available.
Skin* ; Tissue Expansion Devices* ; Transplants*

No abstract available.
Carcinoma* ; Nevus*

From Mar. 1985 to Dec. 1992, 170 cases of osteosarcoma, which were proved histologically were admitted in our department at least one time. Among them we analysed 89 cases of Ennekings stage IIB who took limb-salvage(54) or amputation(35) and followed our protocol, with non-randomized retrospective study. The average age of the 89 patiens was 17.0 years(7 to 57). Fifty-four cases of salvage group took neoadjuvant chemotherapy, 35 cases of amputation group took neoadjuvant or adjuvant chemotherapy. The result revealed prevalences of 2/54, 0/35 as to local recurrence; 15 of 54, 17 of 35 as to metastasis; 14 of 54, 15 of 35 as to death. Of the 2 patients who had a local recurrence, one died of metastasis and the other was lost follow up. According to Kaplan-Meier's plot 5-year continuously disease free survival rate for whole 89 cases of stage IIB was 43.1%, for salvage group 56.4%, for amputation group 34.0%. There were no signifcant difference in survival rate between salvage and amputation groups(p>0.05, by log-rank test). This result means the limb-salvage operation for Enneking's stage IIB osteosarcoma does not hinder patients survival.
Amputation ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Drug Therapy ; Follow-Up Studies ; Humans ; Neoplasm Metastasis ; Osteosarcoma ; Prevalence ; Recurrence ; Retrospective Studies ; Survival Rate

Two cases of unusual giant carcinoma of the pancreas are presented. Each presented with a large tumor mass with or without cystic change, either in the head or tail portion of the pancreas. A pleomorphic gaint cell carcinoma variant (case 1) differed from an epulis type (case 2) with nuclear atypism of giant cells, but widespread metastasis in both cases reflected the accountability of spindle cell element as an important parameter for the determination of their biological behavior.
Neoplasm Metastasis

In 1978, Bjornberg and Friis reported 32 patients with persistent pusi ulosis(PP) on distal extremities, of whom 13 patients were initially diagnosed as scabies. In 1984, Elpern described 7 patients with infantile acropustulosis(IA), of whom 4 patients had antecedant scabies. We report herein a case of PP, which was found in a 18 month-old mal who was treated for scabies at the age of 5 month and 12 month. The pruritic vesicopustules dev',lo ed 2 months after the second treatment for scabies and relapsed for 4 months. We also discuss the relationship between scabies and PP and also between PP and IA.
Extremities ; Humans ; Infant ; Scabies*