1.The Prognostic Significance of p53 Protein and PCNA in Advanced Gastric Carcinoma.
Korean Journal of Pathology 1995;29(4):450-458
The 5 year-survival rates were examined to evaluate the prognositic significance of the expression of the p53 protein and the positivity of the PCNA in 108 cases of advanced gastric carcinoma. The p53 protein and PCNA were stained by immunohistochemistry in the tissue of the gastrectomized specimen. The results were as follows. 1) The overall 5 year-survival rate of advanced gastric carcinoma was 42.3 % and the significant prognostic factors were a pathologic stage and p53 protein(p<0.005). 2) The expanding or infiltrating type by Ming's classification and the intestinal or difftise type by Lauren's classification had similar prognosis. 514_ @@l %R-t 3) The 5 year-survival rate of the p53-positive group was 25.1% and that of p53-negative group was 56.1%(p<0.005). 4) The 5 year-survival rate of the PCNA low-grade tumors by PCNA stain(<50%)was 48.7% and that of the high-grade tumor(>=50%)was 29.9%(p>0.1). 5) There was a tendency to have a good prognosis in the p53-negative group and low grade tumors in the stage 11, III, and IV. There was a significant difference between p53 protein positive and negative groups in the stage III(p<0.005), but no significant differences were found in the other groups. The above results indicate that the p53 protein is an another useful tool for prediction of the prognosis in advanced gastric carcinoma.
Stomach Neoplasms
2.Diagnostic Significance of the CEA, AgNORs and PCNA in the Gastric Dysplasia and Adenocarcinoma.
Weon Cheol HAN ; Hyung Bae MOON
Korean Journal of Pathology 1995;29(1):61-67
This study aimed to differentiate gastric mucosal lesions such as the inflammatory gastric mucosa, gastric dysplasia and adenocarcinoma, using the CEA(carcinoembryonic antigen), AgNORS(Nucleolar organizer regions) and PCNA(proliferating cell nuclear antigen) stains. The tissue samples were taken from 30 cases of inflammatory gastric mucosa (19 gastritis and 11 regenerative hyperplasia), 28 cases of gastric dysplasia (9 mild dysplasia, 10 moderate dysplasia and 9 severe dysplasia) and 21 cases of gastric adenocarcinoma. The CEA was expressed in 16 of 21 adenocarcinomas(76%), but in neither inflammatory nor dysplastic gastric mucosae. The mean number of AgNORs per nucleus was 1.54 in inflammatory gastric mucosa, 1.80 in gastric dysplasia, and 1.88 in adenocarcinoma. The number of AgNORs was increased in dysplasia and adenocarcinoma compared to the inflammatory gastric mucosa without statistical significance. The percentage of the PCN A positive cells was 35.2% in inflammatory gastric mucosa, 44.1 % in gastric dysplasia, and 69.0% in gastric adenocarcinoma. The positivity of the PCNA was significantly increased in adenocarcinoma compared to the inflammatory gastric mucosa and dysplasia. In conclusion, the frequency of the CEA positive staining was increased in the gastric adenocarcinoma, and so CEA stain will be able to provide an additive method for the differential diagnosis between severe dysplasia and adenocarcinoma of the stomach.
Diagnosis, Differential
;
Adenocarcinoma
3.Parathyroid Carcinoma Causing Hyperparathyroidism: A Case Report
Seong Bae KIM ; Jin Hee LEE ; Jong Dae HWANG ; Hyung Bae MOON
The Journal of the Korean Orthopaedic Association 1986;21(2):377-382
A case of carcinoma of the parathyroid gland causing hyperparathyroidism was experienced at the department of orthopaedic surgery, C.A.F.G.H. This patient, a 23 years old male, had complained of a left shoulder pain during the past 3months. And weakness of the lower extremities causing walking disturbance, multiple bone pain, and polyuria had occurred sinoe one month before admission. Physical examination revealed a hard palpable mass in the right anterior region of the neck. Radiologic examination revealed subperiosteal bone resorption in phalanges of the hands and feet, generalized osteoporosis and cystic lesions, and pathologic fracture of the ribs, left humerus, and left femur. Laboratory studies demonstrated hypercalcemia, hypophosphatemia, increased alkaline phosphatase and PTH, hypercalciuria, and hyperphophaturia. Sonogram and C-T scan of the neck revealed a mass in the right inferior portion of the thyroid. Rib biopsy revealed the findings of ostitis fibrosa cystica, and parathyroid gland and regional lymph node biopsy revealed a parathyroid carcinoma with regional lymph node metastasis.
Alkaline Phosphatase
;
Biopsy
;
Bone Resorption
;
Femur
;
Foot
;
Fractures, Spontaneous
;
Hand
;
Humans
;
Humerus
;
Hypercalcemia
;
Hypercalciuria
;
Hyperparathyroidism
;
Hypophosphatemia
;
Lower Extremity
;
Lymph Nodes
;
Male
;
Neck
;
Neoplasm Metastasis
;
Osteoporosis
;
Parathyroid Glands
;
Parathyroid Neoplasms
;
Physical Examination
;
Polyuria
;
Ribs
;
Shoulder Pain
;
Thyroid Gland
;
Walking
4.Infantile Hemangioendothelioma of the Liver: Brief case report.
Hyang Jeong JO ; Ki Jung YUN ; Jae Kyu LEE ; Ji Shin LEE ; Hyung Bae MOON
Korean Journal of Pathology 1997;31(6):586-588
Infantile hemangioendothelioma of the liver is a common vascular tumor in infancy. The tumor is usually multinodular or diffuse and classified into two types. We present a case of infantile hemangioendothelioma of the liver, which predominantly consists of type 2. A 4-month-old female was admitted for an evaulation of an abdominal distension. A CT scan of the liver showed a multinodular mass. The right lobectomy was done. Grossly, the mass consisted of round nodules ranging from 2cm to 5cm in diameter. Microscopically, the tumor revealed proliferation of small vascular channels lined by endothelial cells. Bizarre cells and mitotic cells were frequently noted. Vesicular nuclei and multilayering of the endothelial cells were also noted.
Endothelial Cells
;
Female
;
Hemangioendothelioma*
;
Humans
;
Infant
;
Liver*
;
Tomography, X-Ray Computed
5.Malignant Struma Ovarii: A case report.
Ki Jung YUN ; Hyang Jeong JO ; Weon Cheol HAN ; Hyung Bae MOON
Korean Journal of Pathology 1994;28(4):436-438
Malignant struma ovarii is a rare tumor of the ovary. This can be diagnosed by histologically when carcinomas of the thyroid gland are excluded. We present a case of malignant struma ovarii arising from cystic teratoma. A 42-year-old female was admitted for evaluation of lower abdominal mass. Hysterectomy and both adnexectomy were performed on the basis of a clinical impression of uterine leiomyoma and an ovarian mass. The uterus revealed intramural leiomyoma, measuring 8 cm in diameter. Ovarian mass was predominantly cystic and partly solid. Microscopically, thyroid tissue with papillary structures were found in the solid area Papillae were complex, branching and randomly oriented. These papillae were infiltrated in the adjacent fibrous capsule, Clinical evidence of a primary thyroid carcinoma was not found.
Female
;
Humans
6.Malignant Struma Ovarii: A case report.
Ki Jung YUN ; Hyang Jeong JO ; Weon Cheol HAN ; Hyung Bae MOON
Korean Journal of Pathology 1994;28(4):436-438
Malignant struma ovarii is a rare tumor of the ovary. This can be diagnosed by histologically when carcinomas of the thyroid gland are excluded. We present a case of malignant struma ovarii arising from cystic teratoma. A 42-year-old female was admitted for evaluation of lower abdominal mass. Hysterectomy and both adnexectomy were performed on the basis of a clinical impression of uterine leiomyoma and an ovarian mass. The uterus revealed intramural leiomyoma, measuring 8 cm in diameter. Ovarian mass was predominantly cystic and partly solid. Microscopically, thyroid tissue with papillary structures were found in the solid area Papillae were complex, branching and randomly oriented. These papillae were infiltrated in the adjacent fibrous capsule, Clinical evidence of a primary thyroid carcinoma was not found.
Female
;
Humans
7.Effects of corticosteroid on the paraquat induced lung injury.
Keun CHANG ; An Myung KIM ; Jeong Seong KANG ; Byung Hak JUNG ; Eun Taik JEONG ; Hyung Bae MOON
Tuberculosis and Respiratory Diseases 1992;39(4):325-333
No abstract available.
Lung Injury*
;
Lung*
;
Paraquat*
8.Aggressive Osteoblastoma.
Yong Koo PARK ; Hyung Bae MOON ; Dong Kyuen LEE ; Dae Moo SHIM ; Jung Dal LEE
Korean Journal of Pathology 1986;20(2):235-239
Osteoblastomas were originally thought to be lesions that could be controlled with minimal local therapy, including curettage. However, at least some of the osteoblastomas with an unexpectedly active clinical course had histologic features which differed from ordinary osteoblastomas, and the term aggressive osteoblastoma was given to these lesions. In the aggressive osteoblastoma the osteoblasts are cytologically atypical. In addition, the well organized trabecular patterns of typical osteoblastoma is partly lacking, especially in the areas that are rich in atypical osteoblasts. The case report deals a case of aggressive osteoblastoma of the left iliac wing in a 44 year old male. The interesting radiologic manifestationa(plain x-ray CAT and radionuclide bone scan) and characteristic histologic findings are presented along with review of pertinent literatures.
9.Invasive carcinoma after a simple hysterectomy for microinvasive carcinoma of uterine cervix: a case report.
Dae Jin KANG ; Kee Eun LIM ; Jung Bae YOO ; Hyung MOON ; Doo Sang KIM
Korean Journal of Obstetrics and Gynecology 1993;36(2):264-267
No abstract available.
Cervix Uteri*
;
Female
;
Hysterectomy*
10.Primary Malignant Melanoma arising in Mucosa of the Palatine Tonsil: A case report.
Ki Jung YUN ; Hyang Jeong JO ; Hyung Bae MOON ; Sang Won YOON
Korean Journal of Pathology 1996;30(1):65-67
Maligant melanomas of the oral or nasal cavity, and the vulvovaginal area are relatively common among the melanomas of non-ocular mucosa. But, primary malignant melanoma arising in the mucosa of the palatine tonsil is rare. We present a case of primary malignant melanoma arising in the mucosa of the palatine tonsil. A 36-year-old male was admitted for evaluation of a recurrent sore throat. Tonsillectomy was performed on the basis of clinical suspicion of chronic tonsillitis. Grossly, the left tonsil was focally dark. Microscopically, the tonsillar mucosa was diffusely infiltrated with tumor cells. Tumor cells revealed numerous melanin pigments. Intraepithelial nests of tumor cells were noted, but pagetoid spread of tumor cells was not found. Tumor cells were positive for S-100 protein and HMB45 stain. There was no evidence of melanoma in the skin or eye.
Male
;
Humans