1.Operative Errors in Interlocking Intramedullary Nailing for Tibial Fractures
Chung Nam KANG ; Kwon Jae ROH ; Dong Wook KIM ; Yeo Hon YUN ; Yang Hyun KIM
The Journal of the Korean Orthopaedic Association 1995;30(3):665-672
From retrospective review of 111 tibial fractures treated by interlocking intramedullary nailing, 38 operative errors in 28 cases(25%) were included in this study. The errors were classified into two categories. The first category included eighteen errors that related to fracture reduction; nine angular malalignments, four failures in closed nailing to open the fracture site, two peroneal nerve palsies, two shortenings of tibial length(more than 1cm), and one rotational malalignment. The second category comprised twenty errors that related to the nailing itself; eight protrusions of proximal nail tip, five overdistractions of fracture gap (more than 3mm), four additional fragmentations, two mistakes in interlocking screw insertion, and one ankle joint injury by the distal nail tip. Functional results of those 28 cases at the last follow-up(average, 17.5 months; range, 9 to 29 months) were excellent or good in only 60.8 per cent, while the control group treated by adequate operative technique showed excellent or good results in 92.8 per cent.
Ankle Joint
;
Fracture Fixation, Intramedullary
;
Paralysis
;
Peroneal Nerve
;
Retrospective Studies
;
Tibial Fractures
2.Growth of Human Melanocytes in Human Epidermis Reconstructed by Culture.
Kwang Hyun CHO ; Dong Youn LEE ; Seong Gyu YANG ; Un Cheol YEO ; Kyoung Chan PARK ; Jai Il YOUN
Korean Journal of Dermatology 1997;35(3):526-531
BACKGROUND: Melanocytes grown in pure monolayer culure lack many of the cellular interactions that exist in vivo. This can be partially overcome by growing melanocytes together with other epidermal cells in skin equivalent models. OBJECTIVE: The objective of the present study was to grow human melanocytes in human epidermis reconstructed on dermal substrates in vitro and to examine their response to UV radiation. METHODS: The skin equivalents were prepared by seeding cultured human keratinocytes together with cultured human melanocytes(in a ratio of 5%) onto de-epidermized dermis. After 7 days of culture, they were exposed to UVB irradiation(total 150m J/cm over 5days). On day 12 of air exposure the sections of the skin equivalents were prepared for histology. The structure of the skin equivalents was studied following staining with hematoxylin and eosin. Melanocytes were characterized by DOPA staining and by immunohistochemistry. RESULTS: Melanocytes were localized singly within the basal layer of the reconstructs. Melanin was also visible both in the melanocytes and in neighboring keratinocytes. There was an increase in melanocyte size and dendricity following UV irradiation. Melanocytes became positive to staining with HMB-45 antibody following UV irradiation. CONCLUSION: Our results indicate that melanocytes grown in reconstructed human epidermis are functional and capable of responding to UV irradiation.
Dermis
;
Dihydroxyphenylalanine
;
Eosine Yellowish-(YS)
;
Epidermis*
;
Hematoxylin
;
Humans*
;
Immunohistochemistry
;
Keratinocytes
;
Melanins
;
Melanocytes*
;
Skin
3.Successful Immunoglobulin Treatment in Severe Cryptogenic Organizing Pneumonia Caused by Dermatomyositis.
Dong Hoon LEE ; Jee Hyun YEO ; Young Il KIM ; Seung Jun GIM ; Jang Won SOHN ; Ji Young YHI
Korean Journal of Critical Care Medicine 2015;30(3):212-217
In connective tissue diseases, autoantibodies cause pulmonary interstitial inflammation and fibrosis, and patients require treatment with an immunosuppressive agent such as a steroid. Dermatomyositis is an incurable, uncommon form of connective tissue disease that occasionally causes diffuse pulmonary inflammation leading to acute severe respiratory failure. In such cases, the prognosis is very poor despite treatment with high-dose steroid. In the present case, a 46-year-old man was admitted to our hospital with dyspnea. He was diagnosed with dermatomyositis combined with cryptogenic organizing pneumonia (COP) with respiratory failure and underwent treatment with steroid and an immunosuppressive agent, but the COP was not improved. However, the respiratory failure did improve after treatment with intravenous immunoglobulin, which therefore can be considered a treatment option in cases where steroids and immunosuppressive agents are ineffective.
Autoantibodies
;
Connective Tissue Diseases
;
Cryptogenic Organizing Pneumonia*
;
Dermatomyositis*
;
Dyspnea
;
Fibrosis
;
Humans
;
Immunoglobulins*
;
Immunosuppressive Agents
;
Inflammation
;
Lung Diseases, Interstitial
;
Middle Aged
;
Pneumonia
;
Prognosis
;
Respiratory Insufficiency
;
Steroids
4.Olfactory Function and Its Correlation with Cardiac 123I-MIBG in Patients with Parkinson's Disease and Multiple System Atrophy.
Seung Hyeon YEO ; Dong Hoon SHIN ; Hyun Joon KIM ; Phil Hyu LEE
Journal of the Korean Neurological Association 2007;25(1):38-43
BACKGROUND: Olfactory dysfunction is common in patients with Parkinsons disease (PD) and may precede the development of parkinsonian motor symptoms. Cardiac sympathetic denervation, which can be visualized by a cardiac (123)I-metaiodobenzylguanidine (MIBG) scan, is common in patients with PD. In this study, we evaluated olfactory functions in patients with IPD and MSA, and investigated an association between olfaction and cardiac 123I-MIBG uptake in these patients. METHODS: We prospectively enrolled 26 patients with PD, 19 patients with MSA, and 18 healthy controls. Olfactory function was evaluated with a 12-Item Cross-Cultural Smell Identification Test (CC-SIT) and Butanol threshold. 123I-MIBG (111 mBq) was injected intravenously into each subject, and cardiac uptake was imaged 3 hours later. The regions of interest were the whole heart and the mediastinum of the front image, and the ratio of 123I-MIBG uptake in the heart to that in the mediastinum (H/M ratio) was calculated. The clinical stages of parkinsonism were assessed according to the classification of Hoehn and Yahr (H&Y) and the Unified PD Rating Scale (UPDRS). RESULTS: The mean CC-SIT score in patients with PD was 4.4+/-2.2, which was significantly lower than that in patients with MSA (6.7+/-2.0) or in controls (7.3+/-2.6). There was a significant positive correlation between cardiac 123I-MIBG uptake and the CC-SIT score in patients with PD (r=0.56, p=0.003). Neither the CC-SIT score nor cardiac 123I-MIBG uptake were significantly correlated with the disease duration, the H&Y stage or motor UPDRS score. In the patients with MSA, the CC-SIT and cardiac 123I-MIBG uptake did not show a significant correlation with age (r=0.01 and r=0.11, each p>0.05), and they were not significantly correlated with each other (r=0.01, p>0.05). CONCLUSIONS: Our data suggest that the functional loss of the olfactory and cardiac sympathetic systems is closely coupled in PD.
3-Iodobenzylguanidine
;
Classification
;
Heart
;
Humans
;
Mediastinum
;
Multiple System Atrophy*
;
Olfaction Disorders
;
Parkinson Disease*
;
Parkinsonian Disorders
;
Prospective Studies
;
Smell
;
Sympathectomy
5.Comparative study on the physicochemical properties and cytocompatibility of microporous biphasic calcium phosphate ceramics as a bone graft substitute.
Kwang Bum PARK ; Jin Woo PARK ; Hyun Uk AHN ; Dong Jun YANG ; Seok Kyu CHOI ; Il Sung JANG ; Shil Il YEO ; Jo Young SUH
The Journal of the Korean Academy of Periodontology 2006;36(4):797-808
OBJECTIVE: The purpose of this study was to evaluate the physicochemical properties and cytocompatibility of microporous, spherical biphasic calcium phosphate(BCP) ceramics with a 60/40 hydroxyapatite/beta-tricalcium phosphate weight ratio for application as a bone graft substitute. MATERIALS AND METHODS: Microporous, spherical BCP granules(MGSB) were prepared and their basic characteristics were compared with commercially available BCP(MBCP; Biomatlante, France) and deproteinized bovine bone mineral(Bio-Oss; Geistlich-Pharma, Switzerland, BBP; Oscotec, Korea). Their physicochemical properties were evaluated by scanning electron microscopy, X-ray diffractometry, Fourier-transform infrared spectroscopy, inductively coupled plasma atomic emission spectrometer, and Brunauer-Emmett-Teller method. Cell viability and proliferation of MC3T3-E1 cells on different graft materials were evaluated. RESULTS: MGSB granules showed a chemical composition and crystallinity similar with those in MBCP, they showed surface structure characteristic of three dimensionally, well-interconnected micropores. The results of MTT assay showed increases in cell viablity with increasing incubation times. At 4d of incubation, MGSB, MBCP and BBP showed similar values in optical density, but Bio-Oss exhibited significantly lower optical density compared to other bone substitutes(p < 0.05). MGSB showed significantly greater cell number compared to other bone substitutes at 3, 5, and 7d of incubation(p < 0.05), which were similar with those in polystyrene culture plates. CONCLUSION: These results indicated the suitable physicochemical properties of MGSB granules for application as an effective bone graft substitute, which provided compatible environment for osteoblast cell growth. However, further detailed studies are needed to confirm its biological effects on bone formation in vivo.
Bone Substitutes
;
Calcium*
;
Cell Count
;
Cell Survival
;
Ceramics*
;
Crystallins
;
Microscopy, Electron, Scanning
;
Osteoblasts
;
Osteogenesis
;
Plasma
;
Polystyrenes
;
Spectrum Analysis
;
Switzerland
;
Transplants*
6.Clinical Characteristics of Respiratory Extracorporeal Life Support in Elderly Patients with Severe Acute Respiratory Distress Syndrome.
Woo Hyun CHO ; Dong Wan KIM ; Hye Ju YEO ; Seong Hoon YOON ; Seung Eun LEE ; Doo Soo JEON ; Yun Seong KIM ; Bong Soo SON ; Do Hyung KIM
Korean Journal of Critical Care Medicine 2014;29(4):266-272
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) strategy is proposed to reduce the ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). As ECMO use has increased, a number of studies on prognostic factors have been published. Age is estimated to be an important prognostic factor. However, clinical evidences about ECMO use in elderly patients are limited. Therefore, we investigated clinical courses and outcomes of ECMO in elderly patients with ARDS. METHODS: We reviewed medical records of patients with severe ARDS who required ECMO support. Study patients were classified into an elderly group (> or = 65 years) and a non-elderly group (< 65 years). Baseline characteristics, ECMO related outcomes and associated factors were retrospectively analyzed according to group. RESULTS: From February 2011 to June 2013, a total of 31 patients with severe ARDS were treated with ECMO. Overall, 14 (45.2%) were weaned from ECMO, 9 (29.0%) survived to the general ward and 7 (22.6%) survived to discharge. Among the 18 elderly group patients, 7 (38.9%) were weaned from ECMO, 4 (22.2%) were survived to the general ward and 2 (11.1%) were survived to discharge. Overall intensive care unit survival was inversely correlated with concomitant acute kidney injury or septic shock. CONCLUSIONS: In this study, ECMO outcome was poor in severe ARDS patients aged over 65 years. Therefore, the routine use of ECMO in elderly patients with severe ARDS is not warranted except in highly selective cases.
Acute Kidney Injury
;
Aged*
;
Extracorporeal Membrane Oxygenation
;
Humans
;
Intensive Care Units
;
Medical Records
;
Patients' Rooms
;
Respiratory Distress Syndrome, Adult*
;
Retrospective Studies
;
Shock, Septic
;
Ventilator-Induced Lung Injury
7.A Distribution Weighted Prognostic Scoring Model for Node Status in Advanced Rectal Cancer.
Kwang Hee YEO ; Ho Hyun KIM ; Dong Yi KIM ; Young Jin KIM ; Jae Kyun JU
Cancer Research and Treatment 2014;46(1):41-47
PURPOSE: There are various lymph node-based staging systems. Nevertheless, there is debate over the use of parameters such as the number of involved lymph nodes and the lymph node ratio. As a possible option, the distribution of metastatic lymph nodes may have a prognostic significance in rectal cancer. This study is designed to evaluate the impact of distribution-weighted nodal staging on oncologic outcome in rectal cancer. MATERIALS AND METHODS: From a prospectively maintained colorectal cancer database of our institution, a total of 435 patients who underwent a curative low anterior resection for mid and upper rectal cancer between 1995 and 2004 were enrolled. Patients were divided into 3 groups according to the location of apical metastatic nodes. A location-weighted prognostic score was calculated by a scoring model using a logistic regression test for location based-statistical weight to number of lymph nodes. All cases were categorized in quartiles from lymph node I to lymph node IV using this protocol. RESULTS: The location of lymph node metastasis was an independent factor that was associated with a poor prognostic outcome (p<0.001). Based on this result, the location-weighted-nodal prognostic scoring model did not show lesser significant results (p<0.0001) in both overall survival and cancer-free survival analyses. CONCLUSION: The location of apical nodes among the metastatic nodes does not have a lesser significant impact on oncologic result in patients with advanced rectal cancer. A location-weighted prognostic scoring model, which considered the numbers of involved lymph nodes as the rate of significance according to the location, may more precisely predict the survival outcome in patients with lymph node metastasis.
Colorectal Neoplasms
;
Humans
;
Logistic Models
;
Lymph Nodes
;
Neoplasm Metastasis
;
Neoplasm Staging
;
Prospective Studies
;
Rectal Neoplasms*
8.The effect of Vitamin D(3)addition on bone mineral density in postmenopausal hormone replacement.
Sun Won YOO ; Hyun Hee JO ; Kyeong A YEO ; Young Ok LEW ; Dong Jin KWON ; Gi Wook CHUNG ; Jang Heub KIM ; Jin Hong KIM
Korean Journal of Obstetrics and Gynecology 2000;43(6):992-997
OBJECTIVE: To determine the effect of the addition of Vit. D3 (1,25-Dihydroxychole calciferol D3) to the conventional postmenopausal hormone replacement therapy on bone mineral density(BMD) DESIGN: A 2-year retrospective , randomized study Setting : Department of Obstetrics and Gynecology of Catholic university hospital Patients : 388 postmenopausal women were recruited and divided into 5 groups according to treatment regimen; A: conjugated estrogens only treated group(n=146), B : conjugated estrogens and progesterone treated group(n=103), C : conjugated estrogens and Vit.D3 treated group (n=36), D : conjugated estrogens, progesterone and Vit.D3 treated group (n=41), E : control group (n=60). METHODS: The bone mineral density of the lumbar spines and femoral neck were determined by dual-energy X-ray absorptiometry(DEXA) every 2 years. STATISTICS: The difference between before and after treatment was determined by paired t-test. The comparison among the groups were determined by one way ANOVA test and student's t-test. RESULTS: The addition of progesterone to estrogen showed insignificant increase in the lumbar and femoral neck BMD. The addition of Vit. D3 compared with conventional hormone replacement therapy insignificantly influened bone density in women with initially normal BMD, but definitely increase in women with initially osteopenic and osteoporotic BMD of femoral neck rather than lumar spine(p<0.05). CONCLUSIONS: The use of Vit. D3 combined with postmenopausal estrogen replacement effects the increase of BMD in low bone density than normal bone density, especially femoral neck.
Bone Density*
;
Estrogen Replacement Therapy
;
Estrogens
;
Estrogens, Conjugated (USP)
;
Female
;
Femur Neck
;
Gynecology
;
Hormone Replacement Therapy
;
Humans
;
Obstetrics
;
Progesterone
;
Retrospective Studies
;
Spine
;
Vitamins*
9.Acceleration of Wound Healing Using Adipose-derived Stem Cell Therapy with Platelet Concentrates: Platelet-rich Plasma (PRP) vs. Platelet-rich Fibrin (PRF).
Hyung Min HAHN ; Yeo Reum JEON ; Dong Kyun RHA ; Dae Hyun LEW
Journal of the Korean Society of Plastic and Reconstructive Surgeons 2011;38(4):345-350
PURPOSE: Although platelet-rich plasma (PRP) potentiate the wound healing activity of adipose-derived stem cells (ADSCs), its effect cannot be sustained for a prolonged period of time due to short duration of action. This led us to design and produce platelet-rich fibrin (PRF), in an effort to develop a tool which lasts longer, and apply it on wound healing. METHODS: Two symmetrical skin defects were made on the back of seven nude mice. ADSCs were applied to each wound, combined with either PRP or PRF. The wound area was measured over 14 days. By day 16, the wound was harvested and histologic analysis was performed including counting of the blood vessel. RESULTS: The healing rate was more accelerated in PRP group in the first 5 days (p<0.05). However, PRF group surpassed PRP group after 6 days (p<0.05). The average number of blood vessels observed in the PRF group was 6.53 +/- 0.51, compared with 5.68 +/- 0.71 for the PRP group. CONCLUSION: PRF exerts a slow yet pervasive influence over the two-week course of the wound healing process. Thus, PRF is probably more beneficial for promoting the activity of ADSCs for a sustained period of time.
Acceleration
;
Animals
;
Blood Platelets
;
Blood Vessels
;
Fibrin
;
Mice
;
Mice, Nude
;
Platelet-Rich Plasma
;
Skin
;
Stem Cells
;
Wound Healing
10.A CLINICAL AND STATISTICAL STUDY OF CONDYLAR FRACTURE OF MANDIBLE.
Sang Chull LEE ; Yeo Gab KIM ; Dong Mok RYU ; Baek Soo LEE ; Ok Byung YOON ; Teak Hyun JIN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1998;24(3):326-329
This is a retrospective study on condylar fracture of mandible. The stucy based on a series of 112 patients who had treated for the fractures of mandibular condyle on Kyunghee Dental Hospital from January, 1989 to August 1997. We studied the age and sex distributions, causes of fractures, location of fractures and so on. The results as follow : 1. The ratio of male : female was 4:1, and the highest frequency of condylar fractures was registered among patients aged to 21 to 30 years. 2. The most common cause of condylar fractures was fall-down(47.7%), followed in incidence by direct-blow(27.9%) and traffic accidents(20.7%). 3. Subcondylar fracture had highest incidence(50%), and followed by condyle head(27.4%) and condylar neck(22.6%). 4. 9.7% of condylar fractures had occurred bilaterally and in cases of bilateral condylar fractures, condylar head fractures(58.33%) was hightest incidence. 5. Mandibular symphysis was most commonly involved in condylar fracture(63.4%), and 27.7% of condylar fractures had not any other mandibular fractures.
Female
;
Head
;
Humans
;
Incidence
;
Male
;
Mandible*
;
Mandibular Condyle
;
Mandibular Fractures
;
Retrospective Studies
;
Sex Distribution
;
Statistics as Topic*