No abstract available.
Calcinosis ; Calcium ; Calcium Gluconate ; Gluconates ; Humans ; Infant, Newborn

BACKGROUND: The purpose of the study was to compare the degree of degeneration of the articular and bursal layers of delaminated supraspinatus tendons based on histological examination. METHODS: Fifty-four patients with a full-thickness rotator cuff tear were included in the study. Tendon specimens were harvested during arthroscopic rotator cuff repair from the lateral torn edges of the articular and bursal layers of the delaminated tear. Harvested samples were stained with H&E dye and evaluated based on a semi-quantitative grading scale. RESULTS: There were no significant differences in the seven histological characteristics of tendon degeneration: fiber structure, fiber arrangement, round nuclei, regional variations in cellularity, vascularity, collagen stainability, and hyalinization between the articular and bursal layers of the delaminated rotator cuff tear (all p>0.05). Total degeneration scores of articular and bursal sides were 13.1 ± 3.85 points and 13.2 ± 3.42 points, respectively, and were not significantly different (p=0.958). CONCLUSIONS: The study demonstrates that tendon degeneration was similar in the articular and bursal sides of the delaminated fullthickness rotator cuff tear, suggesting that degeneration would be a main etiology for the rotator cuff tear not only in the articular side but also in the bursal side. Considering potential disadvantages of subacromial decompression, this study tentatively suggests routine use of subacromial decompression as well as the need for halting or recovery from rotator cuff degeneration for better rotator cuff repair.
Collagen ; Decompression ; Humans ; Hyalin ; Rotator Cuff* ; Tears* ; Tendons

To improve the graft survival in cadaveric donor renal transplantation, various factors that affect the results of allograft function has been analysed and reported. From January 1994 through December 1998, 39 cases of renal transplantation were performed using 20 cadaver donor. Thirty five of them were from brain dead donor and four from cardiac arrest donor. The most frequent cause of brain death was head injury by traffic accident, mostly autobicycle accident. Male donor ratio was 85.0% and their mean age were 29.3 years old. Mean cold ischemic time was 347.5 minutes and warm ischemic time of 4 cardiac arrest cases were 55-60 minutes. The number of HLA mismatch more than 4 were 64.1%. There were 8 cases of multiple renal arteries and 4 cases of double ureter. Donor hypotension during and before kidney procurement and warm ischemic time were factors that cause the delayed graft function in our cases. The number of HLA mismatch and use of Cellcept as immunosuppressant were two factors that affected the development of acute rejection during 6 months after renal allograft. Among the 39 kidneys of 20 donors, 12 paired kidneys showed different graft result in each recipient. Recipient age, number of HLA mismatch, cold ischemic time, duration of hemodialysis before transplantation, and level of hemoglobin were factors that cause the diffrerent result in paired kidney. One and two year graft survival rate were 89.6% and 76.5% respectively. In summary, the early results of our cadaver donor renal transplantation was comparable to living donor transplantation. Adequate donor management and HLA matching between donor and recipient are factors that can improve the graft result.
Accidents, Traffic ; Allografts ; Brain Death ; Cadaver* ; Cold Ischemia ; Craniocerebral Trauma ; Delayed Graft Function ; Graft Survival ; Heart Arrest ; Humans ; Hypotension ; Kidney ; Kidney Transplantation* ; Living Donors ; Male ; Renal Artery ; Renal Dialysis ; Tissue Donors* ; Transplants ; Ureter ; Warm Ischemia

To improve the graft survival in cadaveric donor renal transplantation, various factors that affect the results of allograft function has been analysed and reported. From January 1994 through December 1998, 39 cases of renal transplantation were performed using 20 cadaver donor. Thirty five of them were from brain dead donor and four from cardiac arrest donor. The most frequent cause of brain death was head injury by traffic accident, mostly autobicycle accident. Male donor ratio was 85.0% and their mean age were 29.3 years old. Mean cold ischemic time was 347.5 minutes and warm ischemic time of 4 cardiac arrest cases were 55-60 minutes. The number of HLA mismatch more than 4 were 64.1%. There were 8 cases of multiple renal arteries and 4 cases of double ureter. Donor hypotension during and before kidney procurement and warm ischemic time were factors that cause the delayed graft function in our cases. The number of HLA mismatch and use of Cellcept as immunosuppressant were two factors that affected the development of acute rejection during 6 months after renal allograft. Among the 39 kidneys of 20 donors, 12 paired kidneys showed different graft result in each recipient. Recipient age, number of HLA mismatch, cold ischemic time, duration of hemodialysis before transplantation, and level of hemoglobin were factors that cause the diffrerent result in paired kidney. One and two year graft survival rate were 89.6% and 76.5% respectively. In summary, the early results of our cadaver donor renal transplantation was comparable to living donor transplantation. Adequate donor management and HLA matching between donor and recipient are factors that can improve the graft result.
Accidents, Traffic ; Allografts ; Brain Death ; Cadaver* ; Cold Ischemia ; Craniocerebral Trauma ; Delayed Graft Function ; Graft Survival ; Heart Arrest ; Humans ; Hypotension ; Kidney ; Kidney Transplantation* ; Living Donors ; Male ; Renal Artery ; Renal Dialysis ; Tissue Donors* ; Transplants ; Ureter ; Warm Ischemia

Bronchogenic cysts are rare congenital anomalies that are most frequently found in the mediastinum along the tracheobronchial tree, especially in the posterior aspect of the superior mediastinum. Bronchogenic cysts have also been reported in intrapulmonary, intrapericardial, abdominal, and retroperitoneal locations. Herein, we report a case of a retroperitoneal bronchogenic cyst in the presacral space. The patient was diagnosed based on a post-operative histopathological examination.

Light chain deposition disease (LCDD) is characterized by the deposition of abnormal immunoglobulin light chains in many organs, including kidney. It is usually associated with multiple myeloma or other lymphoproliferative disorders. Myeloma usually occurs in old age and may develop after renal transplantation thus being categorized as posttransplant lymphoproliferative disease (PTLD). Renal LCDD usually presents with variable degree of proteinuria and renal insufficiency. The diagnosis of LCDD depends on histologic findings with detection of monoclonal immunoglobulin light chain. Histologically, it is characterized by nodular glomerulosclerosis. We report the first case of de novo LCDD associated with myeloma after renal transplantation in Korea. With advancing renal transplantation and increasing old aged renal recipients, myeloma or LCDD should be included in the differential diagnoses of renal recipient patients with deteriorating renal function.
Aged ; Diabetic Nephropathies ; Diagnosis, Differential ; Humans ; Immunoglobulin Light Chains ; Kidney ; Kidney Transplantation ; Korea ; Light ; Lymphoproliferative Disorders ; Multiple Myeloma ; Proteinuria ; Renal Insufficiency ; Transplantation, Homologous

Leiomyoma of the vulva is rare neoplasm. It is usually located in the labium majors and in the area of the Batholin gland. We experienced two cases of leiomyoma around urethral meatus which displaced urethra. So we report cases with review of literature.
Leiomyoma* ; Urethra* ; Vulva*

Health Technology Research and Development (R&D) national grant system has been progressed by the unique governance of each countries. From this reason, it has historical context and path-dependency. South Korea, also have started their investment from Bio Technology Master Plan of Ministry of Science and Technology (1994) and Korea Health Technology R&D Project of Ministry of Health and Welfare (1995), currently investing around 1.1 trillion won (in the year 2012) into the Ministry of Education, Science and Technology (now, Ministry of Science, ICT and Future Planning), Ministry of Health and Welfare and Ministry of Knowledge Economy (now, Ministry of Trade, Industry and Energy). This paper focuses on the Health Technology R&D national grant system in the aspect of governance, mid-long term strategic plan, main program, planning-evaluation-management system. And last but not least, implications. First, there would be important to build the effective governance, performance based policy and administration mechanisms of national grant system for the Health Technology R&D. Second, main objective of Health Technology R&D, which is improving the quality of life for the public, could not meet their target practically. Third, R&D investment has been enlarged from treatment based to prevention and care focused and from technology-centered into demand-centered, which based on the unmet health needs. Last, most of Health Technology R&D project could not consider sustainable health system, which would be the most important value in healthcare.
Biomedical Technology* ; Delivery of Health Care ; Education ; Financing, Organized ; Investments ; Korea ; Quality of Life

No abstract available.
Carney Complex* ; Hyperplasia* ; Myxoma* ; Nevus, Blue* ; Testis*

PURPOSE: This study investigated the morphological characteristics of hypertrophic scars of various ages. METHODS: This was a retrospective study. Tissue samples from 170 normal skin (control) and 126 scar tissue after undergoing conservative treatment (CT) (n=62) or split thickness skin graft (STSG) (n=64) were obtained. Time from injury (CT) or surgery (STSG) was grouped into periods as follows: first 6 months (period 1), 7~12 months (period 2), 13~24 months (period 3), 25~120 months (period 4), >120 months (period 5). Epidermal thickness (ET), dermal thickness (DT), and dermal collagen fiber thickness and length (CFT, CFL) were measured using an image analyzer. RESULTS: Scar tissue ET was significantly thicker compared to normal skin (P<0.05) and was greatest at period 1. Scar tissue DT was significantly thicker compared to normal skin (P<0.05), which increased until period 3 but then decreased afterwards. Scar tissue CFT was significantly thinner compared to normal skin (P<0.05) except for period 5. Scar tissue CFL was significantly longer compared to normal skin (P<0.05). Significant differences were observed especially in younger scar ET, DT, CFT, and CFL. CONCLUSION: These findings may assist to increase the understanding of the pathohistological changes in burn scar tissues over time and provide guidance in receiving burn treatment.
Burns ; Cicatrix* ; Cicatrix, Hypertrophic* ; Collagen ; Pathology ; Retrospective Studies ; Skin ; Transplants